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Reposted by Aranzazu Arias-Rojas

PLOS Biology @plosbiology.org · 1d

Sleep is often only investigated from a single dimension. @bttyeo.bsky.social &co identify 5 sleep-biopsychosocial profiles that link self-reported #sleep patterns to variability in #health, #cognition & #lifestyle factors in 770 healthy young adults @plosbiology.org 🧪 plos.io/42tRXSc

Canonical correlation analysis reveals five sleep-biopsychosocial profiles (LCs). Scatter plots showing correlations between biopsychosocial and sleep canonical scores. Each dot represents a different participant. The inset shows the null distribution of canonical correlations obtained by permutation testing; note that the null distribution is not centered at zero. The dashed line indicates the actual canonical correlation computed for each LC. The distribution of sleep (top) and biopsychosocial (right) canonical scores is shown on rain cloud plots.

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Reposted by Aranzazu Arias-Rojas

Nature Microbiology @natmicrobiol.nature.com · 7d

#Perspective

Estrela and Huang discuss nutrient starvation in the context of the gut microbiome, outlining what is known and highlighting key questions for future research to address knowledge gaps.

#MicroSky #MicrobiomeSky 🦠

www.nature.com/articles/s41...

How nutrient starvation impacts the gut microbiome - Nature Microbiology

In this Perspective, Estrela and Huang discuss nutrient starvation in the context of the gut microbiome, outlining what is known and highlighting key questions for future research to address knowledge gaps.

www.nature.com

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Reposted by Aranzazu Arias-Rojas

Julie Boisard @protistsforthewin.bsky.social · 12d

Now completely published :)
Really proud of this paper led with Karla at @cstairs.bsky.social lab.
doi.org/10.1093/isme...

Anaerobic breviate protist survival in microcosms depends on microbiome metabolic function

Abstract. Anoxic and hypoxic environments serve as habitats for diverse microorganisms, including unicellular eukaryotes (protists) and prokaryotes. To thr

doi.org

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Aranzazu Arias-Rojas @aranzazuarias.bsky.social · 19d

@eugecc.bsky.social

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Reposted by Aranzazu Arias-Rojas

PLOS Biology @plosbiology.org · 19d

How do your #linguistic, #economic & #gender backgrounds impact your #scientific productivity? @tatsuya-amano.bsky.social & co reveal that being a woman, a non-native English speaker, and from a low-income country is associated with a 70% reduction in productivity @plosbiology.org 🧪 plos.io/4n3RLRQ

Scientific productivity gap based on English-language peer-reviewed papers. Shown are the maximum % differences in the number of peer-reviewed papers published by female native English speakers from a high-income country (-45%), female non-native English speakers from a high-income country (-60%), and female non-native English speakers from a lower-middle income country (-70%), compared to male native English speakers from a high-income country (red flag). Credit: Tatsuya Amano

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Reposted by Aranzazu Arias-Rojas

PLOS Biology @plosbiology.org · 23d

The #Drosophila Dscam1 gene generates 10000s of isoforms, but only a small fraction supports neuronal functions. This study shows that #fitness & #immunity are the likely primary evolutionary drivers of Dscam1 isoform diversity in #arthropods @plosbiology.org 🧪 plos.io/4gp8cWd

Top: Dscam1 gene structure and isoform diversity in pancrustacean species. Top: Schematic diagrams of Drosophila melanogaster Dscam1 gene and protein structure. The variable exons or domains are shown in color, while the constant exons or domains are shown in gray. Middle: Phylogenetic distribution of Dscam1 isoform diversity. A phylogenetic tree of Pancrustacean species is shown in the lower panel. The upper panel shows distribution of the number of exons in variable exon 4, exon 6, or exon 9 clusters in Pancrustacean species, with variable exon clusters shown in different colors. The middle panel shows distribution of the number of potential ectodomains diversity, where species with a special number of diversities are highlighted. Bottom: Reducing the Dscam1 diversity affects adult survival upon Beauveria bassiana infection. Survival curves after Triton or B. bassiana infection for wild-type and exon 4 (left), exon 6 (middle), and exon 9 (right) mutants are shown, respectively. The Triton groups (control) are represented by solid lines, while the B. bassiana groups are represented by dashed lines.

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Reposted by Aranzazu Arias-Rojas

PLOS Biology @plosbiology.org · Sep 8

Many bacteria use #QuorumSensing to control genes based on population density. @jrchandler.bsky.social &co explore a @plosbiology.org study showing that in P. aeruginosa, 2 QS circuits activate each other, enhancing robustness & explaining redundancy 🧪 Paper: plos.io/3I7DhRG Primer: plos.io/4niSZZd

System architecture of quorum-sensing circuits. Top left: Quorum sensing in proteobacteria. A signal synthase (blue) produces a diffusible signal (black circles) that binds to a cytoplasmic signal receptor (light blue). When the signal reaches sufficient concentrations, it binds to and activates the receptor, which causes changes in transcription of target genes. Top right: The las and rhl systems of P. aeruginosa. The lasB gene is activated by both systems. The specific acyl-homoserine lactone signal molecule is pictured for each system. Bottom: Illustration of circuit architecture: reciprocal, hierarchical, and independent. Indicated below are the relative levels of lasB gene activation and sensitivity shown by Thomas and colleagues in experimental and modeling studies.

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Aranzazu Arias-Rojas @aranzazuarias.bsky.social · Aug 28

Felicidades Krystal 🎉🎉

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Reposted by Aranzazu Arias-Rojas

Krystal Maya-Maldonado @krystalmayam.bsky.social · Aug 27

First batch of fly food is ready in the Maya lab! Huge thanks to everyone who helped get us up and running.
Excited to see where the next experiments with flies take us!!

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Reposted by Aranzazu Arias-Rojas

PLOS Biology @plosbiology.org · Aug 19

Early immune education mechanisms remain poorly understood. This Primer explores a @plosbiology.org study which uses math modeling to provide mechanistic insights into how the infant #ImmuneSystem learns to distinguish beneficial & harmful #microbes 🧪 Paper: plos.io/4lsJ8i5 Primer: plos.io/4oHrDNI

A simplified model of immune education. The model developed by Tepekule and colleagues incorporates key inputs such as maternal human milk oligosaccharides (HMOs) and IgA, infant diet, and endogenous IgA produced in the infant gut. These inputs are then modeled within the context of the infant gut lumen, where IgA can mask or neutralize microbial taxa, and HMOs and plant-derived polysaccharides selectively promote different taxa. Model parameters are informed by existing in situ longitudinal IgA-seq data and infant feeding records. The main outputs include the abundance and IgA binding levels of each modeled microbial taxon, allowing for predictions of how variations in inputs (e.g., changes in breastfeeding or diet) shape the developing infant microbiome.

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Reposted by Aranzazu Arias-Rojas

Nature Microbiology @natmicrobiol.nature.com · Aug 11

#NewResearch

Streptomyces use both polar and dispersed cell wall synthesis during rapid, exploratory growth @mcmasteriidr.bsky.social

#BacteriaCellWall #MicroSky 🦠

www.nature.com/articles/s41...

Streptomyces uses both polar and dispersed cell wall synthesis during exploratory growth - Nature Microbiology

Streptomyces venezuelae requires MreB1-dependent dispersed peptidoglycan cell wall synthesis and DivIVA-mediated polar cell wall synthesis during its rapid exploratory growth phase.

www.nature.com

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Reposted by Aranzazu Arias-Rojas

Molly Schumer @mollyschumer.bsky.social · Aug 10

Our review on the last decade+ of hybrid incompatibility research is now out! www.sciencedirect.com/science/arti...

Original thread here: bsky.app/profile/moll...

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Reposted by Aranzazu Arias-Rojas

Nature Microbiology @natmicrobiol.nature.com · Aug 8

#NatMicroPicks

Synthetic evolution overdrive 🦠🔧🚅

A highly mutagenic DNA replication system speeds up evolution in Escherichia coli, without harming the host, opening a new way to accelerate protein engineering.

#SynBio #MicroSky

www.science.org/doi/10.1126/...

An orthogonal T7 replisome for continuous hypermutation and accelerated evolution in E. coli

Systems that perform continuous hypermutation of designated genes without compromising the integrity of the host genome can substantially accelerate the evolution of new or enhanced protein functions....

www.science.org

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Reposted by Aranzazu Arias-Rojas

PLOS Biology @plosbiology.org · Aug 6

Competition & #bacterial #PopulationDynamics. @krishnaaswin77.bsky.social @sonjalehtinen.bsky.social &co show that within-host competition in #Streptococcus increases clearance & reduces establishment; #AntibioticResistance increases susceptibility to competition @plosbiology.org 🧪 plos.io/4lqcZba

Top: Schematics explaining how the categorical variables effective-drug-use, ineffective-drug-use and resistance-without-drug are defined based on the set of drugs consumed by the host and resistances carried on strains. Since these three variables are defined analogous to levels of a categorical variable, their effect sizes are to be interpreted relative to the fitness effect corresponding to ‘baseline for comparison’. Bottom: An example showing how the values of the three covariates vary with time. The first two episodes of carriage are resistant to penicillin. The orange lines indicate the value of the covariates for the first 10A serotype as used in clearance models. The green lines indicate the value for the second 10A serotype as used in establishment models.

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Reposted by Aranzazu Arias-Rojas

Nature Portfolio @natureportfolio.nature.com · Aug 6

A paper in Nature Microbiology reports a smartphone-controlled ingestible capsule that can control and allow for two-way communication with gut bacteria in pigs. The findings could lay the foundation for new diagnostic and treatment strategies for diseases. go.nature.com/44P2OI2 #medsky 🧪

This is Extended Data Figure 2. It shows the basic properties of the optoelectronic capsule used in this study.

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Reposted by Aranzazu Arias-Rojas

Hatzios Lab @hatzioslab.bsky.social · Aug 4

Congrats to postdoc Zhe Zhou on her paper out today in @cp-cellhostmicrobe.bsky.social showing that gut bacteria cross-feed a common dietary antioxidant to produce energy under anaerobic conditions. Thanks to collaborators Angela Jiang and Xiaofang Jiang at NIH.
www.sciencedirect.com/science/arti...

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Reposted by Aranzazu Arias-Rojas

Nature Metabolism @natmetabolism.nature.com · Aug 2

RESEARCH | 🧪
M Cai, G Frost, C Edwards et al
@imperialcollegeldn.bsky.social @quadraminstitute.bsky.social ‬‬‬

This study compares how meals with contrasting cellular structures affect postprandial luminal metabolites, glycaemia, gut hormones and satiety sensation.

www.nature.com/articles/s42...

Upper-gastrointestinal tract metabolite profile regulates glycaemic and satiety responses to meals with contrasting structure: a pilot study - Nature Metabolism

In this randomized crossover pilot study, the authors collected human gastrointestinal digesta using a unique intubation technique to compare how meals with contrasting cellular structures affect post...

www.nature.com

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Reposted by Aranzazu Arias-Rojas

Nature Microbiology @natmicrobiol.nature.com · Jul 30

#News&Views

Remote controlled designer probiotics! 🕹️🦠

#MicroSky

www.nature.com/articles/s41...

Remote control designer probiotics - Nature Microbiology

Zhang and colleagues demonstrate the potential for disease monitoring and therapeutic delivery in the gut by interfacing engineered smart probiotics with a pill-camera-style endoscope.

www.nature.com

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Reposted by Aranzazu Arias-Rojas

Brian Stevenson Ph.D. spirochete lab @bstevensonlab.bsky.social · Jul 6

#MicroSky

Matt Doyle @doylemt1.bsky.social · Jul 6

Check out these amazing lipid-monolayer-trapping oligomeric OMPs published by @lalouxlab.bsky.social and Lovering Labs. The BAM complex in these bugs must be wild!

www.nature.com/articles/s41...

A porin-like protein used by bacterial predators defines a wider lipid-trapping superfamily - Nature Communications

This study reveals that an outer membrane protein from the predator Bdellovibrio bacteriovorus forms a pentameric assembly that traps a lipid monolayer within. This allows the discovery of two superfa...

www.nature.com

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Reposted by Aranzazu Arias-Rojas

Nature Microbiology @natmicrobiol.nature.com · Jul 4

#NatMicroPicks

Cell shape drives bacterial infections! 🦠🔷🟠⬛

Tissue geometry regulates bacterial infection patterns in epithelial layers by modulating cellular forces and Piezo1 localization, offering new mechanobiology-based strategies for infection control.

#MicroSky
www.cell.com/cell/abstrac...

Tissue geometry spatiotemporally drives bacterial infections

Tissue-geometry-regulated cellular traction forces trigger the activation of Piezo1 and its co-localization with bacteria to facilitate the formation of specific bacterial invasion patterns to promote...

www.cell.com

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Reposted by Aranzazu Arias-Rojas

Nature Microbiology @natmicrobiol.nature.com · Jul 4

#NatMicroPicks

Vibrio in competition! 🦠💉

An orphan T6SS effector in non-toxigenic Vibrio cholerae targets susceptible strains by disrupting ion balance, shaping Vibrio population dynamics and offering a model for precision antimicrobials.

#MicroSky

www.cell.com/cell-host-mi...

A Vibrio-specific T6SS effector reshapes microbial competition by disrupting Vibrio bioenergetics

Liu et al. report that a Vibrio-specific T6SS effector, TseVs, selectively disrupts Vibrio bioenergetics while sparing non-target microbes via an immunity-independent mechanism. This work reveals how ...

www.cell.com

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Reposted by Aranzazu Arias-Rojas

Nature Microbiology @natmicrobiol.nature.com · Jun 30

🚨Out now!

The GATE glycoprotein complex enhances cytomegalovirus entry in endothelial cells.

#MicroSky🦠

www.nature.com/articles/s41...

The GATE glycoprotein complex enhances human cytomegalovirus entry in endothelial cells - Nature Microbiology

The gH-associated tropism and entry (GATE) complex consists of glycoprotein H, UL116 and UL141. This complex is abundant on human cytomegalovirus virions and enables entry into human endothelial cells...

www.nature.com

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Reposted by Aranzazu Arias-Rojas

Igor Iatsenko @iatsenkolab.bsky.social · Jun 26

Proud of this work led by a former PhD student @aranzazuarias.bsky.social. Here, we investigated how the host controls the abundance of gut commensals and how some of them can benefit from infection.
#infection #symbiosky #proudPI
#immunity #AcademicSky #insect #symbiosis #Drosophila

Aranzazu Arias-Rojas @aranzazuarias.bsky.social · Jun 26

www.biorxiv.org/content/10.1...

Thrilled to announce the release of my PhD pet project!
The journey has been long, and I'm grateful to all who contributed to this meaningful work.

@markorubinicc.bsky.social @iatsenkolab.bsky.social

Infection-Induced Elevation of Gut Glycosaminoglycans Fosters Microbiota Expansion in Drosophila melanogaster

While host genetics influence the composition of intestinal microbial communities, host genetic factors controlling the abundance of intestinal commensals remain to be determined. Here, we performed a...

www.biorxiv.org

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Aranzazu Arias-Rojas @aranzazuarias.bsky.social · Jun 26

www.biorxiv.org/content/10.1...

Thrilled to announce the release of my PhD pet project!
The journey has been long, and I'm grateful to all who contributed to this meaningful work.

@markorubinicc.bsky.social @iatsenkolab.bsky.social

Infection-Induced Elevation of Gut Glycosaminoglycans Fosters Microbiota Expansion in Drosophila melanogaster

While host genetics influence the composition of intestinal microbial communities, host genetic factors controlling the abundance of intestinal commensals remain to be determined. Here, we performed a...

www.biorxiv.org

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Reposted by Aranzazu Arias-Rojas

Igor Iatsenko @iatsenkolab.bsky.social · May 28

Happy to share our new preprint! We explored the mechanisms underlying differences between male and female #Drosophila in susceptibility to intestinal #infection. #symbiosky
#immunity #AcademicSky #insect #symbiosis

Sex Differences in Drosophila Intestinal Metabolism Contribute to Sexually Dimorphic Infection Outcome and Alter Gut Pathogen Virulence

Sexual dimorphism in infection outcomes is a pervasive phenomenon, the underlying mechanisms of which remain incompletely understood. Here, utilizing Pseudomonas entomophila intestinal infection in Dr...

www.biorxiv.org

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