Lightnews — Scholar-powered news

Reposted by Loïc Labache

Emily G. Jacobs @emilyjacobs.bsky.social · Sep 5

One to watch! 👇🏼🔥 Be sure to tune in Monday for the live event or check out the recording on youtube, along with all our WBHI lectures. Register for the full series at wbhi.ucsb.edu/about/events We’ve got an amazing 25-26 lineup.

2 5

Reposted by Loïc Labache

Jérémie Naudé @jeremie-n.bsky.social · Sep 4

Les espèces classiques de la SVT : se reproduisent 🥱

Les reines des fourmis M. ibericus :
clonent des mâles d'une autre espèce 🤯 pour se reproduire avec et créer des ouvrières hybrides 😤 tout en faisant des mâles de leur espèce pour faire des nouvelles reines 💃💃

www.nature.com/articles/s41...

One mother for two species via obligate cross-species cloning in ants - Nature

In a case of obligate cross-species cloning, female ants of Messor ibericus need to clone males of Messor structor to obtain sperm for producing the worker caste, resulting in males from the same moth...

www.nature.com

4 28 67

Reposted by Loïc Labache

Imaging Neuroscience @imagingneurosci.bsky.social · Jul 3

New paper in Imaging Neuroscience by Elise Roger, Gaelle E. Doucet, et al:

When age tips the balance: A dual mechanism affecting hemispheric specialization for language

doi.org/10.1162/IMAG...

2 10

Loïc Labache @loiclabache.bsky.social · Jul 3

Excited to share that our work is now published in Imaging Neuroscience! 🧠🥳
We show how aging reshapes the brain’s language and memory networks, revealing striking shifts in hemispheric specialization across the lifespan.
Check it out @imagingneurosci.bsky.social

Imaging Neuroscience @imagingneurosci.bsky.social · Jul 3

New paper in Imaging Neuroscience by Elise Roger, Gaelle E. Doucet, et al:

When age tips the balance: A dual mechanism affecting hemispheric specialization for language

doi.org/10.1162/IMAG...

2 7

Loïc Labache @loiclabache.bsky.social · Jul 3

Thanks so much! Great to hear you enjoyed the work.

Reposted by Loïc Labache

Holmes Lab @holmeslab-bhi.bsky.social · Jun 28

Holmes Lab is representing at #OHBM2025! 🧵 Loic
@loiclabache.bsky.social presented in the Language: Anatomy, Networks and Pathology section with his paper on "The molecular and cellular underpinnings of human brain lateralization" 🧠

1 2 5

Reposted by Loïc Labache

Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · Jun 4

🚨 Dataset & Manuscript alert! 🚨 The Transdiagnostic Connectome Project (TCP) manuscript is now available @natureportfolio.nature.com Scientific Data! 🎉

www.nature.com/articles/s41...

🧵1👇

The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry - Scientific Data

Scientific Data - The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry

www.nature.com

2 17 30

Reposted by Loïc Labache

Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · May 30

🚨Preprint!🚨 So excited to share my 1st major study as a postdoc at @holmeslab-bhi.bsky.social!🤘

www.biorxiv.org/content/10.1...

Using a transdiagnostic framework, we found that brain network dynamics were able to discriminate individualized psychiatric symptom profiles with high accuracy 🧵1/9👇

2 19 34

Loïc Labache @loiclabache.bsky.social · May 5

Thanks Donna! I take that as a compliment; hope the surprise wasn't too big.

Reposted by Loïc Labache

Annie G. Bryant @anniegbryant.bsky.social · May 4

🎨🧑‍🎨 Looking for a tool to visualize subcortical/thalamic data in 2D? Check out this python-based package I put together (subcortex-visualization on PyPI), plus a guide for creating your own custom atlas meshes and vector graphics! All feedback/tips welcome 😊

anniegbryant.github.io/subcortex_vi...

4 42 83

Reposted by Loïc Labache

Peter Kirk @peterakirk.bsky.social · May 2

Check our latest work ‘Linking Subjective Experience of Anxiety to Brain Function using Natural Language Processing’. Our analyses link movie-evoked brain activity and subsequent interview recordings in a pediatric sample with and without anxiety disorders (doi.org/10.31234/osf...).

8 15

Reposted by Loïc Labache

Linden Parkes @lindenmp.bsky.social · Apr 28

Excited to share the first major piece of work and preprint from my lab! Led by Jason Kim! 🥳🎉🤘

www.biorxiv.org/content/10.1...

a man applauds with the words so proud of my team above him

ALT: a man applauds with the words so proud of my team above him

media.tenor.com

3 23 44

Reposted by Loïc Labache

Holmes Lab @holmeslab-bhi.bsky.social · Apr 15

Newest #preprint from Holmes lab postdoc @loiclabache.bsky.social 🔥

Loïc Labache @loiclabache.bsky.social · Apr 12

🚨 New #preprint: The molecular and cellular underpinnings of human brain lateralization

🔗 doi.org/10.1101/2025...

🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇

#neuroskyence

The molecular and cellular underpinnings of human brain lateralization

Hemispheric specialization is a fundamental characteristic of human brain organization, where most individuals exhibit left-hemisphere dominance for language and right-hemisphere dominance for visuosp...

doi.org

2 6

Loïc Labache @loiclabache.bsky.social · Apr 15

Thanks, Clyde! I hope you enjoy reading it!

1

Reposted by Loïc Labache

Avram Holmes @avramholmes.bsky.social · Apr 12

The molecular and cellular basis of human brain lateralization. Latest paper from @holmeslab-bhi.bsky.social led by @loiclabache.bsky.social. @rutgersbhi.bsky.social, @cahbir.bsky.social

Loïc Labache @loiclabache.bsky.social · Apr 12

🚨 New #preprint: The molecular and cellular underpinnings of human brain lateralization

🔗 doi.org/10.1101/2025...

🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇

#neuroskyence

The molecular and cellular underpinnings of human brain lateralization

Hemispheric specialization is a fundamental characteristic of human brain organization, where most individuals exhibit left-hemisphere dominance for language and right-hemisphere dominance for visuosp...

doi.org

1 12 27

Loïc Labache @loiclabache.bsky.social · Apr 12

Thanks so much! So glad you found the work interesting. The development of lateralization is a fascinating path to explore!

1

Loïc Labache @loiclabache.bsky.social · Apr 12

Thanks Cedric! 🙏

1 5

Loïc Labache @loiclabache.bsky.social · Apr 12

9/ Huge thanks to @avramholmes.bsky.social @holmeslab-bhi.bsky.social and big ups to collaborators @sidchop.bsky.social and @xi-hanzhang.bsky.social across Yale & Orygen 🦘

7

Loïc Labache @loiclabache.bsky.social · Apr 12

8/ Understanding these biological bases of lateralization has profound implications for evolutionary theory and offers clues to neuropsychiatric conditions characterized by atypical lateralization patterns.

1 6

Loïc Labache @loiclabache.bsky.social · Apr 12

7/ Finally, our findings reveal a distinct cellular and molecular fingerprint demonstrating the brain is organized around two complementary systems: one centered around language and the other around visuospatial attention.

Figure of the organization of the molecular and cellular profiles of the seven canonical intrinsic networks. We are revealing the existence of opposing lateralization profiles in language- and attention-related networks at the molecular and cellular level.

1 7

Loïc Labache @loiclabache.bsky.social · Apr 12

6/ On the cellular level, intratelencephalic-projecting neurons and microglia distributions align with hemispheric specialization, linking specific cell-types to cognitive functions like language and attention.

Figure of the cellular substrates of the neurotransmitter receptor and transporter mode underlying functional cortical lateralization.

1 7

Loïc Labache @loiclabache.bsky.social · Apr 12

5/ We further discovered mitochondrial activity asymmetry aligns with this neurotransmitter axis, suggesting energy management in cells plays a pivotal role in supporting cognitive specialization.

Figure of the molecular substrates of neurotransmitter receptor and transporter modes underlying functional cortical lateralization. We show mitochondrial phenotypes as substrates for lateralization of the acetylcholine-norepinephrine axis.

1 6

Loïc Labache @loiclabache.bsky.social · Apr 12

4/ Left-hemisphere language dominance correlates with higher norepinephrine transporter densities, whereas right hemisphere visuospatial attention is associated with increased acetylcholine receptor densities.

1 6

Loïc Labache @loiclabache.bsky.social · Apr 12

3/ Our multimodal approach integrates fMRI, PET imaging, and transcriptomic analyses, uncovering an acetylcholine-norepinephrine neurotransmitter axis central to functional lateralization.

Canonical Correlation Analysis (CCA) results reveal the neurotransmitter receptor and transporter substrates underlying functional cortical lateralization. We are showing that an acetylcholine-norepinephrine axis
underlines functional lateralization of language and visuospatial attention.

1 6

Loïc Labache @loiclabache.bsky.social · Apr 12

2/ Hemispheric specialization is crucial for human cognition. The left hemisphere typically dominates language, while the right is in charge of visuospatial attention. But what's the biology behind this division?

1 7