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Cosimo Commisso @cosimocommisso.bsky.social · 13d

Thankful for this amazing group. There are many accomplishments to be proud of this year. Looking forward to the discoveries they will continue to make in the future for pancreatic cancer.

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Reposted by Cosimo Commisso

Monte Winslow Lab @winslowlab.bsky.social · 13d

Epigenomic changes are critical non-mutational cancer drivers. Jackie Tang in our lab lead a project to generate a phenotypic roadmap of epigenomic regulators in lung tumorigenesis. Lots of unexpected and interesting tumor suppressors including the HBO1 complex doi.org/10.1158/2159-8290.CD-24-1565

Functional mapping of epigenomic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes

Abstract. Epigenomic dysregulation is widespread in cancer. However, the specific epigenomic regulators and the processes they control to drive cancer phenotypes are poorly understood. We employed a n...

doi.org

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Cosimo Commisso @cosimocommisso.bsky.social · 13d

Thank you for sharing. Very nice to see these results consistent with elifesciences.org/articles/45313

Transcriptional control of subtype switching ensures adaptation and growth of pancreatic cancer

The GLI2 transcription factor is a master regulator of the aggressive basal-like subtype of pancreatic cancer and enables adaptation to oncogenic KRAS ablation.

elifesciences.org

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Cosimo Commisso @cosimocommisso.bsky.social · 18d

Actually ours was the whole Hulu account not Disney itself.

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Cosimo Commisso @cosimocommisso.bsky.social · 18d

Oh wow. We were able to cancel ours ok… I think.

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Cosimo Commisso @cosimocommisso.bsky.social · Sep 2

Thrilled to share our first collaboration with @bemerling.bsky.social 🎉 Fantastic work by first author Dr. Gurpreet Arora showing how PI5P4Kα fuels pancreatic cancer cell fitness and reveals a new therapeutic vulnerability. www.cell.com/cell-reports...

PI5P4Kα promotes glucose and iron acquisition to support metabolic fitness in pancreatic cancer

PI5P4Kα is a critical metabolic gatekeeper in PDAC, promoting glucose and iron acquisition to support tumor survival. Arora et al. demonstrate that PI5P4Kα suppression disrupts the metabolic flexibili...

www.cell.com

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Reposted by Cosimo Commisso

Sandra McAllister, PhD @sandramcallister.bsky.social · Aug 14

It’s out!!!!! We hope our review on aging, immunity, and cancer is helpful.

Such a rewarding group effort led by Melissa Dolan, with Kendra Libby, Alison Ringle, and @vangalenlab.bsky.social

So grateful to @gabriellebrewer.bsky.social @natrevcancer.nature.com for her efforts and support

Nature Reviews Cancer @natrevcancer.nature.com · Aug 14

NEW content online!

Ageing, immune fitness and cancer

Nature Reviews Cancer, Published online: 14 August 2025; doi:10.1038/s41568-025-00858-zAgeing reshapes immune composition, function and regenerative capacity, with profound effects on tumour immunity, cancer progression and treatment outcomes. In this Review, Dolan and colleagues examine how age-resolved immunoprofiling, insights from ageing haematopoiesis and preclinical modelling are uncovering immune ageing dynamics and therapeutic challenges — revealing new opportunities to optimize cancer therapy across diverse age groups.

www.nature.com

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Reposted by Cosimo Commisso

Gina DeNicola @ginadenicola.bsky.social · Aug 12

Join us in at Moffitt! The Metabolism Program is recruiting at the Assistant Member (Assistant Professor) level. Review of applications starts September 1st. Please share! Details here: moffitt-cancer-center-careers.hctsportals.com/jobs/1883440...

Tenure-Earning Assistant Member Metabolism & Physiology Faculty in Tampa, FL - Moffitt Cancer Center CareersTenure-Earning Assistant Member Metabolism & Physiology Faculty in Tampa, FL - Moffitt Cance...

Working at Moffitt Cancer Center is both a career and a mission. All employees are dedicated to patient care, research and education to advance our fight against this disease.

moffitt-cancer-center-careers.hctsportals.com

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Cosimo Commisso @cosimocommisso.bsky.social · Aug 1

‪
That's a wrap on a year as Interim Director of the SBP Cancer Center. I learned a lot—about CCSG, leadership, and myself. Building a strong Center takes great science, a strong team, and real institutional support. Super prepared for complex challenges and leading with purpose!
#Cancer #Leadership

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Cosimo Commisso @cosimocommisso.bsky.social · Jul 29

Thanks Jason!

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Reposted by Cosimo Commisso

Cancer Cell @cp-cancercell.bsky.social · Jul 24

Online Now: Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer

Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer

Zhang et al. demonstrate that macropinocytosis inhibition induces myCAF-to-iCAF conversion through a metabolically stressed, MEK-ERK-dependent intermediate state. This CAF plasticity remodels the pancreatic tumor microenvironment and improves responses to immunotherapy and chemotherapy, supporting macropinocytosis inhibition as a promising approach for combination treatment strategies in pancreatic cancer.

dlvr.it

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Cosimo Commisso @cosimocommisso.bsky.social · Jul 27

Looking forward to the Mechanisms and Models Symposium being held at @salkinstitute.bsky.social in a few days. Amazing set of speakers. Excited to share our work on the tumor stroma, metabolism and aging. #cancer www.salk.edu/events/scien...

Abstract Book - Salk Institute for Biological Studies

Click here for abstract book

www.salk.edu

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Reposted by Cosimo Commisso

Sanford Burnham Prebys @sbpdiscovery.bsky.social · Jul 26

A promising advance for pancreatic cancer published Cancer Cell: Blocking macropinocytosis reduces fibrosis around pancreatic tumors, improving immune cell access & boosting response to chemo & immunotherapy in mice. sbpdiscovery.org/press/reshap... @cosimocommisso.bsky.social @yijuan.bsky.social

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Reposted by Cosimo Commisso

Mara Sherman @marasherman.bsky.social · Jul 24

To distract from your own stress responses (!!!), check out this awesome new study from the Commisso lab linking metabolic stress to regulation of the pancreatic tumor microenvironment! ✨

Cosimo Commisso @cosimocommisso.bsky.social · Jul 24

Excited to share work published in @cp-cancercell.bsky.social by @yijuan.bsky.social showing that macropinocytosis inhibition drives myCAF-to-iCAF conversion, enhancing therapeutic responses in pancreatic cancer. Thank you to our collaborators that contributed! www.sciencedirect.com/science/arti...

Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) tumors are glutamine deficient, and both tumor cells and cancer-associated fibroblasts (CAFs) rely on this ami…

www.sciencedirect.com

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Cosimo Commisso @cosimocommisso.bsky.social · Jul 24

Excited to share work published in @cp-cancercell.bsky.social by @yijuan.bsky.social showing that macropinocytosis inhibition drives myCAF-to-iCAF conversion, enhancing therapeutic responses in pancreatic cancer. Thank you to our collaborators that contributed! www.sciencedirect.com/science/arti...

Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) tumors are glutamine deficient, and both tumor cells and cancer-associated fibroblasts (CAFs) rely on this ami…

www.sciencedirect.com

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Reposted by Cosimo Commisso

Muir Lab @muirlab.bsky.social · Jul 19

Super excited to share new review on metabolic stress and adaptations in pancreatic cancer to these stresses from @cssheehan.bsky.social
jci.org/articles/vie... 1/6

JCI - What’s on the menu?: metabolic constraints in the pancreatic tumor microenvironment

jci.org

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Cosimo Commisso @cosimocommisso.bsky.social · Jul 15

I have an awesome PB&J recipe. I should send it in!

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Reposted by Cosimo Commisso

Gomes Lab @gomeslab.bsky.social · Jul 11

Super excited to share our newest piece out today @natrevcancer.nature.com linking age-induced metabolic reprogramming to cancer development. www.nature.com/articles/s41...

Cancer progression through the lens of age-induced metabolic reprogramming - Nature Reviews Cancer

In this Perspective, Lazure and Gomes argue that metabolic changes that occur as a result of ageing may shape tumour initiation and progression and the development of metastatic disease.

www.nature.com

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Reposted by Cosimo Commisso

Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · Jul 7

"There's a large literature which shows that the rate of return to public R&D is outsized. It's enormous. Some estimates suggest as much as 50% rate of return to public R&D investments. And really, that was what made America great."

Jeremy Berg @jeremymberg.bsky.social · Jul 7

Fascinating piece from Paul Krugman with Jonathan Gruber with a powerful argument for public funding of science.

paulkrugman.substack.com/p/health-car...

1/n

Health Care: Jonathan Gruber

A key founding father of Obamacare on what comes next

paulkrugman.substack.com

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Reposted by Cosimo Commisso

Denis Wirtz @deniswirtz.bsky.social · Jun 29

Ted Koppel interviews my Hopkins colleague Prof. Liz Jaffee, world expert in pancreatic cancer, about the devastating cuts and slow roll out of cancer research funding by the NIH.

See this CBS Sunday morning show video here: www.youtube.com/watch?v=CLwc...

Saving money vs. saving lives

YouTube video by CBS Sunday Morning

www.youtube.com

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Reposted by Cosimo Commisso

Senator Patty Murray @murray.senate.gov · Jun 10

My message to Trump’s NIH Director? No one in America wants us to do LESS cancer research.

No one is asking Trump to make it harder to cure Alzheimer's disease.

Yet Trump is cutting all of this NOW and demanding an $18 BILLION cut to NIH next year. Not on my watch.

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Cosimo Commisso @cosimocommisso.bsky.social · May 31

Congrats!!

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Cosimo Commisso @cosimocommisso.bsky.social · May 28

🚨 New paper out! PSGL-1 is a 🔥 immune checkpoint in pancreatic cancer. Knocking it out=more CD8+ T cells, less tumor, better PD-1 response. 🧬Major props to @jlhope.bsky.social (Drexel) & Linda Bradley (SBP) for leading this awesome collab! #PDAC #Immunotherapy #Tcells www.biorxiv.org/content/10.1...

Disabling PSGL-1 abrogates immune suppression and resistance to PD-1 blockade in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer for which there is a critical need to identify novel therapeutic targets. Herein we define PSGL-1 as a checkpoint inhibitor using a syngeneic...

www.biorxiv.org

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Reposted by Cosimo Commisso

Barbara Marte @barbmarte.bsky.social · May 21

new out in Nature today www.nature.com/articles/s41...

PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer - Nature

PCSK9 regulates low density lipoprotein-cholesterol import and determines organ preference of metastatic pancreatic ductal adenocarcinoma, with PCSK9-low cells metastasizing to the liver and PCSK9-hig...

www.nature.com

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Cosimo Commisso @cosimocommisso.bsky.social · May 22

Important new work from @rushika-perera.bsky.social and team that sheds light on metastatic tropism is PDAC.

Christian Frezza @frezzalab.bsky.social · May 21

PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer

www.nature.com/articles/s41...

Massive congratulations to @rushika-perera.bsky.social Lab!!

PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer - Nature

PCSK9 regulates low density lipoprotein-cholesterol import and determines organ preference of metastatic pancreatic ductal adenocarcinoma, with PCSK9-low cells metastasizing to the liver and PCSK9-hig...

www.nature.com

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