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Cadwell Lab

@cadwelllab.bsky.social

830 followers 260 following 25 posts

We investigate the interface between the immune system and diverse infectious agents ranging from friendly gut microbes and viruses to disease-causing parasites Our Lab: https://www.med.upenn.edu/cadwell-lab/

www.med.upenn.edu

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Julie Pfeiffer @jkpfeiff.bsky.social · Aug 18

Faculty search announcement 2025: Tenure-Track Assistant Professor in Microbiology at UT Southwestern. We seek candidates working in microbial pathogenesis (some preference may be given to bacterial pathogens). Come join our community! (1/5) www.utsouthwestern.edu/departments/...

Department members sit at a very long table in the hallway eating a pre-Thanksgiving potluck feast.

Cadwell Lab @cadwelllab.bsky.social · Jun 27

Overall, we discovered that an intervention as simple as changing cages can control duration of viral infection in mice. Huge shoutout 🙏 to Christin and coauthors, the Gnotobiotics core at both Penn and NYU, and PennCHOP microbiome program for making this study possible 5/5

Cadwell Lab @cadwelllab.bsky.social · Jun 27

Cage change is a stress-inducing event for 🐭! We found that the fluctuation of glucocorticoids (hormones released under stress) contributes to viral clearance, and interference with this hormonal stress response actually inhibits MuAstV clearance after cage change! 4/5

Cadwell Lab @cadwelllab.bsky.social · Jun 27

Although continuous exposure to the viral reservoir does contribute to this persistent infection, we found that there is more at play here 🤔 In fact, cage change induces the activation of CD8 T cells and an interferon response in intestinal epithelial cells, driving the clearance of MuAstV. 3/5

Cadwell Lab @cadwelllab.bsky.social · Jun 27

We found in this study that Murine Astrovirus (MuAstV), an enteric RNA virus that is prevalent in wild, lab, and pet store mice, persists indefinitely in mice when they remain unperturbed in their cage. However, MuAstV is rapidly cleared after we change a mouse’s cage 🤯 2/5

Cadwell Lab @cadwelllab.bsky.social · Jun 27

Congratulations @christinviral.bsky.social and team for publishing this super cool discovery 😎 www.nature.com/articles/s41.... Here’s a quick summary of our cool findings about how stress due to simple mouse husbandry drives clearance of persistent enteric viral infection 🦠🐭 1/5

Environmental stress drives clearance of a persistent enteric virus in mice - Nature Microbiology

Cage change of mice with persistent murine astrovirus infection triggers stress responses marked by corticosterone fluctuation, which is followed by CD8 T cell activation and induction of epithelial a...

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Waggoner Lab @labwaggoner.bsky.social · Jun 17

Review @natimmunol.nature.com @cadwelllab.bsky.social
Gene–environment interactions shape the host–microbial interface in inflammatory bowel disease
www.nature.com/articles/s41...

Cadwell Lab @cadwelllab.bsky.social · Jun 26

Congratulations @christinviral.bsky.social !!! Amazing job starting from an intriguing observation and drilling down to an exciting immune mechanism!

Cadwell Lab @cadwelllab.bsky.social · Jun 26

Thanks for highlighting our paper @lozanzi.bsky.social 🙏

Ivan Zanoni @lozanzi.bsky.social · Jun 26

#ToStressOrNotToStress! @christinviral.bsky.social @cadwelllab.bsky.social show @naturemicrobiol.nature.com that stress drives #interferon stimulated genes to protect against an enteric virus! After immune suppression by stress-induced glucorticoids, CD8 T cells get activated protecting the host!

Environmental stress drives clearance of a persistent enteric virus in mice - Nature Microbiology

Cage change of mice with persistent murine astrovirus infection triggers stress responses marked by corticosterone fluctuation, which is followed by CD8 T cell activation and induction of epithelial a...

Reposted by Cadwell Lab

Carlyn Zwarenstein @carlynzwaren.bsky.social · Jun 1

www.salon.com/2025/06/01/i...

Featuring @cadwelllab.bsky.social and @angierasmussen.bsky.social

It's time to make friends with your viruses

Viruses are in us. They're even part of us. Now researchers want to map the human virome

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Mucosal Immunology @mucosalimmunol.bsky.social · May 28

Chris Hunter @kingofpathogens.bsky.social and colleagues review parasite and host immune factors that impact the development of a mucosal vaccine for #Cryptosporidium : www.mucosalimmunology.org/article/S193...

Cadwell Lab @cadwelllab.bsky.social · May 17

Once again, thank you NIH for making this possible and our amazing coauthors. Special shoutout to coauthors Patty Martin and @torreslab.bsky.social for launching this project 🚀 5/n

Cadwell Lab @cadwelllab.bsky.social · May 17

Maybe ATG16L1 T300A is under balancing selection, like hemoglobin and APOL1 variants that are protective if you have 1 copy but 2 copies are bad (sickle cell/kidney disease)🤷‍♀️? Lots of questions surrounding mechanism that we’re continuing to examine 4/n

Cadwell Lab @cadwelllab.bsky.social · May 17

Turns out mice heterozygous for the variant, but not homozygotes, are highly protected from Salmonella and Listeria due to enhanced inflammasome🔥 activity! Macrophages from T300A heterozygous humans displayed similar enhanced inflammasome 🔥 3/n

Cadwell Lab @cadwelllab.bsky.social · May 17

Most people have at least 1 copy of the ATG16L1 T300A variant even though it’s associated with increased susceptibility to Crohn’s disease. What gives? 2/n

a rabbit from the secret life of pets is making a funny face and saying heh .

ALT: a rabbit from the secret life of pets is making a funny face and saying heh .

media.tenor.com

Cadwell Lab @cadwelllab.bsky.social · May 17

Congratulations Xiaomin Yao and Eugene Rudensky for publishing this story @cp-immunity.bsky.social! Big thank you to NIH for making this work possible. Here’s a brief summary of this 🤯 finding about a gene variant that YOU 🫵 most likely have 1/n

kwnsfk27.r.eu-west-1.awstrack.me

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PennMedCSO @pennmedcso.bsky.social · May 12

Congratulations to Susan Weiss (@PennMicro), Dennis Discher, Cherie Kagan (@pennengineering.bsky.social), Michael Jones-Correa & Sophia Rosenfeld (@PennSAS) on their election to the American Academy of Arts & Sciences! tinyurl.com/rtdecs92

Cadwell Lab @cadwelllab.bsky.social · Apr 30

Fantastic. Congrats!!!

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Rita Strack @ritastrack.bsky.social · Apr 10

Your yearly reminder to acknowledge the core facilities you use and their staff scientists in your papers. These scientists are a crucial part of the scientific ecosystem and to continue to exist they need tangible credit for their work. Plus their associated expertise adds credibility to your work.

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Carl Zimmer @carlzimmer.com · Apr 5

In other airborne news, here's a fabulous visual explanation of what measles does once it floats into your body. Gift link: www.nytimes.com/interactive/...

How Measles Attacks an Unvaccinated Child (Gift Article)

With falling vaccination rates and outbreaks that have caused more than 580 U.S. cases and at least one death, health experts expect hundreds or even thousands more to be infected in the coming months...

www.nytimes.com

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@KingOfPathogens @kingofpathogens.bsky.social · Mar 27

For those still interested in infection and the brain - here is a nice mix of math and pathogens - that tests the function of latency and how the immune system deals with a neuronal infection. Lots going on here to dissect - but turns out latency benefits host and parasite.
rdcu.be/efknc

Immune targeting and host-protective effects of the latent stage of Toxoplasma gondii

Nature Microbiology - In vivo and in silico analyses suggest that bradyzoite-directed immunity contributes to control of cyst numbers, tissue damage and mortality in mice.

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Mel Vazquez Hernandez @melvazquezh.bsky.social · Mar 24

What is up Bluesky!
I'm an Associate Editor working at #PLOSBiology with everything related with #Microbiology and #Immunology
Looking forward to all #science posts!
Also, if you wanna book a meet-the-editor zoom meeting with me and talk about your work, just click scheduler.zoom.us/melissa-vazq...!

Zoom external booking management

scheduler.zoom.us

Cadwell Lab @cadwelllab.bsky.social · Mar 22

Beautiful work @edelblumlab.bsky.social !

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Alec Downie @aedownie.bsky.social · Mar 16

@cadwelllab.bsky.social has already posted about it, but we do have a new paper out about rewilding the immune system! This one is led by Ying-Han Chen (then NYU, now Academia Sinica) and Kimberly Zaldana (NYU), and it dives into the world of B cells.
www.science.org/doi/full/10....

Rewilding catalyzes maturation of the humoral immune system

Releasing laboratory mice into the natural environment enhanced maturation and activation of the humoral immune system.

www.science.org

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Alec Downie @aedownie.bsky.social · Mar 16

There's more exciting work to come from the rewilding experiments, so please do stay tuned for work from @grahammunology.bsky.social @cadwelllab.bsky.social et al.