Anna Kuchina
@annabiosys.bsky.social
110 followers 150 following 4 posts
Assistant Professor at @isbscience.org studying single-cell lifestyles of bacteria.
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annabiosys.bsky.social
How can single-cell transcriptomics profile phage infection in individual microbial cells? Check out our preprint with Anika Gupta, Norma Morella, Dmitry Sutormin & other authors, in collaboration with Georg Seelig (UW) and Neel Dey (Fred Hutch). www.biorxiv.org/content/10.1...
Combinatorial phenotypic landscape enables bacterial resistance to phage infection
Success of phage therapies is limited by bacterial defenses against phages. While a large variety of anti-phage defense mechanisms has been characterized, how expression of these systems is distribute...
www.biorxiv.org
annabiosys.bsky.social
Dmitry explains how surprisingly universal functional patterns emerge once you look closer into a bacterial community. @isbscience.org
isbscience.org
It’s #PostdocAppreciation Week!

@isbscience.org Postdoc Dr. Dmitry Sutormin found gut bacteria form 3 guilds:

Stressors
Metabolizers
Growers

A survival “bet-hedging” strategy that helps them adapt.

🎥 Watch Dmitry explain: youtu.be/5LG_Ae0SiFg
Inside the Hidden Lives of Bacteria
YouTube video by Institute for Systems Biology
youtu.be
annabiosys.bsky.social
What an astonishing achievement, congratulations Mary! @isbscience.org
isbscience.org
This morning, @isbscience.org's Dr. Mary Brunkow was awarded the 2025 Nobel Prize in Physiology or Medicine! Dr. Brunkow shares the award with Fred Ramsdell and Shimon Sakaguchi. Read the press release here: www.nobelprize.org/.../medicine....

What a tremendous honor! Congratulations!
annabiosys.bsky.social
Estimation of diet from the metagenomics data is now possible! Curious to see how this can be applied for reanalyzing existing datasets to link the diet information with the data
cdiener.com
Happy to announce that MEDI, our method to quantify dietary intake through metagenomics is out now. 🧬 🧪🧫🦠 www.nature.com/articles/s42...

#metagenomics #microbiome #microbiomesky

So what is MEDI? A combination of two things:
Metagenomic estimation of dietary intake from human stool - Nature Metabolism
Diener et al. present a method that allows the estimation of dietary intake from human stool by detecting food-derived DNA in faecal metagenomes.
www.nature.com
Reposted by Anna Kuchina
gibbological.bsky.social
What a stupid, petty move (rising to the top of the many many stupid, petty moves by this administration so far).

Dispersing free HIV medication is one of the greatest unequivocally 'good' things the US does for the world. This program has saved 25 million lives. Why the fuck would you cut it?!
apoorvanyt.bsky.social
BREAKING: The Trump administration has instructed organizations in other countries to stop disbursing HIV medications purchased with U.S. aid, even if the drugs have already been obtained and are sitting in local clinics.

www.nytimes.com/2025/01/27/h...
Trump Administration Halts H.I.V. Drug Distribution in Poor Countries (Gift Article)
PEPFAR’s computer systems also are being taken offline, a sign that the program may not return, as Republican critics had hoped.
www.nytimes.com
Reposted by Anna Kuchina
astrokatie.com
I think some people hear “grants” and think that without them, scientists and government workers just have less stuff to play with at work. But grants fund salaries for students, academics, researchers, and people who work in all areas of public service.

“Pausing” grants means people don’t eat.
White House pauses all federal grants, sparking confusion
The Trump administration has put a hold on all federal financial grants and loans, affecting tens of billions of dollars in payments.
www.washingtonpost.com
annabiosys.bsky.social
How can single-cell transcriptomics profile phage infection in individual microbial cells? Check out our preprint with Anika Gupta, Norma Morella, Dmitry Sutormin & other authors, in collaboration with Georg Seelig (UW) and Neel Dey (Fred Hutch). www.biorxiv.org/content/10.1...
Combinatorial phenotypic landscape enables bacterial resistance to phage infection
Success of phage therapies is limited by bacterial defenses against phages. While a large variety of anti-phage defense mechanisms has been characterized, how expression of these systems is distribute...
www.biorxiv.org
Reposted by Anna Kuchina
isbscience.org
ISB @isbscience.org · Dec 2
ISB Associate Professor Dr. Wei Wei has developed a promising new companion diagnostic tool called MetaboCore to help physicians quickly select the most effective systemic therapy for each cancer patient. Learn more: isbscience.org/news/2024/11...
ISB-Developed MetaboCore Offers Precision Cancer Care Faster Than Ever
ISB's MetaboCore is a diagnostic tool that can help physicians quickly select the most effective systemic therapy for each cancer patient.
isbscience.org
Reposted by Anna Kuchina
Reposted by Anna Kuchina
flash-point.bsky.social
Finally caught up with some beautiful work from Alex Meeske in Nature! His lab has identified proteins in Listeria that either substitute for Cas in Cascade complexes (anti-type I-B CRISPR immunity) or degrade crRNA (anti-type VI-A CRISPR immunity). Inspiring stuff!

www.nature.com/articles/s41...
Diverse viral cas genes antagonize CRISPR immunity - Nature
We demonstrate that phages have co-opted cas genes from CRISPR defence systems, which subsequently evolved anti-defence functions.
www.nature.com
Reposted by Anna Kuchina
gibbological.bsky.social
Great highlight by Chandra and @pipethero.bsky.social on recently published work by my colleague @flash-point.bsky.social (from his postdoc work) on endocannabanoids produced by specific members of the gut microbiota that likely impact host satiety/appetite. @isbscience.org

doi.org/10.1016/j.ch...
Redirecting
doi.org