Daniel Lipka
@dblipka.bsky.social
Physician Scientist at DKFZ & NCT Heidelberg
studying 🩸🧬 #epigenomics #DNAmethylation #singleCell #precisiononcology #JMML
www.translational-cancer-epigenomics.de
studying 🩸🧬 #epigenomics #DNAmethylation #singleCell #precisiononcology #JMML
www.translational-cancer-epigenomics.de
Reposted by Daniel Lipka
Same mutation ≠ same leukemia.
Wagenblast et al. show:
• fetal HSCs readily transform
• postnatal HSCs become resistant
• fetal programs create targetable vulnerabilities
Ontogeny matters: state-of-origin shapes biology & therapy response.
doi.org/10.1158/2159...
#pediatric #AML #stemcells
Wagenblast et al. show:
• fetal HSCs readily transform
• postnatal HSCs become resistant
• fetal programs create targetable vulnerabilities
Ontogeny matters: state-of-origin shapes biology & therapy response.
doi.org/10.1158/2159...
#pediatric #AML #stemcells
Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia
AbstractAccumulating evidence links pediatric cancers to prenatal transformation events, yet the influence of the developmental stage on oncogenesis remains elusive. We investigated how hematopoietic ...
doi.org
February 4, 2026 at 6:28 PM
Same mutation ≠ same leukemia.
Wagenblast et al. show:
• fetal HSCs readily transform
• postnatal HSCs become resistant
• fetal programs create targetable vulnerabilities
Ontogeny matters: state-of-origin shapes biology & therapy response.
doi.org/10.1158/2159...
#pediatric #AML #stemcells
Wagenblast et al. show:
• fetal HSCs readily transform
• postnatal HSCs become resistant
• fetal programs create targetable vulnerabilities
Ontogeny matters: state-of-origin shapes biology & therapy response.
doi.org/10.1158/2159...
#pediatric #AML #stemcells
Reposted by Daniel Lipka
JMML stem cells aren’t epigenetically “stuck” in a fetal state.
They mature postnatally—yet show striking transcriptional plasticity, with oncofetal reprogramming in high-risk disease, challenging the classic “maturation block” model.
doi.org/10.1158/2643...
#JMML #epigenetics #hematology #cancer
They mature postnatally—yet show striking transcriptional plasticity, with oncofetal reprogramming in high-risk disease, challenging the classic “maturation block” model.
doi.org/10.1158/2643...
#JMML #epigenetics #hematology #cancer
Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia
AbstractPersistent fetal gene expression in childhood neoplasms is usually explained by a maturation block originating in the prenatal phase. In contrast, reactivation of fetal genes in adult malignan...
doi.org
February 4, 2026 at 6:28 PM
JMML stem cells aren’t epigenetically “stuck” in a fetal state.
They mature postnatally—yet show striking transcriptional plasticity, with oncofetal reprogramming in high-risk disease, challenging the classic “maturation block” model.
doi.org/10.1158/2643...
#JMML #epigenetics #hematology #cancer
They mature postnatally—yet show striking transcriptional plasticity, with oncofetal reprogramming in high-risk disease, challenging the classic “maturation block” model.
doi.org/10.1158/2643...
#JMML #epigenetics #hematology #cancer
Reposted by Daniel Lipka
You’ll help build interoperable, FAIR tools across @scverse.bsky.social and @bioconductor.bsky.social ecosystems. You will work together with a cross-institute team composed of @lucamarconato.bsky.social, @arturmansl.bsky.social and many contributors from #scverse and #Bioconductor!
December 27, 2025 at 3:50 PM
You’ll help build interoperable, FAIR tools across @scverse.bsky.social and @bioconductor.bsky.social ecosystems. You will work together with a cross-institute team composed of @lucamarconato.bsky.social, @arturmansl.bsky.social and many contributors from #scverse and #Bioconductor!
Thank you Tim! Yes, our story has definitely evolved a lot during the review process.
And yes: I will have BCD @aacrjournals.bsky.social definitely on my list for future submissions and so should you!
And yes: I will have BCD @aacrjournals.bsky.social definitely on my list for future submissions and so should you!
December 6, 2025 at 5:14 PM
Thank you Tim! Yes, our story has definitely evolved a lot during the review process.
And yes: I will have BCD @aacrjournals.bsky.social definitely on my list for future submissions and so should you!
And yes: I will have BCD @aacrjournals.bsky.social definitely on my list for future submissions and so should you!