Research that could change lives: A new paper led by Leeds researchers shows DNA by-products may be 'early warning system' for relapse in childhood leukaemia.

Read it in Nature: bit.ly/41zW927

@cclguk.bsky.social @littleprincesses.bsky.social
@bloodcanceruk.bsky.social @ljrusselllab.bsky.social

We are proud to share our latest preprint: "(-)-Englerin A binds a conserved lipid site of TRPC5 and exposes a Met-aromatic motif in channel activation".

www.biorxiv.org/content/10.1...

An absolute pleasure to host @thornsesholdlab.bsky.social in Leeds today for an amazing @astburycentre.bsky.social seminar.

Swinging lever mechanism of myosin shown by time-resolved cryoEM www.nature.com/articles/s41... so glad to finally be able to share this with the community! @astburycentre.bsky.social @astbury-bsl.bsky.social @stemuench.bsky.social @snmcmillan.bsky.social @davidklebl.bsky.social

Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes.

rdcu.be/edRwF

Congratulations to a team of early-career researchers from the Astbury Centre, on winning "Best disruptive food and drink business plan" at the YES24 competition
astbury.leeds.ac.uk/all_news/win...

Done!

Are you interested in proteins as exciting, dynamic interacting species. Come and join us- March 28th 2025.

Places are limited so please register ASAP at sheena-radford-lab.uk/fida.php. (£25.00 registration only, including excellent catering).

We will add Astbury Centre members to the starter pack, but if we have missed anyone one please do DM us!

👋👋 Hi everyone! The Astbury Centre is now on Bluesky. Follow along for updates about exciting Astbury Centre science. For now, we have put together a starter pack of members of the Astbury Centre community.