Amy Conte
@amyconte.bsky.social
41 followers
51 following
1 posts
PhD student - Aaron Whiteley Lab
CU Boulder
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Interested in phage-bacteria conflict ⚔️🦠
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Reposted by Amy Conte
Amy Conte
@amyconte.bsky.social
· Jun 4
PLOS Biology
@plosbiology.org
· Jun 4
DnaJ mediates phage sensing by the bacterial NLR-related protein bNACHT25
Bacteria encode homologs of the human NACHT proteins that form inflammasomes, and use them to defend against phage infection. This study shows that the NLR-related protein bNACHT25 detects diverse pha...
plos.io
Reposted by Amy Conte
Ashley Sullivan
@aesully98.bsky.social
· Mar 31
A minimal CRISPR polymerase produces decoy cyclic nucleotides to detect phage anti-defense proteins
Bacteria use antiphage systems to combat phages, their ubiquitous competitors, and evolve new defenses through repeated reshuffling of basic functional units into novel reformulations. A common theme ...
www.biorxiv.org
Reposted by Amy Conte
Emily Kibby
@emilykibby.bsky.social
· Dec 18
A bacterial NLR-related protein recognizes multiple unrelated phage triggers to sense infection
Immune systems must rapidly sense viral infections to initiate antiviral signaling and protect the host. Bacteria encode >100 distinct viral (phage) defense systems and each has evolved to sense cruci...
www.biorxiv.org