TJ McCorvie
@allostericstate.bsky.social
Revealing the hidden world of shape shifting enzymes using Cryo-EM. Senior research associate at Newcastle University, UK. Currently working as part of Recon4IMD https://www.recon4imd.org Views are my own.
The more cloning and small scale expressions I do, the more I feel justified in my distrust of Maltose Binding Protein as a solubility tag…
fry from futurama is making a silly face with his eyes closed
Alt: fry from futurama is making a silly face with his eyes closed
media.tenor.com
February 6, 2026 at 8:07 PM
The more cloning and small scale expressions I do, the more I feel justified in my distrust of Maltose Binding Protein as a solubility tag…
Reposted by TJ McCorvie
2nd postdoc job alert in the Crick Institute in London. Project will examine the role of motors & the cytoskeleton (actin, septins and microtubules) during vaccinia virus egress using biochemical, structural & cellular approaches + live cell imaging. spread the word.
crick.ac.uk/WayPostdoc20...
crick.ac.uk/WayPostdoc20...
Postdoctoral Fellow - Cellular signalling and cytoskeletal function lab
crick.ac.uk
February 6, 2026 at 8:29 AM
2nd postdoc job alert in the Crick Institute in London. Project will examine the role of motors & the cytoskeleton (actin, septins and microtubules) during vaccinia virus egress using biochemical, structural & cellular approaches + live cell imaging. spread the word.
crick.ac.uk/WayPostdoc20...
crick.ac.uk/WayPostdoc20...
Reposted by TJ McCorvie
🧪🔭⚛️ PhD studentships at Newcastle in physics and astronomy. This is a really nice department and the students I met there seemed happy!
www.findaphd.com/phds/program...
www.findaphd.com/phds/program...
FindAPhD : PhD Studentship in Astrophysics at Newcastle University at Newcastle University
Apply for a PhD: PhD Studentship in Astrophysics at Newcastle University at Newcastle University
www.findaphd.com
February 5, 2026 at 12:40 PM
🧪🔭⚛️ PhD studentships at Newcastle in physics and astronomy. This is a really nice department and the students I met there seemed happy!
www.findaphd.com/phds/program...
www.findaphd.com/phds/program...
Reposted by TJ McCorvie
The IMB at the University of Queensland is looking for a new Mass Spectrometry Facility Manager. See details below.
Closing date 13th of February.
uq.wd3.myworkdayjobs.com/en-GB/uqcare...
Closing date 13th of February.
uq.wd3.myworkdayjobs.com/en-GB/uqcare...
Mass Spectrometry Platform Manager
Institute for Molecular Bioscience Full-time (100%), permanent position Base salary will be in the range $117,958.12 - $132,247.57+ 17% Superannuation (HEW Level 8) Based at our St Lucia Campus About ...
uq.wd3.myworkdayjobs.com
February 5, 2026 at 12:20 AM
The IMB at the University of Queensland is looking for a new Mass Spectrometry Facility Manager. See details below.
Closing date 13th of February.
uq.wd3.myworkdayjobs.com/en-GB/uqcare...
Closing date 13th of February.
uq.wd3.myworkdayjobs.com/en-GB/uqcare...
Reposted by TJ McCorvie
A publisher who lays off a reporter whose pen is freezing because she's covering a frigid war zone while dodging missiles is not an editor you want to work for, in a more perfect world
February 4, 2026 at 5:07 PM
A publisher who lays off a reporter whose pen is freezing because she's covering a frigid war zone while dodging missiles is not an editor you want to work for, in a more perfect world
Reposted by TJ McCorvie
It breaks my heart every time I review a paper that needs a lot of work, it gets rejected, and then I see it out in another journal with no changes whatsoever
February 1, 2026 at 8:31 PM
It breaks my heart every time I review a paper that needs a lot of work, it gets rejected, and then I see it out in another journal with no changes whatsoever
Reposted by TJ McCorvie
We studied how the glycan shield of alphaherpesvirus fusion protein gB mediates host co-receptor interactions. Great work by Sabrina, check it out!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
February 4, 2026 at 10:01 AM
We studied how the glycan shield of alphaherpesvirus fusion protein gB mediates host co-receptor interactions. Great work by Sabrina, check it out!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by TJ McCorvie
"authors also express frustration at the amount of work expected for a single publishable unit, a concern we
share (while humbly noting that it may not be
held by the same authors when they serve as
reviewers of other work)" <-THAT www.nature.com/articles/s41... ht @ritastrack.bsky.social
share (while humbly noting that it may not be
held by the same authors when they serve as
reviewers of other work)" <-THAT www.nature.com/articles/s41... ht @ritastrack.bsky.social
The ever-changing communication of scientific discovery
Nature Biomedical Engineering - We take a look at how scientific articles have evolved over time and envision possible changes to how research findings are communicated in the age of digital media...
www.nature.com
February 3, 2026 at 9:55 PM
"authors also express frustration at the amount of work expected for a single publishable unit, a concern we
share (while humbly noting that it may not be
held by the same authors when they serve as
reviewers of other work)" <-THAT www.nature.com/articles/s41... ht @ritastrack.bsky.social
share (while humbly noting that it may not be
held by the same authors when they serve as
reviewers of other work)" <-THAT www.nature.com/articles/s41... ht @ritastrack.bsky.social
Reposted by TJ McCorvie
'to treat peer review as a throughput problem is to misunderstand what is at stake. Review is not simply a production stage in the research pipeline; it is one of the few remaining spaces where the scientific community talks to itself.' 1/3
AI is not a peer, so it can’t do peer review
If we still believe that science is a vocation grounded in argument, curiosity and care, we can’t delegate judgement to machines, says Akhil Bhardwaj
www.timeshighereducation.com
February 3, 2026 at 8:17 AM
'to treat peer review as a throughput problem is to misunderstand what is at stake. Review is not simply a production stage in the research pipeline; it is one of the few remaining spaces where the scientific community talks to itself.' 1/3
Reposted by TJ McCorvie
Cryo-EM helped us to engineering a "nickase" in Type I-F-HNH to create new genome editing tools
Great work by Anders Fuglsang, Sweta Rout, Eliska Bartl Koutna, Nicholas Sofos and Alehandro Redondo Gallego
Our new paper is out lnkd.in/eq5fTquf
Great work by Anders Fuglsang, Sweta Rout, Eliska Bartl Koutna, Nicholas Sofos and Alehandro Redondo Gallego
Our new paper is out lnkd.in/eq5fTquf
February 2, 2026 at 10:14 PM
Cryo-EM helped us to engineering a "nickase" in Type I-F-HNH to create new genome editing tools
Great work by Anders Fuglsang, Sweta Rout, Eliska Bartl Koutna, Nicholas Sofos and Alehandro Redondo Gallego
Our new paper is out lnkd.in/eq5fTquf
Great work by Anders Fuglsang, Sweta Rout, Eliska Bartl Koutna, Nicholas Sofos and Alehandro Redondo Gallego
Our new paper is out lnkd.in/eq5fTquf
Reposted by TJ McCorvie
Hi all- we are searching for a new manager/operator to run and develop KCL's Cryo-EM Structural Discovery Facility: a JEOL cryoARM200 + k3 and sample preparation equipment. This 200kV set up recently achieved a 1.2 Å apoferritin! www.biorxiv.org/content/10.6...
www.kcl.ac.uk/jobs/137165-...
www.kcl.ac.uk/jobs/137165-...
Cryo-EM Facility Manager | King's College London
www.kcl.ac.uk
February 3, 2026 at 12:37 PM
Hi all- we are searching for a new manager/operator to run and develop KCL's Cryo-EM Structural Discovery Facility: a JEOL cryoARM200 + k3 and sample preparation equipment. This 200kV set up recently achieved a 1.2 Å apoferritin! www.biorxiv.org/content/10.6...
www.kcl.ac.uk/jobs/137165-...
www.kcl.ac.uk/jobs/137165-...
Reposted by TJ McCorvie
iCASE PhD project available in my lab, combining microscopy method development with high throughput screening of bacteria. Applications to antibiotic drug discovery and screening for new cell division proteins. Collaboration with Cairn Research #microsky #bioimaging
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Image-based bacterial phenotyping and antimicrobial drug discovery using smart high-throughput super-resolution microscopy at University of Warwick on FindAPhD.com
PhD Project - Image-based bacterial phenotyping and antimicrobial drug discovery using smart high-throughput super-resolution microscopy at University of Warwick, listed on FindAPhD.com
www.findaphd.com
February 2, 2026 at 11:11 AM
iCASE PhD project available in my lab, combining microscopy method development with high throughput screening of bacteria. Applications to antibiotic drug discovery and screening for new cell division proteins. Collaboration with Cairn Research #microsky #bioimaging
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by TJ McCorvie
🚀 First DAQ-Score DB update of 2026 is live!
Cryo-EM protein model quality evaluations now cover 266,577 protein chains.
🔗 daqdb.kiharalab.org
🏁Check out also our New ChimeraX plugin! It lets you check DAQ scores during modeling!
cxtoolshed.rbvi.ucsf.edu/apps/chimera...
Cryo-EM protein model quality evaluations now cover 266,577 protein chains.
🔗 daqdb.kiharalab.org
🏁Check out also our New ChimeraX plugin! It lets you check DAQ scores during modeling!
cxtoolshed.rbvi.ucsf.edu/apps/chimera...
February 1, 2026 at 10:54 PM
🚀 First DAQ-Score DB update of 2026 is live!
Cryo-EM protein model quality evaluations now cover 266,577 protein chains.
🔗 daqdb.kiharalab.org
🏁Check out also our New ChimeraX plugin! It lets you check DAQ scores during modeling!
cxtoolshed.rbvi.ucsf.edu/apps/chimera...
Cryo-EM protein model quality evaluations now cover 266,577 protein chains.
🔗 daqdb.kiharalab.org
🏁Check out also our New ChimeraX plugin! It lets you check DAQ scores during modeling!
cxtoolshed.rbvi.ucsf.edu/apps/chimera...
Reposted by TJ McCorvie
Pfs48/45 nanobodies block malaria parasite transmission 🦟 and crystal structures provide structural insight to how they bind 💎
Pfs48/45 is one of the leading transmission blocking vaccine candidates and a critical fertilisation antigen 💕
Please share widely- love to hear your feedback!
Pfs48/45 is one of the leading transmission blocking vaccine candidates and a critical fertilisation antigen 💕
Please share widely- love to hear your feedback!
Pfs48/45 nanobodies block Plasmodium falciparum transmission
Author summary Malaria is spread when an infected Anopheles mosquito bites a human. Within the female Anopheles mosquito, malaria parasite fertilisation occurs in the mosquito midgut. If you inhibit p...
journals.plos.org
February 2, 2026 at 8:36 AM
Pfs48/45 nanobodies block malaria parasite transmission 🦟 and crystal structures provide structural insight to how they bind 💎
Pfs48/45 is one of the leading transmission blocking vaccine candidates and a critical fertilisation antigen 💕
Please share widely- love to hear your feedback!
Pfs48/45 is one of the leading transmission blocking vaccine candidates and a critical fertilisation antigen 💕
Please share widely- love to hear your feedback!
Reposted by TJ McCorvie
Epstein's Academics Hall of Shame here:
Academics vying for a spot in Epstein‘s world. There are so many. I feel the need to make a thread, so I don’t keep confusing them. 1/
January 31, 2026 at 9:37 PM
Epstein's Academics Hall of Shame here:
Reposted by TJ McCorvie
My first ion channel study, a decade after I started working on membrane proteins. We report the cryo-EM structure of TWIK-2 & develop a high-throughput automated patch clamp e-phys assay to screen modulars of TWIK-2 channel activity. A great collaborative team effort.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Insights into the structure and modulation of human TWIK-2 - Nature Communications
TWIK-2 is an endolysosomal potassium channel implicated in inflammatory responses. Here, authors present a cryo-EM structure of human TWIK-2 and establish a high-throughput automated patch-clamp elect...
www.nature.com
January 31, 2026 at 5:59 PM
My first ion channel study, a decade after I started working on membrane proteins. We report the cryo-EM structure of TWIK-2 & develop a high-throughput automated patch clamp e-phys assay to screen modulars of TWIK-2 channel activity. A great collaborative team effort.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by TJ McCorvie
As cryoEM becomes automated people forget
Just Because (JB) it's picked Doesn't Mean (DM) it's a ptcl
JB it's measured DM it's the CTF
JB it's a class ave DM it looks like the ptcls
JB it comes out of ab initio DM its the structure
JB FSC=0.143 DM that's the res'n
JB it's modeled DM it fits the map
Just Because (JB) it's picked Doesn't Mean (DM) it's a ptcl
JB it's measured DM it's the CTF
JB it's a class ave DM it looks like the ptcls
JB it comes out of ab initio DM its the structure
JB FSC=0.143 DM that's the res'n
JB it's modeled DM it fits the map
January 31, 2026 at 3:01 AM
As cryoEM becomes automated people forget
Just Because (JB) it's picked Doesn't Mean (DM) it's a ptcl
JB it's measured DM it's the CTF
JB it's a class ave DM it looks like the ptcls
JB it comes out of ab initio DM its the structure
JB FSC=0.143 DM that's the res'n
JB it's modeled DM it fits the map
Just Because (JB) it's picked Doesn't Mean (DM) it's a ptcl
JB it's measured DM it's the CTF
JB it's a class ave DM it looks like the ptcls
JB it comes out of ab initio DM its the structure
JB FSC=0.143 DM that's the res'n
JB it's modeled DM it fits the map
Reposted by TJ McCorvie
A rule I follow when reviewing cryo-EM manuscripts: if a claim relies on the orientation or interactions of a side chain, the evidence supporting the claim (ie the map density) must be shown.
In general, reviewers are responsible for ensuring claims in manuscripts are supported by data.
In general, reviewers are responsible for ensuring claims in manuscripts are supported by data.
January 30, 2026 at 2:04 PM
A rule I follow when reviewing cryo-EM manuscripts: if a claim relies on the orientation or interactions of a side chain, the evidence supporting the claim (ie the map density) must be shown.
In general, reviewers are responsible for ensuring claims in manuscripts are supported by data.
In general, reviewers are responsible for ensuring claims in manuscripts are supported by data.
Reposted by TJ McCorvie
We are hiring for group leaders again — EBI is a great place to start your research group!
embl.wd103.myworkdayjobs.com/EMBL/job/Hin...
embl.wd103.myworkdayjobs.com/EMBL/job/Hin...
Research Group Leader
Do you want to lead groundbreaking research in computational biology? Join us at EMBL-EBI! EMBL's European Bioinformatics Institute (EMBL-EBI) is seeking talented and highly-motivated scientists to jo...
embl.wd103.myworkdayjobs.com
January 30, 2026 at 9:02 AM
We are hiring for group leaders again — EBI is a great place to start your research group!
embl.wd103.myworkdayjobs.com/EMBL/job/Hin...
embl.wd103.myworkdayjobs.com/EMBL/job/Hin...
Reposted by TJ McCorvie
FoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social.
📄 www.science.org/doi/10.1126/...
🌐 search.foldseek.com/foldmason
💾 github.com/steineggerla...
📄 www.science.org/doi/10.1126/...
🌐 search.foldseek.com/foldmason
💾 github.com/steineggerla...
Multiple protein structure alignment at scale with FoldMason
Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...
www.science.org
January 30, 2026 at 6:11 AM
FoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social.
📄 www.science.org/doi/10.1126/...
🌐 search.foldseek.com/foldmason
💾 github.com/steineggerla...
📄 www.science.org/doi/10.1126/...
🌐 search.foldseek.com/foldmason
💾 github.com/steineggerla...
Reposted by TJ McCorvie
The IKI at Ben-Gurion University is looking for a Staff Scientist to join our CryoEM Unit.
If you’re passionate about #spa and #cryoET, this is a rare opportunity to work in an amazing environment with top-tier science and even better collaborators (myself […]
[Original post on tooot.im]
If you’re passionate about #spa and #cryoET, this is a rare opportunity to work in an amazing environment with top-tier science and even better collaborators (myself […]
[Original post on tooot.im]
January 29, 2026 at 4:24 AM
The IKI at Ben-Gurion University is looking for a Staff Scientist to join our CryoEM Unit.
If you’re passionate about #spa and #cryoET, this is a rare opportunity to work in an amazing environment with top-tier science and even better collaborators (myself […]
[Original post on tooot.im]
If you’re passionate about #spa and #cryoET, this is a rare opportunity to work in an amazing environment with top-tier science and even better collaborators (myself […]
[Original post on tooot.im]
Reposted by TJ McCorvie
Research Fellow role at the University of Leeds applying cryoEM and cryoET to understand amyloid polymorphism in Parkinsons and metabolic disease. Closing date: 8th March
www.dementiaresearcher.nihr.ac.uk/job/research...
www.dementiaresearcher.nihr.ac.uk/job/research...
Research Fellow: Structural Biology - DEMENTIA RESEARCHER
University of Leeds is seeking a Research Fellow using cryoEM and cryoET to study amyloid fibril structures in Parkinsons and type 2 diabetes.
www.dementiaresearcher.nihr.ac.uk
January 28, 2026 at 12:42 PM
Research Fellow role at the University of Leeds applying cryoEM and cryoET to understand amyloid polymorphism in Parkinsons and metabolic disease. Closing date: 8th March
www.dementiaresearcher.nihr.ac.uk/job/research...
www.dementiaresearcher.nihr.ac.uk/job/research...
Reposted by TJ McCorvie
It would be great if the take away here is that substacks are blogs and blogs are essays without editors and editors are important and substacks should be read with their absence in mind
But alas, no, I don’t see that being the lesson learned
But alas, no, I don’t see that being the lesson learned
January 28, 2026 at 4:26 AM
It would be great if the take away here is that substacks are blogs and blogs are essays without editors and editors are important and substacks should be read with their absence in mind
But alas, no, I don’t see that being the lesson learned
But alas, no, I don’t see that being the lesson learned
Reposted by TJ McCorvie
🚀 CryoSPARC v5.0 BETA is here!
We’re excited to deploy another major #CryoSPARC release to help enable and accelerate #cryoEM data analysis. v5 has a redesigned underlying software system and many new features - highlights in thread!
Full changelog: cryosparc.com/updates/v5.0.0
We’re excited to deploy another major #CryoSPARC release to help enable and accelerate #cryoEM data analysis. v5 has a redesigned underlying software system and many new features - highlights in thread!
Full changelog: cryosparc.com/updates/v5.0.0
January 27, 2026 at 8:36 PM
🚀 CryoSPARC v5.0 BETA is here!
We’re excited to deploy another major #CryoSPARC release to help enable and accelerate #cryoEM data analysis. v5 has a redesigned underlying software system and many new features - highlights in thread!
Full changelog: cryosparc.com/updates/v5.0.0
We’re excited to deploy another major #CryoSPARC release to help enable and accelerate #cryoEM data analysis. v5 has a redesigned underlying software system and many new features - highlights in thread!
Full changelog: cryosparc.com/updates/v5.0.0
Reposted by TJ McCorvie
LAST DAY for BCA Spring Meeting abstract submissions. We're want submissions from all of structural biology world - #cryoem, #crystallography, #nmr, #moleculardynamics or any other technique, we'd love to hear from you! Submit your abstract here: hg3.co.uk/bca/ TODAY. Learn more: lnkd.in/e4my5ZRm
January 27, 2026 at 10:07 AM
LAST DAY for BCA Spring Meeting abstract submissions. We're want submissions from all of structural biology world - #cryoem, #crystallography, #nmr, #moleculardynamics or any other technique, we'd love to hear from you! Submit your abstract here: hg3.co.uk/bca/ TODAY. Learn more: lnkd.in/e4my5ZRm