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Reposted by Evan Giangrande

Charles Driver @charlesdriver.bsky.social · 13d

Prepping for @dgps.bsky.social Methods, few recent papers pushing ctsem and dynamic models in interesting directions

#1 Developmental changes in twin cognitive correlation (ACE) across age, test instrument, zygosity, with @evangiangrande.bsky.social @ent3c.bsky.social et al

osf.io/preprints/ps...

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Evan Giangrande @evangiangrande.bsky.social · Aug 26

conspiracy theory-type rabbit-holes, where a lot of the online sources are fringe and hotly debated, it's easier to believe what All-Powerful-And-Knowing Chatbot says. Safeguards related to AI literacy could help.

I also really dislike his stigmatizing use of the word "crazy"

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Evan Giangrande @evangiangrande.bsky.social · Aug 26

Agreed, it's odd he implies that psychosis is either genetic or environmental. Most of this boils down to a diathesis-stress model, with AI-provided info as the stressor and, as @dingdingpeng.the100.ci mentions, dynamics. Big issue with AI is the apparent trustworthiness of the source. Cf...

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Evan Giangrande @evangiangrande.bsky.social · Aug 21

Philosophy <--> Science

Carl T. Bergstrom @carlbergstrom.com · Aug 19

1. The philosophy of science sometimes gets an unearned reputation as a purely academic exercise that offers little by way of concrete tools for advancing research.

This is wrong.

And today, as we grapple with how AI is changing the nature of scientific activity, it's desperately wrong.

Evan Giangrande @evangiangrande.bsky.social · Aug 20

The causality facade isn't limited to AI/ML, of course. But the more complex and black-boxy the model, the easier that facade is to ignore/downplay.

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Evan Giangrande @evangiangrande.bsky.social · Aug 20

difficult to validate and built on untestable assumptions about the causal structure, confounds etc. Adding more covariates doesn't necessarily help. See "The Good, the Bad, and the Ugly" section on CausalML here arxiv.org/pdf/2206.15475

arxiv.org

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Evan Giangrande @evangiangrande.bsky.social · Aug 20

This has become my latest pet peeve. "Causal" is sexy and creates the impression that you're uncovering mechanism(s), but "causal estimates" are often just associational and/or reliant on strong assumptions that are rarely met.

E.g., CausalML applied to observational data. Cool, but...

Ewan Birney @ewanbirney.bsky.social · Aug 19

However, AI folk, it is going to be far, far better if we collectively call "back in time" or "left" in the normal way to lay out time as "antecedent" and *not* causal.

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Evan Giangrande @evangiangrande.bsky.social · Aug 15

Big thanks to @margotvdweijer.bsky.social for spearheading this effort! And to our coauthors @appelbap.bsky.social, Emily Bassett, and @lucasjmatthews.bsky.social

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Evan Giangrande @evangiangrande.bsky.social · Aug 15

Check out our preprint on ethical and legal considerations regarding Mendelian Imputation of missing parental genotypes! The method raises tricky questions about informed consent and potential harm. We highlight gaps in current practice and provide recommendations for researchers and IRBs.

Margot van de Weijer @margotvdweijer.bsky.social · Aug 1

New pre-print online: Imputing parental genotypes through Mendelian Imputation: Ethical and Legal Considerations
osf.io/preprints/ps...

OSF

osf.io

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Reposted by Evan Giangrande

Kevin Lala @kevinlala.bsky.social · Jul 25

I'm happy to share our latest manuscript "Impediments to countering racist pseudoscience", coauthored with @gillianrbrown1.bsky.social @kztwyman.bsky.social & Marcus Feldman.

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Evan Giangrande @evangiangrande.bsky.social · Jun 20

Combatting harmful misappropriations of behavioral genetics requires response at multiple levels, including organizational. To that end, the BGA Public Science Committee has released a Statement on the Misuse of Genetics

Behavior Genetics Association @behaviorgenetic.bsky.social · Jun 20

Our public science committee published its first statement, 'against misuse of behavioral genetics research' on the website.

Read it now on the website ⬇️

bga.org/content.aspx...

Misuse of Genetics Statement - Behavior Genetics Association

Misuse of Genetics Statement

bga.org

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Evan Giangrande @evangiangrande.bsky.social · May 23

S/O to my advisors, @jorsmo.bsky.social and Ben Neale; our wonderful collaborators in Finland and @fimm-uh.bsky.social, especially Aarno Palotie and Olli Pietilänen; and the Stanley Center for Psychiatric Research @broadinstitute.org

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Evan Giangrande @evangiangrande.bsky.social · May 23

Global functioning is used widely to inform treatment and prognosis. In our sample, GF scores were associated with important severity- and course-related variables including hospitalization burden and cognitive performance.

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Evan Giangrande @evangiangrande.bsky.social · May 23

We addressed those gaps using the SUPER-Finland study, which includes linked register data for every single psychiatric hospitalization in Finland since 1969. Global functioning has been assessed routinely at inpatient admission and discharge nationwide since 1994. A peek at the raw GF scores:

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Evan Giangrande @evangiangrande.bsky.social · May 23

Some background: recently, interest has increased in using PGS to predict not only lifetime SZ risk, but also clinically relevant disease outcomes. Studies have been limited by small Ns and superficial phenotypes. Here's a nice review of that literature: www.tandfonline.com/doi/full/10....

Polygenic risk scores for predicting outcomes and treatment response in psychiatry: hope or hype?

Over the last years, the decreased costs and enhanced accessibility to large genome-wide association studies datasets have laid the foundations for the development of polygenic risk scores (PRSs). ...

www.tandfonline.com

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Evan Giangrande @evangiangrande.bsky.social · May 23

These results suggest that integrating genomics with clinically relevant, longitudinal phenotypes may help parse heterogeneity in schizophrenia severity, prognosis, and course.

Caveat: as is typical in Psych Gen, effect sizes were small and PGS are not sufficiently predictive for clinical use.

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Evan Giangrande @evangiangrande.bsky.social · May 23

Leveraging ~120k GF measures from a complete hospitalization register, we found that higher SZ PGS predicted worse GF at admission & discharge, and less functional improvement during hospitalization. Higher EA PGS predicted better discharge GF and greater improvement, but worse admit GF

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Evan Giangrande @evangiangrande.bsky.social · May 23

🚨🧬 New preprint! We tested whether PGS predicted global functioning across psychiatric hospitalization among 5991 people with schizophrenia. medrxiv.org/cgi/content/...

Polygenic Scores for Schizophrenia and Educational Attainment Predict Global Functioning Across Psychiatric Hospitalization Among People with Schizophrenia

Question Is variation in global functioning among people with schizophrenia associated with genetic differences? Findings In this genetic association study of 5991 adults with schizophrenia and 59,79...

medrxiv.org

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Evan Giangrande @evangiangrande.bsky.social · May 13

Tomorrow!! Check out a great panel on the communication of polygenic score research

Behavior Genetics Association @behaviorgenetic.bsky.social · May 2

The BGA Public Science Committee will co-host Wednesday, May 14th, 11:00 AM-12:00 PM, US Eastern Time, an online symposium addressing how polygenic scores are communicated to the public, challenges of translating this research, and surrounding ethical & legal issues.
Registration: lnkd.in/eGgKgxmT

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Evan Giangrande @evangiangrande.bsky.social · Jan 30

Deadline tomorrow!! Already shaping up to be a great issue.

Evan Giangrande @evangiangrande.bsky.social · Jan 15

🚨 2 weeks left to submit your abstract for our special issue 🚨

"Behavioral Genetics as a Public Science: Impacts and Implications" 🌏🧬

We welcome both empirical and theoretical articles that explore the broader significance of genetic research on human behavior

👇👇
link.springer.com/journal/1051...

Behavior Genetics

link.springer.com

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Evan Giangrande @evangiangrande.bsky.social · Jan 15

🚨 2 weeks left to submit your abstract for our special issue 🚨

"Behavioral Genetics as a Public Science: Impacts and Implications" 🌏🧬

We welcome both empirical and theoretical articles that explore the broader significance of genetic research on human behavior

👇👇
link.springer.com/journal/1051...

Behavior Genetics

link.springer.com

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Evan Giangrande @evangiangrande.bsky.social · Jan 9

Chapter 7 of Groth-Marnat, Gary (2016). Handbook of Psychological Assessment, Sixth Edition: Wiley.

Geared towards clinicians but provides a thorough history of MMPI development, updates, and psychometrics. PDF is available online!

Evan Giangrande @evangiangrande.bsky.social · Jan 9

This is the first I've heard of "palliative psychiatry," a concept that strikes me as equal parts inaccurate, unnecessary, and potentially harmful.

Worth a read for Paul's insightful comments.

Paul S. Appelbaum, MD @appelbap.bsky.social · Jan 8

This report on the effort to characterize psychiatric treatment of some chronic disorders as "palliative care" includes my thoughts on why that's a really bad idea. psychiatryonline.org/doi/10.1176/...

Is There a Role for Palliative Care of Severe and Chronic Mental Disorders? | Psychiatric News

PsychiatryOnline.org is the platform for all American Psychiatric Association Publishing journals, DSM, and bestselling textbooks, as well as APA Practice Guidelines, and continuing medical education.

psychiatryonline.org

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Reposted by Evan Giangrande

Meghan Costello @meghanacostello.bsky.social · Jan 8

‼️Call for Submissions‼️

Special Issue in @apajournals.bsky.social @scpdiv12.bsky.social CPSP: "The Role of Non-Clinical Providers in Expanding Equitable Access to Effective Youth Mental Health Care"

Email @randimschuster.bsky.social and I with any questions!
docs.google.com/document/d/1...

Call for Abstracts: CPSP Special Issue on Nonclinical Providers

Call for Abstracts Special Issue of Clinical Psychology: Science and Practice: The Role of Non-Clinical Providers in Expanding Equitable Access to Effective Youth Mental Health Care Important date...

docs.google.com

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Reposted by Evan Giangrande

Jeff Spence @jeffspence.github.io · Dec 17

What do GWAS and rare variant burden tests discover, and why?

Do these studies find the most IMPORTANT genes? If not, how DO they rank genes?

Here we present a surprising result: these studies actually test for SPECIFICITY! A 🧵on what this means... (🧪🧬)

www.biorxiv.org/content/10.1...

Specificity, length, and luck: How genes are prioritized by rare and common variant association studies

Standard genome-wide association studies (GWAS) and rare variant burden tests are essential tools for identifying trait-relevant genes. Although these methods are conceptually similar, we show by anal...

www.biorxiv.org

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