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Reposted by Carrisa V. Cocuzza, PhD (she/her)

Holmes Lab @holmeslab-bhi.bsky.social · Aug 21

Great write up of the @nature.com study on MRI economics by @bttyeo.bsky.social's research group!

With @avramholmes.bsky.social @sidchop.bsky.social @carrisacocuzza.bsky.social

The Transmitter @thetransmitter.bsky.social · Aug 20

When powering fMRI studies, sample size is king, but scan duration can also be a powerful tool, improving phenotypic prediction and cost-efficiency, a new analysis shows

By @claudia-lopez.bsky.social

#neuroskyence

www.thetransmitter.org/fmri/longer-...

Longer fMRI brain scans boost reliability—but only to a point

Around 30 minutes of imaging per person seems to be the “sweet spot” for linking functional connectivity differences to traits in an accurate and cost-effective way.

www.thetransmitter.org

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Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · Jun 7

Thanks!! 🙌🏽 No but HCP derivatives are on NDA and a more select set of cleaned data on OpenNeuro (what I used for FC) - I’ll talk to our group about sharing FC!

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Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · Jun 4

Check out my newest preprint to see the TCP dataset in action! 🤘🧠

Brain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease: www.biorxiv.org/content/10.1...

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Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · Jun 4

We rec. you cite the Sci. Data manuscript when using the TCP:

Chopra, S., Cocuzza, C.V., Lawhead, C. et al. The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry. Sci Data 12, 923 (2025). doi.org/10.1038/s415...

Happy sciencing all!! 🎉🧠⚛️

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Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · Jun 4

The TCP dataset is openly available on:

OpenNeuro: openneuro.org/datasets/ds0...
NDA: nda.nih.gov/study.html?i...

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Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · Jun 4

...And validated the use of the TCP for discoverability of large-scale functional network properties and task activation effects 🧵8🧠

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Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · Jun 4

We did extensive QC analyses showing that motion was well-controlled by HCP processing... 🧵7🧠

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Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · Jun 4

MRI data includes high-resolution anatomicals, 4 rest fMRI, & 2 task fMRI (Stroop & Emotional Faces). We used HCP processing pipelines w/ ICA-FIX denoising & encourage the use of TCP for clinical network neuro research questions! 🧵6🧠

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Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · Jun 4

The TCP dataset has 50+ self-report & clinician-assisted behavioral, cognitive, and & clinical measures. We are enthusiastic about the use of TCP toward empirically-driven, dimensional, & hierarchically-informed phenotyping 🧵5🧠

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Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · Jun 4

The TCP dataset includes MRI, fMRI, & richly-sampled behavioral data from participants with and without psychiatric diagnoses, sampled transdiagnostically 🧵4🧠

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Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · Jun 4

And those of the team not (yet) on bsky! 🎉 Connor Lawhead, Poornima Kumar, Arielle Rubenstein, Julia Moses, Lia Chen, Crystal Blankenbaker, Bryce Gillis, & Justin Baker 🧵3🧠

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Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · Jun 4

HUGE congrats and thank you to the team & collaborators!! 🎉@sidchop.bsky.social @jocelynricard.bsky.social @loiclabache.bsky.social labache.bsky.social @neurlo.bsky.social @lauragermine.bsky.social @harpaz-rotem.bsky.social @bttyeo.bsky.social @avramholmes.bsky.social @holmeslab-bhi.bsky.social 🧵2🧠

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Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · Jun 4

🚨 Dataset & Manuscript alert! 🚨 The Transdiagnostic Connectome Project (TCP) manuscript is now available @natureportfolio.nature.com Scientific Data! 🎉

www.nature.com/articles/s41...

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The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry - Scientific Data

Scientific Data - The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry

www.nature.com

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Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · May 30

I’m so pleased to share and discuss this work with our community! A massive thank you to coauthors who supported and guided me in this project!! @avramholmes.bsky.social @sidchop.bsky.social @ashleasegal.bsky.social @loiclabache.bsky.social @rowenaechin.bsky.social & Kaley Joss 🧵9/9🧠

a man with a mustache is holding a piece of paper with the word science written on it .

ALT: a man with a mustache is holding a piece of paper with the word science written on it .

media.tenor.com

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Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · May 30

🚨Conclusions🚨 Brain network dynamics link w/ dimensions of functioning across health & psychiatric disease & flatten w/ cognitive demand in patients, suggesting failure to recruit processing resources. Prominence of cognitive control suggests executive dysfunction cuts across psychopathology 8/9

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Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · May 30

Further emphasizing the importance of cognitive control processing to transdiagnostic symptomatology: rest-to-Stroop-task shifts in connectivity discriminated symptom fingerprints better than all other models 🧵7/9🧠

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Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · May 30

3. Network dynamics discriminated symptom fingerprints w/ high accuracy; more robustly than the presence of disease or primary diagnosis. Simulating lesions to each functional system: this link was established by info. processing along frontoparietal, somato/motor, visual, & thalamic networks 🧵6/9🧠

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Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · May 30

2. Whole-brain functional connectomes from resting- & task-state fMRI were decomposed to reveal dynamic constraints on across-state shifts in connectivity. Relative to healthy participants, patients had *flattened* dynamics, suggesting “de-differentiated” network structure in psychopathology 🧵5/9🧠

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Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · May 30

1. We used hierarchical methods on 110 behavioral, cognitive, & clinical measures & profiled 4 core dimensions of functioning: internalizing, externalizing, cognitive, & social/reward. We then developed *symptom fingerprints* – individualized expression patterns across these 4 dimensions 🧵4/9🧠

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Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · May 30

Using the 11 diagnoses in the Transdiagnostic Connectome Project we tackled 3 Qs: 1. What dimensions of functioning pattern psychiatric symptoms? 2. How are dynamics impaired in patients? 3. Do dynamics classify symptom dimensions > diagnoses? 3/9

in-press Sci. Data: www.medrxiv.org/content/10.1...

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Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · May 30

Brain network dynamics – the nonstationary flow of information across brain systems – map individual diffs. in cognition/behavior better than activity or temporally-fixed connectivity alone. This has been shown in depression and schizophrenia; we asked if this extends transdiagnostically… 🧵2/9🧠

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Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · May 30

🚨Preprint!🚨 So excited to share my 1st major study as a postdoc at @holmeslab-bhi.bsky.social!🤘

www.biorxiv.org/content/10.1...

Using a transdiagnostic framework, we found that brain network dynamics were able to discriminate individualized psychiatric symptom profiles with high accuracy 🧵1/9👇

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Reposted by Carrisa V. Cocuzza, PhD (she/her)

Loïc Labache @loiclabache.bsky.social · Apr 12

🚨 New #preprint: The molecular and cellular underpinnings of human brain lateralization

🔗 doi.org/10.1101/2025...

🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇

#neuroskyence

The molecular and cellular underpinnings of human brain lateralization

Hemispheric specialization is a fundamental characteristic of human brain organization, where most individuals exhibit left-hemisphere dominance for language and right-hemisphere dominance for visuosp...

doi.org

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Reposted by Carrisa V. Cocuzza, PhD (she/her)

Linden Parkes @lindenmp.bsky.social · Apr 28

Excited to share the first major piece of work and preprint from my lab! Led by Jason Kim! 🥳🎉🤘

www.biorxiv.org/content/10.1...

a man applauds with the words so proud of my team above him

ALT: a man applauds with the words so proud of my team above him

media.tenor.com

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Reposted by Carrisa V. Cocuzza, PhD (she/her)

Avram Holmes @avramholmes.bsky.social · Mar 19

Concerned about the neurobiological impacts of long COVID? Interested in brain dynamics? Please do join us for @carrisacocuzza.bsky.social's talk on the 31st (see below).

Rutgers Brain Health Institute @rutgersbhi.bsky.social · Mar 19

📢 Human Neuroscience Trainee Seminar Series
This monthly seminar series offers graduate students and postdoctoral scholars a chance to present their research to the Rutgers University #neuroscience community.
🗓 Monday, March 31, 12 PM
👤 Carrisa Cocuzza, Postdoctoral Fellow (Supervisor: Avram Holmes)

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