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Reposted

Sebastian Shaw @millseba.bsky.social · 11h

Our latest story on Clofazimine resistance in Cryptosporidium! What started as a side project turned into one of the most interesting stories.

Genetics 101 😊

#Cryptosporidium #Apicomplexa #Clofazimine #AntimicrobialResistance #AMR #ParasiteResearch

www.biorxiv.org/content/10.1...

Widespread genomic heterogeneity at the type II NAD(P)H dehydrogenase locus predisposes Cryptosporidium to clofazimine resistance

The parasite Cryptosporidium is a leading cause of life-threatening diarrheal disease, and effective treatment is not available. The discovery of potent anti-Cryptosporidium activity of clofazimine, o...

www.biorxiv.org

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Reposted

Sebastian Shaw @millseba.bsky.social · 20d

🚨 New paper out! 🚨

🧬 Parasite sex as a discovery tool — new insights into Cryptosporidium virulence!

Huge thanks to my co-authors, collaborators & mentors 🙌
#Parasites #Cryptosporidium #Genetics #InfectiousDiseases #ForwardGenetics

www.sciencedirect.com/science/arti...

Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection

The relationship between parasite genotype and pathogenesis is largely unknown for Cryptosporidium, a leading cause of diarrheal disease in children. …

www.sciencedirect.com

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Reposted

University of Glasgow School of Infection & Immunity @uofgsii.bsky.social · Jul 28

🎥 | WATCH | Dr Francesca Florini (@fra-florini.bsky.social | @weillcornell.bsky.social) discusses the immune evasion in malaria using insights from single-cell analysis of Plasmodium falciparum.

The full GRiP-ing seminar is now available on our YouTube channel:

📺 youtu.be/bKU2Cfv79K8?...

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fra-florini.bsky.social @fra-florini.bsky.social · Jul 19

Had such a wholesome experience this past week, helping with the One Health Research workshop at WACCBIP. So much passion and engagement from the students!

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fra-florini.bsky.social @fra-florini.bsky.social · Jul 17

Preprint Alert 🚨 Check out the latest piece of work from the @kirkdeitsch.bsky.social lab, where we characterized the sophisticated molecular layers controlling var2csa expression and antigenic variation in P. falciparum

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · Jul 17

The molecular basis of coordinated antigen switching enabling chronic infection by human malaria parasites https://www.biorxiv.org/content/10.1101/2025.07.16.665170v1

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Reposted

Nature Microbiology @natmicrobiol.nature.com · May 20

🚨Out now!

scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance by @fra-florini.bsky.social @kirkdeitsch.bsky.social

#MicroSky #Plasmodium 🦠🧬

www.nature.com/articles/s41...

scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance - Nature Microbiology

Single-cell transcriptomics revealed that malaria parasites have unexpected flexibility in surface antigen expression, potentially providing parasites with greater adaptive capacity to maintain chroni...

www.nature.com

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fra-florini.bsky.social @fra-florini.bsky.social · May 19

So proud of this work finally out in @natmicrobiol.nature.com! We examined antigenic variation in malaria parasites at single-cell level and found a surprising level of diversity. Make sure to check it out and don’t miss my talk on Thursday to hear about this story! #malaria #scRNA-Seq #EMBLMalaria

Kirk Deitsch @kirkdeitsch.bsky.social · May 16

Very happy to congratulate @fra-florini.bsky.social and Joe Visone for the publication of their recent work on antigenic variation by malaria parasites: rdcu.be/emjbn and an earlier version here: www.biorxiv.org/content/10.1.... Francesca will present some of this work next week at BioMalPar 2025.

scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance

Nature Microbiology - Single-cell transcriptomics revealed that malaria parasites have unexpected flexibility in surface antigen expression, potentially providing parasites with greater adaptive...

rdcu.be

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fra-florini.bsky.social @fra-florini.bsky.social · Apr 28

Something fun (very much needed these days): the @kirkdeitsch.bsky.social and Kirkman labs crushing the CUIMC Team Relay Marathon!

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fra-florini.bsky.social @fra-florini.bsky.social · Mar 28

There’s a new doctor in the @kirkdeitsch.bsky.social lab and we couldn’t be prouder!

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fra-florini.bsky.social @fra-florini.bsky.social · Mar 7

#standupforscience

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fra-florini.bsky.social @fra-florini.bsky.social · Nov 15

What an awesome opportunity it was to present my work today at #EMBLInfectionBiology and connect with so many amazing scientists studying #infectionbiology! Great thanks to the organizers for giving me this chance

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