🔗 Discover more: bit.ly/3LUzM2U
#EMBO #GenomeEditing #CRISPR #SyntheticBiology #Microbiology #Biotechnology #Vilnius #LifeSciences

This work will drive new genome editing technologies and uncover fundamental DNA repair mechanisms, with impact across microbiome research, synthetic biology, industrial biotechnology, and healthcare.

🧬 My project, “Pause-Repair-Edit,” aims to move beyond current CRISPR tools by developing safer genome editing approaches that pause DNA replication to activate natural repair pathways—opening genome editing to many microorganisms that are currently hard to engineer.

Thank you Jens

Thank you Nicholas 😊

Amazing Martin!! All the best with the new lab and the amazing research you do!!!

Big shout-out to first authors Darshana Gupta, (myself :) ) & Harris V. Bassett, senior author Chase L. Beisel, and project initiator Scott P. Collins 🙌

This opens up brand-new possibilities for precision editing and studying DNA repair!

We developed append editing, a genome-editing strategy that installs ADP-ribose groups onto DNA to unlock new repair outcomes:
🔹 In bacteria → precise, scar-free edits via homologous recombination
🔹 In eukaryotes → unique T→A or T→C base substitutions not possible with current editors

Learn more ➡️ www.gmc.vu.lt/en/lsc-embl/...

Deadline: Open until a suitable candidate is found.
📧 Send your CV + Motivation Letter to: [email protected]

🧬 Our work focuses on next-generation genome editing tools for bacteria, yeasts, and phages — with a special focus on DNA replication stalling and repair!

🌍 Based in beautiful Vilnius, Lithuania
🔬 Access to state-of-the-art equipment and facilities
💼 Competitive salary, personalized mentorship, and cutting-edge research!

If you’re passionate about genome editing or synthetic biology…
If you want tailored mentorship to drive independent research and launch your career…
This is the place for you! ✨

Huge thanks to Simona Della Valle, Enrico Orsi and Sjoerd Creutzburg for driving this work.

Happy editing :)

If you want to use SIBR2.0 for your gene/protein of interest, you can visit the SIBR Site Finder site: colab.research.google.com/drive/162gIZ...

SIBR2.0 can virtually control the expression of any gene/protein of interest, in a wide range of (if not all) mesophilic prokaryotes