Lightnews — Scholar-powered news

Chymkowitch lab @chymkowitchlab.bsky.social · 13d

Many thanks to the organisers, sponsors, and members of the poster award committee for this prize and the wonderful conference. The work is supported by The Research Council of Norway.
@biovitenskap.bsky.social @embo.org @uio.no

2

Chymkowitch lab @chymkowitchlab.bsky.social · 13d

🌟 Congratulations to my PhD student Patrizia Nothnagel! 🌟
Patrizia won the "SUMO" poster award at the 2025 EMBO workshop "SUMOylation: From Discovery to Translation" in La Grande-Motte, France. Her work has paid off, and I am proud of her.

1 2

Chymkowitch lab @chymkowitchlab.bsky.social · Aug 6

Many thanks to @biovitenskap.bsky.social and the research council of Norway for supporting this study and @igbmc.bsky.social sequencing facility for processing our samples.

Chymkowitch lab @chymkowitchlab.bsky.social · Aug 6

IRX3 buffers the SUMOylation to promote adipogenesis and block osteogenesis. IRX3 loss boosts SUMOylation, inhibits PPARγ, and pushes cells toward bone fate, which is reversible with SUMOylation inhibition.
IRX3 is an epigenetic gatekeeper.
#Epigenetics #Adipogenesis #ObesityRisk #SUMOylation

1

Chymkowitch lab @chymkowitchlab.bsky.social · Aug 6

I am delighted to share a publication in @natcomms.nature.com. IRX3, linked to obesity via the FTO locus, influences fat vs bone cell fate. It is the result of a wonderful collaboration between S. Dankel, G. Mellgren @unibergen.bsky.social and my lab @biovitenskap.bsky.social 🍾
👉 rdcu.be/ezA5o

IRX3 controls a SUMOylation-dependent differentiation switch in adipocyte precursor cells

Nature Communications - Here, the authors show that IRX3 is a transcriptional master regulator of multiple histone- and chromatin-remodeling enzymes and the SUMOylation pathway in adipocyte...

rdcu.be

2 3 5

Chymkowitch lab @chymkowitchlab.bsky.social · May 12

We are extending the application deadline for this post-doc position! Do not miss the opportunity to join an exciting project in a dynamic and collaborative research environment. @igbmc.bsky.social @pasteur.fr @univbordeaux.bsky.social @uio.no #epigenetics #cellfate #SUMOylation @ncmbm.bsky.social

Postdoctoral Research Fellow in Molecular Biology and Epigenetics (279366) | University of Oslo

Job title: Postdoctoral Research Fellow in Molecular Biology and Epigenetics (279366), Employer: University of Oslo, Deadline: Thursday, May 15, 2025

www.jobbnorge.no

3 3

Chymkowitch lab @chymkowitchlab.bsky.social · Apr 25

Totipotent-like cells in early mouse embryos reorganize their genome via Z-DNA and Zscan4-driven interactions to form a “Z compartment” first supporting ZGA and later compartmentalisation to safeguard the totipotent-like state. Chromatin plasticity at its finest!
www.biorxiv.org/content/10.1...

Z-DNA formation induces the totipotent-like state and primes Zscan4-dependent chromatin compartmentalization

A remarkable transition during murine development is the progression from the 1-cell embryo to the 2-cell stage, accompanied by the activation of a specific set of embryonic genes, epigenome reprogram...

www.biorxiv.org

1

Chymkowitch lab @chymkowitchlab.bsky.social · Apr 23

Thank you @alexis-verger.cpesr.fr !!
I could say the same about you 👍

1

Chymkowitch lab @chymkowitchlab.bsky.social · Apr 23

For this project we collaborate with @amathelier.bsky.social @ncmbm.bsky.social

1

Chymkowitch lab @chymkowitchlab.bsky.social · Apr 23

www.mn.uio.no/ibv/english/...

Transcriptional Regulation Of Cell Fate - Department of Biosciences

We investigate the mechanisms regulating chromatin and gene expression during cellular differentiation and cell cycle progression in yeast and mammals.

www.mn.uio.no

1 1

Chymkowitch lab @chymkowitchlab.bsky.social · Apr 23

This is a 3-year, full-time position in an international research environment.
This position is funded by the Research Council of Norway.
🗓 Start date: ASAP
📅 Deadline: May 15, 2025
Apply here: www.jobbnorge.no/en/available...

Postdoctoral Research Fellow in Molecular Biology and Epigenetics (279366) | University of Oslo

Job title: Postdoctoral Research Fellow in Molecular Biology and Epigenetics (279366), Employer: University of Oslo, Deadline: Thursday, May 15, 2025

www.jobbnorge.no

1

Chymkowitch lab @chymkowitchlab.bsky.social · Apr 23

We’re Hiring!
I am seeking a Pos-doc Researcher in Molecular Biology and Epigenetics. Join our team @biovitenskap.bsky.social @uio.no to explore how SUMOylation regulates epigenetic fate, gene expression, 3D-genome and chromatin during adipogenesis, with implications for obesity and cancer research.

1 4 8

Chymkowitch lab @chymkowitchlab.bsky.social · Apr 14

This study is a very elegant characterisation of the epigenetic and transcriptional divergence between white and beige adipocytes. Very useful to those studying the epigenetic mechanisms supporting cellular reprogramming.
www.biorxiv.org/content/10.1...

Multimodal epigenetic and enhancer network remodeling shape the transcriptional landscape of beige adipocytes

Epigenetic regulation is a key determinant of adipocyte fate and function, conferring phenotypic plasticity to adipose tissue in response to metabolic and thermal challenges. To understand the spatiot...

www.biorxiv.org

1

Reposted by Chymkowitch lab

PLOS Biology @plosbiology.org · Mar 18

Genome sequencing & single-cell transcriptomics continue to produce findings that challenge the idea that #cancer is purely a genetic disease. This Essay delves into #omics data that questions the somatic mutation theory & presents alternative theories based on GRNs & tissue fields.🧪
plos.io/3DRtAEW

A figure depicting the concept of cancer attractor states within Waddington's landscape, and how gene regulatory network dynamics influence these states. The figure shows how cancerous cells derive from those that have accidentally entered into unused attractor states that are usually unoccupied in developmental trajectories.

11 37

Chymkowitch lab @chymkowitchlab.bsky.social · Mar 6

As TAK-981 is in clinical trial for cancer, these findings highlight the need to consider its potential metabolic effects.
Nice collaboration between my group at @uio.no @biovitenskap.bsky.social, Antoine Martinez @ucauvergne.bsky.social
#Adipogenesis #SUMOylation #Metabolism #InVivo #CancerTherapy

1 1

Chymkowitch lab @chymkowitchlab.bsky.social · Mar 6

Our recent in vivo study reveals that inhibiting SUMOylation with TAK-981 disrupts fat accumulation, leading to impaired adipogenesis and increased immune cell infiltration in perigonadal white adipose tissue.
www.tandfonline.com/doi/full/10....

Pharmacological inhibition of SUMOylation with TAK-981 mimics genetic HypoSUMOylation in murine perigonadal white adipose tissue

Post-translational modification by the small ubiquitin-like modifier (SUMO) is essential for cellular differentiation and homeostasis. Here, we investigate the role of SUMOylation in adipose tissue...

www.tandfonline.com

1

Chymkowitch lab @chymkowitchlab.bsky.social · Jan 22

A second position will be soon advertised for molecular biologists. Stay tuned!

Chymkowitch lab @chymkowitchlab.bsky.social · Jan 22

Applications are welcome here: www.jobbnorge.no/en/available...

Postdoctoral Research Fellow in Computational Biology and Epigenetics (273869) | University of Oslo

Job title: Postdoctoral Research Fellow in Computational Biology and Epigenetics (273869), Employer: University of Oslo, Deadline: Friday, February 28, 2025

www.jobbnorge.no

1 1

Chymkowitch lab @chymkowitchlab.bsky.social · Jan 22

The project involves integration of ATAC-seq, ChIP-seq, CAGE and HiC experiments to reveal mechanisms that prevent epigenetic and transcriptional drifting during cellular reprogramming with a particular focus on the adipose tissue.

1

Chymkowitch lab @chymkowitchlab.bsky.social · Jan 22

My group @biovitenskap.bsky.social is #hiring a Post-doc in bioinformatics and biostatistics to work on #epigenetic memory in stem cells and during cell reprogramming. The position is co-supervised by @amathelier.bsky.social from @nordicembl.bsky.social

2 12 11

Chymkowitch lab @chymkowitchlab.bsky.social · Jan 21

Thanks for sharing the first of the two positions that we will propose in the next 6 months @biovitenskap.bsky.social
Stay tuned!

Anthony Mathelier @amathelier.bsky.social · Jan 21

We are #hiring a postdoc to study the epigenetic imprinting of cell fate during adipogenesis.

Cool interdisciplinary project to analyze ChIP-seq, ATAC-seq, Hi-C, and CAGE. The postdoc will be co-supervised by @chymkowitchlab.bsky.social and me.

Spread the word!

www.jobbnorge.no/en/available...

Postdoctoral Research Fellow in Computational Biology and Epigenetics (273869) | University of Oslo

Job title: Postdoctoral Research Fellow in Computational Biology and Epigenetics (273869), Employer: University of Oslo, Deadline: Friday, February 28, 2025

www.jobbnorge.no

5 9

Chymkowitch lab @chymkowitchlab.bsky.social · Jan 21

Thanks @amathelier.bsky.social. The start of a great adventure 😀

1

Reposted by Chymkowitch lab

Department of Biosciences, University of Oslo @biovitenskap.bsky.social · Jan 21

As part of this initiative, two postdoctoral fellowships will soon be advertised. One focusing on Molecular and Cell Biology, and one focusing on bioinformatics and biostatistics.
Stay tuned for more updates and details about these positions!
@chymkowitchlab.bsky.social
www.mn.uio.no/ibv/english/...

Funding to Research on Epigenetic memory - Department of Biosciences

Pierre Chymkowitch at the University of Oslo is awarded 12 million NOK by The Norwegian Research Council, to investigate how SUMOylation influences epigenetic stability and could prevent diseases like...

www.mn.uio.no

1 3

Reposted by Chymkowitch lab

Anthony Mathelier @amathelier.bsky.social · Jan 20

Oslo skeeps.

We will host @michaelhoffman.bsky.social on Mon. Jan. 27th. Looking forward to his seminar about "Identifying transcription factor binding using open chromatin, transcriptome, and methylation data."
You can also book a time to meet him.

More info at www.mn.uio.no/bils/english...

Dr. Michael Hoffman - Bioinformatics in Life Science – BiLS

Dr. Michael Hoffman, Chair of the Computational Biology and Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, and Associate Professor at the Department of Medical ...

www.mn.uio.no

1 4 17

Reposted by Chymkowitch lab

Max Planck Institute of Immunobiology and Epigenetics @mpi-ie.bsky.social · Jan 21

Three more days to register and submit your abstract for the upcoming TriRhena Gene Regulation Club. #epigenetics

Max Planck Institute of Immunobiology and Epigenetics @mpi-ie.bsky.social · Jan 14

The next TriRhena Gene Regulation Club takes place at
IGBMC #Strasbourg. Save your seat & submit a talk. Strengthen your local #epigenetics network & collaborate with peers.

📅 5 Feb. 2025 | 14:00
🎟️ Free entry, registration required
✍️ Register by: 24. Jan.

www.ie-freiburg.mpg.de/gene-regulat...

6 3