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Claudio Cantù

@claudiocantu81.bsky.social

510 followers 960 following 73 posts

Professor of Mol & Dev Bio @ Linköping University 🇮🇹🇸🇪 Group Leader at the Wallenberg Center For Molecular Medicine & SciLifeLab https://liu.se/en/research/cantu-lab Curious to discover what the genome really is, but frankly passionate about all Science.

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Claudio Cantù @claudiocantu81.bsky.social · Mar 18

Our first release in the attempt to build the Transcription Factor Binding (TFB)-OMICS during #DevBio is now out in Development @dev-journal.bsky.social
doi.org/10.1242/dev....
👉We hope many will use our data, and some will want to help mapping their beloved gene regulators in their favorite tissue

Claudio Cantù @claudiocantu81.bsky.social · Dec 3

We are using CUT&RUN-LoV-U to map effectors of Signaling Pathways across tissue and stages of Mouse #DevBio🐭🧬

Do you want to join forces and collaborate to build the future of the TranscriptionFactorBinding(TFB)-OMICS?
www.biorxiv.org/content/10.1...

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Claudio Cantù @claudiocantu81.bsky.social · 22h

I have 7452 unread emails in my professional inbox.

How should an academic deal with this?

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Claudio Cantù @claudiocantu81.bsky.social · Aug 12

The size that matters is that if the gametes

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Claudio Cantù @claudiocantu81.bsky.social · Aug 11

We are the CantùLab
liu.se/en/research/...

liu.se/en/research/...
Supported by
@kawresearch.bsky.social
@Cancerfonden
@vetenskapsradet.bsky.social
@scilifelab.se
@AdditionalVentures

The Cantù Lab - Genome Regulation in Development and Disease

The Cantù Lab at LiU is focused on one important goal: to discover the mechanisms of genome regulation that drive cell differentiation and specialization during embryonic development.

liu.se

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Claudio Cantù @claudiocantu81.bsky.social · Aug 11

SOX2 and NR2F1 cooperate
to make #neurons in the #Thalamus
for visual input from the #retina

#DevBio

journals.biologists.com/bio/article/...
‪
@biologyopen.bsky.social

In collab w Sara Mercurio and Silvia Nicolis @btbsunimib.bsky.social

Driven by Linda Serra and @annanordin.bsky.social

SOX2 and NR2F1 coordinate the gene expression program of the early postnatal visual thalamus

Summary: The transcriptional regulators SOX2 and NR2F1 drive the development of the visual thalamus. Mutations in these genes cause visual impairment in humans.

journals.biologists.com

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Reposted by Claudio Cantù

Claudio Cantù @claudiocantu81.bsky.social · Jul 15

A 6-year long study from the Lab is finally out @genomeresearch.bsky.social

Mastered by @annanordin.bsky.social in collaboration with Chaitali Chakraborty from @remeseiro-lab.bsky.social

Why is our work Important? Discover it in the quick Bluetorial 👇

genome.cshlp.org/content/earl...

Wnt signaling activation induces CTCF binding and loop formation at cis-regulatory elements of target genes

An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms

genome.cshlp.org

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Reposted by Claudio Cantù

Silvia Remeseiro Lab @remeseiro-lab.bsky.social · Aug 1

Now out @genomeresearch.bsky.social this fantastic work in collaboration with Claudio Cantù's lab.

About how #Wnt signalling activation induces #CTCF binding and formation of new #chromatin #loops at #CREs of target genes.

genome.cshlp.org/content/earl...

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Claudio Cantù @claudiocantu81.bsky.social · Jul 25

And of course it is #WNT who decides ⬇️
I wished to see what genes does beta-catenin regulates here!

EvoDevo PanAm @evodevopanam.bsky.social · Jul 25

How "head" and "tail" are positioned in echinoderms and hemichordates? Comparative dev identifies ancient AP determination mechanisms! By Jennifer Fenner #PASEDB2025 #APaxis #seaurchin #wnt #hemichordates

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Claudio Cantù @claudiocantu81.bsky.social · Jul 20

It’s astonishing to see these unanticipated role of DVL proteins as chromatin-associating gene regulators. I wonder how many more proteins have unexpected second functions.
Well done on breaking the DVL paradigm!

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Claudio Cantù @claudiocantu81.bsky.social · Jul 15

We are the CantùLab @liu.se
liu.se/en/research/...
Superb✨collaboration w/ @remeseiro-lab.bsky.social @umeauniversitet.bsky.social

Supported by
@kawresearch.bsky.social
@Cancerfonden
@vetenskapsradet.bsky.social
@scilifelab.se
@AdditionalVentures

The Cantù Lab - Genome Regulation in Development and Disease

The Cantù Lab at LiU is focused on one important goal: to discover the mechanisms of genome regulation that drive cell differentiation and specialization during embryonic development.

liu.se

Claudio Cantù @claudiocantu81.bsky.social · Jul 15

Why this matters?

It shows that extracellular signals (e.g. #WNT) are acute genomic remodellers

The Genome - both sequence and 3D structure - is complex but in a matter of minutes it responds to external clues

This is a beautiful adaptation towards cell plasticity.

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Claudio Cantù @claudiocantu81.bsky.social · Jul 15

Are the CTCF-mediated 3D interactions sites (RUWs) functionally important for #WNT activation ⚒️
Yes.
The evidence?
If individual RUWs are mutated ✂️ they halve (of ~40%) the WNT>induction of ONLY that gene!

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Claudio Cantù @claudiocantu81.bsky.social · Jul 15

We discovered
CTCF/Cohesin Repositioning Under Wnt (RUWs):
✅new CTCF binding sites across the genome in WNT-ON genome-wide
✅RUWs are needed for proper target gene expression
✅Yes, these include the usual suspects (e.g. AXIN2)
✅RUWs are dependent on β-catenin, which interacts with CTCF

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Claudio Cantù @claudiocantu81.bsky.social · Jul 15

Wnt signaling activation induces CTCF binding and loop formation at cis-regulatory elements of target genes

An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms

genome.cshlp.org

1 11 27

Reposted by Claudio Cantù

MwahahahahahadScientist @mads100tist.bsky.social · Jun 29

These NPG spinoff journals are out of control

A picture of a bottle of hummus. It is labeled NATURE HUMMUS

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Reposted by Claudio Cantù

Stacey Ogden 🦔 @labogden.bsky.social · Jun 24

At the WNT GRC and am lowkey obsessed with the ducks of Bates College 🦆 Love seeing them right outside the meeting room 🪶

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Reposted by Claudio Cantù

Claudio Cantù @claudiocantu81.bsky.social · May 12

We had previously shown that TBX3 and #WNT cooperate in limb #DevBio

We now have a shocking finding, just published in @pnas.org

TBX3 physically engages with β-catenin to drive metastasis genes in #ColorectalCancer (CRC)

www.pnas.org/doi/epub/10....

The developmental factor TBX3 engages with the Wnt/β-catenin transcriptional complex in colorectal cancer to regulate metastasis genes

www.pnas.org

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Reposted by Claudio Cantù

Knut and Alice Wallenberg Foundation @kawresearch.bsky.social · Jun 4

The latest upgrading of the #supercomputer Berzelius @liu.se has now been completed. Its doubled capacity enables researchers across Sweden to tackle current and future challenges in areas such as materials science, bioinformatics and machine learning #research #science
tinyurl.com/ydduwzc7

Stronger Berzelius ready for the research of the future

The latest upgrading of the supercomputer Berzelius at LiU has now been completed. Its doubled capacity enables researchers across Sweden to tackle current and future challenges in areas such as mater...

tinyurl.com

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Reposted by Claudio Cantù

Linköping University @liu.se · Jun 4

A big upgrading of the supercomputer Berzelius has been completed thanks to a donation from @kawresearch.bsky.social.
Its doubled capacity enables researchers across Sweden to tackle challenges in areas as materials science, bioinformatics and machine learning.
liu.se/en/news-item... #AcademicSky

Stronger Berzelius ready for the research of the future

liu.se

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Claudio Cantù @claudiocantu81.bsky.social · Jun 2

This ⬇️ is the @liu.se crew @kawresearch.bsky.social @scilifelab.se
On its way to #PALS2025 in superb Göteborg!

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Reposted by Claudio Cantù

Linköping University @liu.se · May 27

A study led by @claudiocantu81.bsky.social show how the protein TBX3, key in early development, resurfaces in aggressive cancers – making them harder to treat.
New insights, new hope for targeted therapies.
🔗 liu.se/en/news-item...
#research #cancer

Mechanism in embryonic development makes cancer aggressive

Tumour cells in colorectal cancer exploit an important signalling pathway that normally controls embryo development. Researchers have now shown how a protein that controls limb development make colore...

liu.se

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Claudio Cantù @claudiocantu81.bsky.social · May 19

Join as for the Nordic #DevBio talks - ZOOM Link upon request 💚

Swedish Developmental Biology Organization @swedbo.bsky.social · May 19

Today talks #DevBio from @ki.se 🇸🇪

Talks by
@genanderlab.bsky.social
and
Ning Xu Landén

We cannot wait! 💚

Swedish Developmental Biology Organization @swedbo.bsky.social · Jan 22

What #DevBio is going on in the North?
🐭🪰🪱🐈‍⬛🐰🫎🇩🇰🇸🇪🇫🇮🇳🇴🇮🇸

Check it out in our monthly Online Seminars:
www.swedbo.se/nordic-devel...

Claudio Cantù @claudiocantu81.bsky.social · May 16

Really compelling mechanism. Great work!

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Reposted by Claudio Cantù

Knut and Alice Wallenberg Foundation @kawresearch.bsky.social · May 16

En ny studie från @ki.se har identifierat en mekanism som celler använder för att hantera näringsbrist. Den nya rönen öppnar för potentiella terapeutiska tillämpningar #forskning med stöd av Knut och Alice Wallenbergs Stiftelse #medicin #biologi @pelechanolab.bsky.social
tinyurl.com/y724wte5

Ny studie avslöjar hur celler anpassar sig till näringsbrist

En ny studie från Karolinska Institutet har identifierat en mekanism som celler använder för att hantera näringsbrist. När näringstillgången är låg gör cellerna små förändringar i hur ribosomer – cell...

tinyurl.com

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Claudio Cantù @claudiocantu81.bsky.social · May 14

Thank you, Tomas!