Repost appreciated:
Open #PhDposition in structural virology in my group! Join us in Umeå, Sweden to uncover how arboviruses remodel infected cells. In situ #cryoET and #cryoEM combined with #virology, #cellbiology, and #biophysics.
Deadline 7 September. More info: www.carlsonlab.se/join/

I am happy our recent study on the human sperm head-tail junction is now online. We find that SUN5 form an hexagonal lattice at the nuclear membrane, rationalising how mutations in SUN5 lead to infertility. Great work of @cryonas.bsky.social !
www.biorxiv.org/content/10.1...

Last but not least I would like to thank everyone involved! Quite excited to join #teamtomo! 4/4

Using subtomogram averaging we further determine the structure of the SUN5 LINC lattice and propose a model in which the lattice, formed by SUN5 trimers, reinforces the head-tail junction. This model could also explain SUN5's role in ASS. Full story here: www.biorxiv.org/content/10.1... 3/4

SUN5 is part of LINC (linker of nucleo- and cytoskeleton) complexes, which do exactly what their name suggests: physically link🔗 the nuclear lamina with the cytoskeleton via the NE. Specifically staining for SUN5, we confirm its localization to the posterior sperm head by fluorescence microscopy.2/4

ASS is short for acephalic spermatozoa syndrome in which head and tail of sperm are detached⛓️‍💥, commonly caused by mutations in the gene encoding for SUN5. Using in situ cryo-ET❄️🔬 we find that SUN5 forms a protein lattice in the nuclear envelope (NE) at the head-tail junction of mammalian sperm.1/4

Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6

Mature #HIV-1 contains >2000 copies of “spacer peptide 2”, but we didn’t know why. We now see that SP2 binds the matrix protein and triggers the change into its mature arrangement. Summary video from @margotriggi.bsky.social