Proteases and Innate immunity lab @ York
@protinnimmunity.bsky.social
Immunology lab led by Dr. Dave Boucher, Unravelling how proteases control innate immune responses to infections and diseases
Boucherlab.org
Boucherlab.org
Reposted by Proteases and Innate immunity lab @ York
Jo in our team - we are looking for a PhD student, postdoc or lab manager!
More information and links to job portal for application submission:
lnkd.in/dcU2Vg7W
lnkd.in/dgVKTARV
Please share widely 🙏🏼
@yefis-immunology.bsky.social @syis-ecr.bsky.social
More information and links to job portal for application submission:
lnkd.in/dcU2Vg7W
lnkd.in/dgVKTARV
Please share widely 🙏🏼
@yefis-immunology.bsky.social @syis-ecr.bsky.social
Postdoc or PhD student position in molecular dissection of cellular crosstalk in the intestinal mucosa
lnkd.in
November 11, 2025 at 6:20 AM
Jo in our team - we are looking for a PhD student, postdoc or lab manager!
More information and links to job portal for application submission:
lnkd.in/dcU2Vg7W
lnkd.in/dgVKTARV
Please share widely 🙏🏼
@yefis-immunology.bsky.social @syis-ecr.bsky.social
More information and links to job portal for application submission:
lnkd.in/dcU2Vg7W
lnkd.in/dgVKTARV
Please share widely 🙏🏼
@yefis-immunology.bsky.social @syis-ecr.bsky.social
Reposted by Proteases and Innate immunity lab @ York
Correct link: www.findaphd.com/phds/?Keywor...
dave boucher PhD Projects, Programmes & Scholarships - 3 PhDs Listed
FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in dave boucher. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.
www.findaphd.com
November 10, 2025 at 7:47 PM
Correct link: www.findaphd.com/phds/?Keywor...
3 PhD positions in the lab for British Students. Inflammasome, cell death and skin immunity, with fantastic colleagues. Check them out or share it with curious and motivated PhD students: www.findaphd.com/phds/?Keywor... @yorkshirebiodtp.bsky.social @ybri-uoy.bsky.social @biologyatyork.bsky.social
dave boucherare PhD Projects, Programmes & Scholarships
FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in dave boucherare. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.
www.findaphd.com
November 10, 2025 at 5:27 PM
3 PhD positions in the lab for British Students. Inflammasome, cell death and skin immunity, with fantastic colleagues. Check them out or share it with curious and motivated PhD students: www.findaphd.com/phds/?Keywor... @yorkshirebiodtp.bsky.social @ybri-uoy.bsky.social @biologyatyork.bsky.social
Reposted by Proteases and Innate immunity lab @ York
📢 Interested in #chromosomes 🧬 & #archaea thriving at the edge of life? PhD project in York,UK on how archaea pass on their genome to daughter cells.Friendly supervisors: me, @steve-quinn-lab.bsky.social & @georgerheath.bsky.social
www.findaphd.com/phds/project...
📅 January 7, 2026
Please RP🙏thx!
www.findaphd.com/phds/project...
📅 January 7, 2026
Please RP🙏thx!
November 9, 2025 at 5:20 PM
📢 Interested in #chromosomes 🧬 & #archaea thriving at the edge of life? PhD project in York,UK on how archaea pass on their genome to daughter cells.Friendly supervisors: me, @steve-quinn-lab.bsky.social & @georgerheath.bsky.social
www.findaphd.com/phds/project...
📅 January 7, 2026
Please RP🙏thx!
www.findaphd.com/phds/project...
📅 January 7, 2026
Please RP🙏thx!
New story from the lab by PhD student Seb Grant. Started as a summer project and developed into an interesting story.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Evolutionary convergence of a Pyroptosis-Apoptosis crosstalk drives non-canonical inflammasome signalling.
The coordination of efficient immune responses to infections is essential to enable pathogen clearance and host survival. Cell death modalities are a crucial component of the innate immune system and ...
www.biorxiv.org
November 3, 2025 at 3:43 PM
New story from the lab by PhD student Seb Grant. Started as a summer project and developed into an interesting story.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Proteases and Innate immunity lab @ York
Interested in joining the Powrie Lab? We’re looking for a Postdoctoral Researcher to study the neutralisation capacity of human anti-IL-10 autoantibodies. You’ll be part of our new MRC CoRE in Exposome Immunology!🧫🦠
Find out more here & apply by 11th Nov: bulletin.ndorms.ox.ac.uk/c/126QDJVBd0...
Find out more here & apply by 11th Nov: bulletin.ndorms.ox.ac.uk/c/126QDJVBd0...
bulletin.ndorms.ox.ac.uk
October 29, 2025 at 8:55 PM
Interested in joining the Powrie Lab? We’re looking for a Postdoctoral Researcher to study the neutralisation capacity of human anti-IL-10 autoantibodies. You’ll be part of our new MRC CoRE in Exposome Immunology!🧫🦠
Find out more here & apply by 11th Nov: bulletin.ndorms.ox.ac.uk/c/126QDJVBd0...
Find out more here & apply by 11th Nov: bulletin.ndorms.ox.ac.uk/c/126QDJVBd0...
Reposted by Proteases and Innate immunity lab @ York
🔔 Chech out this new cool story on non-canonical inflammasome signaling in NK cells by @protinnimmunity.bsky.social
Non-canonical inflammasome drives intrinsic anti-microbial responses in human Natural Killer (NK) cells. https://www.biorxiv.org/content/10.1101/2025.10.20.682800v1
October 21, 2025 at 7:38 PM
🔔 Chech out this new cool story on non-canonical inflammasome signaling in NK cells by @protinnimmunity.bsky.social
Reposted by Proteases and Innate immunity lab @ York
SAVE THE DATE!
The 2026 UK CellularMicrobiologyNetwork meeting will be held 22nd - 23rd of June at @wwiem-qub.bsky.social in Belfast.
Researchers from the UK and beyond are invited to share exciting work on the mechanisms of host-pathogen interactions.
Follow us to stay tuned! www.ukcellmicro.org
The 2026 UK CellularMicrobiologyNetwork meeting will be held 22nd - 23rd of June at @wwiem-qub.bsky.social in Belfast.
Researchers from the UK and beyond are invited to share exciting work on the mechanisms of host-pathogen interactions.
Follow us to stay tuned! www.ukcellmicro.org
October 6, 2025 at 10:11 AM
SAVE THE DATE!
The 2026 UK CellularMicrobiologyNetwork meeting will be held 22nd - 23rd of June at @wwiem-qub.bsky.social in Belfast.
Researchers from the UK and beyond are invited to share exciting work on the mechanisms of host-pathogen interactions.
Follow us to stay tuned! www.ukcellmicro.org
The 2026 UK CellularMicrobiologyNetwork meeting will be held 22nd - 23rd of June at @wwiem-qub.bsky.social in Belfast.
Researchers from the UK and beyond are invited to share exciting work on the mechanisms of host-pathogen interactions.
Follow us to stay tuned! www.ukcellmicro.org
Reposted by Proteases and Innate immunity lab @ York
The second day of the @dib-unil.bsky.social #PRR symposium kicks off with more excellent talks including our own Jakub Began.
October 2, 2025 at 8:09 AM
The second day of the @dib-unil.bsky.social #PRR symposium kicks off with more excellent talks including our own Jakub Began.
Reposted by Proteases and Innate immunity lab @ York
📢A new effector-triggered immunity role for GBP1! No place for pathogens to hide now that GBP1 can detect extracellular pathogens that hijack the actin cytoskeleton. Surprise*suprise* GBP1 does this independently of LPS! 🧵
biorxiv.org/content/10.1...
biorxiv.org/content/10.1...
September 28, 2025 at 10:36 AM
📢A new effector-triggered immunity role for GBP1! No place for pathogens to hide now that GBP1 can detect extracellular pathogens that hijack the actin cytoskeleton. Surprise*suprise* GBP1 does this independently of LPS! 🧵
biorxiv.org/content/10.1...
biorxiv.org/content/10.1...
Reposted by Proteases and Innate immunity lab @ York
For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
currentprotocols.onlinelibrary.wiley.com
September 19, 2025 at 2:39 PM
For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
Ready to start 2 days of everything innate immunity and inflammation #bsiinflammation2025
@britsocimm.bsky.social
@britsocimm.bsky.social
September 11, 2025 at 8:00 AM
Ready to start 2 days of everything innate immunity and inflammation #bsiinflammation2025
@britsocimm.bsky.social
@britsocimm.bsky.social
Reposted by Proteases and Innate immunity lab @ York
Looking for passionate candidate to apply to PhD fellowship to University of Murcia call:
www.um.es/documents/d/...
Interested students contact me!
www.um.es/documents/d/...
Interested students contact me!
www.um.es
September 7, 2025 at 4:57 PM
Looking for passionate candidate to apply to PhD fellowship to University of Murcia call:
www.um.es/documents/d/...
Interested students contact me!
www.um.es/documents/d/...
Interested students contact me!
Reposted by Proteases and Innate immunity lab @ York
#MycobiotaPower! Exciting work @nature.com by Behnsen, Jaswal &co showing that #Salmonella uses type 3 secretion system to hijack #Candida_albicans to produce arginine in the gut, boosting Salmonella infectivity & reducing the immune response! www.nature.com/articles/s41...
Commensal yeast promotes Salmonella Typhimurium virulence - Nature
Commensal Candida albicans enhances the virulence and dissemination of Salmonella enterica subsp. enterica serovar Typhimurium.
www.nature.com
September 3, 2025 at 5:09 PM
#MycobiotaPower! Exciting work @nature.com by Behnsen, Jaswal &co showing that #Salmonella uses type 3 secretion system to hijack #Candida_albicans to produce arginine in the gut, boosting Salmonella infectivity & reducing the immune response! www.nature.com/articles/s41...
Reposted by Proteases and Innate immunity lab @ York
So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.
#NLRP3 is a target for antiinflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @colllab.bsky.social et al characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. rupress.org/jem/article/...
#Inflammasome
#Inflammasome
September 2, 2025 at 4:22 PM
So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.
Still time to register for the BSI inflammation meeting 2025! Don’t miss out on this fantastic meeting !.
🔥 Last call! Today’s the FINAL day to submit your abstract for “Innate immunity & inflammation: UK inflammation 2025.”
Don’t miss your chance to get involved! Submit now and join leading experts this September in Manchester.
Event & submission info: bit.ly/43q9x9r
Don’t miss your chance to get involved! Submit now and join leading experts this September in Manchester.
Event & submission info: bit.ly/43q9x9r
September 1, 2025 at 6:02 AM
Still time to register for the BSI inflammation meeting 2025! Don’t miss out on this fantastic meeting !.
10 things you wish you knew about inflammatory caspases: a holistic review of their biochemistry, activation, and signalling - Journal of Biological Chemistry www.jbc.org/article/S002...
10 things you wish you knew about inflammatory caspases: a holistic review of their biochemistry, activation, and signalling
Caspases are a family of cysteine proteases conserved across all multicellular life
which play critical functions that range from cell death, inflammation and cellular
differentiation. Caspases cleave...
www.jbc.org
August 3, 2025 at 8:20 PM
10 things you wish you knew about inflammatory caspases: a holistic review of their biochemistry, activation, and signalling - Journal of Biological Chemistry www.jbc.org/article/S002...
Reposted by Proteases and Innate immunity lab @ York
(1/3) We've been catching up with our GenerationResearch students so far this summer..!
"Hi, I am Naomi, a Biomedical Sciences student going into the final year of my Integrated Masters at York. I am currently doing my Generation Research studentship in Dave Boucher's Lab.
"Hi, I am Naomi, a Biomedical Sciences student going into the final year of my Integrated Masters at York. I am currently doing my Generation Research studentship in Dave Boucher's Lab.
July 22, 2025 at 1:30 PM
(1/3) We've been catching up with our GenerationResearch students so far this summer..!
"Hi, I am Naomi, a Biomedical Sciences student going into the final year of my Integrated Masters at York. I am currently doing my Generation Research studentship in Dave Boucher's Lab.
"Hi, I am Naomi, a Biomedical Sciences student going into the final year of my Integrated Masters at York. I am currently doing my Generation Research studentship in Dave Boucher's Lab.
Reposted by Proteases and Innate immunity lab @ York
🔥 Last call! Today’s the FINAL day to submit your abstract for “Innate immunity & inflammation: UK inflammation 2025.”
Don’t miss your chance to get involved! Submit now and join leading experts this September in Manchester.
Event & submission info: bit.ly/43q9x9r
Don’t miss your chance to get involved! Submit now and join leading experts this September in Manchester.
Event & submission info: bit.ly/43q9x9r
July 15, 2025 at 10:25 AM
🔥 Last call! Today’s the FINAL day to submit your abstract for “Innate immunity & inflammation: UK inflammation 2025.”
Don’t miss your chance to get involved! Submit now and join leading experts this September in Manchester.
Event & submission info: bit.ly/43q9x9r
Don’t miss your chance to get involved! Submit now and join leading experts this September in Manchester.
Event & submission info: bit.ly/43q9x9r
Reposted by Proteases and Innate immunity lab @ York
Still time to register to the next BSI Innate Immunity and Inflammation meeting. Join us for 2 days packed with great science and networking opportunities!
Interested in innate immunity and inflammation? Join us in September for a great meeting! Superb lineup of speaker and lots of opportunities for Ecrs to present!
Dive into cutting-edge innate immunity & inflammation science at our event on September 11!
From immune cell roles to inflammasome signalling, discover advances shaping clinical care.
📆Abstract deadline: 15 July
🐦Early bird registration ends: 27 August
🔗 bit.ly/43q9x9r
From immune cell roles to inflammasome signalling, discover advances shaping clinical care.
📆Abstract deadline: 15 July
🐦Early bird registration ends: 27 August
🔗 bit.ly/43q9x9r
July 7, 2025 at 6:58 PM
Still time to register to the next BSI Innate Immunity and Inflammation meeting. Join us for 2 days packed with great science and networking opportunities!
Still time to register to the next BSI Innate Immunity and Inflammation meeting. Join us for 2 days packed with great science and networking opportunities!
Interested in innate immunity and inflammation? Join us in September for a great meeting! Superb lineup of speaker and lots of opportunities for Ecrs to present!
Dive into cutting-edge innate immunity & inflammation science at our event on September 11!
From immune cell roles to inflammasome signalling, discover advances shaping clinical care.
📆Abstract deadline: 15 July
🐦Early bird registration ends: 27 August
🔗 bit.ly/43q9x9r
From immune cell roles to inflammasome signalling, discover advances shaping clinical care.
📆Abstract deadline: 15 July
🐦Early bird registration ends: 27 August
🔗 bit.ly/43q9x9r
July 7, 2025 at 6:58 PM
Still time to register to the next BSI Innate Immunity and Inflammation meeting. Join us for 2 days packed with great science and networking opportunities!
Reposted by Proteases and Innate immunity lab @ York
Congratulations to the winner of the 2025 BSI Outstanding Leadership Award, sponsored by @ceijournal.bsky.social … Professor Clare Bryant, @clarebryant.bsky.social
June 18, 2025 at 7:41 PM
Congratulations to the winner of the 2025 BSI Outstanding Leadership Award, sponsored by @ceijournal.bsky.social … Professor Clare Bryant, @clarebryant.bsky.social
Interested in innate immunity and inflammation? Join us in September for a great meeting! Superb lineup of speaker and lots of opportunities for Ecrs to present!
Dive into cutting-edge innate immunity & inflammation science at our event on September 11!
From immune cell roles to inflammasome signalling, discover advances shaping clinical care.
📆Abstract deadline: 15 July
🐦Early bird registration ends: 27 August
🔗 bit.ly/43q9x9r
From immune cell roles to inflammasome signalling, discover advances shaping clinical care.
📆Abstract deadline: 15 July
🐦Early bird registration ends: 27 August
🔗 bit.ly/43q9x9r
May 28, 2025 at 5:43 PM
Interested in innate immunity and inflammation? Join us in September for a great meeting! Superb lineup of speaker and lots of opportunities for Ecrs to present!
Reposted by Proteases and Innate immunity lab @ York
Interested in #InnateImmunity ? Register now to secure your spot — abstracts can be submitted later!
More info: wp.unil.ch/immunobiolog...
#ImmunoSky
More info: wp.unil.ch/immunobiolog...
#ImmunoSky
May 1, 2025 at 11:22 AM
Interested in #InnateImmunity ? Register now to secure your spot — abstracts can be submitted later!
More info: wp.unil.ch/immunobiolog...
#ImmunoSky
More info: wp.unil.ch/immunobiolog...
#ImmunoSky
Great work by the @inflammasomelab.bsky.social @s-burgener.bsky.social and colleagues showing in vivo the importance of caspase-1 inactivation in controlling inflammation! Impressive amount of work behind it, glad to see this out!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases
Signal shutdown mechanisms must exist to silence the potent inflammatory programs initiated by the caspase-1 (CASP1) protease, to allow inflammation to resolve and reinstate tissue homeostasis. It is ...
www.biorxiv.org
May 1, 2025 at 7:52 AM
Great work by the @inflammasomelab.bsky.social @s-burgener.bsky.social and colleagues showing in vivo the importance of caspase-1 inactivation in controlling inflammation! Impressive amount of work behind it, glad to see this out!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...