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Cold Spring Harbor Laboratory Press @cshlpress.bsky.social · 6d

The new issue of @genomeresearch.bsky.social is now live. Follow the link to new research on microglia in neurodegenerative diseases, intron retention in nuclear RNA complexes, and more! tinyurl.com/Genome-Res-3...

Cold Spring Harbor Laboratory Press @cshlpress.bsky.social · Sep 3

The new issue of @genomeresearch.bsky.social is now live. Follow the link to new research on HER2 isoform diversity and drug resistance in breast cancer, off-target site detection in prime editing, and more! tinyurl.com/Genome-Res-3...

Cold Spring Harbor Laboratory Press @cshlpress.bsky.social · Aug 4

The new issue of @genomeresearch.bsky.social is now live. Follow the link to new research on oxygen stress and gene regulation in the brain, a new C. elegans reference genome, and more! tinyurl.com/Genome-Res-3...

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Cold Spring Harbor Laboratory Press @cshlpress.bsky.social · Aug 1

New issue of Genes & Development! Inspired by the 2025 CSHL Symposium on Aging & Senescence, this issue features a collection of Outlook, Perspective, and Review articles on the impact of aging on metabolism, immunity, reproductive health & cancer. Online now: genesdev.cshlp.org/content/39/15-16.toc

Cold Spring Harbor Laboratory Press @cshlpress.bsky.social · Jul 2

The new issue of @genomeresearch.bsky.social is now live. Follow the link to new research on single-cell multiomics of muscle response to endurance exercise, a method for Nanopore data compression, and more! tinyurl.com/Genome-Res-3...

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Cold Spring Harbor Laboratory Press @cshlpress.bsky.social · Jun 3

The new issue of @genomeresearch.bsky.social is now live. Follow the link to new research on TP53 regulation of transposable elements in cancer, gut microbiome–associated protists, and more! tinyurl.com/Genome-Res-3...

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Cold Spring Harbor Laboratory Press @cshlpress.bsky.social · May 7

Call for Papers! @genomeresearch.bsky.social is now encouraging submissions for a Special Issue on The Genetics and Genomics of Somatic Mosaicism, Guest Edited by Drs. Gilad Evrony, Eunjung (Alice) Lee, and Raheleh Rahbari. tinyurl.com/Call-for-pap... #BOG25 #KSMosaicism25 #MITS25 #somaticmosaicism

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Cold Spring Harbor Laboratory Press @cshlpress.bsky.social · May 5

The new issue of Genome Research is now live! Follow the link to a new ultra-long nanopore sequencing toolkit, a unified analysis of atlas single-cell data, and more! tinyurl.com/Genome-Res-3...

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Reposted by Cold Spring Harbor Laboratory Press

Genes & Development @genesdev.bsky.social · May 2

📽️ G&D Tapes 📽️

G&D author, Jelani Lyda talks about a new study in #GenesDev by Riley et al. reporting the role of ClpCP protease and novel protein MdfA in driving metabolic differentiation and dormancy during bacterial sporulation. #OpenAccess

Learn more here:
➡️ tinyurl.com/gd352535

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Cold Spring Harbor Laboratory Press @cshlpress.bsky.social · Apr 17

SF3B1: from core splicing factor to oncogenic driver — this #RNASpecialIssue article explores how SF3B1-mutant splicing drives cancer, with insights into prognosis, phenotypes & the need for targeted therapies. bit.ly/4bqmRy2

Cold Spring Harbor Laboratory Press @cshlpress.bsky.social · Apr 17

RNA-binding proteins at the crossroads of disease: Fragile X & SMA. This #RNASpecialIssue article traces how SMN complex, RNP assembly, and more emerged from curiosity-driven, collaborative RNA research. bit.ly/3Xv2hGX

RNA-binding proteins in disease etiology: fragile X syndrome and spinal muscular atrophy

A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms

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Reposted by Cold Spring Harbor Laboratory Press

Genome Research @genomeresearch.bsky.social · Apr 14

SPECIAL ISSUE Part 2! This month @genomeresearch.bsky.social publishes a diverse collection of articles offering novel biological and clinical insights gained using long-read DNA and RNA sequencing technologies and other long molecule approaches.
tinyurl.com/Genome-Res-3...

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Cold Spring Harbor Laboratory Press @cshlpress.bsky.social · Apr 15

Connecting genotype and phenotype in minor spliceosome diseases.
This article from the #RNASpecialIssue outlines the current structural and functional knowledge of the minor spliceosome, and discusses emerging challenges in connecting molecular dysfunctions to clinical phenotypes. bit.ly/4bt3aWz

Cold Spring Harbor Laboratory Press @cshlpress.bsky.social · Apr 11

This Perspective from the #RNASpecialIssue summarizes the current knowledge of translation dysregulation in cancer, with emphasis on the eukaryotic translation initiation factor 4F complex. It outlines recent endeavors to develop novel treatment strategies to combat cancer: bit.ly/3F4Sv8g

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Cold Spring Harbor Laboratory Press @cshlpress.bsky.social · Apr 9

Adenosine-to-inosine RNA editing by ADARs, first discovered in the 1980s, plays a complex role in disease. This #RNASpecialIssue review explores current knowledge, therapeutic potential, and key unanswered questions. bit.ly/3F3Vqy1

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Cold Spring Harbor Laboratory Press @cshlpress.bsky.social · Apr 7

Exploring the therapeutic potential of modulating nonsense-mediated mRNA decay.
This paper from the #RNASpecialIssue explores promising approaches employed to regulate NMD for therapeutic purposes, and highlights potential challenges in future clinical development. bit.ly/3F86Ron

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Cold Spring Harbor Laboratory Press @cshlpress.bsky.social · Apr 4

This review from the #RNASpecialIssue discusses the distribution, regulation, and mechanisms of cytoplasmic polyadenylation element-binding proteins (CPEBs), highlighting their dual roles in either promoting or repressing gene expression depending on cellular context. bit.ly/41pFqhp

Cytoplasmic regulation of the poly(A) tail length as a potential therapeutic target

A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms

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Reposted by Cold Spring Harbor Laboratory Press

Cold Spring Harbor Laboratory @cshlnews.bsky.social · Apr 2

🧬 This National Children's Book Day, meet the tiny heroes inside us all! Stem Cells to the Rescue from CSHL Press is a science adventure that shows kids how our bodies heal. #ChildrensBookDay #STEMforKids #CSHLPress

www.cshlpress.com/default.tpl?...

www.cshlpress.com

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Cold Spring Harbor Laboratory Press @cshlpress.bsky.social · Apr 2

Alternative splicing (AS) is vital for heart function, and its disruption is linked to disease. This #RNASpecialIssue article highlights nonsplicing roles of AS factors and proposes a novel disease mechanism involving pathogenic RNA granules and disrupted AS factor localization. bit.ly/3DkHM9d

Cold Spring Harbor Laboratory Press @cshlpress.bsky.social · Mar 31

Cytoplasmic viruses alter nuclear trafficking, causing RNA-binding proteins (RBPs) to relocate and act as antiviral defenses. This article from the #RNASpecialIssue explores host–virus interactions and the unanswered questions about their mechanisms. bit.ly/3QJOjNG

Cold Spring Harbor Laboratory Press @cshlpress.bsky.social · Mar 26

This article examines how RNA sensors bind ligands and trigger type I interferon-stimulated genes. It also explores how mutations in RNA sensors and RNA homeostasis genes are linked to autoimmune and autoinflammatory diseases. bit.ly/4bowQEb #RNASpecialIssue

Cold Spring Harbor Laboratory Press @cshlpress.bsky.social · Mar 24

Viral quasispecies are dynamic mutant distributions that arise from high RNA replication error rates. This article from the #RNASpecialIssue reviews the molecular basis of mutant swarm formation, its role in viral disease and epidemics, and more: bit.ly/4kovSf0

Cold Spring Harbor Laboratory Press @cshlpress.bsky.social · Mar 20

This article examines RNA gain-of-function mutations from expanded short tandem repeats (STRs) in developmental and degenerative diseases. It discusses STR roles in RNA processing, their impact on myotonic dystrophy, and relevance to other STR expansion disorders: bit.ly/4igE5jS #RNASpecialIssue

RNA gain-of-function pathomechanism in DM1. Bidirec-
tional transcription of DM1 DMPK produces sense CUGexp RNAs
that bind MBNL proteins (red ovals), which undergo RNA–RNA,
RNA–protein, and protein–protein multivalent interactions to form
RNA foci or condensates (1). In contrast to sense transcription, anti-
sense transcription yields very low-abundance RNAs with/without
CAGexp repeats (Gudde et al. 2017). MBNL sequestration in these
foci together with phosphorylated CELF (blue sphere with black P)
overexpression promotes fetal splicing patterns for target RNAs in
adult tissues, and in DM1 skeletal muscle, exon 7A inclusion in
CLCN1 mRNA (fetal isoform) (2) results in nonsense-mediated decay
(NMD), CLCN1 loss, and myotonia (3). Somatic CTG expansions result
in extremely long CUGexp tracts that deplete MBNL (4) from the dilute
nucleoplasmic pool, leading to release of intact or fragmented mutant
DMPK mRNAs into the cytoplasm where they undergo RAN transla-
tion, giving rise to toxic RAN proteins (green and brown/yellow beads)
(5). Mutant DMPK antisense transcripts may be exported into the cy-
toplasm at a low level, resulting in RAN translation of polyGln (Zu et al.
2011), and possibly polySer and polyAla, proteins.

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Reposted by Cold Spring Harbor Laboratory Press

Prof. Rivka Isaacson @rli22.bsky.social · Mar 18

🧪Awesome Lizzie from the press office @kingsnmes.bsky.social has written a story about our new papers in Genes & Development @cshlpress.bsky.social which identify MdfA, a new protein that helps bacteria shut down their metabolism as they transform into spores: www.kcl.ac.uk/news/scienti...

Scientists discover protein key to bacteria's survival in extreme environments

The discovery sheds light on how certain bacteria form spores for survival, enabling superbugs to evade hospital cleaning

www.kcl.ac.uk

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Cold Spring Harbor Laboratory Press @cshlpress.bsky.social · Mar 19

Fragile X syndrome (FXS) is caused by CGG repeat expansion in FMR1, leading to DNA methylation and loss of FMRP. This #RNASpecialIssue paper explores how splice-switching ASOs and kinase inhibition can restore FMR1 expression, offering new therapeutic potential: bit.ly/4i2UpF2 #FragileX #RNAsplicing