Frederica Theodoulou
@freddietheodoulou.bsky.social
400 followers 160 following 87 posts
Plant scientist, interested in proteostasis, hypoxia, and baking.
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freddietheodoulou.bsky.social
Happy to share that our multi-omic analysis comparing two Arabidopsis accessions is now published 🌿 The first story from our @ukri.org BBSRC sLoLa #plant #proteostasis project. A great collaboration between @rothamsted.bsky.social @richardmott.bsky.social @ucl.ac.uk and Kathryn Lilley at Cambridge.
richardmott.bsky.social
We have just published a paper in Genome Biology, rdcu.be/eIMLf. We explore the information flow between genome, gene body methylation, transcriptome, translatome and proteome in Arabidopsis. This is part of a BBSRC-funded collaboration with UCL, Rothamsted Research and University of Cambridge.
Information flow between omic  levels in Arabidopsis thaliana
freddietheodoulou.bsky.social
Happy to share that our multi-omic analysis comparing two Arabidopsis accessions is now published 🌿 The first story from our @ukri.org BBSRC sLoLa #plant #proteostasis project. A great collaboration between @rothamsted.bsky.social @richardmott.bsky.social @ucl.ac.uk and Kathryn Lilley at Cambridge.
richardmott.bsky.social
We have just published a paper in Genome Biology, rdcu.be/eIMLf. We explore the information flow between genome, gene body methylation, transcriptome, translatome and proteome in Arabidopsis. This is part of a BBSRC-funded collaboration with UCL, Rothamsted Research and University of Cambridge.
Information flow between omic  levels in Arabidopsis thaliana
freddietheodoulou.bsky.social
Hello to all my floodie friends currently in Nagoya! 🌾🌊👋 I'm so sorry I couldn't make it to #ISPLORE2025JP this time: will be following the posts from @isplore.bsky.social and feeling wistful all week. Hope you have a great meeting ☺️
isplore.bsky.social
#ISPLORE2025JP is about to start in beautiful Nagoya! We're excited for a full week of low-oxygen and flooding #plantscience 🌱🌊
freddietheodoulou.bsky.social
Great to be sharing exciting progress with #PrecisionBreeing in our #GreenEngineering BBSRC institute strategic programme @rothamsted.bsky.social Several valuable traits in the pipeline @ukri.org #PBO #GeneEditing
rothamsted.bsky.social
It was a great pleasure to host 15 of the
@euinuk.bsky.social agrifood counsellors in London to campus this week. Lots of discussion around future crops and precision breeding...🧬🌱
freddietheodoulou.bsky.social
It's been far too long since my last baking post, so I wanted to announce a recent acquisition: a cake dome which I am launching with a grown up but still childish slab of cake. Dark chocolate icing with sprinkles tasted better than it looks!
A slightly wonky square cake, covered in chocolate icing, with far too many sugar sprinkles, topped with a glass dome.
Reposted by Frederica Theodoulou
yoselin.bsky.social
I can't stress it more. This conference has been designed for us by us. Support @blackinplantsci.bsky.social conference at the University of Leeds funded by the SEB, Faculty of Biological Science at Leeds, the Grow More and New Phytologist foundations and Gastby. Join us on 24/10, details below.
blackinplantsci.bsky.social
📢Deadlines fast approaching for the BiPS Conference 2025!

Join us for a day of connection and celebration where we'll be hearing from the renowned academics Nicola Patron and Kevin Cox. With workshops on a variety of topics and a chance for you to build your community.

Register: buff.ly/J9PM0Wj
Reposted by Frederica Theodoulou
rsasidharan.bsky.social
🚨Job Alert!! Assistant professor vacancy ‘plant abiotic stress resilience’ in our group @uuplants.bsky.social Come for the science, stay for the amazing colleagues 😀More details here www.uu.nl/en/organisat... Please share!!
freddietheodoulou.bsky.social
👏 Great to see plant scientists among the ERC StG winners 🌿 congrats all!
suaybuestuen.bsky.social
erc.europa.eu
The new ERC Starting Grant - funded projects include:

✴️ redefining false memories

✴️ making artificial touch feel more natural and realistic

✴️ how aging reshapes human tissues

✴️ ADHD in adults vs childhood

✴️ how plants shield from excessive sun exposure

Discover more 👉 buff.ly/APfNmCK
freddietheodoulou.bsky.social
Great news, huge congratulations Vinay! 🥂
freddietheodoulou.bsky.social
So very sad to hear this. Andrew was hugely supportive of our engineering biology work at Rothamsted. A rigorous scientist and so full of interesting ideas.
freddietheodoulou.bsky.social
Job opportunity: come join the excellent and friendly #ProteostasisUK community!
delladavid-lab.bsky.social
Exciting news📣: #ProteostasisUK is hiring a network manager to help drive an ambitious, #BBSRC funded initiative connecting and expanding #Proteostasis research across the UK. Position initially for 3 years. Deadline September 28th. More info: tinyurl.com/f83rp673 & proteostasisuk.co.uk Please RT
hireful.
tinyurl.com
Reposted by Frederica Theodoulou
rm0sher.bsky.social
Had to look up an old paper to get the doi. It still completely boggles my mind that TWO Nobel prizes have been given for small RNAs and this work wasn't recognized by either. Abstract is literally like "yeah, we found these tiny antisense RNAs and think they're probably causing gene silencing"
A Species of Small Antisense RNA in Posttranscriptional Gene Silencing in Plants by Andrew J. Hamilton and David C. Baulcombe 
Abstract
Posttranscriptional gene silencing (PTGS) is a nucleotide sequence–specific defense mechanism that can target both cellular and viral mRNAs. Here, three types of transgene-induced PTGS and one example of virus-induced PTGS were analyzed in plants. In each case, antisense RNA complementary to the targeted mRNA was detected. These RNA molecules were of a uniform length, estimated at 25 nucleotides, and their accumulation required either transgene sense transcription or RNA virus replication. Thus, the 25-nucleotide antisense RNA is likely synthesized from an RNA template and may represent the specificity determinant of PTGS.
freddietheodoulou.bsky.social
Epic structure paper from @clausenlab.bsky.social @dangrabarczyk.bsky.social and collaborators providing mechanistic insight into how the UBR4 complex (=BIG in plants 🌿😊) fulfils apparently disparate roles in protein turnover 🤩
dangrabarczyk.bsky.social
Glad to share the final version of our story about the UBR4 complex, an E4 ligase protein quality control hub @science.org. Now with more cryo-EM structures and a deeper dive into substrate recognition, especially escaped mitochondrial proteins @clausenlab.bsky.social www.science.org/doi/10.1126/...
freddietheodoulou.bsky.social
🤩 Wonderful work- huge congratulations! 🥂🥂🥂 Sets the scene beautifully for our whole plant experiments on Arabidopsis UBR4 😊🌿
freddietheodoulou.bsky.social
🤯
jrossibarra.bsky.social
This always blows my mind. Dude mapped qtl for a quantitative trait to a chromosome in 1923!
jrossibarra.bsky.social
Related but cool combo of cytogenetics and phenotype. Know when the first QTL was mapped?

Sax, K. 1923. The association of size differences with seed coat pattern and pigmentation in Phaseolus vulgaris. Genetics 8:552-560.
freddietheodoulou.bsky.social
Congratulations Lucia and all the best for the move! 🥂
freddietheodoulou.bsky.social
Congrats Seven and Lindsay- great to see this project being supported by ERC! 🥂
freddietheodoulou.bsky.social
Academics never go on vacation, they just read papers and emails on beaches..... 🌴
freddietheodoulou.bsky.social
Good candidate for a caption competition!
freddietheodoulou.bsky.social
Left myself a message for tomorrow morning
A piece of paper with the message: "STOP FAFFING AROUND AND START WRITING A GRANT"
Reposted by Frederica Theodoulou
daphnejacksontr.bsky.social
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Breaking down barriers to reignite research careers.
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Reposted by Frederica Theodoulou
freddietheodoulou.bsky.social
Sorry to be missing this!
suaybuestuen.bsky.social
Fantastic talk by @djgibbs.bsky.social at #SEBconference on how the N-Degron pathway regulates histone methylation to coordinate plant development #proteostasis @sebiology.bsky.social - see also @drosborneplantsci.bsky.social latest publication www.cell.com/developmenta...