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Reposted by ernstlaboratory.bsky.social

CU Cancer Center @cucancercenter.bsky.social · 8d

In a Flint Animal Cancer Center canine clinical trial, they are testing a novel combination of orally delivered drugs targeting metastasis-promoting white blood cells (WBC), in combination with reprogramming the patient’s cancer fighting WBC to seek out and destroy osteosarcoma.

Miss Rosie, a black and white dog, with staff at the Flint Animal Cancer Center.

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ernstlaboratory.bsky.social @ernstlaboratory.bsky.social · 15d

So jealous. ANA is the best too.

Mick Milsom @milsommick.bsky.social · 17d

Excited to be heading out to #ISEH2025 in Kumamoto @isehsociety.bsky.social

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Reposted by ernstlaboratory.bsky.social

ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · 29d

@eirinipapapetrou.bsky.social from the Icahn School of Medicine at Mount Sinai is excited for the rooftop party after the iPSC symposium the day before #ISEH2025 🏯 begins 🌃 Learn more about this event and register! sites.google.com/view/2025ips...

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Reposted by ernstlaboratory.bsky.social

ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · 25d

Take advantage of the chance to see your international friends like Hitoshi Takizawa, PhD from Kumamoto University will be doing at #ISEH2025 🏯. Register for the meeting here: www.iseh.org/2025Registration

Q: Who are you looking forward to meeting or catching up with at #ISEH2025?
A: “Old colleagues and friends whom I have not seen for years, as I missed the last ISEH meeting in Chicago. Of course, I am also looking forward to making new friends this year.“

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ernstlaboratory.bsky.social @ernstlaboratory.bsky.social · 16d

Lucky you!

edwardevansjr.bsky.social @edwardevansjr.bsky.social · 20d

Super excited to attend the 54th @isehsociety.bsky.social
conference in Japan next week! First time in Japan. First time at a hematology conference. Great chance to network with the world's best and share our CH work in Down Syndrome.
@crnicinstitute.bsky.social @cuanschutz.bsky.social

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ernstlaboratory.bsky.social @ernstlaboratory.bsky.social · 19d

This is really cool. I have had a fantasy of knocking out pol II since the 90s, so it is really nice to see it finally done and thoroughly analyzed.

Jesper Svejstrup @jsvejstrup.bsky.social · 20d

Extremely proud to share the impressive work done by Anouk Olthof et al. on how cells maintain healthy levels of RNAPII, and how they respond when levels are too low. Fascinating stuff, we think www.biorxiv.org/content/10.1...

Systems-level feedback loops maintain gene expression homeostasis following RNA polymerase II dosage perturbation

Transcription is regulated by sequence-specific transcription factors and enzymes allowing access to genes in chromatin. However, recent data indicate that the abundance of RNA polymerase II (RNAPII) ...

www.biorxiv.org

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ernstlaboratory.bsky.social @ernstlaboratory.bsky.social · Sep 9

Thank you so much!

American Society of Hematology @ash.hematology.org · Sep 8

Hill Day ready! 💪👏 ASH Advocacy Leadership Institute participants prepped to advocate for the Sickle Cell Disease Care Act & NIH funding to support lifesaving blood disorder research. Tomorrow, they take their message to Capitol Hill.

Join the fight: https://bit.ly/3YeapvY

#Fight4Hematology

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ernstlaboratory.bsky.social @ernstlaboratory.bsky.social · Sep 8

and MCO [email protected]

ernstlaboratory.bsky.social @ernstlaboratory.bsky.social · Sep 5

Yeah Varuna's thesis work is out!!!!! congratulations Varuna and Sabrina et al

Science Magazine @science.org · Sep 5

New experiments in #ScienceSignaling have uncovered how melanoma and other types of cancer cells can evade therapies by relying on a cell cycle protein—a discovery that could inform more effective combination therapies for these hardy tumors. https://scim.ag/41yQYQf

ernstlaboratory.bsky.social @ernstlaboratory.bsky.social · Sep 5

Yeah Varuna's thesis work is out!!!!! congratulations Varuna and Sabrina et al

Science Magazine @science.org · Sep 5

New experiments in #ScienceSignaling have uncovered how melanoma and other types of cancer cells can evade therapies by relying on a cell cycle protein—a discovery that could inform more effective combination therapies for these hardy tumors. https://scim.ag/41yQYQf

MAPK and mTORC1 signaling converge to drive cyclin D1 protein production to enable cell cycle reentry in melanoma persister cells

Cyclin D1 accumulation enables a switch in melanoma cells from drug-induced quiescence to proliferation.

scim.ag

Reposted by ernstlaboratory.bsky.social

Science Magazine @science.org · Sep 5

New experiments in #ScienceSignaling have uncovered how melanoma and other types of cancer cells can evade therapies by relying on a cell cycle protein—a discovery that could inform more effective combination therapies for these hardy tumors. https://scim.ag/41yQYQf

MAPK and mTORC1 signaling converge to drive cyclin D1 protein production to enable cell cycle reentry in melanoma persister cells

Cyclin D1 accumulation enables a switch in melanoma cells from drug-induced quiescence to proliferation.

scim.ag

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ernstlaboratory.bsky.social @ernstlaboratory.bsky.social · Aug 25

jobrxiv.org/job/chu-de-q...

RESEARCHERS IN ONCOLOGY | QUEBEC CITY

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobrxiv.org

Reposted by ernstlaboratory.bsky.social

CU Cancer Center @cucancercenter.bsky.social · Aug 17

We have new members! Welcome to the CU Cancer Center! 👏

Welcome New Members graphic. Nicole Kaiser, PharmD, Vicki Catenacci, MD, Mohammad Bilal, MD, John Janetzko, PhD, Wyatt Shields, PhD, Christine Conageski, MD, Ally Nguyen, PhD, Matthew Witkowski, PhD, Peter Fecci, MD, PhD, Stephanie McGrath, DVM, Glen Peterson, DNP, Brenna McGinn, PhD, MSM.

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ernstlaboratory.bsky.social @ernstlaboratory.bsky.social · Aug 13

Congratulations @mary-flores.bsky.social‬! what an honor for the lab too ‪@chrmosimann.bsky.social‬

mary-flores.bsky.social @mary-flores.bsky.social · Aug 13

I’m honored to be selected as a Pew Latin American Fellow 2025! 🐟🧬🔬
With this opportunity, I will continue my postdoctoral training in the @chrmosimann.bsky.social lab at @cupediatrics.bsky.social/ @cudevbio.bsky.social , and it opens the door for me to return and established a lab in LATAM. 🇲🇽😍

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ernstlaboratory.bsky.social @ernstlaboratory.bsky.social · Aug 8

www.biorxiv.org/content/10.1...

Non-linear transcriptional responses to gradual modulation of transcription factor dosage

Genomic loci associated with common traits and diseases are typically non-coding and likely impact gene expression, sometimes coinciding with rare loss-of-function variants in the target gene. However...

www.biorxiv.org

ernstlaboratory.bsky.social @ernstlaboratory.bsky.social · Aug 5

link.springer.com/epdf/10.1007...

Nicotinamide riboside treatment enhances stress sensitivity and modulates hematological dynamics in aged mice

link.springer.com

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ernstlaboratory.bsky.social @ernstlaboratory.bsky.social · Jul 27

www.biorxiv.org/content/10.1...

ernstlaboratory.bsky.social @ernstlaboratory.bsky.social · Jul 27

www.biorxiv.org/content/10.1...

Future classic

www.biorxiv.org

ernstlaboratory.bsky.social @ernstlaboratory.bsky.social · Jul 21

The Myeloid Workshop is back in ASH! Please contact the organizers if you have an exciting story that will not be out by December they are: Zuzana Tothova ,
@ernstlaboratory.bsky.social
@steidluli.bsky.social
@ericpietras.bsky.social
@kathrinbernt.bsky.social
@gritsmanlab.bsky.social

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ernstlaboratory.bsky.social @ernstlaboratory.bsky.social · May 20

Cool stuff, lots of @isehsociety.bsky.social royalty
www.biorxiv.org/content/10.1...

In vivo CRISPR screening identifies SAGA complex members as key regulators of hematopoiesis

The biological mechanisms that sustain the vast blood production required for healthy life remain incompletely understood. To search for novel regulators of hematopoiesis, we performed genome-wide in ...

www.biorxiv.org

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ernstlaboratory.bsky.social @ernstlaboratory.bsky.social · Apr 29

Thank you!

American Society of Hematology @ash.hematology.org · Apr 29

ASH members are at Capitol Hill to stand up for hematology and advocate for policies that protect access to care for individuals with blood disorders.

#Fight4Hematology #HemeSky

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ernstlaboratory.bsky.social @ernstlaboratory.bsky.social · Apr 25

Finally, reading that couples my love of both Campari and epigenetics
biorxiv.org/content/earl...

Hangover regulates gene expression by limiting NSL-mediated H4K16 acetylation

The RNA-binding protein hangover is essential for several stress responses in Drosophila melanogaster. Here, we discover a novel function of hangover in the regulation of gene expression. Hangover bin...

biorxiv.org

Reposted by ernstlaboratory.bsky.social

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Apr 23

Everyone please read and act! 👇

Jeremy Berg @jeremymberg.bsky.social · Apr 23

ACTION ITEM-----ACTION ITEM

Implementation of Schedule F

This is what a lot of us have been worried about.

This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.

BUT THERE IS A COMMENT PERIOD...

1/n

the word alert is in a purple circle

ALT: the word alert is in a purple circle

media.tenor.com

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Reposted by ernstlaboratory.bsky.social

News Eye @newseye.bsky.social · Apr 5

NEW: BOSTON HAS TURNED OUT!

Thousands join the #HandsOff protest against Trump & Musk on Boston Common.

#FiftyFiftyOne #Resist @youranoncentral.bsky.social
handsoff2025.com

(🎥 Activism Works)

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Reposted by ernstlaboratory.bsky.social

Alexandria Ocasio-Cortez @aoc.bsky.social · Mar 22

Tonight an unbelievable **34,000 people** gathered for our Denver rally to take on billionaires and win our country back.

This was the largest political gathering in Denver since Obama in 2008.

Also bigger than the 2024 DNC.

And the largest ever rally in Bernie’s career (and obviously, mine too).

AOC and Bernie in front of the rally crowd in Denver

Zoomed out crowd shot of 34,000 people in downtown Denver with Colorado mountains in the background

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ernstlaboratory.bsky.social @ernstlaboratory.bsky.social · Mar 11

F*cked up. Another round of calling my representatives to try and dissipate my angst

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