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Audrey Desgrange

@audreydsg.bsky.social

510 followers 680 following 6 posts

Permanent researcher at INSERM. Working at Institut Imagine and Institut Pasteur (Paris, France). Morphogenesis addict. L’Oréal UNESCO FWIS ambassadress

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Audrey Desgrange @audreydsg.bsky.social · 14d

Ventricle position can be remodeled after heart looping!
In a model of heterotaxy we uncovered a new asymmetric morphogenesis process during which the heart reorients its chambers.
So grateful to all the authors for their expertise and input during this long (but fun) ride 💪
Read more here ⬇️

Sigolène Meilhac @meilhacsigolene.bsky.social · 14d

New publication | Science Advances www.science.org/doi/10.1126/...

Plasticity of ventricle position after heart looping in heterotaxy with right isomerism

The left/right position of ventricles needs to be maintained after heart looping, an unexpected step affected in heterotaxy.

www.science.org

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Audrey Desgrange @audreydsg.bsky.social · 14d

Sigolène Meilhac @meilhacsigolene.bsky.social · 14d

New publication | Science Advances www.science.org/doi/10.1126/...

Plasticity of ventricle position after heart looping in heterotaxy with right isomerism

The left/right position of ventricles needs to be maintained after heart looping, an unexpected step affected in heterotaxy.

www.science.org

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Reposted by Audrey Desgrange

Miguel Torres @miguel-torres-1963.bsky.social · May 27

Here we study the origin of the cardiac cell lineages in the mouse embryo. Separate but coordinated lineages independently specified at gastrulation generate the myocardium and endocardium. Credits: Miquel Sendra & coll: Jorge Dominguez, K. McDole and L. Guinard
authors.elsevier.com/sd/article/S...

ScienceDirect.com | Science, health and medical journals, full text articles and books.

authors.elsevier.com

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Audrey Desgrange @audreydsg.bsky.social · Apr 2

Very happy to share our latest paper identifying Notch3 as a new left gene required for #heart #morphogenesis 💜
Many thanks to all the authors!

PLOS Biology @plosbiology.org · Apr 1

Creating an asymmetric heart: @tbonnely.bsky.social @audreydsg.bsky.social @meilhacsigolene.bsky.social &co identify Notch3 as a novel asymmetric factor in lateral plate mesoderm that acts as a genetic modifier of NODAL to regulate #heart #morphogenesis @plosbiology.org 🧪 plos.io/42q6H4L

Left: Expression of Notch3 (white) detected by whole mount RNAscope ISH in an E8.5d wild-type embryo, shown in frontal views (top, cranial part of the embryo) and transverse section (bottom). Filled and empty arrowheads point to high and low expression, respectively. Right: Segmentation of the cardiac region in 3D images, to quantify gene expression in the left (white) or right (yellow) heart field. The heart tube is colored in red. Somites are outlined by white dotted lines. Expression of Notch3 within the segmented second heart field is extracted in the right panel.

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Reposted by Audrey Desgrange

Institut Pasteur | 130 years of biomedical research @pasteur.fr · Mar 6

Science, research & public health face unprecedented attacks in the U.S.

We stand with our American colleagues & support the Stand Up for Science call.

Join the global march tomorrow, incl. in Paris! 🧪✊

📍 March 7, 13:30 – Place Jussieu
🔗 More info: standupforscience.fr

#StandUpForScience

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Reposted by Audrey Desgrange

Institut Pasteur Education @pasteuredu.bsky.social · Mar 7

📢Aujourd'hui l'Institut Pasteur se mobilise pour la science, l'inclusion & l'avenir du savoir avec l'organisation du symposium «Excellence Scientifique : et si l'inclusion était la clé ?» en écho avec la Journée Internationale des Droits des Femme & la participation au mouvement #StandUpForScience !

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Reposted by Audrey Desgrange

Stand Up for Science! @standupforscience.bsky.social · Mar 6

SO MANY STAND UP FOR SCIENCE EVENTS TO CHOOSE FROM—153 and COUNTING!

To get more information on our local events and to register your own, head to www.standupforscience2025.org/local-event-information/ ☀️⬇️🌎

List of Stand Up for Science events—official events in red, solidarity events in blue.

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Reposted by Audrey Desgrange

Institut Imagine @institutimagine.bsky.social · Feb 11

📣 Journée internationale des femmes et des filles de science à l'Institut Imagine !

Nous célébrons aujourd'hui toutes celles qui, par leur passion et leur détermination, font avancer la recherche et l’innovation : cette journée permet de mettre en lumière leur parcours, parfois semé d’obstacles.

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Audrey Desgrange @audreydsg.bsky.social · Feb 11

Imagine a world with more women in science 🧪 #InternationalDayofWomen&GirlsinScience #EveryVoiceInScience

Reposted by Audrey Desgrange

Institut Imagine @institutimagine.bsky.social · Jan 24

🧬 Join Institut Imagine as a Junior Group Leader!

- Junior Group Leader in Systems and Computational Biology
- Junior Group Leader in RNA Biology and Epigenomics
- Junior Group Leader in Artificial Intelligence for Genetics, Biology & Medicine

To submit your application : lnkd.in/enm-U2tH

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Audrey Desgrange @audreydsg.bsky.social · Jan 27

🚨 Postdoc wanted 🚨

Ever wondered how mechanical forces shape the heart tube during embryogenesis?…

I am looking for a postdoc with a background in developmental biology or biophysics to investigate this new topic as part of an ANR-JCJC 🚀🔬

Don’t hesitate to contact me 🤓🔗

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Reposted by Audrey Desgrange

Sandrine Lévêque Fort 🔬 @slfort.bsky.social · Jan 14

#MiFoBio2025 the autumn microscopy school by @gdrimabio.bsky.social will take place from 10th to 16th October 2025. The call for workshops to share pratical knowledges is open till 31/01 ateliers-mifobio.fr
We'll bring stuff as usual, stay tuned ! @cnrsingenierie.bsky.social

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Audrey Desgrange @audreydsg.bsky.social · Nov 29

Welcome here! Team4 is now complete under this new sky 🙌

Audrey Desgrange @audreydsg.bsky.social · Nov 20

Thanks for this list! May I be added please?

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