Anaïs Pillan
@anaispillan.bsky.social
PhD student in the Cell Cycle and Development lab at Institut Jacques Monod
Reposted by Anaïs Pillan
AlphaFold modeling & new assays for mitotic kinase activation in E. coli (#MITOKINAC) reveal molecular basis of specific Aurora A & PLK1 activation through Bora during mitotic entry
Lionel Pintard @ccdlab.bsky.social et al
#RefereedPreprint ℅ @reviewcommons.org
link.springer.com/article/10.1...
Lionel Pintard @ccdlab.bsky.social et al
#RefereedPreprint ℅ @reviewcommons.org
link.springer.com/article/10.1...
Molecular basis for the activation of Aurora A and Plk1 kinases during mitotic entry - The EMBO Journal
The evolutionarily conserved, intrinsically disordered protein Bora is critical for initiating the activation of mitotic kinases. Once phosphorylated at Ser112 by Cyclin A-Cdk1 kinase, phospho-Bora ac...
link.springer.com
January 28, 2026 at 2:44 PM
AlphaFold modeling & new assays for mitotic kinase activation in E. coli (#MITOKINAC) reveal molecular basis of specific Aurora A & PLK1 activation through Bora during mitotic entry
Lionel Pintard @ccdlab.bsky.social et al
#RefereedPreprint ℅ @reviewcommons.org
link.springer.com/article/10.1...
Lionel Pintard @ccdlab.bsky.social et al
#RefereedPreprint ℅ @reviewcommons.org
link.springer.com/article/10.1...
Reposted by Anaïs Pillan
Additional complementary evidence
by Arianna Esposito Verza, @andrea-musacchio.bsky.social et al
link.springer.com/article/10.1...
and by Anais Pillan, Lionel Pintard @ccdlab.bsky.social et al
link.springer.com/article/10.1...
in our sister journal @embojournal.org
by Arianna Esposito Verza, @andrea-musacchio.bsky.social et al
link.springer.com/article/10.1...
and by Anais Pillan, Lionel Pintard @ccdlab.bsky.social et al
link.springer.com/article/10.1...
in our sister journal @embojournal.org
Molecular requirements for PLK1 activation by T-loop phosphorylation - The EMBO Journal
Activation of PLK1, a master mitotic kinase, requires phosphorylation of its activation segment on Thr210, within a basic consensus sequence for Aurora kinases. Aurora B-dependent phosphorylation of T...
link.springer.com
January 28, 2026 at 3:53 PM
Additional complementary evidence
by Arianna Esposito Verza, @andrea-musacchio.bsky.social et al
link.springer.com/article/10.1...
and by Anais Pillan, Lionel Pintard @ccdlab.bsky.social et al
link.springer.com/article/10.1...
in our sister journal @embojournal.org
by Arianna Esposito Verza, @andrea-musacchio.bsky.social et al
link.springer.com/article/10.1...
and by Anais Pillan, Lionel Pintard @ccdlab.bsky.social et al
link.springer.com/article/10.1...
in our sister journal @embojournal.org
Reposted by Anaïs Pillan
See also the great News&Views comment by Monica Gobran and @plenart.bsky.social - highlighting all three papers!
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Mitotic entry: Bora takes Polo to Aurora, and gives them a hug - The EMBO Journal
The EMBO Journal - Cell division involves the complete reorganization of the cellular architecture, requiring precise coordination of cellular processes in space and time, but how does this control...
link.springer.com
January 28, 2026 at 2:48 PM
See also the great News&Views comment by Monica Gobran and @plenart.bsky.social - highlighting all three papers!
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Anaïs Pillan
#ResultatScientifique🔎| La protéine Bora coordonne simultanément l’activation de deux kinases majeures pour l'entrée en mitose
✍️ Lionel Pintard
👋 @cnrs-idf-villejuif.bsky.social @upcite.bsky.social @ijmonod.bsky.social
@ccdlab.bsky.social
📕 @embojournal.org
buff.ly/efYoPqr
✍️ Lionel Pintard
👋 @cnrs-idf-villejuif.bsky.social @upcite.bsky.social @ijmonod.bsky.social
@ccdlab.bsky.social
📕 @embojournal.org
buff.ly/efYoPqr
Bora, le chef d’orchestre moléculaire qui déclenche l’entrée en mitose
Pour qu’une cellule se divise correctement, l’entrée en mitose doit être déclenchée avec une précision extrême.
buff.ly
January 29, 2026 at 5:01 PM
#ResultatScientifique🔎| La protéine Bora coordonne simultanément l’activation de deux kinases majeures pour l'entrée en mitose
✍️ Lionel Pintard
👋 @cnrs-idf-villejuif.bsky.social @upcite.bsky.social @ijmonod.bsky.social
@ccdlab.bsky.social
📕 @embojournal.org
buff.ly/efYoPqr
✍️ Lionel Pintard
👋 @cnrs-idf-villejuif.bsky.social @upcite.bsky.social @ijmonod.bsky.social
@ccdlab.bsky.social
📕 @embojournal.org
buff.ly/efYoPqr
Reposted by Anaïs Pillan
✍️ The Pintard Lab ( @ccdlab.bsky.social ) published a new article
📖 @embojournal.org
📃 Molecular basis for the activation of Aurora A and Plk1 kinases during mitotic entry
🔗 link.springer.com/article/10.1...
📖 @embojournal.org
📃 Molecular basis for the activation of Aurora A and Plk1 kinases during mitotic entry
🔗 link.springer.com/article/10.1...
January 30, 2026 at 9:22 AM
✍️ The Pintard Lab ( @ccdlab.bsky.social ) published a new article
📖 @embojournal.org
📃 Molecular basis for the activation of Aurora A and Plk1 kinases during mitotic entry
🔗 link.springer.com/article/10.1...
📖 @embojournal.org
📃 Molecular basis for the activation of Aurora A and Plk1 kinases during mitotic entry
🔗 link.springer.com/article/10.1...
Reposted by Anaïs Pillan
Joly & @ccdlab.bsky.social reveal how the enzyme Katanin prevents wasting energy during microtubule remodeling. They show how Katanin links activation to microtubule binding, avoiding unnecessary ATP consumption & providing insights important for cell biology & disease. rupress.org/jcb/article/...
November 19, 2025 at 5:00 PM
Joly & @ccdlab.bsky.social reveal how the enzyme Katanin prevents wasting energy during microtubule remodeling. They show how Katanin links activation to microtubule binding, avoiding unnecessary ATP consumption & providing insights important for cell biology & disease. rupress.org/jcb/article/...