UMich Biophysics has an open search for a new faculty member. Application materials are due 5/15. Search is open rank (despite the title in the link). Would love to bring more structural biology colleagues to Biophysics. #NMR careers.umich.edu/job_detail/2...

Lund University, Sweden, is recruiting an Assistant Professor in Biophysical Chemistry with a focus on NMR Spectroscopy lu.varbi.com/en/what:job/... #NMRjobs #NMRchat #NMR #chemsky 🧲

We would love feedback on a new NCBI-BLAST service we are launching today: sky-blast.com

Under the hood it's the same BLAST executable and databases provided by NCBI, with a replica of the NIH's interface - providing an alternative to the US gov service that's less congested, faster & more reliable

The AAUP wholly condemns this punitive weaponization of federal grant funding. This attempt to discipline & control a university campus is a transparent hallmark of authoritarian rule & harshly violates the central mission of education to serve the public good.

www.nytimes.com/2025/03/07/n...

For International Women's Day, here are twelve more women from chemistry history, with achievements ranging from developing antifungal medicines to creating milk substitutes for people with lactose intolerance 👩🏽‍🔬👩🏻‍🔬

www.compoundchem.com/2025/03/07/i...

#IWD2025 #ChemSky 🧪

Please share:
@delauro.house.gov is cochair of the US House Congressional Rapid Response Task Force and Litigation Working Group.

They are looking for instances where the impoundment and restriction of NIH/NSF funds is having a negative impact. Submit examples here delauro.house.gov/constituent-...

RNA xkcd.com/3056

Science IRL decisions went out today!

We were able to fund 13 of the 77 proposals that were submitted. They are communicating science in stage productions, boxes at bus stations, interactive frog statues, musical performances, farmers market tables, backs of cars, knitting clubs, and much more.

If you have an undergrad that will graduate this year but who needs a little more research experience before their next step, encourage them to apply to the UConn RAMP program.

genome-postbac.biology.clas.uconn.edu. The application deadline for the 2025 cohort is February 21st.
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Today is the International Day of Women and Girls in Science 👩‍🔬🧑🏽‍🔬

The Women in Chemistry category on the Ci site has a range of graphics on women in chemistry, both historical and present-day! www.compoundchem.com/category/wom...

#ChemSky 🧪 #WomenInScience

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

Special Bluetorial: The benefits of different life experiences

The scientific community has folks with a very wide range of life experiences. We have a lot to learn from one another.

Preprint, In situ light-driven pH modulation for NMR studies, Aarav Barde, Ruixian Han, Martin A. Olson, Marco Tonelli, Chad M. Rienstra, Katherine Henzler-Wildman, Thirupathi Ravula www.biorxiv.org/content/10.1... #NMRchat #NMR

Let's make a thread of RNA-related conferences in 2025 🧵 (add missing!)

Let me give a concrete example of the importance of applications with high risk-high reward as well as the role of NIH staff in taking risks.

Decades ago, a physical chemist proposed ideas about doing mass spectrometry on proteins (when this was deemed probably impossible).

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Upcoming Magnetic Resonance Events, Workshops and Conferences (pinned) #NMRchat #NMRevents #NMR

Happy #TryptophanWednesday!

📣 Final version of our @elife.bsky.social article is now online! We show how the human tRNA methyltransferase TRMT1 is recognized, cleaved, and inactivated by the SARS-CoV-2 main protease to disrupt host tRNA modification!

elifesciences.org/articles/91168

A short bluetorial... 🧵 1/9

PUI chem profs, ACS Omega is doing a call for PUI papers! Also, the OA charges are covered for PUI's that participate in the ACS PUI OA program (there's a list of participating schools, I'll post that list as a comment to this post). axial.acs.org/cross-discip...

Our work suggests that the tryptophan cage motif plays a structural role, rather than in RNA recognition. An NMR structural ensemble of the hnRNPR-like protein DND1 eRRM1-RRM2 domains bound to RNA (PDB ID 7Q4L), solved by the Allain group, showed that this region does not contact RNA:

Finally, we compare to previously solved structures of hnRNPR-like proteins hnRNPRQ and DND1 to identify common features in the eRRM motif.

To see if these residues are biologically significant, we surveyed the COSMIC database and found several cancer-associated missense mutations in the tryptophan cage motif and residues in the Next-RRM interface:

Alanine substitution of residues in the Next-RRM interface or tryptophan cage reduce thermal stability and increase conformational dynamics, indicating an important role in protein folding: