Rainero lab
@erainerolab.bsky.social
880 followers
730 following
93 posts
We are in @mcb-sheffield.bsky.social, School of Biosciences at the University of Sheffield. We are interested in understanding how the extracellular matrix controls cancer cell migration, growth and metabolism. @plosbiology.org Editorial Board Member
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Reposted by Rainero lab
Rainero lab
@erainerolab.bsky.social
· Sep 8
Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer
Zhang et al. demonstrate that macropinocytosis inhibition induces myCAF-to-iCAF conversion
through a metabolically stressed, MEK-ERK-dependent intermediate state. This CAF plasticity
remodels the panc...
click.notification.elsevier.com
Reposted by Rainero lab
Reposted by Rainero lab
Rainero lab
@erainerolab.bsky.social
· Aug 18
The kinesin KIF3AC recycles endocytosed integrin to polarize new adhesion formation toward the leading edge - PubMed
The recycling of integrin endocytosed during focal adhesion (FA) disassembly is critical for cell migration and contributes to the polarized formation of new FAs toward the leading edge. How this occu...
pubmed.ncbi.nlm.nih.gov
Rainero lab
@erainerolab.bsky.social
· Jul 22
EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration - PubMed
Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different cancers. The roles of EPLIN isoforms (α/β) remain l...
pubmed.ncbi.nlm.nih.gov
Rainero lab
@erainerolab.bsky.social
· Jul 7
Live-cell magnetic manipulation of recycling endosomes reveals their direct effect on actin protrusions to promote invasive migration - PubMed
Endocytic recycling pathways play key roles in a broad range of cellular processes, and many vesicle trafficking regulators are implicated in progression of disease such as cancer. The Rab11 family (R...
pubmed.ncbi.nlm.nih.gov
Rainero lab
@erainerolab.bsky.social
· Jul 2
Outside influences: The impact of extracellular matrix mechanics on cell migration - PubMed
"No cell is an island" - highlights the interconnectedness of cellular behavior and the extracellular matrix (ECM). Cell migration is inherently contextual, as cells navigate and adapt to their enviro...
pubmed.ncbi.nlm.nih.gov
Rainero lab
@erainerolab.bsky.social
· Jun 24
Vimentin intermediate filaments coordinate actin stress fibers and podosomes to determine the extracellular matrix degradation by macrophages
Huang et al. demonstrate that the intermediate filaments protein vimentin orchestrates
actin stress fibers and podosomes, thereby facilitating efficient extracellular matrix
(ECM) degradation via inte...
www.cell.com
Reposted by Rainero lab
