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Anthony Mathelier

@amathelier.bsky.social

1.7K followers 360 following 170 posts

Computational biologist interested in gene expression regulation. Associate Director and Group Leader at Norwegian Centre for Molecular Biosciences and Medicine, University of Oslo, Nordic EMBL Partnership for Molecular Medicine. https://mathelierlab.com

mathelierlab.com

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Anthony Mathelier @amathelier.bsky.social · Nov 18

🧵 Bioinformatics faces a critical challenge: despite its importance, software quality often falls short due to the lack of proper development practices.

In our latest paper, we advocate for improving software quality in bioinformatics through teamwork.

academic.oup.com/bioinformati...

Illustration comparing the improvement process in software writing to rock climbing.

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Reposted by Anthony Mathelier

ralucagordan.bsky.social @ralucagordan.bsky.social · 5d

I'm very pleased to announce the official publication of our lab's paper "DNA mutagenesis driven by transcription factor competition with mismatch repair" in today's issue of Cell! www.cell.com/cell/abstrac...

DNA mutagenesis driven by transcription factor competition with mismatch repair

Competition between transcription factors and mismatch repair machinery drives localized hypermutation at regulatory elements, with implications for cancer and genome evolution.

www.cell.com

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Anthony Mathelier @amathelier.bsky.social · 21d

Fantastic work! Congrats

Reposted by Anthony Mathelier

kasitc.bsky.social @kasitc.bsky.social · Aug 18

Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...

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Reposted by Anthony Mathelier

Arnaud Krebs @arnaudkr.bsky.social · Aug 18

This is not a HiC map! Ever wondered if multiple enhancers get activated simultaneously? We measured chromatin accessibility on thousands of molecules by nanopore to create genome-wide co-accessibility maps. Proud of @mathias-boulanger.bsky.social @kasitc.bsky.social Biology in the thread👇

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Reposted by Anthony Mathelier

Kurianlab @kurianlab.bsky.social · Sep 7

www.nature.com/articles/s41...

Multiple overlapping binding sites determine transcription factor occupancy - Nature

A new method enables comprehensive screening and identification of low-affinity DNA binding sites for transcription factors, and reveals that nucleotides flanking high-affinity binding sites create ov...

www.nature.com

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Reposted by Anthony Mathelier

EMBL-EBI @ebi.embl.org · Sep 3

Meet our newest Research Group Leader: Jess Ewald @ewaldlab.org ‬🇨🇦

Jess’s group takes a multi-disciplinary approach to identify and characterise chemical hazards to humans and ecosystems, using cell profiling data, machine learning, and integrative data analysis.

www.ebi.ac.uk/about/news/p...

🖥️🧬

Welcome: Jess Ewald

Jess Ewald, Research Group Leader at EMBL-EBI, uses cell profiling and AI to find and characterise chemical hazards to humans and ecosysystems.

www.ebi.ac.uk

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Anthony Mathelier @amathelier.bsky.social · Sep 3

Great talk by Kata Ferenc on improving bioinformatics software quality through teamwork, sharing how we’ve approached this at @ncmbm.bsky.social

It sparked discussion on taking action within our Bioinformatics in Life Science initiative at @uio.no @biovitenskap.bsky.social

doi.org/10.1093/bioi...

Katalin Ferenc presenting how to improve bioinformatics software quality through teamwork.

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Anthony Mathelier @amathelier.bsky.social · Aug 21

Great read:
Beyond AlphaFold: how AI is decoding the grammar of the genome

www.nature.com/articles/d41...

Beyond AlphaFold: how AI is decoding the grammar of the genome

Scientists are seeking to decipher the role of non-coding DNA in the human genome, helped by a suite of artificial-intelligence tools.

www.nature.com

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Reposted by Anthony Mathelier

Ragnhild Eskeland @ragnhildes.bsky.social · Aug 18

Two days left to apply for a 3-year postdoc in #Chromatin #Cancer #Epigenetics at University of Oslo, Norway, co-supervised by @amathelier.bsky.social You will be part of @cancelluio.bosky.social. We focus on #Sarcoma #Epigenome #CRISPR and Drug screen studies. Find out more here: shorturl.at/DtLHM

Postdoctoral Research Fellowship in Chromatin Biology and Cancer Epigenetics (283381) | University of Oslo

Job title: Postdoctoral Research Fellowship in Chromatin Biology and Cancer Epigenetics (283381), Employer: University of Oslo, Deadline: Wednesday, August 20, 2025

shorturl.at

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Reposted by Anthony Mathelier

Ragnhild Eskeland @ragnhildes.bsky.social · Aug 12

We are hiring! A 3-year postdoc in #Chromatin #Cancer #Epigenetics at University of Oslo, Norway and co-supervised by @amathelier.bsky.social You will be part of @cancelluio.bosky.social. We focus on #Sarcoma #Epigenome #CRISPR and Drug screen studies. Find out more and apply here: shorturl.at/DtLHM

Postdoctoral Research Fellowship in Chromatin Biology and Cancer Epigenetics (283381) | University of Oslo

Job title: Postdoctoral Research Fellowship in Chromatin Biology and Cancer Epigenetics (283381), Employer: University of Oslo, Deadline: Wednesday, August 20, 2025

shorturl.at

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Reposted by Anthony Mathelier

Charlotte Boccara @charlotteboccara.bsky.social · Aug 7

Only one more week to apply to do a postdoc with our group and this of
@thomasdwkim.bsky.social
@ncmbm.bsky.social
@nordicembl.bsky.social
! If you are interested, contact us or apply directly to the add. Please RT.
www.jobbnorge.no/en/available...

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Reposted by Anthony Mathelier

EMBL @embl.org · Aug 7

We’re looking for curious, innovative science leaders at EMBL Heidelberg! 🔬🧬🦠

Join a vibrant, interdisciplinary community where collaboration and innovation are nurtured at all levels.

Take a look at these four open positions 👇

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Anthony Mathelier @amathelier.bsky.social · Aug 8

Feel free to reach out if you wanna discuss these positions.

Reposted by Anthony Mathelier

Norwegian Centre for Molecular Biosciences and Medicine (NCMBM) @ncmbm.bsky.social · Aug 8

🌟 Looking to launch your independent research career in an environment built for collaboration, clinical relevance, and scientific excellence?

🔗To apply👉 www.jobbnorge.no/en/available...

📅 Deadline: 8 September 2025

www.jobbnorge.no

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Reposted by Anthony Mathelier

Norwegian Centre for Molecular Biosciences and Medicine (NCMBM) @ncmbm.bsky.social · Aug 8

📢One month left to apply to our Group Leader position!

🌟A chance to be part of @nordicembl.bsky.social: “The Partnership connects us with an exceptional network of researchers, facilities, and complementary expertise. It opens doors to meaningful scientific exchange”, says @amathelier.bsky.social.

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Reposted by Anthony Mathelier

Richard Sever @richardsever.bsky.social · Jul 24

"criteria for retraction have long included major errors that undermine a paper’s findings, not just fabrication and falsification" <- important to emphasize this. Retraction=/ misconduct

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Reposted by Anthony Mathelier

Luca Pinello @lucapinello.bsky.social · Jul 25

It was indeed fantastic! Thank you so much to all the organizers for supporting this community. 🙏

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Anthony Mathelier @amathelier.bsky.social · Jul 24

And BIG thanks to #RegSys track organizers @abardet.bsky.social A. Emad J. Welch R. Gordan @xiuweizhang.bsky.social R. Beekman @martamele.bsky.social @anniquec.bsky.social @shaunmahony.bsky.social @ferhatay.bsky.social and co-chairs @alemedinarivera.bsky.social and @themarcelschulz.bsky.social

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Anthony Mathelier @amathelier.bsky.social · Jul 24

What a fantastic #ISMBECCB2025 conference it has been, with an outstanding #RegSys @iscb-regsys.bsky.social COSI track!

Thanks, everyone, for submitting, attending, presenting, and organizing @iscb.bsky.social @eccb-europe.bsky.social

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Reposted by Anthony Mathelier

Lucia Peixoto @sciencenlucia.bsky.social · Jul 22

#ISMBECCB2025 It is good to be at a conference in 2025 of a society that reminds us that “equity, diversity and inclusion are essential to how the Society operates, evolves and envisions the future”. www.iscb.org/iscb-news-it... @iscb.bsky.social

June 23, 2025: ISCB's June 2025 Newsletter

ISCB - International Society for Computational Biology

www.iscb.org

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Anthony Mathelier @amathelier.bsky.social · Jul 23

And go to poster C-476 presented by Katalin Ferenc to learn more about inMOTIFin: a lightweight end-to-end simulation software for regulatory sequences

doi.org/10.48550/arX...

#RegSys #ISMBECCB2025

inMOTIFin: a lightweight end-to-end simulation software for regulatory sequences

The accurate development, assessment, interpretation, and benchmarking of bioinformatics frameworks for analyzing transcriptional regulatory grammars rely on controlled simulations to validate the und...

doi.org

Anthony Mathelier @amathelier.bsky.social · Jul 23

Congratulations, so well deserved!

Reposted by Anthony Mathelier

Marcel Schulz @themarcelschulz.bsky.social · Jul 23

Next is
@damlaob to talk about putting new Deep learning models of TFs into #Jaspardb #RegSys #ismbeccb2025 @amathelier.bsky.social

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Anthony Mathelier @amathelier.bsky.social · Jul 23

Our own Damla @damlaob.bsky.social making a great presentation of the upcoming updates of JASPAR and UniBind with BPnet DL models at #RegSys @iscb-regsys.bsky.social #ISMBECCB2025
Chat with her at her poster D-485.

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Reposted by Anthony Mathelier

Saez-Rodriguez Group @saezlab.bsky.social · Jul 22

🎉 The revised version of CORNETO, our unified Python framework for knowledge-driven network inference from omics data, is published in peer reviewed form
🔗 Paper: www.nature.com/articles/s42...
📖 News & Views: www.nature.com/articles/s42...
💻 Code: corneto.org
🧵 Thread 👇

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