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Reposted by Pavel Kielkowski

Thorn-Seshold Lab @thornsesholdlab.bsky.social · 7d

What can HaloTag do for you?

Triggered fluorogenic labelling?
Molecular recording?
Photo-Chemically Induced Dimerisation?

Philipp Mauker's CHalo motif lets reagents do all three, and more.

Read the preprint here -
doi.org/10.1101/2025...

#chembio #fluorescence #cellbio #SLP

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Pavel Kielkowski @pavelkielkowski.bsky.social · 7d

Great work! Congratulations.

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Pavel Kielkowski @pavelkielkowski.bsky.social · 14d

Thank you Felix!

Pavel Kielkowski @pavelkielkowski.bsky.social · 15d

The final version of our article about PLD3 AMPylation is now out shorturl.at/iTxWx. One protein, many proteoforms. Congratulations to Laura and thanks to @marleenberouti.bsky.social @v-hornung.bsky.social @jaelab.bsky.social @hellmichgroup.bsky.social

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Reposted by Pavel Kielkowski

Hocek lab @hoceklab.bsky.social · 29d

New paper in great collaboration with @cardosolab.bsky.social on Super-Resolution Compatible DNA Labeling Technique Reveals Chromatin Mobility and Organization Changes During Differentiation published in Advanced Science: doi.org/10.1002/advs... @iocbprague.bsky.social

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Reposted by Pavel Kielkowski

Gene Center Munich @LMU Munich @genecenter-lmu.bsky.social · Aug 27

LMU remains the best German university www.lmu.de/en/newsroom/...

LMU remains the best German university

In the latest Academic Ranking of World Universities, LMU ranks among the world’s top 50 research-intensive universities.

www.lmu.de

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Reposted by Pavel Kielkowski

Milena Schuhmacher @mschuhmacher.bsky.social · Aug 12

We are hiring!

If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland!

More information on www.epfl.ch/labs/gr-schu...

Open positions

GR-SCHUHMACHER

www.epfl.ch

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Reposted by Pavel Kielkowski

RentmeisterLab @rentmeisterlab.bsky.social · Jul 14

Great talk by Ronald Micura about Challenges in biological RNA chemistry @lmumuenchen.bsky.social 😀

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Reposted by Pavel Kielkowski

Marleen Bérouti @marleenberouti.bsky.social · Jun 30

I am very excited to share the second paper of my PhD published in @cp-cell.bsky.social.
Many thanks to all co-authors, especially from Thomas Carell's group, and my supervisor @v-hornung.bsky.social for their great support and collaboration!

www.cell.com/cell/fulltex...

Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement

Toll-like receptors (TLRs) 7 and 8 detect RNA degradation products to sense infection. However, modified nucleosides common in self-RNA—most notably pseudouridine—evade recognition. This study finds t...

www.cell.com

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Reposted by Pavel Kielkowski

Stephan Hammer @stephanhammer.bsky.social · Jun 27

Join us! We are looking for a new team member (PhD student) with strong background in organic chemistry.
🙏 RETWEET (We want to recruit internationally)

Organic chemistry meets #DirectedEvolution
Highly interdisciplinary & passionate research group

uni-bielefeld.hr4you.org/job/view/433...

Research Position (PhD) in organic chemistry and b...

<div style="text-align: justify;">The  research  group  „Organic  Chemistry  and&nb...

uni-bielefeld.hr4you.org

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Reposted by Pavel Kielkowski

Nadace Experientia @experientiacz.bsky.social · Jun 18

🎉 Nadace Experientia zná stipendisty pro rok 2025!

👨‍🔬 Jakub Copko z @iocbprague.bsky.social díky stipendiu ve výši 1 060 000 Kč vycestuje na University of Göttingen.

👨‍🔬 Lukáš Janecký z @iocbprague.bsky.social získal stipendium ve výši 1 215 000 Kč a zamíří na Stockholm University.

Gratulujeme!

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Reposted by Pavel Kielkowski

Michaela Prothiwa @mprothiwa.bsky.social · Jun 14

🚀 PhD position at the intersection of medicinal chemistry and chemical biology.
You'll develop ferroptosis inhibitors to combat bacterial lung infections

🧪 Research (50%) /🎓 Teaching (50%)

Looking for someone with:
➡️ Strong background in organic synthesis
➡️ Passion for working across disciplines

Graduate teaching & research assistant medicinal chemistry and/or chemical biology | University of Antwerp

YUFE vacancies

www.uantwerpen.be

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Reposted by Pavel Kielkowski

Kusterlab @kusterlab.bsky.social · Apr 22

One algorithm to rule them all? CHIMERYS bridges the gap — DDA,DIA and PRM — together at last!
With #CHIMERYS, we can now directly compare DDA and DIA data — 🍎 to 🍎 finally made possible.
doi.org/10.1038/s41592-025-02663-w
#KusterLab #WilhelmLab #MSAID #Proteomics

Unifying the analysis of bottom-up proteomics data with CHIMERYS - Nature Methods

CHIMERYS is a spectrum-centric and data acquisition method-agnostic algorithm for the analysis of MS2 spectra. It is capable of deconvoluting any MS2 spectrum, regardless of whether it was acquired by...

doi.org

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Reposted by Pavel Kielkowski

RentmeisterLab @rentmeisterlab.bsky.social · Apr 15

Come join our team! We have an opening for a research associate ("Ratsstelle"). Expertise in nucleotide chemistry and LC-MS is required. 👉 job-portal.lmu.de/jobposting/b... Deadline for application is June 01, 2025.

Research associate (Ratsstelle) for the duration of 5 years with the option to be tenured (m/f/x)

job-portal.lmu.de

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Reposted by Pavel Kielkowski

Tomáš Pluskal @pluskal-lab.org · Apr 11

Back in July 2023 we organized a small bioML symposium at @iocbprague.bsky.social, and it turned out to be a very pleasant and successful event. This summer we are following up with a great line-up of speakers. Please register for free, deadline May 30. tinyurl.com/bioMLPrague25

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Pavel Kielkowski @pavelkielkowski.bsky.social · Apr 10

Great to see the new concept of protein PTMs functionalization published in @chemicalscience.rsc.org! The GlyTACs enable selective degradation of glycoproteins in living cells. Congratulation to Haoyu and Liu. Have a look on the full story here: pubs.rsc.org/en/Content/A... #chembio

Self-assembled PROTACs enable glycoproteins degradation in the living cells

We report here a two-component proteolysis targeting chimeras (PROTACs) strategy selectively targeting O-GalNAcylated and O-GlcNAcylated proteins for proteasomal degradation, which leads to severe tox...

pubs.rsc.org

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Reposted by Pavel Kielkowski

Virtual ChemBioTalks @chembiotalks.bsky.social · Apr 2

We are happy to announce the new team that will organize the Virtual ChemBioTalks from this edition onwards
Marina Rubini
@mlakemeyer.bsky.social
@michellefrei17.bsky.social
Hana Macíčková Cahová
@drglycoben.bsky.social
@borisvauzeilles.bsky.social
@stephanhacker2.bsky.social
(1/4)
#ChemBio #ChemSky

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Reposted by Pavel Kielkowski

Stephan Hacker @stephanhacker2.bsky.social · Mar 31

The flash talk session and the posters were a highlight of #ABPP2025. We heard a lot of exciting research into #covalent #fragment screening, #antibiotic development, #microbiome activities, posttranslational modifications #PTMs and lysine-directed #kinase inhibitors.
#ABPP #ChemSky #ChemBio

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Reposted by Pavel Kielkowski

Michal Juríček @michaljuricek.bsky.social · Mar 19

The first chemistry.unwrapped video in the ENERGY series is out 💥🔥

Watch on YouTube in full quality:
www.youtube.com/watch?v=OdPT...

@chemistryunwrapped.bsky.social @juriceklab.bsky.social #ChemSky #PiSky

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Reposted by Pavel Kielkowski

IOCB Prague @iocbprague.bsky.social · Mar 13

#research #chirality

Stereoanalysis of the Antiparasitic Natural Product Callunene and Its Synthetic Intermediates (Ferenczei, Perlíková) - JNP @acs.org: pubs.acs.org/doi/10.1021/...

@iocbprague.bsky.social #UCTPrague @czechacademy.bsky.social

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Reposted by Pavel Kielkowski

Hocek lab @hoceklab.bsky.social · Mar 10

Our newest paper on enzymatic synthesis of hypermodified zwitterionic DNA bearing 4 different cationic groups has just been published in NAR. doi.org/10.1093/nar/...

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Reposted by Pavel Kielkowski

Matthieu Sollogoub @msollogoub.bsky.social · Mar 10

We are looking for PhD candidates to work in Paris at @sorbonne-universite.fr on synthesis & (photo)catalysis inside cyclodextrins with bimetallic complexes in collaboration with @metallacycle.bsky.social

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Reposted by Pavel Kielkowski

What a week, huh? all Wednesdays @whataweekhuh.bsky.social · Feb 26

Captain Haddock looking very frazzled, saying, “What a week, huh?”
Tintin leans into the frame and says, “Captain, it’s Wednesday.”
Snowy is very excited about the drink he has found.

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Reposted by Pavel Kielkowski

Gene Center Munich @LMU Munich @genecenter-lmu.bsky.social · Feb 20

🥳Congratulations, Matthias Tschöp! 🥂
Following our successful past collaborations in promoting young PIs to tenure-track professorships, we look forward to working with you to shape LMU’s future🤩

LMU München @lmumuenchen.bsky.social · Feb 20

Herzlichen Glückwunsch, Matthias Tschöp. Der derzeitige CEO des Helmholtz Zentrums München wurde heute zum neuen Präsidenten der LMU gewählt. Seine sechsjährige Amtszeit beginnt am 1. Oktober 2025. www.lmu.de/de/newsroom/...

Matthias Tschöp zum neuen Präsidenten der LMU gewählt

Matthias Tschöp folgt im Oktober 2025 auf Bernd Huber, der seit 2002 an der Spitze der LMU steht.

www.lmu.de

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Reposted by Pavel Kielkowski

Service-Center für gutes Lehren und Lernen (SeLL) @sell-hhu.bsky.social · Feb 19

Bei ihr trifft Fachwissen auf didaktische Kompetenz: Die Studierenden von Prof. Dr. Lena Daumann @daumannl.bsky.social aus der Chemie @hhu.de sind begeistert und haben sie für den #hhuLehrpreis2025 nominiert. 🧪

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