billgrey.bsky.social
William (Bill) Grey
@billgrey.bsky.social
110 followers 140 following 10 posts
Group Leader, Leukaemia U.K. John Goldman Fellow, MRC CDA Fellow. We study proteostasis in healthy and malignant blood stem cells. www.proteostem.co.uk
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Reposted by William (Bill) Grey
milsommick.bsky.social
Mick Milsom @milsommick.bsky.social · 8d
Surprising finding that standard chemo renders AML resistant to subsequent treatment with menin inhibitors. Published in @isehsociety.bsky.social journal Exp. Hem.: www.exphem.org/article/S030...
Upfront Menin-inhibitor resistance in multiply pretreated leukemias
10% of acute leukemias carry rearrangements of the KMT2A gene (Mixed-Lineage Leukemia-1, MLL-1). More than 80 fusion partners have been identified, and differences in fusion partner have been linked t...
www.exphem.org
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Reposted by William (Bill) Grey
syedmian.bsky.social
Syed Mian @syedmian.bsky.social · 9d
We all must take the responsibility and don’t just complaint about these problems. Take action and don’t be a spectator!
natbiotech.nature.com
Nature Biotechnology @natbiotech.nature.com · 10d
Breaking the cycle of institutional betrayal and the culture of silence requires decisive actions to promote transparency, accountability and supportive environments in both academia and industry go.nature.com/482BUOY
rdcu.be/eIcEI
Chronic silencing is a critical barrier to breaking the cycle of bullying in academia and industry - Nature Biotechnology
Breaking the cycle of institutional betrayal and the culture of silence requires decisive actions to promote transparency, accountability and supportive environments in both academia and industry.
go.nature.com
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Reposted by William (Bill) Grey
epicentr.bsky.social
Epithelial Cell Biology in ENT Research Group UCL @epicentr.bsky.social · 22d
Our latest work is available on BioRxiv!

WS6 allows extended culture of basal epithelial cells and allows clonal expansion of primary airway epithelial cells after CRISPR editing, with clonal populations retaining their differentiation capacity.

www.biorxiv.org/content/10.1...
WS6 enables scalable ex vivo expansion and gene editing of epithelial basal stem cells
Modeling human epithelial diseases and developing cell-based therapies require robust methods to expand and manipulate epithelial stem and progenitor cells in vitro. Basal stem/progenitor cells from s...
www.biorxiv.org
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Reposted by William (Bill) Grey
syedmian.bsky.social
Syed Mian @syedmian.bsky.social · Aug 23
Humanized MPN xenograft model that offers valuable insights into how human BM MSCs interact with JAK2V617F mutant clone.

onlinelibrary.wiley.com/doi/10.1002/... @hemasphere-journal.bsky.social
Mesenchymal stromal cells from JAK2V617F myeloproliferative neoplasms support healthy and malignant hematopoiesis in a humanized scaffold model in vivo
Myeloproliferative Neoplasms (MPN) are malignancies of hematopoietic stem and progenitor cells (HSPCs) that lead to the overproduction of mature blood cells. These disorders include Essential Thrombo....
onlinelibrary.wiley.com
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Reposted by William (Bill) Grey
tiagocluis.bsky.social
Tiago C. Luís @tiagocluis.bsky.social · Jul 21
New Preprint 🚨. Our latest work is now available in biorXiv: A new double reporter strategy reveals a subset of non-migratory hematopoietic stem cells localized in a dynamic bone marrow niche. www.biorxiv.org/content/10.1...
Immunofluorescence image of and Hoxb5+Vwf+ and an Hoxb5+Vwf- cells in the bone marrow niche
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Reposted by William (Bill) Grey
boierslab.bsky.social
Charlotta Böiers, MD, PhD @boierslab.bsky.social · Jul 19
Congratulations to everyone!
It’s incredibly exciting to see our lab getting recognition with the postdoc grant to Keiki.

www.stemcellcenter.lu.se/article/thre...
Three researchers receive Barncancerfonden funding to investigate the causes of childhood leukemia
Lund University. This spring Barncancerfonden, the Swedish Childhood Cancer Foundation, awarded SEK 64 million to 29 researchers across the country. The funding includes positions of up to six years f...
www.stemcellcenter.lu.se
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Reposted by William (Bill) Grey
boierslab.bsky.social
Charlotta Böiers, MD, PhD @boierslab.bsky.social · Jul 14
Thrilled to share our latest research just published in Leukemia. www.nature.com/articles/s41...
Grateful to all co-authors for their dedicated effort and collaboration. @lundstem.bsky.social @lunduniversity.bsky.social
Ontogeny-specific induction of the KMT2A::AFF1-fusion drives development of a distinct CD24 positive pre-leukemic state - Leukemia
Leukemia - Ontogeny-specific induction of the KMT2A::AFF1-fusion drives development of a distinct CD24 positive pre-leukemic state
www.nature.com
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Reposted by William (Bill) Grey
robhynds.bsky.social
Rob Hynds @robhynds.bsky.social · Jul 3
Excited to share our collaborative work with Sheila Singh's lab: we performed an in vivo genome-wide CRISPRa screen using a lung TRACERx PDX model to uncover drivers of brain metastasis. BACE1 - already investigated as target in Alzheimer's - was as a key hit.

www.science.org/doi/10.1126/...
A genome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis
Beta-secretase 1 promotes the spread of lung cancers to the brain through epidermal growth factor receptor signaling.
www.science.org
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Reposted by William (Bill) Grey
rhysmorganlab.bsky.social
Rhys Morgan @rhysmorganlab.bsky.social · Jun 25
Following on from our recent paper showing novel post-transcriptional roles for B-catenin in leukaemia cells, a very well done to Drs Sevim & Park for writing a superb review in @natureportfolio.nature.com Oncogene summarising our current understanding of this field.

www.nature.com/articles/s41...
Post-transcriptional control of gene expression by β-catenin: expanding the non-canonical ARMoury - Oncogene
Oncogene - Post-transcriptional control of gene expression by β-catenin: expanding the non-canonical ARMoury
www.nature.com
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Reposted by William (Bill) Grey
protinnimmunity.bsky.social
Proteases and Innate immunity lab @ York @protinnimmunity.bsky.social · May 28
Interested in innate immunity and inflammation? Join us in September for a great meeting! Superb lineup of speaker and lots of opportunities for Ecrs to present!
britsocimm.bsky.social
British Society for Immunology @britsocimm.bsky.social · May 28
Dive into cutting-edge innate immunity & inflammation science at our event on September 11!

From immune cell roles to inflammasome signalling, discover advances shaping clinical care.

📆Abstract deadline: 15 July
🐦Early bird registration ends: 27 August

🔗 bit.ly/43q9x9r
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Reposted by William (Bill) Grey
keisukeito-lab.bsky.social
Keisuke Ito @keisukeito-lab.bsky.social · May 23
Excited to see the first commentary in Experimental Hematology (@isehsociety.bsky.social)! Kudos to Aishwarya, Linde ‪@lindemileslab.bsky.social, and Grant @challenlab.bsky.social for highlighting recent papers in Exp Hem on cell-extrinsic factors in Tet2-mutant clonal hematopoiesis!! bit.ly/4k3pEAI
Cell-extrinsic factors contribute toward myeloid-biased expansion in Tet2-mutant clonal hematopoiesis
Hematopoietic stem cells (HSCs) acquire somatic mutations throughout life, with the frequency of mutational incidence increasing with age [1]. Occasionally, certain mutations confer a fitness advantag...
bit.ly
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Reposted by William (Bill) Grey
syedmian.bsky.social
Syed Mian @syedmian.bsky.social · May 1
Excited to share our perspective just out in @leukemia journal! What is bone marrow niche doing in shaping clonal dynamics in MDS and Leukemias.

www.nature.com/articles/s41...
Is the bone marrow microenvironment the hidden catalyst in malignant haematopoiesis? - Leukemia
Leukemia - Is the bone marrow microenvironment the hidden catalyst in malignant haematopoiesis?
www.nature.com
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Reposted by William (Bill) Grey
leukaemiauk.bsky.social
Leukaemia UK @leukaemiauk.bsky.social · Apr 25
We're excited to see the launch of the TARGET study, co-led by @billgrey.bsky.social, to tackle AML relapse by targeting chemo-resistant stem cells.

This could mean oral treatments at home, fewer side effects, and safer options for all. 🧡
lthtresearchcomms.bsky.social
Leeds Teaching Hospitals NHS Trust Research and Innovation @lthtresearchcomms.bsky.social · Apr 24
A new research study @leedsth.nhs.uk and @york.ac.uk is set to transform treatments for one of the most aggressive and hard-to-treat blood cancers.

Read ▶️ www.leedsth.nhs.uk/news/new-res...

@leukaemiauk.bsky.social @bloodcanceruk.bsky.social @cbr-uoy.bsky.social
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Reposted by William (Bill) Grey
lthtresearchcomms.bsky.social
Leeds Teaching Hospitals NHS Trust Research and Innovation @lthtresearchcomms.bsky.social · Apr 24
A new research study @leedsth.nhs.uk and @york.ac.uk is set to transform treatments for one of the most aggressive and hard-to-treat blood cancers.

Read ▶️ www.leedsth.nhs.uk/news/new-res...

@leukaemiauk.bsky.social @bloodcanceruk.bsky.social @cbr-uoy.bsky.social
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Reposted by William (Bill) Grey
jasmeenoberoi.bsky.social
Jasmeen Oberoi @jasmeenoberoi.bsky.social · Apr 16
📢 New PhD Opportunity

🧬🧪 Excited to share a fully funded PhD studentship is available in my lab @gdsc-sussex.bsky.social

📅 Deadline: 2nd May 2025

👉 www.sussex.ac.uk/study/fees-f...

Please share with anyone who might be interested.
PhD Studentship: Structure and function of tyrosine fusion kinases in leukaemia and their regulation by the HSP90 molecular chaperone at University of Sussex
Discover a PhD Studentship: Structure and function of tyrosine fusion kinases in leukaemia and their regulation by the HSP90 molecular chaperone on jobs.ac.uk. Apply now and explore other PhD opportun...
www.jobs.ac.uk
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Reposted by William (Bill) Grey
epicentr.bsky.social
Epithelial Cell Biology in ENT Research Group UCL @epicentr.bsky.social · Apr 14
🚨Today our phenotypic screening work with primary human airway basal cells is published @jcellsci.bsky.social!

We found that multiple Wnt activating compounds promote basal cell proliferation and validated 1-azakenpaullone in vivo.

doi.org/10.1242/jcs....
Compound screening in human airway basal cells identifies Wnt pathway activators as potential pro-regenerative therapies
Summary: A high-throughput screen of 1429 compounds in primary human airway epithelial cells was used to identify that Wnt pathway-activating compounds increase cell proliferation.
doi.org
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Reposted by William (Bill) Grey
smckinneyfreeman.bsky.social
Shannon McKinney-Freeman @smckinneyfreeman.bsky.social · Feb 10
Excited to share our work - online today as a preprint. Here, we characterize precocious aging in HSCs of mice and people with sickle cell disease. Excitingly, we demonstrate the potential of senolytics to restore HSC function to the bone marrow of mice with SCD.

www.biorxiv.org/content/10.1...
Senolytics Restore Hematopoietic Stem Cells Function in Sickle Cell Disease
Sickle Cell Disease (SCD) is a blood disorder affecting millions worldwide. Emerging evidence reveals that SCD pathophysiology increases risk of myeloid malignancies and hematopoietic stem cell (HSC) ...
www.biorxiv.org
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billgrey.bsky.social
William (Bill) Grey @billgrey.bsky.social · Feb 11
Thank you for having me. Really great to hear about work across all the research groups and an especially strong Haem core.
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Reposted by William (Bill) Grey
milsommick.bsky.social
Mick Milsom @milsommick.bsky.social · Feb 5
New pre-print from Thomas Höfer, Daniel Hübschmann, @haas_lab and myself, with first authors @Esther_RCorrea @FloGrunschlager and Tamar Nizharadze doi.org/10.1101/2025... @DKFZ @NCT_HD @ChariteBerlin @hi_stem_lab BIH & MDC
A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells
Residing at the top of the hematopoietic hierarchy, long-term hematopoietic stem cells (HSCs) are capable of self-renewal and sustained blood cell regeneration. Over the past decades, single-cell and ...
doi.org
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Reposted by William (Bill) Grey
isehsociety.bsky.social
ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · Jan 30
ICYMI... #ExpHem featured incredible research in 2024. Our journal has a variety of different content available, including Special Issues. Check out our collections, including guest editors @krikirschner.bsky.social @keisukeito-lab.bsky.social and more on www.exphem.org/content/spec....
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Reposted by William (Bill) Grey
smckinneyfreeman.bsky.social
Shannon McKinney-Freeman @smckinneyfreeman.bsky.social · Jan 28
Really enjoyed talking about the value of joining our community of scientists, working to solve the most difficult problems in hematopoiesis, HSPCs, leukemia and more. The International Society for Experimental Hematology welcomes burgeoning scientists and group leaders. Join! #ISEH #HSC #leukemia
isehsociety.bsky.social
ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · Jan 28
Watch the latest interview with ISEH President @smckinneyfreeman.bsky.social on #SimplyBlood🩸 to hear more on ISEH benefits, advice for young investigators, and the future direction of ISEH and experimental hematology. www.simplyblood.org
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Reposted by William (Bill) Grey
isehsociety.bsky.social
ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · Jan 22
The first issue of #ExpHem for 2025 is here, marking the beginning of what promises to be a great year of new science! Don't miss articles in this issue from @charles-debock.bsky.social, Lev Kats, Hitoshi Takizawa, and more! www.exphem.org/issue/S0301-...
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Reposted by William (Bill) Grey
kiranbatta.bsky.social
kiranbatta.bsky.social @kiranbatta.bsky.social · Jan 24
ehaweb.org/research/eha...
EHA Mentorship Program
A new, career-focused program that provides individual mentoring support for early and mid-career clinicians and researchers in hematology.The call for mentees is open until 15:00 (CET) on February 20...
ehaweb.org
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Reposted by William (Bill) Grey
bloodandtime.bsky.social
Grant Rowe @bloodandtime.bsky.social · Jan 24
Here's a new preprint from our group. This manuscript continues our efforts to understand the mechanisms that distinguish fetal/juvenile versus adult hematopoiesis to better understand pediatric blood diseases.
www.biorxiv.org/content/10.1...
Dynamic activity of Erg promotes aging of the hematopoietic system
Hematopoiesis changes to adapt to the physiology of development and aging. Temporal changes in hematopoiesis parallel age-dependent incidences of blood diseases. Several heterochronic regulators of he...
www.biorxiv.org
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Reposted by William (Bill) Grey
milsommick.bsky.social
Mick Milsom @milsommick.bsky.social · Jan 22
In the Jan issue of @isehsociety.bsky.social journal, the very first “Society Voices article: Advice for effective leadership and hitting the ground running as a new group leader - Experimental Hematology www.exphem.org/article/S030...
Advice for effective leadership and hitting the ground running as a new group leader
Congratulations—you have just been appointed a new group leader! That position that you coveted from the time you first set foot in a laboratory as an undergraduate student. You have a great hypothesi...
www.exphem.org
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