Lightnews — Scholar-powered news

Reposted by Charlie Arber

Deborah Kronenberg-Versteeg @debkrov.bsky.social · 6d

✨ It's happening again! 🚀 Registration for Stem Cells in Neuroscience 2026 has officially opened! 🧠 Don't miss your chance to attend this exciting event with great keynote speakers, thought-provoking workshops and ample networking opportunities 👉🏼 www.stemcelltuebingen.com #neuroscience #stemcells

4 8

Charlie Arber @celarber.bsky.social · 16d

Thank you @alzsocresearch.bsky.social and @dementiaresearcher.bsky.social for chatting with me about our recent paper.

So grateful for all the coauthors and mentors who made this work possible.

Certainly a team effort!

alzsocresearch.bsky.social @alzsocresearch.bsky.social · 16d

"It’s been fantastic to come up with an idea... and have an output like this."

On @dementiaresearcher.bsky.social, we spoke to Dr Charlie Arber @celarber.bsky.social about his first senior author paper from his Alzheimer's Society funded fellowship: www.dementiaresearcher.nihr.ac.uk/blog-first-a...

Dr Charlie Arber - Blog – First and last of publication authorship

Dr Charlie Arber shares his journey to senior authorship, developing iPSC astrocyte and microglia models to explore inflammation in Alzheimer’s disease.

www.dementiaresearcher.nihr.ac.uk

3 6

Charlie Arber @celarber.bsky.social · 20d

Thanks so much for the support Patrick. It is at Silverstone. So hopefully a quick pit stop for some new wheels half way.

Charlie Arber @celarber.bsky.social · 21d

Eeek. I've signed up to run my first ever half marathon, raising money for Race Against Dementia, funders for research into dementia.

Any contributions very much appreciated and any tips even more so! 🏃‍♂️🍝

www.givengain.com/project/char...

Join Me in the Race Against Dementia

I’m excited to run my first half marathon around the track at Silverstone. I am doing this to support Race Against Dementia, a charity that holds special significance for me and which began with Sir J...

www.givengain.com

1 2 4

Reposted by Charlie Arber

UCL Faculty of Brain Sciences @uclbrainscience.bsky.social · 25d

Differences in the distribution of certain proteins and markers in the brain may explain why some people first experience vision changes instead of memory loss in Alzheimer’s disease, a study by @uclqsion.bsky.social researchers found.
buff.ly/dBRRQvY #WorldAlzheimersMonth

Key differences between visual- and memory-led Alzheimer’s discovered

Differences in the distribution of certain proteins and markers in the brain may explain why some people first experience vision changes instead of memory loss in Alzheimer’s disease, finds a new…

www.ucl.ac.uk

3 7

Reposted by Charlie Arber

UCL Faculty of Brain Sciences @uclbrainscience.bsky.social · 22d

🧠 This #WorldAlzheimersMonth, discover how UCL’s AI tool SuStaIn is transforming Alzheimer’s diagnosis and care—by identifying subtypes and predicting progression from just a snapshot of data.
buff.ly/DmzYSlb @uclengineering.bsky.social

SuStaIn has the potential to really help clinicians with Alzheimer’s diagnoses, which in turn is beneficial for patients who get more personalised advice when it comes to making care plans.

1 1

Charlie Arber @celarber.bsky.social · Sep 7

So much in here for dementia researchers to take note of!

Reposted by Charlie Arber

James R Evans @jamesrevans.bsky.social · Sep 1

Out now on biorxiv! Excited to share our latest collaborative work investigating the earliest stages of Parkinson’s disease.

www.biorxiv.org/content/10.1...

Thanks to all the amazing co-authors Melissa Grant-Peters @jsbeckwith.bsky.social @stevethechemist.bsky.social Mina Ryten Sonia Gandhi

Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson's disease

Parkinson's disease (PD) is characterised by insoluble α-synuclein (αSyn) aggregates in Lewy bodies (LBs) within the substantia nigra, with cortical pathology appearing as the disease progresses. Late...

www.biorxiv.org

6 6

Reposted by Charlie Arber

Selina Wray @selinawray.bsky.social · Aug 22

Excited contribute to this year’s lunch hour lecture program! It’s a free event and accessible to a non-specialist audience so please come and join me :)

UCL Faculty of Brain Sciences @uclbrainscience.bsky.social · Aug 22

🧠 What if we could watch dementia unfold in a dish—and stop it before it starts?

Join Prof @selinawray.bsky.social (@uclqsion.bsky.social) on 18 Sept for a free @UCL Lunch Hour Lecture exploring the future of dementia research.

📅 1–2pm | 💻 Online
🔗 www.ucl.ac.uk/events/event...

5 9

Reposted by Charlie Arber

Oded Rechavi @odedrechavi.bsky.social · Aug 20

Post a non-religious photo you think of as holy

1 29

Reposted by Charlie Arber

Denis Wirtz @deniswirtz.bsky.social · Aug 11

These are the most challenging times for early-career scientists and engineers.

My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers.

We found 437 of them.

Download it freely here: research.jhu.edu/rdt/funding-...

6 200 310

Reposted by Charlie Arber

Selina Wray @selinawray.bsky.social · Jul 29

I’m a huge fan of the work done by @typlab.bsky.social - so it was great to have the opportunity to write a preview of their work describing an in vitro triculture model of Alzheimer’s (with @celarber.bsky.social & Tatiana). Check it out & go read their paper!

www.sciencedirect.com/science/arti...

Reconstructing Alzheimer’s disease one cell type at a time using in vitro tricultures

In a recent study, Lish and colleagues used a fully human-based, induced pluripotent stem cell (iPSC)-derived triculture model of neurons, astrocytes,…

www.sciencedirect.com

2 4

Charlie Arber @celarber.bsky.social · Jul 21

What a treat to share a walkies and a BBQ with my colleagues.

The rain in the background caught us on the way home. But that’s normal for a British bbq, right?

2 5

Reposted by Charlie Arber

UCL Faculty of Brain Sciences @uclbrainscience.bsky.social · Jul 5

💊 First ever treatment for Friedreich’s ataxia – for which @uclqsion.bsky.social and UCLH led the UK trial – has been approved for use in the UK by the medicines’ regulator.
buff.ly/3dSwwzJ #ResearchersAppreciationDay

First treatment for rare disease approved by UK medicines regulator

The first ever treatment for the rare neurodegenerative disease Friedreich’s ataxia – for which UCL and UCLH led the UK trial – has been approved for use in the UK by the medicines’ regulator.

www.ucl.ac.uk

2 3

Charlie Arber @celarber.bsky.social · Jul 4

Woohoo. Congrats Steph.

Reposted by Charlie Arber

Stefan Hauser @stefanhauser.bsky.social · Jul 1

'Stem Cells in Neuroscience' is returning to Tübingen, Germany.

SAVE THE DATE: February 25-27, 2026.
More info: stemcelltuebingen.com

Please share
#stemcelltuebingen2026

@dzne.science
@hih-tuebingen.bsky.social
@unituebingen.bsky.social
@tueneurocampus.bsky.social

1 7 7

Reposted by Charlie Arber

Milner Therapeutics Institute 🧪 @milnerinst.bsky.social · Jun 30

Currently listening to Mina Ryten (@ukdri.ac.uk) describing advances towards improved transcriptomic maps, providing new insights into variant to function for Alzheimer’s disease 🧠 #MilnerSymp25

2 3

Reposted by Charlie Arber

Steven Sloan @sloanlab.bsky.social · Jun 30

I've been really hoping to see more manuscript threads here on 🦋, so here comes one!!! This is brand new work from the lab that took us in very unexpected directions and to exciting findings led by the amazing @emily-hill.bsky.social. Preprint here www.biorxiv.org/content/10.1...
and 🧵below:

2 10 24

Charlie Arber @celarber.bsky.social · Jun 26

My first last author paper. Time for the posh whisky the lab got me! 🥃

Charlie Arber @celarber.bsky.social · Jun 26

Huge credit to @selinawray.bsky.social, and all authors who made this work possible.

Thanks also to @alzheimerssoc.bsky.social and @alzheimersresearchuk.org, and race against dementia who supported this work.

1 1

Charlie Arber @celarber.bsky.social · Jun 26

It's out!

More than just making amyloid?
What if mutations in PSEN1 also predispose inflammation.

We asked if Alzheimer's disease mutations affect cytokine signalling using stem cell derived astrocytes. molecularneurodegeneration.biomedcentral.com/articles/10.....

Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis - Molecular Neurodegeneration

Background Mutations in PSEN1 cause familial Alzheimer’s disease with almost complete penetrance. Age at onset is highly variable between different PSEN1 mutations and even within families with the sa...

molecularneurodegeneration.biomedcentral.com

1 4 12

Reposted by Charlie Arber

Gan Lab @liganlab.bsky.social · Jun 24

🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway

The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cau…

www.sciencedirect.com

3 16 46

Reposted by Charlie Arber

Molecular Neurodegeneration @molneurodegen.bsky.social · Jun 20

'Mutations in #PSEN1 predispose #inflammation in an #astrocyte model of familial #AlzheimersDisease through disrupted regulated intramembrane proteolysis'

Oliver J. Ziff... @selinawray.bsky.social & Charles Arber @uclqsion.bsky.social‬‬

molecularneurodegeneration.biomedcentral.com/articles/10....

Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis - Molecular Neurodegeneration

Background Mutations in PSEN1 cause familial Alzheimer’s disease with almost complete penetrance. Age at onset is highly variable between different PSEN1 mutations and even within families with the sa...

molecularneurodegeneration.biomedcentral.com

3 7

Reposted by Charlie Arber

Selina Wray @selinawray.bsky.social · Jun 21

New paper from the lab, under the leadership of @celarber.bsky.social !

Molecular Neurodegeneration @molneurodegen.bsky.social · Jun 20

'Mutations in #PSEN1 predispose #inflammation in an #astrocyte model of familial #AlzheimersDisease through disrupted regulated intramembrane proteolysis'

Oliver J. Ziff... @selinawray.bsky.social & Charles Arber @uclqsion.bsky.social‬‬

molecularneurodegeneration.biomedcentral.com/articles/10....

Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis - Molecular Neurodegeneration

Background Mutations in PSEN1 cause familial Alzheimer’s disease with almost complete penetrance. Age at onset is highly variable between different PSEN1 mutations and even within families with the sa...

molecularneurodegeneration.biomedcentral.com

11 34

Reposted by Charlie Arber

Andrew MacAskill @macaskillaf.bsky.social · Jun 19

🚨🚨Job Alert🚨🚨!! Neuroscience, Physiology and Pharmacology are recruiting a new lecturer/associate professor! an amazing opportunity to join our fantastic dept! @ucl.ac.uk @ucllifesciences.bsky.social @uclnpp.bsky.social post here:
www.nature.com/naturecareer...

Lecturer / Associate Professor - London, England job with University College London (UCL) | 12840324

About usThe Division of Biosciences at UCL is one of the world's foremost centres for research and teaching in the biological sciences. We have an out

www.nature.com

2 39 44