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Dr Rebecca Coll @colllab.bsky.social · 3d

Yay immunology! Tregs FTW! www.nobelprize.org/prizes/medic...

Nobel Prize in Physiology or Medicine 2025

The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

www.nobelprize.org

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Dr Rebecca Coll @colllab.bsky.social · 3d

Very excited that this meeting will be in Belfast next year!

Gunnar N. Schroeder @gunnarns.bsky.social · 3d

SAVE THE DATE!

The 2026 UK CellularMicrobiologyNetwork meeting will be held 22nd - 23rd of June at @wwiem-qub.bsky.social in Belfast.

Researchers from the UK and beyond are invited to share exciting work on the mechanisms of host-pathogen interactions.

Follow us to stay tuned! www.ukcellmicro.org

Reposted by Dr Rebecca Coll

Journal of Experimental Medicine @jem.org · 6d

Discovery of potent and selective inhibitors of human #NLRP3 with a novel mechanism of action by Kevin Wilhelmsen, Rebecca Coll @colllab.bsky.social @wwiem-qub.bsky.social et al: rupress.org/jem/article/...

From our #InnateImmunity collection: rupress.org/jem/collecti...

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Reposted by Dr Rebecca Coll

Franklin_LAB @franklinlab.bsky.social · 8d

Check out this new thermo-hot paper from the @colllab.bsky.social Lab. Glad to contribute and work with her team.

www.biorxiv.org/content/10.1...

NLRP3 is a thermosensor that is negatively regulated by high temperature

Inflammation is an essential response to infection and injury, but unregulated inflammation is damaging and must be limited by negative feedback signalling. Inflammasome signalling drives local inflam...

www.biorxiv.org

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Dr Rebecca Coll @colllab.bsky.social · 7d

So proud of the new Dr @emmamckay.bsky.social for smashing her PhD viva! Huge thank you to her examiners @kesslerbenedikt001.bsky.social @gunnarns.bsky.social for great discussions on NLRP3 inflammasomes and proteomics - first student co-supervised with Prof Ben Collins 😊

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Dr Rebecca Coll @colllab.bsky.social · 8d

Thank you Franklin!! 🔥😃

Dr Rebecca Coll @colllab.bsky.social · 13d

Nice to see our recent study on novel NLRP3 inhibitors with
Bioage Labs in @jem.org highlighted by @natrevdrugdiscov.nature.com - 🔦💊🔥 😍
Overcoming roadblocks to anti-inflammatory NLRP3 inhibitors nature.com/articles/d41...

Overcoming roadblocks to anti-inflammatory NLRP3 inhibitors

Discover the world’s best science and medicine | Nature.com

nature.com

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Reposted by Dr Rebecca Coll

Journal of Experimental Medicine @jem.org · 22d

@colllab.bsky.social et al. show that both BAL-0028 & BAL-0598 inhibit select hyperactive #NLRP3 mutations associated with #autoinflammation more potently than MCC950. BAL-0028 & BAL-0598 represent a new modality for NLRP3 inhibition in inflammatory diseases rupress.org/jem/article/...
#Inflammasome

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Reposted by Dr Rebecca Coll

Journal of Experimental Medicine @jem.org · 29d

Discovery of potent and selective inhibitors of human #NLRP3 with a novel mechanism of action. New study from Kevin Wilhelmsen (BioAge Labs), Rebecca Coll @colllab.bsky.social @wwiem-qub.bsky.social and colleagues: rupress.org/jem/article/...

#Inflammasome #Inflammation

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Dr Rebecca Coll @colllab.bsky.social · Sep 2

So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.

Journal of Experimental Medicine @jem.org · Sep 2

#NLRP3 is a target for antiinflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @colllab.bsky.social et al characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. rupress.org/jem/article/...
#Inflammasome

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Dr Rebecca Coll @colllab.bsky.social · Aug 22

Had a brilliant couple of days in Galway with the lab at the Irish Society for Immunology meeting - great science and great craic!!!

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Dr Rebecca Coll @colllab.bsky.social · Aug 15

Very exciting to see a new NLRP3 inhibitor enter the clinic! Great work from BioAge Labs www.globenewswire.com/news-release...

BioAge Labs Announces First Participant Dosed in Phase 1 Clinical Trial of BGE-102, a Novel Brain-Penetrant NLRP3 Inhibitor

First-in-human study evaluating safety, tolerability, pharmacokinetics, and pharmacodynamics of BGE-102, an orally available small molecule with potential...

www.globenewswire.com

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Dr Rebecca Coll @colllab.bsky.social · Aug 15

Congratulations to our latest cohort of summer students @WWIEM @qubelfastofficial.bsky.social for a fantastic final poster session - the standard was exceptionally high. Special shout out to Timothy Okafor who was a pleasure to host in my lab!!

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Reposted by Dr Rebecca Coll

David Wearing @davidwearing.bsky.social · Jul 19

Absolutely dystopian juxtaposition from the Guardian front page. Difficult to understand how anyone of decency and conscience can defend this government at this point. Just sheer moral degeneracy to arm a state that does this and arrest people for objecting. Wtf are we doing as a country?

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Reposted by Dr Rebecca Coll

Broz Lab @brozlab.bsky.social · Jul 19

Congrats to @malvinapiz.bsky.social and @inflammasomelab.bsky.social on their new paper on the role of cardiolipin in non canonical inflammasome activation. We’re happy to have contributed to the story 🎉🦠!!

www.embopress.org/doi/full/10....

Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11 | The EMBO Journal

imageimageAvailable caspase-4/11 (CASP4/11) inhibitors also block the activity of caspase-1 (CASP1), which complicates interpretation of results in functional studies and limits their clinical potenti...

www.embopress.org

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Dr Rebecca Coll @colllab.bsky.social · Jul 1

Paper accepted!!!

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Dr Rebecca Coll @colllab.bsky.social · Jun 25

Huge congratulations to the new Dr Thea Mawhinney!! Thank you to her fantastic examiners Prof Suzanne Cloonan @suzcloo.bsky.social and Prof Cliff Taggart @wwiem-qub.bsky.social

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Reposted by Dr Rebecca Coll

Science Magazine @science.org · Jun 7

Cockatoos have learned to operate drinking fountains in Australia.

The behavior—never before seen in birds—may be a developing cultural tradition among one population: scim.ag/4kIi12G

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Dr Rebecca Coll @colllab.bsky.social · May 13

I'm delighted to be hosting a #NLRP3 InflammaZoom spectacular next week! With Alex Weber and Ana Tapia Abellan - please join us on Monday 19th May. Register here: events.abcam.com/event/Inflam...

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Reposted by Dr Rebecca Coll

Inflammasome Lab @inflammasomelab.bsky.social · May 1

Inflammatory signalling must eventually be turned off (e.g. by feedback inhibition) to prevent chronic inflammation. We didn't know how #inflammasomes turn off their signalling in vivo ... until now! (🧵: 1/3)
shorturl.at/8lWxW

Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases

Signal shutdown mechanisms must exist to silence the potent inflammatory programs initiated by the caspase-1 (CASP1) protease, to allow inflammation to resolve and reinstate tissue homeostasis. It is ...

shorturl.at

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Reposted by Dr Rebecca Coll

Eva Frickel @frickellab.bsky.social · Apr 13

🔥 Open postdoc position in human inflammation-driven control of infection! 🔥
Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)

Please share!

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Dr Rebecca Coll @colllab.bsky.social · Apr 4

Agreed it's not quite beach weather yet!

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Dr Rebecca Coll @colllab.bsky.social · Apr 4

Oh 100% it's barely 16 - we need our vitamin D!

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Dr Rebecca Coll @colllab.bsky.social · Apr 3

You've got to love the Irish enthusiasm for a bit of good weather 16°C=summertime 😎

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