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francescocardamone.bsky.social
Francesco Cardamone
@francescocardamone.bsky.social
62 followers 250 following 4 posts
PhD Student at Iovino Lab, Max Planck Institute of Immunobiology and Epigenetics.
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francescocardamone.bsky.social
Francesco Cardamone @francescocardamone.bsky.social · 12d
Feeling inspired after presenting some #3Dgenome & #single-cell data at the #EDRC2025 in the beautiful #Alicante🇪🇸🧬🪰
Looking forward to the next amazing sessions to exchange ideas and connect with the community!
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francescocardamone.bsky.social
Francesco Cardamone @francescocardamone.bsky.social · 15d
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene | Science www.science.org/doi/10.1126/...
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...
www.science.org
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Reposted by Francesco Cardamone
alexis-verger.cpesr.fr
Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · Aug 28
If you like transcription regulation and its mechanisms, this WIP list is for you.

I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list.

go.bsky.app/8vTgeXB
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Reposted by Francesco Cardamone
dariloops.bsky.social
Darío Lupiáñez @dariloops.bsky.social · Jul 17
How bats developed their wings? 🦇

Turns out they reutilize existing gene programs 🔧

Find out more in our paper @natecoevo.nature.com in collaboration with @fany-real.bsky.social and @stemundi.bsky.social labs

www.nature.com/articles/s41...
Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development - Nature Ecology & Evolution
Single-cell comparison of developing bat and mouse limbs reveals conservation of cell populations and gene expression patterns, and suggests repurposing of genes involved in proximal limb development ...
www.nature.com
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Reposted by Francesco Cardamone
arantxarojas.bsky.social
Arantxa Rojas @arantxarojas.bsky.social · Jun 17
Our News&views with Germano @cecerelab.bsky.social about the role of H3K27me3 in epigenetic control of piRNA transcription in worms 🪱 and flies 🪰 is out in @natsmb.nature.com
rdcu.be/erkld
H3K27me3 expands the epigenetic control of piRNA transcription
Nature Structural & Molecular Biology - Constitutive heterochromatin can promote piRNA transcription, a crucial step in genome defense. Two studies now show that piRNA transcription in...
rdcu.be
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Reposted by Francesco Cardamone
axelvisel.bsky.social
Axel Visel @axelvisel.bsky.social · Jun 18
Textbooks: “Enhancers are just a bunch of TFBSs”

But how do they REALLY work?

New paper with many contributors here @berkeleylab.lbl.gov, @anshulkundaje.bsky.social, @anusri.bsky.social

A 🧵 (1/n)

Free access link: rdcu.be/erD22
A meme-style comic panel with three parts. Left: A stylized enhancer with a mutation, surrounded by colored blocks representing functional motifs, a neural network diagram, chromatin accessibility signal traces, and a sequence motif. Two cartoon mouse embryos below show different LacZ reporter activity patterns. Top right: A hand hovers anxiously between two red buttons labeled “Experiments” and “AI,” with the caption “HOW DO ENHANCERS REALLY WORK?” Bottom right: A sweating superhero wipes his forehead, looking stressed about the difficult choice.
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Reposted by Francesco Cardamone
mpi-ie.bsky.social
Max Planck Institute of Immunobiology and Epigenetics @mpi-ie.bsky.social · Jun 10
👀 New study: The stability of circular RNAs makes them ideal for long-lasting regulatory tasks in neurons. Researchers from the @hilgerslab.bsky.social have now identified the protein ELAV protein as a master regulator of circular RNA production in the nervous system, crucial for brain function.
Running circles in my head
Researchers in Freiburg have identified the protein ELAV as a key regulator of circular RNA production in the nervous system, which is crucial for brain function.
www.ie-freiburg.mpg.de
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Reposted by Francesco Cardamone
mpi-ie.bsky.social
Max Planck Institute of Immunobiology and Epigenetics @mpi-ie.bsky.social · May 14
The next TriRhena Gene Regulation Club takes place at the MPI-IE #Freiburg. Save your seat & submit a talk. Strengthen your local #epigenetics network & collaborate with peers.

📅 16 Jun 2025 | 14:00
🎟️ Free entry, registration required
✍️ Register by: 6. Jun

www.ie-freiburg.mpg.de/gene-regulat...
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Reposted by Francesco Cardamone
mpi-ie.bsky.social
Max Planck Institute of Immunobiology and Epigenetics @mpi-ie.bsky.social · Apr 15
Interested in the latest advancements of #epigenetics of #mammalian early embryogenesis? Then join our upcoming mini-symposium in Freiburg!

📅 April 24, 2025, 14:00-19:00 PM
📌 Max Planck Institute, Freiburg (only on-site!)
🛠️ Organized by: @iovino-lab.bsky.social

Register & join free of charge.
Symposium: Epigenetics of early mouse development
We are delighted to invite you to to the second symposium, “Epigenetics of Early Mouse Development”, taking place on April 24, 2025, at the Max Planck Institute of Immunobiology and Epigenetics in Fre...
www.ie-freiburg.mpg.de
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Reposted by Francesco Cardamone
iovino-lab.bsky.social
Iovino-Lab @iovino-lab.bsky.social · Apr 14
Exciting news! Our latest work in the Nicola Iovino Lab, “Chromatin landscape at cis-regulatory elements orchestrates cell fate decisions in early embryogenesis,” is now published in Nature Communications!
www.nature.com/articles/s41...
Chromatin landscape at cis-regulatory elements orchestrates cell fate decisions in early embryogenesis - Nature Communications
Germ layer specification during zygotic genome activation is regulated by chromatin state. Here, the authors use single-cell multiome profiling in Drosophila to show that H3K27me3 and H3K27ac at cis-r...
www.nature.com
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francescocardamone.bsky.social
Francesco Cardamone @francescocardamone.bsky.social · Apr 8
About a week ago, our new story in the #IovinoLab about chromatin factors and germ layer specification during ZGA in Drosophila embryos was published!

Missed it? 🔎 Check out this resume article by our Institute!

#chromatin #epigenetics #development
mpi-ie.bsky.social
Max Planck Institute of Immunobiology and Epigenetics @mpi-ie.bsky.social · Apr 7
How does a single fertilized egg know how to become muscle, brain, or skin? 🤔

A new study by the @iovino-lab.bsky.social shows how epigenetic mechanisms ensure that the right genes are activated at the right time, allowing each cell to assume its designated role in the body. #drosophila #chromatin
From one to the right
A study by the Max Planck Institute for Immunobiology and Epigenetics investigates how epigenetic mechanisms control early cell differentiation in the embryo. Similar to an orchestra, certain epigenet...
www.ie-freiburg.mpg.de
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francescocardamone.bsky.social
Francesco Cardamone @francescocardamone.bsky.social · Apr 2
Amazing piece of work from @ninacabezas.bsky.social Lab! Congratulations Jasmin, Mari & team!
mpi-ie.bsky.social
Max Planck Institute of Immunobiology and Epigenetics @mpi-ie.bsky.social · Apr 2
New research by the @ninacabezas.bsky.social lab & collaborators from @uniklinik-fr.bsky.social.

A vitamin A metabolite may offer a targeted therapeutic strategy for heart attack patients by regulating HSCs to minimize excessive inflammation and preserve long-term heart function.
Healing a broken heart
A vitamin A metabolite, 4-oxo-retinoic acid, can regulate the activity of hematopoietic stem cells and thereby reduce inflammation after a heart attack, ultimately improving heart function in the long...
www.ie-freiburg.mpg.de
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