Anoushka Dua MD
@anoushkaduamd.bsky.social
2nd Year GI fellow at UC Irvine by way of UCLA Internal Med 💙💛 #WomeninGI ACG Women in GI Committee | ACG EBGI ambassador | views = my own
THE GREAT DEBATE: Blood-Based Testing:
🔹⬇️ in CRC incidence/mortality NOT as dramatic as for FIT & colonoscopy
🔹High sensitivity for any stage CRC, though notably lower for stage 1 CRC and low for advanced precancerous lesions
🔹Would take a VERY ⬆️ participation to be = FIT
🔹⬇️ in CRC incidence/mortality NOT as dramatic as for FIT & colonoscopy
🔹High sensitivity for any stage CRC, though notably lower for stage 1 CRC and low for advanced precancerous lesions
🔹Would take a VERY ⬆️ participation to be = FIT
May 5, 2025 at 3:24 AM
THE GREAT DEBATE: Blood-Based Testing:
🔹⬇️ in CRC incidence/mortality NOT as dramatic as for FIT & colonoscopy
🔹High sensitivity for any stage CRC, though notably lower for stage 1 CRC and low for advanced precancerous lesions
🔹Would take a VERY ⬆️ participation to be = FIT
🔹⬇️ in CRC incidence/mortality NOT as dramatic as for FIT & colonoscopy
🔹High sensitivity for any stage CRC, though notably lower for stage 1 CRC and low for advanced precancerous lesions
🔹Would take a VERY ⬆️ participation to be = FIT
It is our responsibility as GI doctors to directly inform patients who are found to have advanced adenomas:
✅Future surveillance should occur at no > 5y intervals
✅Children? If so, should be screened starting at age 40!
I always ☎️ patients to tell them verbally!🗣️
#GISky #Gastrosky
✅Future surveillance should occur at no > 5y intervals
✅Children? If so, should be screened starting at age 40!
I always ☎️ patients to tell them verbally!🗣️
#GISky #Gastrosky
April 23, 2025 at 4:58 AM
It is our responsibility as GI doctors to directly inform patients who are found to have advanced adenomas:
✅Future surveillance should occur at no > 5y intervals
✅Children? If so, should be screened starting at age 40!
I always ☎️ patients to tell them verbally!🗣️
#GISky #Gastrosky
✅Future surveillance should occur at no > 5y intervals
✅Children? If so, should be screened starting at age 40!
I always ☎️ patients to tell them verbally!🗣️
#GISky #Gastrosky
Day 1 of the Scrubs & Heels Annual Summit, catching up with friends and mentors!
It’s going to be a great weekend ❤️
#GISky
#GastroSky
#WomeninMedicine
It’s going to be a great weekend ❤️
#GISky
#GastroSky
#WomeninMedicine
April 5, 2025 at 5:14 AM
Day 1 of the Scrubs & Heels Annual Summit, catching up with friends and mentors!
It’s going to be a great weekend ❤️
#GISky
#GastroSky
#WomeninMedicine
It’s going to be a great weekend ❤️
#GISky
#GastroSky
#WomeninMedicine
So grateful for the support of our leadership in facilitating my vision for our first annual Dress in Blue Day at UCI Health!
🔹Average risk screening begins at age 45
🔹Both structural and stool-based screening tests available
🔹The best test is the one that gets done!
#ColorectalCancerAwarenessMonth
🔹Average risk screening begins at age 45
🔹Both structural and stool-based screening tests available
🔹The best test is the one that gets done!
#ColorectalCancerAwarenessMonth
March 26, 2025 at 5:22 AM
So grateful for the support of our leadership in facilitating my vision for our first annual Dress in Blue Day at UCI Health!
🔹Average risk screening begins at age 45
🔹Both structural and stool-based screening tests available
🔹The best test is the one that gets done!
#ColorectalCancerAwarenessMonth
🔹Average risk screening begins at age 45
🔹Both structural and stool-based screening tests available
🔹The best test is the one that gets done!
#ColorectalCancerAwarenessMonth
Outstanding @amcollegegastro.bsky.social VGR yesterday by Dr. Carol Burke on my favorite topic!
👇🏽Who to test for polyposis syndrome vs Lynch syndrome
👇🏽Types of multigene panels
🧬10-34% of CRC attributed to a germline pathogenic variant, depending on age group! 😮
#Gastrosky
👇🏽Who to test for polyposis syndrome vs Lynch syndrome
👇🏽Types of multigene panels
🧬10-34% of CRC attributed to a germline pathogenic variant, depending on age group! 😮
#Gastrosky
March 22, 2025 at 3:30 AM
Outstanding @amcollegegastro.bsky.social VGR yesterday by Dr. Carol Burke on my favorite topic!
👇🏽Who to test for polyposis syndrome vs Lynch syndrome
👇🏽Types of multigene panels
🧬10-34% of CRC attributed to a germline pathogenic variant, depending on age group! 😮
#Gastrosky
👇🏽Who to test for polyposis syndrome vs Lynch syndrome
👇🏽Types of multigene panels
🧬10-34% of CRC attributed to a germline pathogenic variant, depending on age group! 😮
#Gastrosky
March 19, 2025 at 2:17 AM
11/
References📄:
1. bit.ly/3RdSnpA
2. bit.ly/3FKSRky
3. bit.ly/4bxcAQR, bit.ly/42bmcgR
4. bit.ly/4iBxnoH, bit.ly/4hEie4T
References📄:
1. bit.ly/3RdSnpA
2. bit.ly/3FKSRky
3. bit.ly/4bxcAQR, bit.ly/42bmcgR
4. bit.ly/4iBxnoH, bit.ly/4hEie4T
March 19, 2025 at 2:17 AM
11/
References📄:
1. bit.ly/3RdSnpA
2. bit.ly/3FKSRky
3. bit.ly/4bxcAQR, bit.ly/42bmcgR
4. bit.ly/4iBxnoH, bit.ly/4hEie4T
References📄:
1. bit.ly/3RdSnpA
2. bit.ly/3FKSRky
3. bit.ly/4bxcAQR, bit.ly/42bmcgR
4. bit.ly/4iBxnoH, bit.ly/4hEie4T
10/
Q5: What are some of the latest advancements in the treatment of hereditary colorectal cancer syndromes?
#Gastrosky
Q5: What are some of the latest advancements in the treatment of hereditary colorectal cancer syndromes?
#Gastrosky
March 19, 2025 at 2:17 AM
10/
Q5: What are some of the latest advancements in the treatment of hereditary colorectal cancer syndromes?
#Gastrosky
Q5: What are some of the latest advancements in the treatment of hereditary colorectal cancer syndromes?
#Gastrosky
9/
VUS: genetic alteration w/ unknown disease risk
🧬 Common, found in 30-50% of patients undergoing multigene panel testing
🧬 >90% of VUS are re-classified as benign over ⏰
⚠️ Do 🚫 recommend changing medical management based on VUS alone!
VUS: genetic alteration w/ unknown disease risk
🧬 Common, found in 30-50% of patients undergoing multigene panel testing
🧬 >90% of VUS are re-classified as benign over ⏰
⚠️ Do 🚫 recommend changing medical management based on VUS alone!
March 19, 2025 at 2:17 AM
9/
VUS: genetic alteration w/ unknown disease risk
🧬 Common, found in 30-50% of patients undergoing multigene panel testing
🧬 >90% of VUS are re-classified as benign over ⏰
⚠️ Do 🚫 recommend changing medical management based on VUS alone!
VUS: genetic alteration w/ unknown disease risk
🧬 Common, found in 30-50% of patients undergoing multigene panel testing
🧬 >90% of VUS are re-classified as benign over ⏰
⚠️ Do 🚫 recommend changing medical management based on VUS alone!
8/
Q4: What are the implications of identifying a ”variant of uncertain significance” on genetic testing🧬?
#Gastrosky
Q4: What are the implications of identifying a ”variant of uncertain significance” on genetic testing🧬?
#Gastrosky
March 19, 2025 at 2:17 AM
8/
Q4: What are the implications of identifying a ”variant of uncertain significance” on genetic testing🧬?
#Gastrosky
Q4: What are the implications of identifying a ”variant of uncertain significance” on genetic testing🧬?
#Gastrosky
7/
NCCN guidelines excellent but complex 👇🏽
bit.ly/4iQwTei
Broadly speaking, think about referring if:
🔎 Early onset cancer age < 50
🔎 Multiple cancers or >10 polyps
🔎 Multiple cancers on same side of family
Note: absence of family hx does not 🚫 a hereditary syndrome!
NCCN guidelines excellent but complex 👇🏽
bit.ly/4iQwTei
Broadly speaking, think about referring if:
🔎 Early onset cancer age < 50
🔎 Multiple cancers or >10 polyps
🔎 Multiple cancers on same side of family
Note: absence of family hx does not 🚫 a hereditary syndrome!
March 19, 2025 at 2:17 AM
7/
NCCN guidelines excellent but complex 👇🏽
bit.ly/4iQwTei
Broadly speaking, think about referring if:
🔎 Early onset cancer age < 50
🔎 Multiple cancers or >10 polyps
🔎 Multiple cancers on same side of family
Note: absence of family hx does not 🚫 a hereditary syndrome!
NCCN guidelines excellent but complex 👇🏽
bit.ly/4iQwTei
Broadly speaking, think about referring if:
🔎 Early onset cancer age < 50
🔎 Multiple cancers or >10 polyps
🔎 Multiple cancers on same side of family
Note: absence of family hx does not 🚫 a hereditary syndrome!
6/
Q3: In what clinical scenarios should gastroenterology providers think about referring patients for genetic testing🧬?
#Gastrosky
Q3: In what clinical scenarios should gastroenterology providers think about referring patients for genetic testing🧬?
#Gastrosky
March 19, 2025 at 2:17 AM
6/
Q3: In what clinical scenarios should gastroenterology providers think about referring patients for genetic testing🧬?
#Gastrosky
Q3: In what clinical scenarios should gastroenterology providers think about referring patients for genetic testing🧬?
#Gastrosky
5/
📝Simple 3Q screening tool (Kastrinos et al. 2009) is feasible!
1. FDR < 50 with CRC, CA of uterus, ovary, stomach, small intestine, urinary tract, bile duct, pancreas, brain?
2. CRC or polyps at age < 50?
3. 3+ relatives w/ CRC?
✅High sensitivity
✅Supported by MSTF on CRC
📝Simple 3Q screening tool (Kastrinos et al. 2009) is feasible!
1. FDR < 50 with CRC, CA of uterus, ovary, stomach, small intestine, urinary tract, bile duct, pancreas, brain?
2. CRC or polyps at age < 50?
3. 3+ relatives w/ CRC?
✅High sensitivity
✅Supported by MSTF on CRC
March 19, 2025 at 2:17 AM
5/
📝Simple 3Q screening tool (Kastrinos et al. 2009) is feasible!
1. FDR < 50 with CRC, CA of uterus, ovary, stomach, small intestine, urinary tract, bile duct, pancreas, brain?
2. CRC or polyps at age < 50?
3. 3+ relatives w/ CRC?
✅High sensitivity
✅Supported by MSTF on CRC
📝Simple 3Q screening tool (Kastrinos et al. 2009) is feasible!
1. FDR < 50 with CRC, CA of uterus, ovary, stomach, small intestine, urinary tract, bile duct, pancreas, brain?
2. CRC or polyps at age < 50?
3. 3+ relatives w/ CRC?
✅High sensitivity
✅Supported by MSTF on CRC
4/
Q2: What are the key elements of a family history that should be collected to assess the risk of hereditary colorectal cancer?
#Gastrosky
Q2: What are the key elements of a family history that should be collected to assess the risk of hereditary colorectal cancer?
#Gastrosky
March 19, 2025 at 2:17 AM
4/
Q2: What are the key elements of a family history that should be collected to assess the risk of hereditary colorectal cancer?
#Gastrosky
Q2: What are the key elements of a family history that should be collected to assess the risk of hereditary colorectal cancer?
#Gastrosky
3/
Hereditary CRC makes up:
🔹10% of all CRC
🔹16% of all CRC in age < 50
Most common: Lynch syndrome
Caused by:
🧬MMR gene mutations including MLH1, MSH2, MSH6, PMS2
or
🧬EPCAM mutation which sits upstream of MSH2)
Prevalence: 1/279 individuals in general population👥
Hereditary CRC makes up:
🔹10% of all CRC
🔹16% of all CRC in age < 50
Most common: Lynch syndrome
Caused by:
🧬MMR gene mutations including MLH1, MSH2, MSH6, PMS2
or
🧬EPCAM mutation which sits upstream of MSH2)
Prevalence: 1/279 individuals in general population👥
March 19, 2025 at 2:17 AM
3/
Hereditary CRC makes up:
🔹10% of all CRC
🔹16% of all CRC in age < 50
Most common: Lynch syndrome
Caused by:
🧬MMR gene mutations including MLH1, MSH2, MSH6, PMS2
or
🧬EPCAM mutation which sits upstream of MSH2)
Prevalence: 1/279 individuals in general population👥
Hereditary CRC makes up:
🔹10% of all CRC
🔹16% of all CRC in age < 50
Most common: Lynch syndrome
Caused by:
🧬MMR gene mutations including MLH1, MSH2, MSH6, PMS2
or
🧬EPCAM mutation which sits upstream of MSH2)
Prevalence: 1/279 individuals in general population👥
March 19, 2025 at 2:17 AM
1/12 Wanted to share my 5-question "Q&A with an Expert" on 🧬Hereditary Colorectal Cancer Risk🧬 with @swatipatelmd.bsky.social
Put together as part of my involvement in the @amcollegegastro.bsky.social Evidence-Based GI group for #ColorectalCancerAwarenessMonth!
🧠 Scroll to learn more 👇🏽
Put together as part of my involvement in the @amcollegegastro.bsky.social Evidence-Based GI group for #ColorectalCancerAwarenessMonth!
🧠 Scroll to learn more 👇🏽
March 19, 2025 at 2:17 AM
1/12 Wanted to share my 5-question "Q&A with an Expert" on 🧬Hereditary Colorectal Cancer Risk🧬 with @swatipatelmd.bsky.social
Put together as part of my involvement in the @amcollegegastro.bsky.social Evidence-Based GI group for #ColorectalCancerAwarenessMonth!
🧠 Scroll to learn more 👇🏽
Put together as part of my involvement in the @amcollegegastro.bsky.social Evidence-Based GI group for #ColorectalCancerAwarenessMonth!
🧠 Scroll to learn more 👇🏽
Months of planning our first annual #DressinBlueDay came to fruition today at UCI Health!
☑️Educating staff and visitors about CRC
☑️Trivia and prizes, courtesy of @fightcrc.bsky.social and Colon Cancer Coalition
☑️Photo station
☑️Line dancing - physical inactivity is a modifiable risk factor!
☑️Educating staff and visitors about CRC
☑️Trivia and prizes, courtesy of @fightcrc.bsky.social and Colon Cancer Coalition
☑️Photo station
☑️Line dancing - physical inactivity is a modifiable risk factor!
March 8, 2025 at 2:21 AM
Months of planning our first annual #DressinBlueDay came to fruition today at UCI Health!
☑️Educating staff and visitors about CRC
☑️Trivia and prizes, courtesy of @fightcrc.bsky.social and Colon Cancer Coalition
☑️Photo station
☑️Line dancing - physical inactivity is a modifiable risk factor!
☑️Educating staff and visitors about CRC
☑️Trivia and prizes, courtesy of @fightcrc.bsky.social and Colon Cancer Coalition
☑️Photo station
☑️Line dancing - physical inactivity is a modifiable risk factor!
Gearing up for Colorectal Cancer Awareness month 💙
…by making my non-medical husband create a colon photo frame for my institution’s “Dress in Blue day” event on Friday 😋
#CRCawarenessmonth
…by making my non-medical husband create a colon photo frame for my institution’s “Dress in Blue day” event on Friday 😋
#CRCawarenessmonth
March 2, 2025 at 5:17 AM
Gearing up for Colorectal Cancer Awareness month 💙
…by making my non-medical husband create a colon photo frame for my institution’s “Dress in Blue day” event on Friday 😋
#CRCawarenessmonth
…by making my non-medical husband create a colon photo frame for my institution’s “Dress in Blue day” event on Friday 😋
#CRCawarenessmonth
Really enjoyed my time at the @amcollegegastro.bsky.social #2ndyearfellowscourse practicing lifting and EMR with the talented DrBloodandGuts (Andy Tau!)🩸💉✂️
January 21, 2025 at 10:17 PM
Really enjoyed my time at the @amcollegegastro.bsky.social #2ndyearfellowscourse practicing lifting and EMR with the talented DrBloodandGuts (Andy Tau!)🩸💉✂️