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Reposted by Elif Karagöz

Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 1d

A good day to remember John Gurdon’s school report from his biology master at Eton

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Elif Karagöz @gekaragoz.bsky.social · 5d

Happy 10th year birthday to the amazing Bücker lab! Many more fun, successful years to come!

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Susan Shao @sshaolab.bsky.social · 6d

Beautiful reconstitution of amino acid stress-dependent ISR activation by my @harvardcellbio.bsky.social colleagues presenting a unifying mechanism for GCN2 activation, which requires ribosome collisions and is enhanced by cognate uncharged tRNA in the A site! www.science.org/doi/10.1126/...

GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling

During nutrient deprivation, activation of the protein kinase GCN2 regulates cell survival and metabolic homeostasis. In addition to amino acid stress, GCN2 is activated by a variety of cellular stres...

www.science.org

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John Ngo @johntngo.bsky.social · 16d

🚀 Our new paper is out @natmethods.nature.com!

Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.

🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/

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Laura Lorenzo Orts @lorenzoorts.bsky.social · 24d

I am excited to announce that I will be moving to IMB Mainz next year! The Winter call for the IPP PhD program is now open; if you are interested in maternal #mRNA regulation and #translation in early vertebrate development, please apply! Deadline: 16 October.

More info: www.imb.de/students-pos...

Laura Lorenzo Orts

IMB Mainz

www.imb.de

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Itay Budin @ibudin.bsky.social · 23d

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...

Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology

An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...

www.nature.com

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Max Perutz Labs Vienna @maxperutzlabs.ac.at · 28d

Opportunity for skilled hands and sharp minds - at any career stage! 💪 The Köhler Lab is seeking a full-time lab technician to support their research on nuclear envelope biology, chromatin regulation, and cellular stress resilience - apply here ➡️ tinyurl.com/bdfy3w2h

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Olivia Coleman @ocoleman.bsky.social · Sep 7

Thank you for including our Paper as a highlight! for anyone interested in the accompanying blog post: go.nature.com/4mFNYdb

Unravelling how the stress sensor ATF6 stirs up trouble (and tumors)

go.nature.com

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Karolin Luger @nucleosomepolice.bsky.social · Sep 4

Fantastic opportunity. Vienna rocks!

Anna Obenauf @obenaufa.bsky.social · Sep 4

Exciting FULL PROFESSORSHIP at the Vienna BioCenter - Molecular Mechanisms of Disease Mechanisms: www.maxperutzlabs.ac.at/news/open-po... Come be our colleague!

Full Professorship in Molecular Mechanisms of Disease

The Max Perutz Labs - one of Europe’s leading institutes for basic research in the life sciences - invite applications for a Full Professorship in Molecular Mechanisms of Disease. We are seeking outst...

www.maxperutzlabs.ac.at

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Luisa Cochella @lcochella.bsky.social · Sep 3

Our work on the function of miR-51/miR-100 is out! miR-100 is widely conserved across eumetazoans but its function has been mysterious. Emilio Santillán found in worms it regulates signaling and extracellular matrix genes, some of which seem to be conserved targets! www.science.org/doi/10.1126/...

An ancient and essential miRNA family controls cellular interaction pathways in C. elegans

A microRNA that arose at the origin of eumetazoans regulates cell adhesion and signaling in C. elegans through conserved targets.

www.science.org

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Martin Loose @nartimsoole.bsky.social · Sep 1

We are looking for a Master’s student to join a project on in vitro reconstitution of signaling networks in pathogen–host interactions: combine protein biochemistry, fluorescence microscopy & image analysis. Deadline: September 15.
Find out more and apply here: ist.ac.at/en/job/maste...

Master Thesis Position – Loose Research Group

Our Group The Loose lab at the Institute of Science and Technology Austria (ISTA) is looking for a highly motivated Master student to join our research on the in vitro reconstitution of signaling n...

ist.ac.at

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Nature Cell Biology @natcellbio.nature.com · Sep 2

💫NEW: Mauthe et al. find that protein aggregate clearance requires fragmentation of the aggregate by a chaperone module and a proteasomal regulatory particle for recruitment and clustering of selective #autophagy receptors to initiate phagophore formation.
bit.ly/3JJeJPp

A chaperone-proteasome-based fragmentation machinery is essential for aggrephagy - Nature Cell Biology

Mauthe et al. find that protein aggregate clearance requires fragmentation of the aggregate by a chaperone module and a proteasomal regulatory particle for recruitment and clustering of selective auto...

bit.ly

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Elif Karagöz @gekaragoz.bsky.social · Aug 29

Another amazing story! Congrats Dan and the Clausen lab!

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Dan Grabarczyk @dangrabarczyk.bsky.social · Aug 28

Glad to share the final version of our story about the UBR4 complex, an E4 ligase protein quality control hub @science.org. Now with more cryo-EM structures and a deeper dive into substrate recognition, especially escaped mitochondrial proteins @clausenlab.bsky.social www.science.org/doi/10.1126/...

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Elif Karagöz @gekaragoz.bsky.social · Aug 28

Great work! Congrats, Dan!!!

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Dan Grabarczyk @dangrabarczyk.bsky.social · Aug 27

Happy to share our work on the structure and function of the unusual E3 ligase ZNFX1 @cp-cell.bsky.social. It uses a nucleic acid-activated transthiolation mechanism, ubiquitinating and clustering RNA to protect cells in an immune response. @clausenlab.bsky.social
www.cell.com/cell/fulltex...

A split-site E3 ligase mechanism enables ZNFX1 to ubiquitinate and cluster single-stranded RNA into ubiquitin-coated nucleoprotein particles

Grabarczyk et al. show the structure and mechanism of a non-canonical ubiquitin ligase, which is activated through nucleic-acid-induced oligomerization and is critical for cell survival during immune ...

www.cell.com

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paulschanda.bsky.social @paulschanda.bsky.social · Aug 25

📢 New preprint: Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.

We addressed a long-standing question that people debated already in the 1970s - but it still remained open:
Do proteins in crystals move as they do in solution? We used ring flips to find out.
1/n

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Elif Karagöz @gekaragoz.bsky.social · Aug 13

Congrats, Anna!!! Beautiful work!

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Elif Karagöz @gekaragoz.bsky.social · Aug 12

Exciting new work from Dagdas lab! Congrats to Alibek and all the team!

Yasin Dagdas @plantophagy.bsky.social · Aug 11

If you’re enjoying some calm while others are on holiday, here’s a #NEW #preprint to dive into — led by the brilliant @vbcscitraining.bsky.social student A. Abdrakhmanov:
👇 A quick thread + link:
www.biorxiv.org/content/10.1...

Ancestral P-body proteins rewired for autophagic recycling in the early land plant Marchantia polymorpha

Processing bodies (P-bodies) are conserved ribonucleoprotein (RNP) granules central to RNA metabolism across eukaryotes. Although the mechanisms underlying their assembly are well understood, the path...

www.biorxiv.org

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Carolin Klose @carolinklose.bsky.social · Aug 5

Excited to share our latest study in @natcomms.nature.com , where we characterize the chaperone function of the ER membrane protein complex (EMC)—supporting membrane protein biogenesis beyond insertion!
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www.nature.com/articles/s41...

The EMC acts as a chaperone for membrane proteins - Nature Communications

Membrane proteins are essential for any cell but difficult to fold. Here, the authors show that the EMC acts as a chaperone for membrane proteins. They dissect client recognition and provide a molecul...

www.nature.com

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Christa Buecker @chribue.bsky.social · Jul 16

My colleagues are awesome!

Max Perutz Labs Vienna @maxperutzlabs.ac.at · Jul 16

🔬 Big boost for bold ideas! Four group leaders have secured over €1.9 million in @fwf-at.bsky.social funding. Congratulations to Erinc Hallacli, @huis.bsky.social, @martinleeb.bsky.social, and Joao Matos! ➡️ tinyurl.com/2paphtc6
@univie.ac.at
@meduniwien.ac.at

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Marco Hein @marco.heinlab.org · Jul 8

Join us at the Perutz, part of the Vienna Biocenter!
Opening for a full professorship in Molecular Mechanisms of Disease 👇🏻
@maxperutzlabs.bsky.social @viennabiocenter.bsky.social
@univie.ac.at

Max Perutz Labs Vienna @maxperutzlabs.ac.at · Jul 7

📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Molecular Mechanisms of Disease. More information ➡️ tinyurl.com/3yn883b8

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Max Perutz Labs Vienna @maxperutzlabs.ac.at · Jul 7

📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Molecular Mechanisms of Disease. More information ➡️ tinyurl.com/3yn883b8

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SFB Targeted Protein Degradation @sfb-tpd-vienna.bsky.social · Jul 2

👏 Big CONGRATS to @sramundo.bsky.social for receiving an FWF @fwf-at.bsky.social ASTRA Award 🌠✨
See all about it 👇

Gregor Mendel Institute of Molecular Plant Biology @gmivienna.bsky.social · Jun 25

Congratulations to Silvia Ramundo, Group Leader at the GMI, who has been awarded an ASTRA Award from the Austrian Science Fund (FWF) in recognition of her research on chloroplast biology!

Read more: https://thegmi.science/049300

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Cristian Prieto-Garcia @prieto-garcia.bsky.social · Nov 15

It is finally out! My first Science paper is online and it does not seem real😃. I am Incredibly happy! Really thanks to all my coauthors and special mention to my incredible supervisor Ivan Dikic for all the support and trust ! 🫶. #RNA #Proteostasis #ubiquitin #autophagy #RP
doi.org/10.1126/scie...

Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy

RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanis...

doi.org

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