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Reposted by David Landeira

Guillermo Peris 🧬💻 @waltzingpiglet.bsky.social · 14d

Y aquí tenéis la noticia en vídeo con entrevista a @davidlandeira.bsky.social en @canalsurradiotv.bsky.social (sí, parece que ha salido en un programa infantil; despertando vocaciones ☺️). labanda.canalsur.es/noticias/and...

El envejecimiento empieza en el embrión, antes de nacer

El programa infantil de Canal Sur. Desde 1994 para todos los niños andaluces. ¡En La Banda Tú Mandas!

labanda.canalsur.es

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David Landeira @davidlandeira.bsky.social · 16d

Our new study supports that aging begins in the early stages of embryo development, and not only in adulthood @canalugr canal.ugr.es/noticia/a-ne...

A new study suggests that aging begins in the early stages of embryo development, and not only in adulthood - Canal UGR

This work by the University of Granada, published in Nature Communications, opens up a new paradigm in biomedicine by examining the role of the BMAL1 protein in aging and the… Seguir Leyendo A new stu...

canal.ugr.es

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David Landeira @davidlandeira.bsky.social · 26d

When and how do we start aging? Our recent work, led by Amador Gallardo, suggests that aberrant expression of ancient viral remnants in our genome—already during embryonic development—may induce aging in adults. 😮https://www.nature.com/articles/s41467-025-63778-4.pdf

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Reposted by David Landeira

Guillermo Peris 🧬💻 @waltzingpiglet.bsky.social · 28d

🔴 ¡Acaba de publicarse en Nature Communications (@natcomms.nature.com)! 🎉 Feliz de haber contribuido a este increíble trabajo del grupo de David Landeira (@davidlandeira.bsky.social), con Amador Gallardo como primer autor. (1/2)

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David Landeira @davidlandeira.bsky.social · 27d

Ahi va la nota redactada por nuestro equipo de divulgación sobre nuestro ultimo trabajo! canal.ugr.es/noticia/enve...

Un nuevo estudio sugiere que el envejecimiento empieza en las primeras fases del desarrollo del embrión, y no solo en la vida adulta - Canal UGR

Este trabajo de la UGR, publicado en Nature Communications, abre un paradigma en biomedicina al examinar el papel de la proteína BMAL1 en la vejez y el desarrollo de enfermedades

canal.ugr.es

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David Landeira @davidlandeira.bsky.social · 27d

www.science.org/doi/10.1126/...

Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival

Postnatal knockout of a core clock gene in mice prompts reevaluation of the systemic role of the molecular clock in the biology of aging.

www.science.org

David Landeira @davidlandeira.bsky.social · 27d

“From a different angle, our study also supports that BMAL1 regulates the transition from the totipotent to the pluripotent state during early development, by facilitating MERVL transposon repression and the downstream 3D organization and function of the genome.”

David Landeira @davidlandeira.bsky.social · 27d

Building on a previous report from the Fitzgerald lab showing that loss of Bmal1 during embryogenesis accelerates aging in adulthood, our findings support the idea that preserving the epigenome during embryogenesis is crucial to slow the pace of aging later in life.

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David Landeira @davidlandeira.bsky.social · 27d

Huge thanks to collaborating labs Bellora, Estevez, @herassr.bsky.social @mamartirenom.bsky.social @waltzingpiglet.bsky.social and @canalugr.bsky.social

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David Landeira @davidlandeira.bsky.social · 27d

Thrilled to share our story in its final form! nature.com/articles/s41... 💥 After ~10 years, we show that BMAL1 represses transposons via chromatin regulation in embryonic stem cells—rather than circadian rhythms as in adult tissues.

https://nature.com/articles/s41467-025-63778-4💥

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Reposted by David Landeira

Guillermo Peris 🧬💻 @waltzingpiglet.bsky.social · Sep 6

Thomas Mann describiendo con un asombroso realismo las redes sociales (como esta) en «La montaña mágica», escrito hace más de 100 años.

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Reposted by David Landeira

European Research Council (ERC) @erc.europa.eu · Jul 1

💬 “Science is the mother of industry”

In the latest ERC Magazine, Jean-François van Boxmeer of the European Round Table for Industry argues Europe must do more to turn scientific discovery into economic value; and that research is central to future strength and sovereignty.

🔗 europa.eu/!m3hK7c

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Reposted by David Landeira

Nature Reviews Genetics @natrevgenet.nature.com · May 13

From the archives: Transposable elements shape the evolution of mammalian development go.nature.com/4mfy7lI #Review by Anna D. Senft & Todd S. Macfarlan

Transposable elements shape the evolution of mammalian development - Nature Reviews Genetics

In this Review, Senft and Macfarlan discuss the diverse ways by which transposable elements (TEs) contribute to mammalian development and evolution, including direct contributions through TE-derived r...

go.nature.com

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Reposted by David Landeira

Nature @nature.com · May 10

A strain of bacterium that often causes infections in hospital can break down plastic

https://go.nature.com/3SvsiTC

Microbe that infests hospitals can digest medical-grade plastic ― a first

Nature - The bacterium Pseudomonas aeruginosa produces an enzyme that breaks down biodegradable plastics.

go.nature.com

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Reposted by David Landeira

Juliane Glaser @julianeg.bsky.social · May 7

Beautiful work 🤩

Cedric Feschotte @cedricfeschotte.bsky.social · Apr 30

💥🥳 At long last, our latest paper is out!

Gag proteins of endogenous retroviruses are required for zebrafish development

www.pnas.org/doi/10.1073/...

Led heroically by Sylvia Chang & @jonowells.bsky.social

A study which has changed the way I think of #transposons! No less! 🧵 1/n

Gag proteins encoded by endogenous retroviruses are required for zebrafish development | PNAS

Transposable elements (TEs) make up the bulk of eukaryotic genomes and examples abound of TE-derived sequences repurposed for organismal function. ...

www.pnas.org

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Reposted by David Landeira

Enhanced Genomics @enhancedgenomics.bsky.social · May 1

📢 Register! us02web.zoom.us/webinar/regi...
@akispapantonis.bsky.social presents "Senescent cells co-opt CTCF on nuclear speckles to sustain their splicing program" on May 8, 4PM UK, moderated by @stefanschoenfelder.bsky.social
#GenomeArchitecture #Senescence

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Reposted by David Landeira

Francesca Mattiroli @fmattiroli.bsky.social · May 4

Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....

Always on the Move: Overview on Chromatin Dynamics within Nuclear Processes

Our genome is organized into chromatin, a dynamic and modular structure made of nucleosomes. Chromatin organization controls access to the DNA sequence, playing a fundamental role in cell identity and...

doi.org

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Reposted by David Landeira

Nature @nature.com · May 2

US President Donald Trump’s proposed budget for fiscal year 2026 calls for unprecedented cuts to scientific agencies that, if enacted, would deal a devastating blow to US science, policy specialists say.

https://go.nature.com/4jYv3IP

Trump proposes unprecedented budget cuts to US science

Huge reductions, if enacted, could have ‘catastrophic’ effects on US competitiveness and the scientific pipeline, critics say.

go.nature.com

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David Landeira @davidlandeira.bsky.social · May 3

Los librepensadores son unos chaqueteros, y deberian ser explicitamente castigados por el codigo penal :p

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David Landeira @davidlandeira.bsky.social · May 2

Very interesting reflection. I would include in primary and secondary school curriculas a yearly dedicated class to teach ways to identify truth in the post-truth era.

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Reposted by David Landeira

DORA @dorassessment.bsky.social · May 1

We are excited to have Emmanuel Boakye (African Reproducibility Network), Henk Kummeling (Utrecht University, CoARA), and Andiswa Mfengu (PhD) (University of Cape Town) sharing perspectives for the Africa&Europe launch, hosted by DORA Vice-Chair @rnls.bsky.social. Register at bit.ly/Africa-Europ...

An event poster inviting for an online panel with the photos of the 3 panelists and 1 host named in the post.

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Reposted by David Landeira

Nature @nature.com · May 2

A new policy from the US National Institutes of Health (NIH) will end billions of dollars of funding to laboratories and hospitals outside the United States, imperiling thousands of projects on topics such as emerging infectious diseases and cancer.

https://go.nature.com/4jEDppr

Exclusive: NIH to suspend funds for research abroad as it overhauls policy

Move by US biomedical agency threatens thousands of projects on infectious diseases, cancer and more.

go.nature.com

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Reposted by David Landeira

Nature @nature.com · Apr 26

Nature research paper: Cold memories control whole-body thermoregulatory responses

https://go.nature.com/4iAvCHU

Cold memories control whole-body thermoregulatory responses - Nature

Cold-sensitive engrams contribute to learned thermoregulation in mice that are returned to an environment in which they previously experienced a cold challenge, through a network formed between the hippocampus and hypothalamus that enables the recall of cold-related memories.

go.nature.com

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Reposted by David Landeira

Max Kozlov @maxkozlov.bsky.social · Apr 10

NEW: Entire scientific fields have been wiped out by the nearly 800 grants cancelled at NIH, finds a @nature.com analysis of the unprecedented cuts.

About half of all 2024 NIH projects related to LGBT+ health or vaccine hesitancy — gone.

See the other topics and US states hardest hit here:

How Trump 2.0 is slashing NIH-backed research — in charts

Nature analyses which fields of science and US states are being hit hardest by grant terminations.

www.nature.com

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David Landeira @davidlandeira.bsky.social · Apr 14

Congras sergi! That is a start!

Sergi Cuartero @scuartero.bsky.social · Apr 14

Extremely happy to share that the first paper from our lab is now published! Driven by the very talented PhD student Maria Cadefau, we studied how CEBPA mutations shape transcriptional programs in AML. A thread 🧵👇

www.nature.com/articles/s41...

Mutant CEBPA promotes tolerance to inflammatory stress through deficient AP-1 activation - Nature Communications

CEBPA is frequently mutated in acute myeloid leukemia (AML), but the transcriptional impact of the AML-associated isoform remains unclear. Here, the authors show that CEBPA-mutant cells have reduced i...

www.nature.com

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