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Crisis Management @crisismgmt.bsky.social · 10d

Given what the opposition ISN’T doing, I fully concur.

Crisis Management @crisismgmt.bsky.social · 10d

Weekend activity: infiltrating conspiracy theory groups to make them stupider. "I keep trying to get autism the the vaccines DON'T WORK"

[May #Tylenol cure this intractable political #Headache.]
#CrisisManaged

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The Bully Pulpit 🇨🇦 @thebullypulpit.bsky.social · 13d

NOT ONE WORD—EVER—on how a rise in cancer might be due to COVID. The growing body of research would like a word:

𝘚𝘈𝘙𝘚-𝘊𝘰𝘝-2 𝘪𝘯𝘧𝘦𝘤𝘵𝘪𝘰𝘯 𝘩𝘦𝘪𝘨𝘩𝘵𝘦𝘯𝘴 𝘳𝘪𝘴𝘬 𝘰𝘧 𝘥𝘦𝘷𝘦𝘭𝘰𝘱𝘪𝘯𝘨 𝘏𝘗𝘝-𝘳𝘦𝘭𝘢𝘵𝘦𝘥 𝘤𝘢𝘳𝘤𝘪𝘯𝘰𝘮𝘢 𝘪𝘯 𝘴𝘪𝘵𝘶 𝘢𝘯𝘥 𝘤𝘢𝘯𝘤𝘦𝘳—Discover Oncology

𝘚𝘈𝘙𝘚-𝘊𝘰𝘝-2 𝘪𝘯𝘧𝘦𝘤𝘵𝘪𝘰𝘯 𝘢𝘸𝘢𝘬𝘦𝘯𝘴 𝘮𝘦𝘵𝘢𝘴𝘵𝘢𝘵𝘪𝘤 𝘣𝘳𝘦𝘢𝘴𝘵 𝘤𝘢𝘯𝘤𝘦𝘳 𝘤𝘦𝘭𝘭𝘴 𝘪𝘯 𝘭𝘶𝘯𝘨𝘴—Nature

This study aims to investigate the impact of SARS-CoV-2 infection on HPV-
related cancer and carcinoma in situ.

Method: We utilized data from TriNetX, a database encompassing 106 healthcare
organizations spanning 15 countries and comprising information from over 124 million participants. Propensity score matching was utilized to compare two cohorts: SARS-CoV-2 infection and non- SARS-CoV-2 infection groups. The cohorts consisted of females aged 18–90 with no previous history of HPV-related cancers before SARS-CoV-2 infection in 2020 and no HPV vaccine before 2020. We utilized Cox proportional hazard regression analysis to estimate hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs). Subgroup analyses were performed based on age and race to validate the findings.

Results: The study included a total of 4,872,295 patients, with 1,281,997 in the SARS-CoV-2 infection group and 3,590,298 in the non-infection group. After propensity score matching, both groups comprised 1,281,997 patients each. Over a 3-year follow-up period, individuals with SARS-CoV-2 infection had significantly higher risks of developing HPV-related cancers compared to those without infection: a 67% increase in cervical cancer, 131% in vaginal cancer, 98% in vulvar cancer, 92% in anal cancer, and 78% in oropharyngeal cancer. Similar trends were observed for carcinoma in situ, with increased risks of 34% for cervical, 61% for vaginal, 74% for vulvar, 96% for anal, and 78% for oropharyngeal carcinoma in situ. Subgroup analyses stratified by age and race
demonstrated consistent results.

Conclusion: SARS-CoV-2 infection is associated with elevated risks of HPV-related carcinoma in situ and cancer, irrespective of age or race. The findings underscore the importance of understanding the interplay between viral infections and cancer development, particularly in the context of the COVID-19 pandemic.

Source: https://doi.org/10.1007/s12672-025-03403-4

Since the onset of the COVID-19 pandemic, the potential influence of SARS-CoV-2 on cancer progression has been a crucial question in the research community. Although species differences warrant caution in interpreting mouse data, UK Biobank analyses show that cancer survivors had increased cancer mortality after SARS-CoV-2 infection. This risk peaked in the months after infection, paralleling mouse models showing greater than 100-fold DCC expansion into metastatic lesions within two weeks. Analyses based on the Flatiron Health database further reveal a marked rise in metastatic lung disease among breast cancer survivors following COVID-19. Collectively, these findings underscore the substantial metastatic risk COVID-19 posed to cancer survivors, with dormant DCC reactivation potentially driving this phenomenon.

Our studies highlight the importance of developing interventions to minimize the risk of lung DCC awakening and metastatic disease in the millions of cancer survivors who experience respiratory virus infections. As well as primary prevention strategies, treatments for managing severe COVID-19 that have been approved by the US Food and Drug Administration include antagonistic antibodies against IL-6R46 and orally available JAK1/2 inhibitors, raising the prospect of interventions that could reduce the risk of infection-induced metastatic cancer progression. The effectiveness and safety of these interventions, and the timing of their application to avoid impeding the resolution of the infection, will need to first be tested in preclinical and clinical studies.

In conclusion, our studies reveal how respiratory virus infections can increase cancer recurrence risk and underscore the need for public health and clinical strategies to mitigate the increased risk of metastatic progression associated with SARS-CoV2 and other respiratory virus infections.

Source: https://doi.org/10.1038/s41586-025-09332-0

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Crisis Management @crisismgmt.bsky.social · 14d

This strip is quite the feet

Haus of Decline @hausofdecline.bsky.social · 14d

Early transition Alex still looking like a boy with stubble balances a pill of estradiol on her thumb and asks herself "I wonder what the biggest change on estrogen will be." Alex pops the pill on her tongue. She says "I no longer care for the movies of Quentin Tarantino." A look of passionate sadness comes over her face and she continues "except for Jackie Brown, which I relate to even more."

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Crisis Management @crisismgmt.bsky.social · 14d

This strip is quite the feet.

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Gianmarco Soresi @gianmarcosoresi.bsky.social · 15d

Thoughts on Jimmy Kimmel’s return

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Crisis Management @crisismgmt.bsky.social · 15d

Great, now Australia’s gonna have a bunch of sex-crazed, autistic koalas.

[Note to the US government and MAGA writ large: no, they won’t. Not how ANY of this works]

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Crisis Management @crisismgmt.bsky.social · 15d

I know it.
It's a problem.
Even here, where the bots and trolls don't reign supreme.

Onion headlines can barely compete with the NYTimes.

Time for a hard reset.
Of everything.

Except the #Habs young lineup. Those kids are gonna give us a Stanley Cup.

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Crisis Management @crisismgmt.bsky.social · 15d

Only drawing attention to the fact that moral bankruptcy doesn’t suddenly become moral solvency once you’re in power.

And that Establishment Democrats are utterly bankrupt.

Democracy is about mandates. (What the people want). Not just "winning" (as has become politics’ sole cynical obsession)

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Crisis Management @crisismgmt.bsky.social · 15d

Exactly.

The old Nazis were great at gaining and retaining power. Just not so great at conquering Russia. Do what they did! Get Realpolitik!

(You’ll notice this account tends towards satire: the management advice suggested in posts containing #CrisisManaged is always epically bad. As is this one)

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Crisis Management @crisismgmt.bsky.social · 16d

Y'all are trippin'. Establishment Dems are right: You do what the other guys did—copy-paste

Because it brought them to power & THAT's the whole point!

Only then do you push policies that might save us from imminent collapse…but only if it doesn't mess with your 𝘳𝘦𝘵𝘢𝘪𝘯𝘪𝘯𝘨 power #CrisisManaged

Kamala Harris says Biden should've invited Elon Musk to the White House in 2021

The former VP writes in her new book that Musk set off her "spidey senses" long before his MAGA pivot in 2024.

www.businessinsider.com

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Crisis Management @crisismgmt.bsky.social · 16d

Y'all are trippin'. Establishment Dems are right: You do what the other guys did—copy-paste

Because it brought them to power & THAT's the whole point!

Only then do you push policies that might save us from imminent collapse…but only if it doesn't mess with your 𝘳𝘦𝘵𝘢𝘪𝘯𝘪𝘯𝘨 power #CrisisManaged

Kamala Harris says Biden should've invited Elon Musk to the White House in 2021

The former VP writes in her new book that Musk set off her "spidey senses" long before his MAGA pivot in 2024.

www.businessinsider.com

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Crisis Management @crisismgmt.bsky.social · 19d

Wait…
You have people INTERACTING with something you said?

With stuff you said THREE MONTHS AGO?!!!

I can’t even get my mother to return my call…

Maybe I should block more.
Or post more.
Or make some goddam sense.
…
Or just keep yelling into the void. Since that’s really all this is: Futile. 😞

Crisis Management @crisismgmt.bsky.social · 20d

NGL, kinda loving the matriarchal lineage. Go Janettes Jarrow!

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Crisis Management @crisismgmt.bsky.social · 20d

Breaking: Unsealed copies of the Panama Papers reveal that Janette Keene Taylor’s actual name is Janette Jarrow III. She does not own stock in Jarrow.

She IS Jarrow.

(One would hope some companies out there still have a standards and ethics. Seems like the bare minimum)

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Crisis Management @crisismgmt.bsky.social · 20d

Road reflector manufacturing plant?

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DrMacLeodCartoons @macltoons.bsky.social · 27d

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Tennessee Brando @tnbrando.bsky.social · 27d

So now MAGA is saying that Tyler Robinson was friends with a trans person. Donald Trump was friends for 15 years with a child sex trafficker and they didn’t bat an eye.