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Chemical Probes Portal @chemicalprobes.org · 3d

Happening today and tomorrow (7 October)!
Join Müge Sarper, Scientific Coordinator of the Chemical Probes Portal at the @icr.ac.uk, at the poster sessions of the 5th Crick International Cancer Conference.

Stop by to learn how the Portal supports cancer and biomedical research.

#CrickCancerConf

Chemical Probes Portal @chemicalprobes.org · 16d

Join her at the poster sessions & learn how the Portal empowers robust and reproducible cancer research.

#CrickCancerConf @icr.ac.uk

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Chemical Probes Portal @chemicalprobes.org · 16d

Excited to share that Müge Sarper, Scientific Coordinator of the Chemical Probes Portal at the Institute of Cancer Research, London (ICR), will present a poster at the 5th Crick International Cancer Conference (5–7 October 2025, London).

www.crick.ac.uk/whats-on/5th...

5th Crick International Cancer Conference

www.crick.ac.uk

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Chemical Probes Portal @chemicalprobes.org · Aug 7

🎉 The Chemical Probes Portal turns 10!
We’re honoured to be featured in Dr Dan Erlanson’s latest Practical Fragments blog, reflecting on a decade of advancing chemical biology and open science.

🔗 Read the blog: practicalfragments.blogspot.com/2025/08/the-...
#ChemicalProbes #Target2035

The Chemical Probes Portal turns ten. Use it!

Last week we highlighted a new tool to computationally predict whether a molecule might aggregate, thereby causing false positives. This do...

practicalfragments.blogspot.com

Reposted by Chemical Probes Portal

Aled Edwards S.G. @aledmedwards.bsky.social · Jul 23

After 5 years of planning and pilot projects, Target2035, which aims to develop and share pharmacological probes for all human proteins by 2035, is coming out of stealth mode. Our Roadmap for accelerating small molecule hit discovery is now published.

rdcu.be/exxi7

Protein–ligand data at scale to support machine learning

Nature Reviews Chemistry - Target 2035 aims to develop a potent and selective pharmacological modulator for every human protein by 2035 with the results made publicly available. This Roadmap...

rdcu.be

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Chemical Probes Portal @chemicalprobes.org · Jul 22

Read more: www.chemicalprobes.org/news/a-decad... #chemprobes10

Chemical Probes Portal @chemicalprobes.org · Jul 21

🚀 On July 21, the Chemical Probes Portal celebrates 10 years! Launched after the landmark 2015 @NatChemBio paper by Arrowsmith et al., it now features >1150 compounds, >600 targets, and 1600+ expert reviews—powering better biomedical research. 🧪🔬
👉 chemicalprobes.org #ChemicalBiology @icr.ac.uk

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Chemical Probes Portal @chemicalprobes.org · Jul 4

🧪 As a complement to CCT251545 and CCT251921, the study also highlights MSC2530818 as a valuable orthogonal CDK8/19 probe, further strengthening confidence in on-target effects and enabling robust mechanistic studies.
#ChemicalProbes #CDK8 #TargetValidation

Chemical Probes Portal @chemicalprobes.org · Jul 3

New @ACSChemBio study provides strong evidence that the effects of CDK8/19 inhibitors CCT251545 and CCT251921 are on-target.
Using CRISPR knockouts + phosphoproteomics, authors show transcriptional & antitumor effects depend on CDK8/19.
🔗 pubs.acs.org/doi/10.1021/...
#ChemicalProbes #CDK8 #OnTarget

Mediator Kinase Inhibitor Selectivity and Activity in Colorectal Cancer

The Mediator complex is a regulator of gene expression, influencing chromatin structure and RNA polymerase II-mediated transcription. Its activity is controlled by a protein kinase module, which inclu...

pubs.acs.org

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Chemical Probes Portal @chemicalprobes.org · Jun 11

📣 Happening today!
Join the Babraham Distinguished Lecture with Prof Paul Workman | 1–2pm, 12 June
🧬 “Probing and drugging stress pathways: Chemical Biology and therapeutic discovery”
#Cancer#StressResponse#DrugDiscovery#ChemicalBiology #TargetValidation#MolecularPharmacology #TranslationalResearch

Babraham Institute @babrahaminst.bsky.social · Jun 9

Last chance to register for our next distinguished lecture! 🎟️

Babraham Institute @babrahaminst.bsky.social · May 19

We're excited to be welcoming Prof Paul Workman as the next speaker in our distinguished lecture series! Paul will cover the 15-year rollercoaster journey to discover the cancer drug NXP800 and its mechanisms 🧪

Register now to join us on 12th June: www.babraham.ac.uk/seminars/202...

Chemical Probes Portal @chemicalprobes.org · May 15

Julio et al. reveal that covalent fragments, often used in screens, can trigger stress/proteostasis responses, complicating target validation. Key takeaway: Rigorous controls are crucial to distinguish genuine on-target effects. #ChemBio #DrugDiscovery #Proteostasis www.nature.com/articles/s41...

Delineating cysteine-reactive compound modulation of cellular proteostasis processes - Nature Chemical Biology

A cysteine-reactive degrader of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nonstructural protein 14 (nsp14) was identified, which mediates degradation through electrophile-induced gl...

www.nature.com

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Chemical Probes Portal @chemicalprobes.org · Apr 28

🏅 Also, congratulations to Professor Workman on being inducted into the AACR Academy — a wonderful recognition of his contributions to cancer research.
(Photos below from the AACR Academy Award Ceremony.)

#AACR2025 #CancerResearch #DrugDiscovery #PrecisionOncology #PersonalizedMedicine

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Chemical Probes Portal @chemicalprobes.org · Apr 28

Reminder: Tomorrow, Professor Paul Workman will give his Meet the Expert Lecture at #AACR:
Personalized Molecular Medicine Enabled by Multidisciplinary Approaches to Cancer Drug Discovery and Clinical Development.
Details: www.abstractsonline.com/pp8/#!/20273...
#AACR2025 #CancerResearch

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Chemical Probes Portal @chemicalprobes.org · Apr 16

🎧 Listen: lnkd.in/gpK4BkuD

#Degraders #PROTACs #DrugDiscovery #OpenScience #PodcastSeries

This link will take you to a page that’s not on LinkedIn

lnkd.in

Chemical Probes Portal @chemicalprobes.org · Apr 16

Have you caught Episode 6 of the #Target2035 Podcast? 🎙️
Danette Daniels (@ FoghornTx) joins Milka Kostic, to dive into the power of #ProteinDegradation – what sets degraders apart, why #TPD is surging, and how we speed discovery.

Plus: championing #WomenInSTEM 💪

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Chemical Probes Portal @chemicalprobes.org · Apr 15

AKT research and drug discovery has been enabled by the use of chemical probes. See here for those listed on the Chemical Probes Portal www.chemicalprobes.org/search?q=AKT

Welcome to the Chemical Probes Portal

Chemical Probes Portal Portal

www.chemicalprobes.org

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Chemical Probes Portal @chemicalprobes.org · Apr 15

Capivasertib – the first-in-class AKT inhibitor – is now approved by NICE for NHS use in England & Wales, following FDA and EMA approvals for cancer treatment. #Oncology #CancerResearch #AKT #TargetedTherapy #NICE @icr.ac.uk
www.icr.ac.uk/about-us/icr...

ICR welcomes NICE recommendation of capivasertib for advanced breast cancer

www.icr.ac.uk

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Chemical Probes Portal @chemicalprobes.org · Mar 16

🎧 New Target 2035 Podcast!

Rachel Harding & Matthieu Schapira dive into #CACHEChallenges — a global effort to refine small-molecule discovery algorithms with real-world validation.

🔬 How does CACHE boost #DrugDiscovery? Find out: lnkd.in/gcwkUXup

#AIinDrugDiscovery #OpenScience #MachineLearning

This link will take you to a page that’s not on LinkedIn

lnkd.in

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Reposted by Chemical Probes Portal

Cheryl Arrowsmith @carrowsm.bsky.social · Mar 2

This excellent commentary is a must-read for cancer biologists (and all biologists, really).
Probing cancer with small-molecule tools—Progress and challenges: Cancer Cell www.cell.com/cancer-cell/...

Chemical Probes Portal @chemicalprobes.org · Feb 28

Our Cancer Cell Commentary reviews progress on chemical probes since Arrowsmith et al. (Nat Chem Biol 2015) and the launch of the Chemical Probes Portal. We highlight key issues, propose solutions, and outline a path to a quality probe for every human protein. #ChemicalProbes

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Chemical Probes Portal @chemicalprobes.org · Mar 12

Session ME09: Personalized Molecular Medicine Enabled by Multidisciplinary Approaches to Cancer Drug Discovery & Clinical Development
www.abstractsonline.com/pp8/#!/20273...

Program Planner

www.abstractsonline.com

Chemical Probes Portal @chemicalprobes.org · Mar 12

📢Looking ahead to #AACR25 in Chicago — only 6 weeks away!

Join the Meet-the-Expert session with Prof. Paul Workman, where he’ll emphasize the critical role of high-quality chemical probes in drug discovery.

📅 April 29, 2025 | ⏰ 5:00-5:45 PM
Learn more👇

#CancerResearch

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Chemical Probes Portal @chemicalprobes.org · Mar 11

Congratulations to our Chemical Probes Portal Executive Director, Professor Paul Workman, on his election as a Fellow of the AACR Academy Class of 2025! 🎉 An incredible recognition of his lasting impact on cancer research. #AACR #CancerResearch #DrugDiscovery

The Institute of Cancer Research @icr.ac.uk · Mar 10

🎉 We are delighted that Professor Paul Workman has been elected as a Fellow of The American Association for Cancer Research Academy @theaacr.bsky.social

Professor Workman is honoured for his impact on cancer research and is among the 33 new AACR Fellows in 2025.

www.icr.ac.uk/about-us/icr...

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Chemical Probes Portal @chemicalprobes.org · Mar 5

The Chemical Probes Portal now covers 601 protein targets, expanding resources for chemical biology & drug discovery! 🧪🔬 New high-quality probes target DCTPP1, MASTL, HCN1, plus E3 ligases & PROTACs for protein degradation. Learn more: www.chemicalprobes.org/news/600-tar... #ChemicalProbes

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Chemical Probes Portal @chemicalprobes.org · Mar 2

We provide a new checklist for selecting & using chemical probes—valuable for researchers, journal editors, reviewers, and vendors. Ensure best practices in chemical biology! 🧪✅

🔗 Supplementary material: ars.els-cdn.com/content/imag...

#ChemicalProbes #DrugDiscovery #ChemicalBiology

ars.els-cdn.com

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Chemical Probes Portal @chemicalprobes.org · Feb 28

Our Cancer Cell Commentary reviews progress on chemical probes since Arrowsmith et al. (Nat Chem Biol 2015) and the launch of the Chemical Probes Portal. We highlight key issues, propose solutions, and outline a path to a quality probe for every human protein. #ChemicalProbes

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