Suleman Bhana, MD
@drbhana.bsky.social
Rheumatologist and tech nerd. OG Rheum Twitter alumni and former podcaster. Work in biopharma. Views are my own. #RheumSky
It’s really too bad Twitter got rid of 3rd party app API’s. It would’ve free to have an app that has feeds from both BlueSky and Twitter/X
October 24, 2025 at 8:07 PM
It’s really too bad Twitter got rid of 3rd party app API’s. It would’ve free to have an app that has feeds from both BlueSky and Twitter/X
In honor of attendance at #EULAR2025 I watched “Vicky Christina Barcelona” on my flight. Plot is a mess but the locale is 🧑🍳 😚 Stop me in the hallway if you see me wandering around!
June 10, 2025 at 4:26 AM
In honor of attendance at #EULAR2025 I watched “Vicky Christina Barcelona” on my flight. Plot is a mess but the locale is 🧑🍳 😚 Stop me in the hallway if you see me wandering around!
www.freethink.com/biotech/evo-.... —new Al in medicine term to learn: “Generative Biology”. Evo 2, an Al trained on DNA of more than 100,000 species is able to spot patterns in genes across species, identify disease-causing mutations
, and even write brand new genomes up to 1 million base pairs long
, and even write brand new genomes up to 1 million base pairs long
Arc Institute’s new AI can read and write the code of life
Training on the DNA of nearly 130,000 species taught Evo 2 how to generate DNA sequences the same way other AIs do text or images.
www.freethink.com
March 6, 2025 at 3:58 AM
www.freethink.com/biotech/evo-.... —new Al in medicine term to learn: “Generative Biology”. Evo 2, an Al trained on DNA of more than 100,000 species is able to spot patterns in genes across species, identify disease-causing mutations
, and even write brand new genomes up to 1 million base pairs long
, and even write brand new genomes up to 1 million base pairs long
Reposted by Suleman Bhana, MD
"In an unprecedented move, the US National Institutes of Health (NIH) has begun mass terminations of research grants that fund active scientific projects because they no longer meet 'agency priorities'"
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Exclusive: NIH to terminate hundreds of active research grants
Studies that touch on LGBT+ health, gender identity and DEI in the biomedical workforce could be terminated, according to documents obtained by Nature.
www.nature.com
March 6, 2025 at 3:08 AM
"In an unprecedented move, the US National Institutes of Health (NIH) has begun mass terminations of research grants that fund active scientific projects because they no longer meet 'agency priorities'"
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Suleman Bhana, MD
CDC invites back about 180 fired employees, including some who help fight outbreaks
The employees were laid off about two weeks ago
The employees were laid off about two weeks ago
CDC invites back about 180 fired employees, including some who help fight outbreaks
The CDC is inviting about 180 employees back to work, about two weeks after laying them off.
www.statnews.com
March 6, 2025 at 3:35 AM
CDC invites back about 180 fired employees, including some who help fight outbreaks
The employees were laid off about two weeks ago
The employees were laid off about two weeks ago
Reposted by Suleman Bhana, MD
Researchers are organizing protests and making their voices heard as Trump officials slash funding and lay off federal scientists
https://go.nature.com/4koFGpq
https://go.nature.com/4koFGpq
US science is under threat ― now scientists are fighting back
Researchers are organizing protests and making their voices heard as Trump officials slash funding and lay off federal scientists.
go.nature.com
March 4, 2025 at 12:13 PM
Researchers are organizing protests and making their voices heard as Trump officials slash funding and lay off federal scientists
https://go.nature.com/4koFGpq
https://go.nature.com/4koFGpq
Reposted by Suleman Bhana, MD
The College notes with sadness the death of legendary gastroenterologist Dr. John Fordtran at age 93 on February 23rd
Among his contributions to GI was the development of bowel preparation for colonoscopy
#GastroSky
issuu.com/amcollegegas...
Among his contributions to GI was the development of bowel preparation for colonoscopy
#GastroSky
issuu.com/amcollegegas...
issuu.com
March 4, 2025 at 12:39 PM
The College notes with sadness the death of legendary gastroenterologist Dr. John Fordtran at age 93 on February 23rd
Among his contributions to GI was the development of bowel preparation for colonoscopy
#GastroSky
issuu.com/amcollegegas...
Among his contributions to GI was the development of bowel preparation for colonoscopy
#GastroSky
issuu.com/amcollegegas...
Reposted by Suleman Bhana, MD
I’m encouraged by the so-far-so-good results of #CAR-T cells in human clinical trials for autoimmune diseases! Side note: If you’re interested in a clever twist of CAR-T, called “CAART,” that could reduce global immunosuppression, check out Dr. Aimee Payne’s work @columbiauniversity.bsky.social
Living Drugs for the Skin, and Beyond
In the lab, Aimee Payne, Columbia’s new chair of dermatology, is transforming cells into living drugs for autoimmune diseases of the skin.
www.cuimc.columbia.edu
February 15, 2025 at 6:08 PM
I’m encouraged by the so-far-so-good results of #CAR-T cells in human clinical trials for autoimmune diseases! Side note: If you’re interested in a clever twist of CAR-T, called “CAART,” that could reduce global immunosuppression, check out Dr. Aimee Payne’s work @columbiauniversity.bsky.social
Reposted by Suleman Bhana, MD
Sat down with former NIH director Monica Bertagnolli yesterday at #aaasmtg to talk about layoffs set to hit the NIH and other agencies
“We’re going to lose the next generation, that is the most difficult loss," she said, adding she got very little sleep Friday 🧪
www.statnews.com/2025/02/16/n...
“We’re going to lose the next generation, that is the most difficult loss," she said, adding she got very little sleep Friday 🧪
www.statnews.com/2025/02/16/n...
Trump administration layoffs set to hit NIH are ‘devastating,’ former director Monica Bertagnolli says
Sweeping layoffs are set to hit federal health and science agencies, including at the NIH, and former director Monica Bertagnolli called the situation at the NIH “devastating.”
www.statnews.com
February 16, 2025 at 3:34 PM
Sat down with former NIH director Monica Bertagnolli yesterday at #aaasmtg to talk about layoffs set to hit the NIH and other agencies
“We’re going to lose the next generation, that is the most difficult loss," she said, adding she got very little sleep Friday 🧪
www.statnews.com/2025/02/16/n...
“We’re going to lose the next generation, that is the most difficult loss," she said, adding she got very little sleep Friday 🧪
www.statnews.com/2025/02/16/n...
Reposted by Suleman Bhana, MD
Ferrari cars are often red. A red car is a Ferrari.
Wrong? Then why claim this without functional antigen-specif data:
Exhausted T cells often express PD-1. A T cell expressing PD-1 is exhausted.
It is similarly incorrect. PD'1 and other markers are also expressed on activated and memory T cells.
Wrong? Then why claim this without functional antigen-specif data:
Exhausted T cells often express PD-1. A T cell expressing PD-1 is exhausted.
It is similarly incorrect. PD'1 and other markers are also expressed on activated and memory T cells.
February 22, 2025 at 9:57 AM
Ferrari cars are often red. A red car is a Ferrari.
Wrong? Then why claim this without functional antigen-specif data:
Exhausted T cells often express PD-1. A T cell expressing PD-1 is exhausted.
It is similarly incorrect. PD'1 and other markers are also expressed on activated and memory T cells.
Wrong? Then why claim this without functional antigen-specif data:
Exhausted T cells often express PD-1. A T cell expressing PD-1 is exhausted.
It is similarly incorrect. PD'1 and other markers are also expressed on activated and memory T cells.
Reposted by Suleman Bhana, MD
If are shocked or outraged by this but you haven’t already found ways to channel that, here’s a small starting place - bsky.app/profile/ucsu...
Your first step doesn’t need to be big or perfect, it just has to happen. Take it, and then we can figure out the next one.
Your first step doesn’t need to be big or perfect, it just has to happen. Take it, and then we can figure out the next one.
February 18, 2025 at 7:21 PM
If are shocked or outraged by this but you haven’t already found ways to channel that, here’s a small starting place - bsky.app/profile/ucsu...
Your first step doesn’t need to be big or perfect, it just has to happen. Take it, and then we can figure out the next one.
Your first step doesn’t need to be big or perfect, it just has to happen. Take it, and then we can figure out the next one.
Reposted by Suleman Bhana, MD
Are you interested in analyzing small samples from marginalized communities and aren't sure how?
My new commentary in AJE's collection on Methods in Social Epidemiology lays out rec's for researchers, public health practitioners, and data owners.
DM your email address if you need access.
My new commentary in AJE's collection on Methods in Social Epidemiology lays out rec's for researchers, public health practitioners, and data owners.
DM your email address if you need access.
Insufficient sample size or insufficient attention to marginalized populations? A practical guide to moving observational research forward
Naomi Harada Thyden; Insufficient sample size or insufficient attention to marginalized populations? A practical guide to moving observational research for
doi.org
February 18, 2025 at 6:11 PM
Are you interested in analyzing small samples from marginalized communities and aren't sure how?
My new commentary in AJE's collection on Methods in Social Epidemiology lays out rec's for researchers, public health practitioners, and data owners.
DM your email address if you need access.
My new commentary in AJE's collection on Methods in Social Epidemiology lays out rec's for researchers, public health practitioners, and data owners.
DM your email address if you need access.
Reposted by Suleman Bhana, MD
Explore this gift article from The New York Times. You can read it for free without a subscription. www.nytimes.com/2025/02/10/h...
#medsky
#medsky
The Physicians Really Are Healing Themselves, With Ozempic (Gift Article)
At cardiology conferences and diabetes meetings, doctors can’t help noticing that thin seems to be very in.
www.nytimes.com
February 18, 2025 at 10:46 PM
Explore this gift article from The New York Times. You can read it for free without a subscription. www.nytimes.com/2025/02/10/h...
#medsky
#medsky
Reposted by Suleman Bhana, MD
The January issue of the journal #Rheumatology is now online. This month includes:
1️⃣ The BAD-BSR Behcet's living guideline
1️⃣ Star Trek quote 👀
4️⃣ Systematic reviews on FMF, Still's, MAS & ILD
7️⃣ Graphical abstracts
Plus, the brand new 2025 cover 😍
academic.oup.com/rheumatology...
1️⃣ The BAD-BSR Behcet's living guideline
1️⃣ Star Trek quote 👀
4️⃣ Systematic reviews on FMF, Still's, MAS & ILD
7️⃣ Graphical abstracts
Plus, the brand new 2025 cover 😍
academic.oup.com/rheumatology...
Volume 64 Issue 1 | Rheumatology | Oxford Academic
The official journal of the British Society for Rheumatology. Publishes high-quality scientific (basic and translational) and clinical-epidemiological papers on a wide range of paediatric and adult rh...
academic.oup.com
January 6, 2025 at 11:53 AM
The January issue of the journal #Rheumatology is now online. This month includes:
1️⃣ The BAD-BSR Behcet's living guideline
1️⃣ Star Trek quote 👀
4️⃣ Systematic reviews on FMF, Still's, MAS & ILD
7️⃣ Graphical abstracts
Plus, the brand new 2025 cover 😍
academic.oup.com/rheumatology...
1️⃣ The BAD-BSR Behcet's living guideline
1️⃣ Star Trek quote 👀
4️⃣ Systematic reviews on FMF, Still's, MAS & ILD
7️⃣ Graphical abstracts
Plus, the brand new 2025 cover 😍
academic.oup.com/rheumatology...
Good summary of Lipoprotein(a). The next frontier of ASCVD risk/event reduction. Really interesting to see the intersection of Cardiology, Rheumatology, and Hematology. #CardioMetabolic #RheumSky #CardioSky #HemeSky
Lipoprotein(a) as a Pharmacological Target: Premises, Promises, and Prospects.
www.ahajournals.org/doi/10.1161/...
@ahajournals.bsky.social
#CardioSky #MedSky #Cardiology #Lipoprotein_a #AHAJournals #Circulation
www.ahajournals.org/doi/10.1161/...
@ahajournals.bsky.social
#CardioSky #MedSky #Cardiology #Lipoprotein_a #AHAJournals #Circulation
February 14, 2025 at 10:38 PM
Good summary of Lipoprotein(a). The next frontier of ASCVD risk/event reduction. Really interesting to see the intersection of Cardiology, Rheumatology, and Hematology. #CardioMetabolic #RheumSky #CardioSky #HemeSky
Reposted by Suleman Bhana, MD
⚠️ Cytokine Release Syndrome is a serious side effect of #CAR-T cell therapies. This article examines the pathways driving cytokine production in T cells during #immunotherapy: 🔗 doi.org/10.1093/imma... (6/8)
Regulation of temporal cytokine production by co-stimulation receptors in TCR-T cells is lost in CAR-T cells
Abstract. CD8+ T cells contribute to immune responses by producing cytokines when their T-cell receptors (TCRs) recognise peptide antigens on major-histoco
doi.org
February 4, 2025 at 11:25 AM
⚠️ Cytokine Release Syndrome is a serious side effect of #CAR-T cell therapies. This article examines the pathways driving cytokine production in T cells during #immunotherapy: 🔗 doi.org/10.1093/imma... (6/8)
Reposted by Suleman Bhana, MD
February 12, 2025 at 10:02 PM
Really promising case series n=6 #SScl pts undergoing CD19 targeting #CAR-T cell therapy.⬇️ mRRS, ⬇️ digital ulcers, ⬇️ Raynaud’s attacks and pain, ⬆️ FVC, ⬇️ Scl70 Ab. Minimal cases of cytokine release syndrome and no reported immune effector cell-associated neurotoxicity syndrome #RheumSky
ICYMI, in our Feb issue—CD19-targeting #CAR T-cell therapy in patients with diffuse #SystemicSclerosis: a case series www.thelancet.com/journals/lan... #Medsky #Rheumsky
Plus, linked Comment www.thelancet.com/journals/lan...
Plus, linked Comment www.thelancet.com/journals/lan...
CD19-targeting CAR T-cell therapy in patients with diffuse systemic sclerosis: a case series
We provide the first evidence that CD19-targeting CAR T-cell therapy might intercept
with the progression of fibrotic organ manifestations in patients with systemic sclerosis.
www.thelancet.com
February 14, 2025 at 3:31 AM
Good review article on the few studies published using #CAR-T cell therapy in SScl. Quick and free read
🦠CD19-targeting CAR-T cell treatment in patients with diffuse systemic sclerosis
#CAR-T #SystemicSclerosis #SS #autoimmune
www.thelancet.com/journals/lan...
#CAR-T #SystemicSclerosis #SS #autoimmune
www.thelancet.com/journals/lan...
CD19-targeting CAR-T cell treatment in patients with diffuse systemic sclerosis
Systemic sclerosis is a severe autoimmune disease characterised by progressive fibrosis
and multiorgan involvement, leading to the highest mortality rate among rheumatic
diseases. Unlike systemic lupu...
www.thelancet.com
February 14, 2025 at 3:15 AM
Good review article on the few studies published using #CAR-T cell therapy in SScl. Quick and free read
Reposted by Suleman Bhana, MD
🌊 Proud to share our new paper showing how during a historic 2022 drought in n. Kenya chronic #stress (via nail cortisol) & high levels of #waterinsecurity were assoc. with ⬆️ levels of inflammation. Climate change negatively affects human health & biology. onlinelibrary.wiley.com/doi/10.1002/...
February 7, 2025 at 2:52 PM
🌊 Proud to share our new paper showing how during a historic 2022 drought in n. Kenya chronic #stress (via nail cortisol) & high levels of #waterinsecurity were assoc. with ⬆️ levels of inflammation. Climate change negatively affects human health & biology. onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Suleman Bhana, MD
A: hs-CRP. Covariable-adjusted hazard ratios for the primary end point in comparison of the top with the bottom quintile were 1.70 (95% confidence interval [CI], 1.52 to 1.90) for high-sensitivity CRP, 1.36 (95% CI, 1.23 to 1.52) for LDL cholesterol, & 1.33 (95% CI, 1.21 to 1.47) for lipoprotein(a).
❤️ Celebrating #WearRedDay! Do you know which biomarker was the strongest predictor of cardiovascular risk over 3 decades in the Women’s Health Study? 1. Low-density lipoprotein cholesterol (LDL-C) 2. Lipoprotein(a) [Lp(a)] 3. High-sensitivity C-reactive protein (hs-CRP) ♥️ #CardioSky #MedSky
February 8, 2025 at 12:54 AM
A: hs-CRP. Covariable-adjusted hazard ratios for the primary end point in comparison of the top with the bottom quintile were 1.70 (95% confidence interval [CI], 1.52 to 1.90) for high-sensitivity CRP, 1.36 (95% CI, 1.23 to 1.52) for LDL cholesterol, & 1.33 (95% CI, 1.21 to 1.47) for lipoprotein(a).
Reposted by Suleman Bhana, MD
Finally a minimum of 5 trials of orflorglipron reading out in 2025 with the first trial to readout in April or May. As noted it's an oral GLP-1 non peptide drug. It's easily mass produced, requires no special dosing or refrigeration. Lilly expects worldwide launch January 2026 for obesity & DM2
February 6, 2025 at 5:57 PM
Finally a minimum of 5 trials of orflorglipron reading out in 2025 with the first trial to readout in April or May. As noted it's an oral GLP-1 non peptide drug. It's easily mass produced, requires no special dosing or refrigeration. Lilly expects worldwide launch January 2026 for obesity & DM2
Reposted by Suleman Bhana, MD
Very pleased to confirm that my research investigating racism and Islamophobia discourses around cardiometabolic disease will be presented at the World Critical Dietetics Conference on the 14th Feb 💞
Tickets can be found at the WCD website: worldcriticaldietetics.org
Tickets can be found at the WCD website: worldcriticaldietetics.org
February 7, 2025 at 11:16 AM
Very pleased to confirm that my research investigating racism and Islamophobia discourses around cardiometabolic disease will be presented at the World Critical Dietetics Conference on the 14th Feb 💞
Tickets can be found at the WCD website: worldcriticaldietetics.org
Tickets can be found at the WCD website: worldcriticaldietetics.org
Worth reposting this and highlighting the monumental work of @fackelmeister.bsky.social and colleagues. #CardioMetabolic #GastroSky #RheumSky #microbiome #plantbased
A new study of 21,561 people found that plant-based diets shape healthier microbiomes and have better cardiometabolic outcomes.
Plant-based diets linked to healthier gut microbiomes and cardiometabolic benefits in large study
www.nutritioninsight.com/news/plant-b...
#health #plantbased #diet #eat
Plant-based diets linked to healthier gut microbiomes and cardiometabolic benefits in large study
www.nutritioninsight.com/news/plant-b...
#health #plantbased #diet #eat
Plant-based diets linked to healthier gut microbiomes and cardiometabolic benefits in large study
A new study of 21,561 people found that plant-based diets shape healthier microbiomes and have better cardiometabolic outcomes. Omnivore, vegetarian, and vegan diets are gaining popularity and are spo...
www.nutritioninsight.com
January 30, 2025 at 1:24 AM
Worth reposting this and highlighting the monumental work of @fackelmeister.bsky.social and colleagues. #CardioMetabolic #GastroSky #RheumSky #microbiome #plantbased