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Reposted by Danette Daniels

Georg Winter @georgwinter.bsky.social · Jan 30

Excited about programming biology via induced proximity? Then mark June 2026 in your calendar and consider participating in the GRC Conference on Induced Proximity Modalities and Therapeutics that I am co-organizing with @danetteldaniels.bsky.social
tinyurl.com/brtuffam

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Enable Cluster in Frankfurt @enablefrankfurt.bsky.social · Jan 30

Congratulations to the two winners of the Women in TPD & Induced Proximity conference travel scholarships @jessicagraham1.bsky.social and Leyna Duong.
We look forward to welcoming you at our #FCQC2025 in March!

@womenintpd.bsky.social @danetteldaniels.bsky.social

Women in TPD & Induced Proximity @womenintpd.bsky.social · Jan 28

Congratulations to Jessica Graham from @crick.ac.uk and Leyna Duong from Stanford who have been awarded Women in TPD & Induced Proximity conference travel scholarships to attend the 4th Frankfurt Conference on Quality Control in Life Processes!

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jessicagraham1.bsky.social @jessicagraham1.bsky.social · Jan 28

Thank you so much to the @womenintpd.bsky.social for this opportunity! What a fab initiative empowering women in science. Excited to connect in Frankfurt

Women in TPD & Induced Proximity @womenintpd.bsky.social · Jan 28

Congratulations to Jessica Graham from @crick.ac.uk and Leyna Duong from Stanford who have been awarded Women in TPD & Induced Proximity conference travel scholarships to attend the 4th Frankfurt Conference on Quality Control in Life Processes!

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Danette Daniels @danetteldaniels.bsky.social · Jan 28

Kudos Jessica and Leyna! Looking forward to meeting both of you in Frankfurt ☺️

Women in TPD & Induced Proximity @womenintpd.bsky.social · Jan 28

Congratulations to Jessica Graham from @crick.ac.uk and Leyna Duong from Stanford who have been awarded Women in TPD & Induced Proximity conference travel scholarships to attend the 4th Frankfurt Conference on Quality Control in Life Processes!

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Danette Daniels @danetteldaniels.bsky.social · Jan 24

Congratulations to both of you! @WomeninTPD first official scholarship award winners ☺️

Women in TPD & Induced Proximity @womenintpd.bsky.social · Jan 24

Congratulations to @alesalerno.bsky.social from University of Dundee CeTPD and Christine Ng from @stanford-chemh.bsky.social who have been selected as recipients of our conference travel scholarships to attend the Proximity-based Therapeutics Keystone conference @keystonesymposia.bsky.social!

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Alessandra Salerno 👩‍🔬 @alesalerno.bsky.social · Jan 24

Big thanks to @womenintpd.bsky.social for this amazing initiative and support in empowering women in the field! Grateful and excited to attend @keystonesymposia.bsky.social soon and make the most of this incredible experience! ✨️

Women in TPD & Induced Proximity @womenintpd.bsky.social · Jan 24

Congratulations to @alesalerno.bsky.social from University of Dundee CeTPD and Christine Ng from @stanford-chemh.bsky.social who have been selected as recipients of our conference travel scholarships to attend the Proximity-based Therapeutics Keystone conference @keystonesymposia.bsky.social!

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Danette Daniels @danetteldaniels.bsky.social · Jan 9

Exciting advancement!

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Women in TPD & Induced Proximity @womenintpd.bsky.social · Jan 9

If you are working on degradation of membrane proteins this work co-led by Camilla Ruffilli along with colleagues at AstraZeneca is a nice systematic look at best methods to quantitate and validate loss! www.nature.com/articles/s41...

Orthogonal validation of PROTAC mediated degradation of the integral membrane proteins EGFR and c-MET - Scientific Reports

Scientific Reports - Orthogonal validation of PROTAC mediated degradation of the integral membrane proteins EGFR and c-MET

www.nature.com

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Danette Daniels @danetteldaniels.bsky.social · Dec 23

So happy to see the growth of our initiative to now offer conference scholarships! Apply below for consideration.
Happy 2025 ☺️☀️☺️

Women in TPD & Induced Proximity @womenintpd.bsky.social · Dec 23

HAPPY HOLIDAYS and EXCITING NEWS!!!
We are offering two conference scholarships for 2025 to early career scientists! One for the Keystone Proximity-Based Therapeutics Conference and one to Frankfurt Conference on Quality Control in Life Processes. Application and details: forms.gle/aP4n7HTujetb...

Women in TPD & Induced Proximity Conference Scholarship Application

We are thrilled to be offering two conference scholarships in 2025 to early career members of our initiative! Each scholarship will cover the cost of registration and hotel. Awardees will be responsib...

forms.gle

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Derek Lowe @dereklowe.bsky.social · Dec 20

A look at why some targeted oncology drugs have succeeded in some areas and totally failed in others. The short answer: kill cancer cells - don't just slow 'em down.

Targeted Cancer Drugs, Succeeding and Failing

www.science.org

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Women in TPD & Induced Proximity @womenintpd.bsky.social · Dec 19

Congratulations Alejandra Rodríguez Gimeno on this review covering approaches to develop new E3 ligase binders/handles!
chemistry-europe.onlinelibrary.wiley.com/doi/full/10....

Drug Discovery Approaches to Target E3 Ligases

Comprehensive review presenting the different drug discovery approaches that until now have been employed in academic and pharmaceutical settings to identify new E3 ligase small molecules ligands and...

chemistry-europe.onlinelibrary.wiley.com

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Women in TPD & Induced Proximity @womenintpd.bsky.social · Dec 18

New work out co-led by Xin Yu and colleagues at Baylor showing development of a selective RIPK1 degrader (VHL) and its synergy with anti-PD1 immunotherapy. Interesting potential combination to address resistance to and enhance activity of immune checkpoint inhibitors.
www.nature.com/articles/s41...

Development of a RIPK1 degrader to enhance antitumor immunity - Nature Communications

It has been shown that targeting receptor-interacting protein kinase 1 (RIPK1) can improve response to immune checkpoint inhibitors. Here, using PROTAC technology, the authors report the design and ch...

www.nature.com

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Danette Daniels @danetteldaniels.bsky.social · Dec 16

A-ha! 🧐(MassSpec humor) 🤣🤣🤣

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Danette Daniels @danetteldaniels.bsky.social · Dec 16

Congrats Cris and team!

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Women in TPD & Induced Proximity @womenintpd.bsky.social · Dec 16

Work out co-led by Inés García Pérez and @crismayorruiz.bsky.social showing the importance of targeting KRasG12V for treatment of lung adenocarcinoma. Degradation of KRasG12V is achieved using dTAG knock-in, allowing them to building relevant mouse models.
www.biorxiv.org/content/10.1...

Targeted KRAS(G12V) degradation elicits efficient and durable lung adenocarcinoma regression in vivo

Recent drug discovery breakthroughs led to the approval of KRASG12C inhibitors in lung adenocarcinoma (LUAD). Unfortunately, clinical responses remain limited due to rapid resistance onset. Proteolysi...

www.biorxiv.org

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Mark Dawson @mafdawson.bsky.social · Dec 13

Thrilled to share a wonderful collaboration with Scott Armstrong, Florian Perner & Shellaina Gordon - exciting times ahead!

www.biorxiv.org/content/10.1...

Catalytic inhibition of KAT6/KAT7 enhances the efficacy and overcomes primary and acquired resistance to Menin inhibitors in MLL leukaemia

Understanding the molecular pathogenesis of MLL fusion oncoprotein (MLL-FP) leukaemia has spawned epigenetic therapies that have improved clinical outcomes in this often-incurable disease. Using genet...

www.biorxiv.org

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Danette Daniels @danetteldaniels.bsky.social · Dec 6

Congratulations!

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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Dec 5

Amazing new work from the lab of @aliceyting.bsky.social @stanfordmedicine.bsky.social @stanfordbiosci.bsky.social, engineered GPCRs for ligand-activated cell responses

www.nature.com/articles/s41...

Synthetic GPCRs for programmable sensing and control of cell behaviour - Nature

Modular synthetic G-protein-coupled receptors with nanobody-based ligand-recognition domains can be designed and used to programme transgene expression, real-time fluorescence or endogenous G-protein ...

www.nature.com

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Women in TPD & Induced Proximity @womenintpd.bsky.social · Dec 4

Incredible meeting #CSChemBio2024 in San Francisco including talks from @fleurmferguson.bsky.social, @danetteldaniels.bsky.social, Michelle Arkin, Ingrid Wertz, and @mishtudey.bsky.social!

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Danette Daniels @danetteldaniels.bsky.social · Dec 4

Fantastic also to promote this group!

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Danette Daniels @danetteldaniels.bsky.social · Dec 3

Beautiful!!! Another E3 ligase that brings substrates into the center ring - incredible insight on the mechanism.

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Derek Lowe @dereklowe.bsky.social · Dec 3

That awkward moment when someone publishes a paper saying that they can’t find any evidence that your compounds bind to what your own series of papers say that they bind to. . .

Do They Even Bind?

www.science.org

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Keith Hornberger @krhornberger.bsky.social · Nov 29

Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets

Refreshing to see papers that go to great pains to set the record straight being published in a high profile setting

Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets - Nature Communications

Autophagosome tethering compounds (ATTECs) are small molecule degraders hijacking the autophagy system. Here, the authors show that current ATTEC ligands did not bind to their designated targets but e...

www.nature.com

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Micha Rapé Lab @micharapelab.bsky.social · Nov 26

Excited to report our discovery of an important component of the oxidative stress response: the E3 ligase TRIP12. It acts as a chain elongation factor that amplifies CUL3-KEAP1 activity to drive NRF2 degradation as cells recover from stress.

www.biorxiv.org/content/10.1...

Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12

The oxidative stress response is centered on the transcription factor NRF2 and protects cells from reactive oxygen species (ROS). While ROS inhibit the E3 ligase CUL3-KEAP1 to stabilize NRF2 and elici...

www.biorxiv.org

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Danette Daniels @danetteldaniels.bsky.social · Nov 26

Congratulations! Exciting story indeed

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