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drglycoben.bsky.social
Ben Schumann
@drglycoben.bsky.social
1.6K followers 390 following 56 posts
Full Prof of Biochemistry at TU Dresden, visiting at The Crick & Imperial College. We are making next-generation chemical tools to understand glycans in biology. he/him
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drglycoben.bsky.social
Ben Schumann @drglycoben.bsky.social · 1d
Check our new venture into drug discovery #glycotime!
drglycoben.bsky.social
Ben Schumann @drglycoben.bsky.social · 1d
Check out our new preprint "Convergent Lead Discovery Strategies Yield Covalent and Non-covalent Inhibitors of Human UDP-Galactose-4-Epimerase" on Chemrxiv led by Will Browne in close collab with GSK @jtbush.bsky.social

chemrxiv.org/engage/chemr...
Convergent Lead Discovery Strategies Yield Covalent and Non-covalent Inhibitors of Human UDP-Galactose-4-Epimerase
O-GalNAc (N-acetylgalactosaminyl) glycosylation is an abundant posttranslational modification in mammalian cells. Dysregulation of O-GalNAc glycosylation is implicated in cancer metastasis and immune ...
chemrxiv.org
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drglycoben.bsky.social
Ben Schumann @drglycoben.bsky.social · 1d
The entire paper is supported by (often sub-A resolution) crystal structure magic by @stephcrystallab.bsky.social and Andy Purkiss @crick.ac.uk. My favourite one is of the covalent linkage of WBC10 with Tyr211 - a thing of beauty! Next --> Application!
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drglycoben.bsky.social
Ben Schumann @drglycoben.bsky.social · 1d
In parallel, Will performed a covalent, sulfonyl fluoride-targeted fragment screen and found Tyr211 to be especially reactive. Because Tyr211 is around the same binding pocket for our non-covalent inhibitors, we decided to merge these chemotypes. And it worked!
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drglycoben.bsky.social
Ben Schumann @drglycoben.bsky.social · 1d
The Bertozzi and Ferguson labs have targeted GALE in the early 2000s (references in the paper!), so we knew it could be drugged. Will did a tour de force fragment screen with colleages @crick.ac.uk at XChem @diamondlightsource.bsky.social. Rounds of iteration got him a good non-covalent inhibitor.
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drglycoben.bsky.social
Ben Schumann @drglycoben.bsky.social · 1d
The human UDP-Gal-4-epimerase is important for cellular biosynthesis of UDP-Gal and UDP-GalNAc. Both are important precursors for glycosylation. GALE KO abrogates cellular levels of these metabolites. GALE plays a role in cancer (pubmed.ncbi.nlm.nih.gov/31908526/) - so we decided to drug it!
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drglycoben.bsky.social
Ben Schumann @drglycoben.bsky.social · 1d
Check out our new preprint "Convergent Lead Discovery Strategies Yield Covalent and Non-covalent Inhibitors of Human UDP-Galactose-4-Epimerase" on Chemrxiv led by Will Browne in close collab with GSK @jtbush.bsky.social

chemrxiv.org/engage/chemr...
Convergent Lead Discovery Strategies Yield Covalent and Non-covalent Inhibitors of Human UDP-Galactose-4-Epimerase
O-GalNAc (N-acetylgalactosaminyl) glycosylation is an abundant posttranslational modification in mammalian cells. Dysregulation of O-GalNAc glycosylation is implicated in cancer metastasis and immune ...
chemrxiv.org
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Reposted by Ben Schumann
nadlerlab.bsky.social
André Nadler @nadlerlab.bsky.social · Jun 26
Here's a job at my institute that just opened up: Max Planck Director in Biological AI. This is an amazing opportunity -
www.mpi-cbg.de/news-outreac...
Open Call: Max Planck Director in Biological Artificial Intelligence
Expressions of interest or nominations to lead research in the field of Biological Artificial Intelligence at MPI-CBG.
www.mpi-cbg.de
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drglycoben.bsky.social
Ben Schumann @drglycoben.bsky.social · Jun 26
Check out our first PhD advert, primarily for enthusiastic students with a chemical/chemoenzymatic synthesis background:

www.verw.tu-dresden.de/StellAus/stelle.asp?id=12186&lang=en&style=cms2
drglycoben.bsky.social
Ben Schumann @drglycoben.bsky.social · Jun 26
🥳 Thrilled to share that I am starting a new position as W3 Full Professor of Biochemistry at @tudresden.bsky.social. From Aug 2025, the Chemical Glycobiology Lab will continue our mission to generate Chemical Precision Tools for #glycotime in one the most beautiful places in Germany 😊
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drglycoben.bsky.social
Ben Schumann @drglycoben.bsky.social · Jun 26
A special Thank You to @crick.ac.uk and @imperialchemistry.bsky.social, all my friends, mentors, colleagues and collaborators for their amazing support throughout the years - we had (and will continue to have) a lot of fun in London, it is a special place!
drglycoben.bsky.social
Ben Schumann @drglycoben.bsky.social · Jun 26
A huge Thank You to my amazing lab, everybody has been so supportive.

Dresden is an amazingly collaborative place with a unique, multidisciplinary scientific infrastructure. Our lab will be based in the Faculty of Chemistry and Food Chemistry, with lots of interactions and collabs.
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drglycoben.bsky.social
Ben Schumann @drglycoben.bsky.social · Jun 26
🥳 Thrilled to share that I am starting a new position as W3 Full Professor of Biochemistry at @tudresden.bsky.social. From Aug 2025, the Chemical Glycobiology Lab will continue our mission to generate Chemical Precision Tools for #glycotime in one the most beautiful places in Germany 😊
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drglycoben.bsky.social
Ben Schumann @drglycoben.bsky.social · Jun 25
🔥 Job alert! We are looking for an enthusiastic PhD candidate in the new Chemical Glycobiology Lab at @tudresden.bsky.social! Master in Chem or similar, experience in organic chem including chemoenzymatic, and most importantly: enthusiasm!

Deadline 8th July:

www.verw.tu-dresden.de/StellAus/ste...
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
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Reposted by Ben Schumann
chembiotalks.bsky.social
Virtual ChemBioTalks @chembiotalks.bsky.social · Jun 10
Thank you to our organizers for putting together this program:
@stephanhacker2.bsky.social
Marina Rubini
@borisvauzeilles.bsky.social
@michellefrei17.bsky.social
Hana Macíčková Cahová
@drglycoben.bsky.social
@mlakemeyer.bsky.social
Shixian Lin
@rubenragg.bsky.social
Meghan Lucas
(4/4)
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Reposted by Ben Schumann
pavelkielkowski.bsky.social
Pavel Kielkowski @pavelkielkowski.bsky.social · Apr 10
Great to see the new concept of protein PTMs functionalization published in @chemicalscience.rsc.org! The GlyTACs enable selective degradation of glycoproteins in living cells. Congratulation to Haoyu and Liu. Have a look on the full story here: pubs.rsc.org/en/Content/A... #chembio
Self-assembled PROTACs enable glycoproteins degradation in the living cells
We report here a two-component proteolysis targeting chimeras (PROTACs) strategy selectively targeting O-GalNAcylated and O-GlcNAcylated proteins for proteasomal degradation, which leads to severe tox...
pubs.rsc.org
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drglycoben.bsky.social
Ben Schumann @drglycoben.bsky.social · May 27
#chembio, #glycotime and #bioorganic crowd, join us tomorrow online ✨for free✨!!
drglycoben.bsky.social
Ben Schumann @drglycoben.bsky.social · May 23
🔥 Exciting online, free #chembio event on 28th May!!

Please join us online for the hybrid ESBOC Satellite meeting! Setup as a teaser to allow for accessibility and see some of the speakers that will attend ESBOC in Gregynog/Wales. To attend, please register by sending an email: lnkd.in/e-U7C6Jb
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Reposted by Ben Schumann
poldresden.bsky.social
Physics of Life Dresden @poldresden.bsky.social · May 27
Great news for @tudresden.bsky.social! 🎉 In addition to Physics of Life, 4 additional Excellence Clusters were funded at the TUD by the DFG @dfg.de. Congratulations to all our friends and colleagues, and especially to the Speakers of the Clusters and the TUD rector!

Read more: tud.link/cfwd9z
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drglycoben.bsky.social
Ben Schumann @drglycoben.bsky.social · May 23
Registration link: www.esboc.org.uk?p=1235
Satellite meeting – ESBOC
www.esboc.org.uk
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drglycoben.bsky.social
Ben Schumann @drglycoben.bsky.social · May 23
The awesome lineup on 28th May 2025 UK time:

9.30 – 10:00 Craig Markin (Manchester)
10:00 – 10.30 Yi Jin (Manchester)
10.30 – 11:00 Barbara Imperiali (MIT)
11:00 – 11.30 Roman Dembinski (Oakland University)
11.30 – 12:00 Stephen Cochrane (Queen’s University Belfast)
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drglycoben.bsky.social
Ben Schumann @drglycoben.bsky.social · May 23
🔥 Exciting online, free #chembio event on 28th May!!

Please join us online for the hybrid ESBOC Satellite meeting! Setup as a teaser to allow for accessibility and see some of the speakers that will attend ESBOC in Gregynog/Wales. To attend, please register by sending an email: lnkd.in/e-U7C6Jb
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drglycoben.bsky.social
Ben Schumann @drglycoben.bsky.social · May 13
It's a big #glycotime family!
drglycoben.bsky.social
Ben Schumann @drglycoben.bsky.social · May 13
It doesn't happen very often that you receive an award on the same day as your mentor. Congratulations to Peter Seeberger on winning the @rsc.org Khorana Award #glycotime! And I am very thankful to the amazing lab members, colleagues and mentors that led to winning the Norman Heatley Award!
Seeberger receiving the Khorana award RSC Heatley Award medal
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drglycoben.bsky.social
Ben Schumann @drglycoben.bsky.social · May 13
We had a blast at yesterday's @rsc.org Chemical Biology Symposium. Congratulations to Teresa and Freya who were awarded a prestigious poster prize!
Schumann lab Schumann lab poster award winners
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drglycoben.bsky.social
Ben Schumann @drglycoben.bsky.social · Apr 8
Nice one - congrats @nmriley.bsky.social! Well deserved for #glycotime!
biochemsoc.bsky.social
Biochemical Society @biochemsoc.bsky.social · Apr 8
A world-class researcher and scholar, we are thrilled to present Nicholas Riley with an Early Career Research Award in 2026! @nmriley.bsky.social's research group pursues an exciting vision that leverages new technology development to solve critical problems in glycoscience (and beyond!).
The Biochemical Society 2026 Awards. Early Career Research Award: Dr Nicholas M. Riley of University of Washington, USA
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Reposted by Ben Schumann
chembiotalks.bsky.social
Virtual ChemBioTalks @chembiotalks.bsky.social · Apr 2
We are happy to announce the new team that will organize the Virtual ChemBioTalks from this edition onwards
Marina Rubini
@mlakemeyer.bsky.social
@michellefrei17.bsky.social
Hana Macíčková Cahová
@drglycoben.bsky.social
@borisvauzeilles.bsky.social
@stephanhacker2.bsky.social
(1/4)
#ChemBio #ChemSky
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Reposted by Ben Schumann
gbmev.bsky.social
GBM (Gesellschaft für Biochemie und Molekularbiologie) @gbmev.bsky.social · Mar 31
Join us for the #GBMLunch Lunch on April 9 (12.30 PM)
Speaker: Ben Schumann @drglycoben.bsky.social from @crick.ac.uk
Title: Chemical Precision Tools to Dissect Protein Glycosylation
Chair: Oliver Thorn-Seshold @oliverthornseshold.bsky.social (Technische Universität Dresden)
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