Led by @maddalenastn.bsky.social , Niccolò Cirone & Marta Biondo, in a fun collaboration with Matteo Osella

How can we quantify cell potency from scRNAseq data?
In our latest preprint, we show that intrinsic dimensionality (ID) tracks potency in single cells across reprogramming datasets, and we provide IDEAS, a Python toolkit for ID-based potency analysis: www.biorxiv.org/content/10.1...

🎤 Apply to speak @our TALENT FORUM by July 31!
Showcase YOUR research in Epigenetics & NucleicAcids @www.helmholtz-munich.de & connect with leading scientists

🧳Travel+accommodation covered if selected!
📝 Info+how to apply: lnkd.in/drkRvz7N

#postdoc #career #groupleader #HelmholtzMunich #research

NEW PAPER ALERT!!

🥚And a new powerful tool for modeling early human development!

@antonio-scialdone.bsky.social ’s lab @www.helmholtz-munich.de & A. Surani’s lab at University Cambridge uncover key insights into early #humandevelopment with 3D human #gastruloids.

Read our news: shorturl.at/7FjGT

Human #gastruloids as a model for the emergence of #PGCs www.science.org/doi/10.1126/...; early days but it promises as it follows the earlier work of @nmoris.bsky.social on mouse PGCs shorturl.at/FO1p0

Here’s our latest study on human gastruloids:
www.science.org/doi/10.1126/...

With the Surani lab, we combine imaging, scRNA-seq and genetic perturbation to investigate the emergence of amnion-&PGC-like cells.
Congrats to Jitesh Neupane, Gabriele Lubatti and all co-authors for their great work!

Great collaboration with @evahoermanseder.bsky.social's lab, led by Tomas Zikmund and Jonathan Fiorentino

Why do some cells resist nuclear reprogramming? Using nuclear transfer, we tracked single-cell fate changes in vivo and uncovered cell-type-specific barriers to reprogramming. Suppressing the old identity boosts success!

www.cell.com/stem-cell-re...

Great team effort, led by @marcostock.bsky.social , with Corinna Losert, @mattezambon.bsky.social, Niclas Popp, Gabriele Lubatti, @evahoermanseder.bsky.social & Matthias Heinig

How can we improve gene regulatory network inference from noisy scRNA-seq data? Our new review in @molsystbiol.org explores the latest methods integrating prior knowledge to enhance reliability. Plus, some suggestions on how to improve benchmarking!
www.embopress.org/doi/full/10....

Join our lab for a summer internship at Helmholtz Munich! Only 1 week left to apply!

✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨

📄 Check it out here:
doi.org/10.1101/2025...

👇 Highlights below

Join us at the next conference on the frontiers between Biological Physics and Statistical Mechanics:
indico.unina.it/event/91/
Contributed talk submission is open.

Please RS/RT. #GordonConference on "Histone and DNA Modifications" #epigenetics #chromatin 20-25. July 2025. Il Ciocco, Italy. Great speaker lineup.
➡️Register now www.grc.org/histone-and-...