AlphaFold can predict protein, DNA, or RNA complexes.. BUT is it easy to determine the reliable interactions?🤔

➡️ AlphaBridge will identify the most confident interactions, making your analysis easier!

🌐Try it here: alpha-bridge.eu
👀Read more: www.biorxiv.org/content/10.1...

Great community assessment here. Still unable to find alternate conformations. Protein dynamics the next big obstacle clearly 👀

Updated version of our coarse-grained CALVADOS model 🍎

We show that a Calpha representation of the folded domains can give rise to too compact conformations of multi-domain proteins (MDPs), and that a centre-of-mass representation in the folded domains improves agreement with experiments. 🧬🧶

CASP16 will start later this year, so to celebrate that here is a short thread on the uncanny valley separating experimental structures & computational models of proteins. Even though the latter are extremely accurate, there are still some weird differences that are hard to pin down.  🧪🧶🧬🧵

AlphaFold structures might be as good as experimental structures for virtual screening

Today's the day: PDB no longer has 3-character chemical component IDs for incoming depositions. First structure with a 5-character CCD has been deposited.

Details at wwPDB: PDB Entries with Novel Ligands Now Distributed Only in PDBx/mmCIF and PDBML File Formats
www.wwpdb.org/news/news?ye...

oh no...

Is Protein BLAST a thing of the past? doi.org/10.1038/s414...