Constantinos Patinios
@copabio.bsky.social
Group leader at VU LSC-EMBL PI for Genome Editing Technologies, Vilnius, Lithuania
Genome engineer
CRISPR-Cas
DNA replication stall and repair
Genome engineer
CRISPR-Cas
DNA replication stall and repair
🚀 Excited to share that I’ve been awarded an EMBO Installation Grant to establish my research group at the EMBL Partnership Institute, Vilnius University Life Sciences Center! The grant provides €50,000/year for 5 years to build an internationally competitive lab and advance genome editing research.
January 20, 2026 at 3:30 PM
🚀 Excited to share that I’ve been awarded an EMBO Installation Grant to establish my research group at the EMBL Partnership Institute, Vilnius University Life Sciences Center! The grant provides €50,000/year for 5 years to build an internationally competitive lab and advance genome editing research.
Reposted by Constantinos Patinios
Our paper is out! Hiding in plain sight among Cas12a nucleases, Cas12a3 cleaves not its RNA target but the 3′ ends of tRNA. Huge thanks to all who made this possible, especially the Beisel lab, Biao & Dirk for the structure, & @sebastianglatt.bsky.social for all things tRNA. doi.org/10.1038/s415...
RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity - Nature
Cas12a3 nucleases constitute a distinct clade of type V CRISPR–Cas bacterial immune systems that preferentially cleave the 3′ tails of tRNAs after recognition of target RNA to induce growth arres...
www.nature.com
January 7, 2026 at 4:15 PM
Our paper is out! Hiding in plain sight among Cas12a nucleases, Cas12a3 cleaves not its RNA target but the 3′ ends of tRNA. Huge thanks to all who made this possible, especially the Beisel lab, Biao & Dirk for the structure, & @sebastianglatt.bsky.social for all things tRNA. doi.org/10.1038/s415...
Reposted by Constantinos Patinios
Openness means more than access.
We’re pleased to announce that we now publish Replication Studies, helping make science more reliable, transparent, and trustworthy.
buff.ly/Gebypvq
We’re pleased to announce that we now publish Replication Studies, helping make science more reliable, transparent, and trustworthy.
buff.ly/Gebypvq
September 24, 2025 at 10:28 PM
Openness means more than access.
We’re pleased to announce that we now publish Replication Studies, helping make science more reliable, transparent, and trustworthy.
buff.ly/Gebypvq
We’re pleased to announce that we now publish Replication Studies, helping make science more reliable, transparent, and trustworthy.
buff.ly/Gebypvq
Reposted by Constantinos Patinios
Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes - @helmholtz-hiri.bsky.social go.nature.com/4n7zDpG
Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes - Nature Biotechnology
Append editing of ADP-ribosyl to thymine is used for precise modifications in bacteria and eukaryotes.
go.nature.com
September 4, 2025 at 3:20 PM
Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes - @helmholtz-hiri.bsky.social go.nature.com/4n7zDpG
🚀 New publication alert! 🚀
We just published in @natbiotech.nature.com:
👉 Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes
doi.org/10.1038/s415...
We just published in @natbiotech.nature.com:
👉 Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes
doi.org/10.1038/s415...
Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes - Nature Biotechnology
Append editing of ADP-ribosyl to thymine is used for precise modifications in bacteria and eukaryotes.
doi.org
September 4, 2025 at 6:51 PM
🚀 New publication alert! 🚀
We just published in @natbiotech.nature.com:
👉 Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes
doi.org/10.1038/s415...
We just published in @natbiotech.nature.com:
👉 Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes
doi.org/10.1038/s415...
🚀 Join the Patinios Lab at the VU LSC - EMBL Partnership Institute for Genome Editing Technologies!
We are looking for a Postdoctoral Researcher to join our growing team! 🔎
We are looking for a Postdoctoral Researcher to join our growing team! 🔎
May 7, 2025 at 3:26 PM
🚀 Join the Patinios Lab at the VU LSC - EMBL Partnership Institute for Genome Editing Technologies!
We are looking for a Postdoctoral Researcher to join our growing team! 🔎
We are looking for a Postdoctoral Researcher to join our growing team! 🔎
Reposted by Constantinos Patinios
Good news on this 35th anniversary of the #Restoration of #Independence in #Lithuania!
A new ERC project from a Lithuanian researcher can now go ahead, as they were able to secure alternative EU funding for her ERC Consolidator Grant.
How did this happen? Find out in the thread 🧵👇
A new ERC project from a Lithuanian researcher can now go ahead, as they were able to secure alternative EU funding for her ERC Consolidator Grant.
How did this happen? Find out in the thread 🧵👇
March 11, 2025 at 12:34 PM
Good news on this 35th anniversary of the #Restoration of #Independence in #Lithuania!
A new ERC project from a Lithuanian researcher can now go ahead, as they were able to secure alternative EU funding for her ERC Consolidator Grant.
How did this happen? Find out in the thread 🧵👇
A new ERC project from a Lithuanian researcher can now go ahead, as they were able to secure alternative EU funding for her ERC Consolidator Grant.
How did this happen? Find out in the thread 🧵👇
Excited to see our SIBR work out in Trends in Biotechnology :)
doi.org/10.1016/j.ti...
This is the first study I have coordinated from start to finish, and it brings me immense satisfaction to see it published.
For a brilliant description of the tech check this: www.linkedin.com/feed/update/...
doi.org/10.1016/j.ti...
This is the first study I have coordinated from start to finish, and it brings me immense satisfaction to see it published.
For a brilliant description of the tech check this: www.linkedin.com/feed/update/...
Redirecting
doi.org
March 14, 2025 at 10:37 AM
Excited to see our SIBR work out in Trends in Biotechnology :)
doi.org/10.1016/j.ti...
This is the first study I have coordinated from start to finish, and it brings me immense satisfaction to see it published.
For a brilliant description of the tech check this: www.linkedin.com/feed/update/...
doi.org/10.1016/j.ti...
This is the first study I have coordinated from start to finish, and it brings me immense satisfaction to see it published.
For a brilliant description of the tech check this: www.linkedin.com/feed/update/...
SIBR2.0 is now out in a preprint!! doi.org/10.1101/2024...
Streamlined and efficient genome editing in Cupriavidus necator H16 using an optimised SIBR-Cas system
Cupriavidus necator H16 is a promising microbial platform strain for CO2 valorisation. While C. necator is amenable to genome editing, existing tools are often inefficient or rely on lengthy protocols...
doi.org
November 25, 2024 at 1:47 PM
SIBR2.0 is now out in a preprint!! doi.org/10.1101/2024...
How about a new genome editing tool?? #Append Editing, #ADPr-TAE, #Homologous recombination, #Base mutagenesis. doi.org/10.1101/2024...
Thread: 🧵
Thread: 🧵
Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes
Base editors create precise genomic edits by directing nucleobase deamination or removal without inducing double-stranded DNA breaks. However, a vast chemical space of other DNA modifications remains ...
doi.org
November 20, 2024 at 10:46 AM
How about a new genome editing tool?? #Append Editing, #ADPr-TAE, #Homologous recombination, #Base mutagenesis. doi.org/10.1101/2024...
Thread: 🧵
Thread: 🧵