Sreya Ghosh
@artistinscience.bsky.social
Artsy & Science-y • Innately Immunologist • Postdoc @lozanzi.bsky.social • PhD @fitzgeraldkate.bsky.social
Reposted by Sreya Ghosh
#SpookyInflammasome 🎃
With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis.
... more to come on the priming !
With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis.
... more to come on the priming !
#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇
Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3.
Activation of the NLRP3 inflammasome leads to the production of bioactive interleukin (IL)-1β fostering atherosclerosis. The current dogma is that NLRP3 must be first primed by microbial stimuli, know...
www.biorxiv.org
October 31, 2025 at 5:37 PM
#SpookyInflammasome 🎃
With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis.
... more to come on the priming !
With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis.
... more to come on the priming !
Tremendous body of work by @danielboehmer.bsky.social & @lozanzi.bsky.social with the beautiful, detailed artwork!
#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...
August 22, 2025 at 2:31 AM
Tremendous body of work by @danielboehmer.bsky.social & @lozanzi.bsky.social with the beautiful, detailed artwork!
Reposted by Sreya Ghosh
The www.zanonilab.com just turned 10-year-old today! 🎂🎉 I feel so grateful to my mentors & all the amazing friends & trainees that shared these years of passion, excitement, & hard work! In our job, every day is a new start, but let’s celebrate some of our achievements in… #10 posts! 1/
HOME | ZanoniLaboratory
Welcome to Zanoni Laboratory! We unravel inflammatory networks to understand homeostasis and fight inflammatory disorders
www.zanonilab.com
January 16, 2025 at 3:42 PM
The www.zanonilab.com just turned 10-year-old today! 🎂🎉 I feel so grateful to my mentors & all the amazing friends & trainees that shared these years of passion, excitement, & hard work! In our job, every day is a new start, but let’s celebrate some of our achievements in… #10 posts! 1/
Reposted by Sreya Ghosh
#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...
Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair
Intestinal damage following colitis or irradiation induces type III interferons (IFNs), which delay the healing of the intestinal epithelium. IFN-λ directs the sensing of Z-form nucleic acids generated during gut injury and repair, triggering cell death and altering healthy epithelial regeneration.
www.cell.com
December 26, 2024 at 5:24 PM
#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...
Reposted by Sreya Ghosh
#InterferonPower! Fantastic @science.org by @nandangokhale.bsky.social @ramlabuw.bsky.social &co! MAVS is intrinsically capable to sense via an unstructured region the 3’ UTRs of self mRNA (ISGs too!) to potentiate the response to viral RNA via phosphorylation of IRF3 & NFkB!
Cellular RNA interacts with MAVS to promote antiviral signaling
Antiviral signaling downstream of RIG-I–like receptors (RLRs) proceeds through a multi-protein complex organized around the adaptor protein mitochondrial antiviral signaling protein (MAVS). Protein co...
www.science.org
December 19, 2024 at 9:39 PM
#InterferonPower! Fantastic @science.org by @nandangokhale.bsky.social @ramlabuw.bsky.social &co! MAVS is intrinsically capable to sense via an unstructured region the 3’ UTRs of self mRNA (ISGs too!) to potentiate the response to viral RNA via phosphorylation of IRF3 & NFkB!
Reposted by Sreya Ghosh
Feel so lucky to be working with an amazing group of passionate, talented, kind, and smart scientists that makes me better every day! #ZanoniLabHolidayParty #LoveMyJob #LoveMyLab #LoveScience (lot of #love during the Holiday time 😉)!
December 16, 2024 at 3:01 PM
Feel so lucky to be working with an amazing group of passionate, talented, kind, and smart scientists that makes me better every day! #ZanoniLabHolidayParty #LoveMyJob #LoveMyLab #LoveScience (lot of #love during the Holiday time 😉)!
Reposted by Sreya Ghosh
#Bittersweet! Today we say goodbye to Tomi Kostevc, an amazingly talented international PhD student in the lab that did an amazing work on #DendriticCell biology (#FirstLove!)! Physically back to @ChariteBerlin @CharitePhdnet, but we will keep doing more cool #science together 😎!!
November 27, 2024 at 6:16 PM
#Bittersweet! Today we say goodbye to Tomi Kostevc, an amazingly talented international PhD student in the lab that did an amazing work on #DendriticCell biology (#FirstLove!)! Physically back to @ChariteBerlin @CharitePhdnet, but we will keep doing more cool #science together 😎!!
Reposted by Sreya Ghosh
I go around saying that tissue repair and tumorigenesis are two faces of the same coin. @ejvillablanca.bsky.social &co now show that this is not always the case and the two processes can be "unlinked" in the gut! @natureportfolio.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Liver X receptor unlinks intestinal regeneration and tumorigenesis - Nature
Liver X receptor drives epithelial Areg-mediated intestinal regeneration, while preventing tumour growth through adaptive immune responses.
www.nature.com
November 20, 2024 at 7:04 PM
I go around saying that tissue repair and tumorigenesis are two faces of the same coin. @ejvillablanca.bsky.social &co now show that this is not always the case and the two processes can be "unlinked" in the gut! @natureportfolio.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sreya Ghosh
Hi everyone! New to Bluesky, but happy to share the final chapter of my PhD @uconnhealth.bsky.social out today in Nature Immunology! Here, we uncovered a noncanonical function of the glucose transporter GLUT4 in regulating RLR signaling in muscle and adipocytes
www.nature.com/articles/s41...
www.nature.com/articles/s41...
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling - Nature Immunology
Wang and colleagues show that in skeletal muscle cells and cardiomyocytes, the glucose transporter GLUT4 is a negative regulator of RIG-I-like receptor signaling during viral infection by redistributi...
www.nature.com
November 20, 2024 at 7:28 PM
Hi everyone! New to Bluesky, but happy to share the final chapter of my PhD @uconnhealth.bsky.social out today in Nature Immunology! Here, we uncovered a noncanonical function of the glucose transporter GLUT4 in regulating RLR signaling in muscle and adipocytes
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sreya Ghosh
For #InterferonLovers 👇👇👇
👋 fellow immunologists, it’s a pleasure to be with you all on bsky! I work on type I #interferons, I figured it would be neat to have a starter pack for those of us working on all things IFN! I’ll keep adding to it, let me know if you want to be included! #immunology #immunosky go.bsky.app/71vKZJA
November 20, 2024 at 11:47 AM
For #InterferonLovers 👇👇👇
Reposted by Sreya Ghosh
We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how:
docs.bsky.app/docs/advance...
#AcademicSky #HigherEd #Altmetrics
docs.bsky.app/docs/advance...
#AcademicSky #HigherEd #Altmetrics
Action Intent Links | Bluesky
Authors, websites, and apps can use action intent links to implement "Share on Bluesky" buttons, or similar in-app actions. Logged-in users will be directed to the corresponding action view in the Blu...
docs.bsky.app
November 18, 2024 at 2:48 PM
We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how:
docs.bsky.app/docs/advance...
#AcademicSky #HigherEd #Altmetrics
docs.bsky.app/docs/advance...
#AcademicSky #HigherEd #Altmetrics
Reposted by Sreya Ghosh
Physician/scientists, let me know if you want to be added to this list: go.bsky.app/9PwKh1k
November 18, 2024 at 8:06 AM
Physician/scientists, let me know if you want to be added to this list: go.bsky.app/9PwKh1k
Reposted by Sreya Ghosh
go.bsky.app/2bqX3T7 - please send me your @bsky.app handles to include in this growing community.
November 17, 2024 at 10:05 PM
go.bsky.app/2bqX3T7 - please send me your @bsky.app handles to include in this growing community.
Reposted by Sreya Ghosh
November 16, 2024 at 10:13 PM
Neutrophils in and as The Dark Knight: playing the good guy seemingly turned bad in colorectal cancer.
Our review on the current understanding of how neutrophils interact with the tumor microenvironment affecting outcome in colon cancer.
aacrjournals.org/cancerimmuno...
Our review on the current understanding of how neutrophils interact with the tumor microenvironment affecting outcome in colon cancer.
aacrjournals.org/cancerimmuno...
November 17, 2024 at 5:23 PM
Neutrophils in and as The Dark Knight: playing the good guy seemingly turned bad in colorectal cancer.
Our review on the current understanding of how neutrophils interact with the tumor microenvironment affecting outcome in colon cancer.
aacrjournals.org/cancerimmuno...
Our review on the current understanding of how neutrophils interact with the tumor microenvironment affecting outcome in colon cancer.
aacrjournals.org/cancerimmuno...