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Eduardo Marbán, MD, PhD @eduardomarban.bsky.social · 15d

Delighted to welcome these three new stars to our faculty: Stephen Nageotte and Mark Sklansky to our congenital heart program, and Eli Friedman to lead #SportsCardiology!

Smidt Heart Institute @smidtheart.bsky.social · 16d

We are delighted to welcome 3 new members to the Dept of Cardiology. Dr. Eli Friedman, Director of Sports Cardiology; Dr. Stephen Nageotte, Director of the Congenital Catheterization Lab; Dr. Mark Sklansky, Medical Director of the Pediatric and Fetal Cardiology Outreach Congenital Heart Program.

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Reposted by Eduardo Marbán, MD, PhD

Smidt Heart Institute @smidtheart.bsky.social · Jul 29

For the 12th year in a row, @smidtheart.bsky.social has been ranked #1 in California for Cardiology, Heart, and Vascular Surgery by @usnews.com!
www.cedars-sinai.org/newsroom/ced...

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Eduardo Marbán, MD, PhD @eduardomarban.bsky.social · Jun 3

Fascinating @smidtheart.bsky.social research seminar by Farah Sheikh of @ucsandiego.bsky.social on #ARVC— #BenchToBedside journey towards AAV gene therapy with PKP2, now in clinical trials!

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Eduardo Marbán, MD, PhD @eduardomarban.bsky.social · May 19

Our lab hosts a few select UCLA #undergraduates as #interns. One of our stellar interns, working with #postdoc Junlang Li, just presented her work at the Undergraduate Research & Creativity Showcase— #EVs from #iPSCs— check it out!

youtu.be/ElnJW6-UrqQ

Medical Research: Prerecorded - Panel 9 - Presentation 4

YouTube video by UCLA Undergraduate Research Centers

youtu.be

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Eduardo Marbán, MD, PhD @eduardomarban.bsky.social · May 7

Congrats Sumeet!

www.beckershospitalreview.com/hospital-exe...

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Reposted by Eduardo Marbán, MD, PhD

The American Society for Clinical Investigation @the-asci.org · May 2

Healing the heart!

@eduardomarban.bsky.social & team discover the long non-coding RNA BCYRN1 contained in extracellular vesicles from cardiosphere-derived cells modulates Tregs and reduces damage in a mouse heart-attack model: buff.ly/n1q0Bac

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Reposted by Eduardo Marbán, MD, PhD

Journal of Clinical Investigation @jci.org · May 2

Healing the heart!

@eduardomarban.bsky.social & team discover the long non-coding RNA BCYRN1 contained in extracellular vesicles from cardiosphere-derived cells modulates Tregs and reduces damage in a mouse heart-attack model: buff.ly/n1q0Bac

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Eduardo Marbán, MD, PhD @eduardomarban.bsky.social · May 1

Pleased to share our paper: #EVs released from #heart #postMI travel to #brain and cause #neuroinflammation, underlying #depression. Work of Ke Liao, PhD

ahajournals.org/doi/epub/10.11…

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Reposted by Eduardo Marbán, MD, PhD

Russell Rogers, Ph.D. @russellrogers.bsky.social · Apr 22

Wonderful Research In Progress update by NIH T32 Fellow, Jonah Zarrow, on developing novel #ncRNA drugs for #Duchenne muscular dystrophy. Important work for #DMD!

@eduardomarban.bsky.social
@smidtheart.bsky.social
@mda.org

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Reposted by Eduardo Marbán, MD, PhD

Eugenio Cingolani, MD @eugeniocingolani.bsky.social · Apr 9

Great #Breakout #Session at Cedars Sinai Faculty Retreat #NewTherapies from #Concept to #Clinic
Fantastic panel ➡️ Dr. Eduardo Marban @eduardomarban.bsky.social describing his pathway to #clinic #CDCs followed by Dr. Anand Karumanchi going over his experiences towards #translation #regulatorypathways

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Eduardo Marbán, MD, PhD @eduardomarban.bsky.social · Apr 8

Brilliant @smidtheart.bsky.social research seminar by Rajan Sah MD PhD of Washington University on SWELL channels and their role in #platelet #thrombosis. Big implications for therapeutics of #MI and #stroke.
#CardioSky

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Eduardo Marbán, MD, PhD @eduardomarban.bsky.social · Apr 8

Provocative @smidtheart.bsky.social #cardiology grand rounds by Rita Redberg who highlights the low bar set for @fda.gov approval of medical devices. Hard clinical endpoints in adequately powered trials sorely lacking. No wonder investors prefer devices over drugs or novel biological therapies!

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Eduardo Marbán, MD, PhD @eduardomarban.bsky.social · Apr 6

Inspiring start to Cedars Sinai’s academic retreat by Shlomo Melmed, MD, who emphasizes how our unique structure enables progress towards science-based clinical innovation.

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Eduardo Marbán, MD, PhD @eduardomarban.bsky.social · Apr 3

New discoveries abound in @ahmedgibrahim.bsky.social as evidenced today by #labmeeting on #EVs and #ncRNAs from genetically engineered #fibroblasts that pulled a Jekyll and Hyde, becoming salutary post- #MI. Great work of Hiroaki Komuro!
#CardioSky

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Reposted by Eduardo Marbán, MD, PhD

Smidt Heart Institute @smidtheart.bsky.social · Mar 28

Let's get #ACC25 started!
⬇️Check out the agenda and don't miss hearing from @smidtheart.bsky.social!
Follow us all weekend for highlights!
@accintouch.bsky.social

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Reposted by Eduardo Marbán, MD, PhD

Smidt Heart Institute @smidtheart.bsky.social · Mar 27

Recent paper published in @jclinical-invest.bsky.social from @eduardomarban.bsky.social & Ke Liao finds a #ncRNA that enhances #Treg cells that could potentially repair heart muscle damage after a #HeartAttack & be applied to a variety of inflammatory disorders.
www.cedars-sinai.org/newsroom/pre...

Preclinical Study: After Heart Attack, a Boost in Anti-Inflammatory Cells Promoted Healing

A scientific technique that rapidly increases the body’s production of anti-inflammatory cells promoted healing from heart attacks in mice, according to a new study by investigators from the Smidt Hea...

www.cedars-sinai.org

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Eduardo Marbán, MD, PhD @eduardomarban.bsky.social · Mar 25

Check out the in-press preview of our @jclinicalinvest paper on regulatory #Tcells — we discovered a #ncRNA that can enhance #Treg dynamics fast enough to improve #MI healing in vivo. New hope for refractory inflammatory and immune conditions?
🔗 www.jci.org/articles/vie...

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Reposted by Eduardo Marbán, MD, PhD

Smidt Heart Institute @smidtheart.bsky.social · Mar 21

We’re ready for day 2 of the #HFpEFSummit listening in on sessions about exercise intolerance and the new and late breaking clinical trials!
Exciting day ahead!

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Eduardo Marbán, MD, PhD @eduardomarban.bsky.social · Mar 21

@russellrogers.bsky.social discussed experiments w/Lefer Lab taking advantage of the mechanistic differences between #GLP1RA & #ncRNA #TY1 as therapeutics for #HFpEF. Compelling evidence for synergistic benefits in two rodent models! Potential for less skeletal muscle loss?
@smidtheart.bsky.social

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Eduardo Marbán, MD, PhD @eduardomarban.bsky.social · Mar 20

The incomparable @mkittlesonmd.bsky.social teaches us that #HFpEF is a diagnosis of exclusion— rule out AS, HCM, pericardial constriction and, above all, #amyloidosis.

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Reposted by Eduardo Marbán, MD, PhD

Russell Rogers, Ph.D. @russellrogers.bsky.social · Mar 20

Pleased to share out latest work on cell therapy for #Duchenne. We show #deramiocel therapy initiated early protects against disease-related decline in muscle function.

@eduardomarban.bsky.social @smidtheart.bsky.social @stemcellreports.bsky.social @mda.org

Long-term preservation of muscle function and structure by repeated administration of cardiosphere-derived cells in mdx mice

Duchenne muscular dystrophy (DMD) is a progressive disease associated with functional decline. Chronic administration of cardiosphere-derived cell therapy prevents disease-related functional decline f...

www.cell.com

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Eduardo Marbán, MD, PhD @eduardomarban.bsky.social · Mar 20

Single nuclei #RNAseq of human #HFpEF heart biopsies by Virginia Hahn of @hopkinsheart.bsky.social reveals interesting #macrophage specific changes. Lots of provocative findings!

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Eduardo Marbán, MD, PhD @eduardomarban.bsky.social · Mar 20

Great opening lecture by #HFpEF pioneer @dakheartguy.bsky.social on #sarcomere abnormalities— huge differences in #calcium activated force in #myocytes from obese vs morbidly obese patients. Clinical correlation less evident…
@smidtheart.bsky.social #CardioSky

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Reposted by Eduardo Marbán, MD, PhD

Smidt Heart Institute @smidtheart.bsky.social · Mar 19

The final agenda is up!
We can't wait to see you tomorrow.
Follow us Thursday and Friday for meeting highlights!
#HFpEF

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Reposted by Eduardo Marbán, MD, PhD

Smidt Heart Institute @smidtheart.bsky.social · Feb 28

We are less than 3 weeks away from the start of the #HFpEF Conference! There's still a few spots left, grab your seat now.
Registration🔗 hfpefsummit.org

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