Thank you for highlighting our recent work - we’re honored and excited to continue contributing to the field!

It was a great honor to be invited to give a talk at @kiroxford.bsky.social University of Oxford today. Many thanks to Dr. @y-luo.bsky.social for the kind invitation. I truly enjoyed the inspiring discussions with the brilliant scientists here!

⭐️ Successfully benchmarking on both simulation and real single-cell datasets: Reveals activated monocytes in COVID-19 severity, fibroblast transitions in chronic inflammation, and therapy (anti-PD1 treatment) induced T cell changes in TNBC.
⭐️ Software available: github.com/fanzhanglab/...

Excited 🎉 to share our lab's new paper CellPhenoX, an #explainable #MachineLearning tool 🔨 for #SingleCell data, published advanced.onlinelibrary.wiley.com/doi/10.1002/...
⭐️ CellPhenoX detects both linear, nonlinear, and even subtle interaction effects underlying clinical single-cell datasets!

More on the gut-joint connection.

We are #hiring #Postdoc/#Bioinformatician:
- Innovate computational methods for single-cell spatial transcriptomics.
- Develop prediction models for longitudinal single-cell.
⭐️Send your CV to me at [email protected]
⭐️ More at our lab website: fanzhanglab.org

Thrilled 🎉 to shared I received my R01 NoA today @NIH_NIAMS! We will continue pushing the frontiers of autoimmune research by developing novel #AI #MachineLearning for #SingleCell #SpatialTranscriptomics 🧬💻💊! @cuanschutz.bsky.social @cudeptofmedicine.bsky.social @cubiomedinfo.bsky.social

Next week! Join us on Thursday, August 14 at 6PM ET in Cambridge, MA (or online) for a Broad Discovery Series talk with @soumya-boston.bsky.social, “Arthritis, autoimmunity, and how the genome works.” Register: broadinstitute.swoogo.com/DiscoverySeries25

An analysis shows that current deep learning models do not beat linear baselines in predicting gene perturbation effects, thus emphasizing the importance of further method development and evaluation. @const-ae.bsky.social @wkhuber.bsky.social @s-anders.bsky.social

www.nature.com/articles/s41...

Contact me if you are interested in joining us fanzhanglab.org
@cuanschutz.bsky.social

Excited 🎉 to receive the grant from the "Leadership Scholars Program in Women’s Health, Autoimmune Diseases, and Immune-Mediated Diseases" supported by NIH Office of Research on Women's Health and AMP-AIM network: orwh.od.nih.gov/in-the-spotl....
We have openings for bioinformaticians and postdocs!

Distinguishing individuals at risk for rheumatoid arthritis from healthy controls!

@fanzhangphd.bsky.social, Deepak A. Rao & team define specific lymphocyte phenotypes during the preclinical stage of rheumatoid arthritis: buff.ly/WdjB8VD

Thanks for sharing!

Really appreciate the huge collaborations with #AcceleratingMedicinesPartnership, Deepak Rao, and @cudeptofmedicine.bsky.social

⭐️ Paper: www.jci.org/articles/vie...
⭐️ Data availability: www.synapse.org/Synapse:syn6... & arkportal.synapse.org/Explore/Data...

Excited 🎉to share our work led [email protected] out in JCI @jclinical-invest.bsky.social! Using cross-cohort #singlecell (CyTOF & CITE-seq), we found key T cell expansions in at-risk RA: CCR2+T with Th17/Th22 phenotype and Tph, for #RheumatoidArthritis prevention! www.jci.org/articles/vie...