Olivia Coleman
@ocoleman.bsky.social
Young Investigator @TU_Muenchen curious about the intestinal microbiota, mucus and colorectal cancer. Travel lover, dog lover, rum lover, proud mum and wife.
Pinned
Olivia Coleman
@ocoleman.bsky.social
· Sep 2
ATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation - Nature Metabolism
The transcription factor ATF6 causes an enrichment in long-chain fatty acids in the colonic epithelium, which leads to changes in the gut microbiota and contributes to the development of colorectal ca...
www.nature.com
Very happy to share our latest publication unravelling how the #ERstress sensor ATF6 stirs up trouble (and tumors) in #colorectalcancer. ATF6 drives CRC by reshaping lipid #metabolism and the intestinal #microbiota. A huge thank you to all co-authors! #lifesciences
www.nature.com/articles/s42...
www.nature.com/articles/s42...
It‘s been a pleasure to host @mucubacter.bsky.social as a guest speaker for the CRC1371 #microbiomesignatures here at #TUM. Fantastic talk on #microbiome #diet #antibiotic and #mucus projects, and great exchanges! Thank you for your visit Björn! #mucusmatters
October 22, 2025 at 10:32 AM
It‘s been a pleasure to host @mucubacter.bsky.social as a guest speaker for the CRC1371 #microbiomesignatures here at #TUM. Fantastic talk on #microbiome #diet #antibiotic and #mucus projects, and great exchanges! Thank you for your visit Björn! #mucusmatters
Reposted by Olivia Coleman
RESEARCH |
@ocoleman.bsky.social , Sorbie, Haller et al. (TUM)
ATF6 causes an enrichment in long-chain fatty acids in the colon, which contributes to the development of colorectal cancer🧪
@ocoleman.bsky.social , Sorbie, Haller et al. (TUM)
ATF6 causes an enrichment in long-chain fatty acids in the colon, which contributes to the development of colorectal cancer🧪
ATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation - Nature Metabolism
The transcription factor ATF6 causes an enrichment in long-chain fatty acids in the colonic epithelium, which leads to changes in the gut microbiota and contributes to the development of colorectal cancer in humans and mice, thereby linking endoplasmic reticulum stress responses to lipid metabolism and tumorigenesis.
bit.ly
October 18, 2025 at 6:45 PM
RESEARCH |
@ocoleman.bsky.social , Sorbie, Haller et al. (TUM)
ATF6 causes an enrichment in long-chain fatty acids in the colon, which contributes to the development of colorectal cancer🧪
@ocoleman.bsky.social , Sorbie, Haller et al. (TUM)
ATF6 causes an enrichment in long-chain fatty acids in the colon, which contributes to the development of colorectal cancer🧪
I recently had the pleasure of a short stay at the University of Gothenburg, hosted by Elisabeth Nyström. Many thanks to Liz and everyone in the Mucin Biology groups for the warm welcome and stimulating scientific exchange. Looking forward to continuing our collaboration! #mucusmatters
October 10, 2025 at 8:17 PM
I recently had the pleasure of a short stay at the University of Gothenburg, hosted by Elisabeth Nyström. Many thanks to Liz and everyone in the Mucin Biology groups for the warm welcome and stimulating scientific exchange. Looking forward to continuing our collaboration! #mucusmatters
Reposted by Olivia Coleman
@ocoleman.bsky.social way to go!
Researchers identified a #cellularmechanism that alters the #gutmicrobiome in a way that promotes #cancer. The study could demonstrate the increased formation of long-chain #fattyacids – the preferred food of certain cancer-promoting #bacteria: go.tum.de/864170
📷A.Eckert
📷A.Eckert
How chronic cellular stress alters the gut microbiome
TUM researchers have identified a cellular mechanism through which cancer-promoting bacteria in the gut can multiply and adapt the gut microbiome.
go.tum.de
September 25, 2025 at 8:16 AM
@ocoleman.bsky.social way to go!
Reposted by Olivia Coleman
@ocoleman.bsky.social way to go!
This week selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: ATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation www.nature.com/articles/s42...
Highlight: ATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation www.nature.com/articles/s42...
bims-proteo 2025-09-07 papers
biomed.news
September 7, 2025 at 6:47 AM
@ocoleman.bsky.social way to go!
For an extra read on our new publication in #naturemetabolism, read my Blog Post: Unravelling how the stress sensor ATF6 stirs up trouble (and tumors)
communities.springernature.com/posts/unrave...
#lifesciences #colorectalcancer #microbiota #erstress #metabolism
communities.springernature.com/posts/unrave...
#lifesciences #colorectalcancer #microbiota #erstress #metabolism
Unravelling how the stress sensor ATF6 stirs up trouble (and tumors)
communities.springernature.com
September 4, 2025 at 4:39 AM
For an extra read on our new publication in #naturemetabolism, read my Blog Post: Unravelling how the stress sensor ATF6 stirs up trouble (and tumors)
communities.springernature.com/posts/unrave...
#lifesciences #colorectalcancer #microbiota #erstress #metabolism
communities.springernature.com/posts/unrave...
#lifesciences #colorectalcancer #microbiota #erstress #metabolism
Very happy to share our latest publication unravelling how the #ERstress sensor ATF6 stirs up trouble (and tumors) in #colorectalcancer. ATF6 drives CRC by reshaping lipid #metabolism and the intestinal #microbiota. A huge thank you to all co-authors! #lifesciences
www.nature.com/articles/s42...
www.nature.com/articles/s42...
ATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation - Nature Metabolism
The transcription factor ATF6 causes an enrichment in long-chain fatty acids in the colonic epithelium, which leads to changes in the gut microbiota and contributes to the development of colorectal ca...
www.nature.com
September 2, 2025 at 7:01 PM
Very happy to share our latest publication unravelling how the #ERstress sensor ATF6 stirs up trouble (and tumors) in #colorectalcancer. ATF6 drives CRC by reshaping lipid #metabolism and the intestinal #microbiota. A huge thank you to all co-authors! #lifesciences
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted by Olivia Coleman
🚀 What’s it like to launch a new lab? Hans-Georg Sprenger shares challenges, early wins & the joy of mentoring in molecular metabolism research. @mpiage.bsky.social
Read the interview: febs.onlinelibrary.wiley.com/doi/10.1002/...
#ScienceCareers #Mentoring #ResearchLife
Read the interview: febs.onlinelibrary.wiley.com/doi/10.1002/...
#ScienceCareers #Mentoring #ResearchLife
August 8, 2025 at 12:43 PM
🚀 What’s it like to launch a new lab? Hans-Georg Sprenger shares challenges, early wins & the joy of mentoring in molecular metabolism research. @mpiage.bsky.social
Read the interview: febs.onlinelibrary.wiley.com/doi/10.1002/...
#ScienceCareers #Mentoring #ResearchLife
Read the interview: febs.onlinelibrary.wiley.com/doi/10.1002/...
#ScienceCareers #Mentoring #ResearchLife
Road trip starts tomorrow. Journal proofs still MIA. Guess the laptop’s coming after all… #academiclife #firstauthorpriviliges
a man wearing headphones sits at a desk with a laptop on it on the beach
ALT: a man wearing headphones sits at a desk with a laptop on it on the beach
media.tenor.com
July 31, 2025 at 8:15 PM
Road trip starts tomorrow. Journal proofs still MIA. Guess the laptop’s coming after all… #academiclife #firstauthorpriviliges
Reposted by Olivia Coleman
This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥
www.nature.com/articles/s42...
www.nature.com/articles/s42...
The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism
This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.
www.nature.com
July 28, 2025 at 3:02 PM
This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥
www.nature.com/articles/s42...
www.nature.com/articles/s42...
This isn't the crispest image, unfortunately, but getting my mouse intestinal organoid to take on the shape of a mouse (nibbling on a chow pellet?) is my achievement of the week 🤩
p.s. @gobletcellguy.bsky.social: this is the mCherry Muc2...the signal is definitely there 🤜
p.s. @gobletcellguy.bsky.social: this is the mCherry Muc2...the signal is definitely there 🤜
July 27, 2025 at 6:07 PM
This isn't the crispest image, unfortunately, but getting my mouse intestinal organoid to take on the shape of a mouse (nibbling on a chow pellet?) is my achievement of the week 🤩
p.s. @gobletcellguy.bsky.social: this is the mCherry Muc2...the signal is definitely there 🤜
p.s. @gobletcellguy.bsky.social: this is the mCherry Muc2...the signal is definitely there 🤜
Happy to share our latest paper showing that intestinal inflammation (IL10-/-) + an UPRER diva protein (ATF6) = a perfect storm for colon cancer: Susceptibility to inflammatory bowel diseases promotes invasive carcinomas in a murine model of ATF6-driven colon cancer. academic.oup.com/ecco-jcc/art...
Susceptibility to inflammatory bowel diseases promotes invasive carcinomas in a murine model of ATF6-driven colon cancer
AbstractBackground and aims. Chronic inflammation in inflammatory bowel disease (IBD) patients represents a risk factor for developing colitis-associated c
academic.oup.com
July 23, 2025 at 9:38 AM
Happy to share our latest paper showing that intestinal inflammation (IL10-/-) + an UPRER diva protein (ATF6) = a perfect storm for colon cancer: Susceptibility to inflammatory bowel diseases promotes invasive carcinomas in a murine model of ATF6-driven colon cancer. academic.oup.com/ecco-jcc/art...
Reposted by Olivia Coleman
The 5th Ghent Gut Inflammation Group Meeting #GGIG2025 is live! 🚨 Hosted by Ghent University & VIB, this 2-day event spotlights junior scientists in gut research. Great start with Jochem Bernink of @amsterdamumc.bsky.social on immune-mediated regeneration in the gut! More info: vibbio.tech/GGIG2025
May 15, 2025 at 9:02 AM
The 5th Ghent Gut Inflammation Group Meeting #GGIG2025 is live! 🚨 Hosted by Ghent University & VIB, this 2-day event spotlights junior scientists in gut research. Great start with Jochem Bernink of @amsterdamumc.bsky.social on immune-mediated regeneration in the gut! More info: vibbio.tech/GGIG2025
Reposted by Olivia Coleman
Happy to see this finally published 🙌 Thanks to the editors and reviewers for the constructive process 😎
The colonic mucus barrier & sentinel goblet cells protect the distal gut from microbial challenges. Johansson, @gobletcellguy.bsky.social et al show that microbial colonization drives sequential development of both of these barrier mechanisms in the pre-weaning intestine. rupress.org/jem/article/...
May 5, 2025 at 4:25 PM
Happy to see this finally published 🙌 Thanks to the editors and reviewers for the constructive process 😎
It‘s been a pleasure to host @mucusman.bsky.social as a guest speaker for the CRC1371 #microbiomesignatures here at #TUM. Two days filled with productive and fun #gobletcell exchanges and a fantastic talk on #mucus #autphagy #erstress and #antibiotics. Thanks for making the trip Shai! #mucusmatters
February 19, 2025 at 4:21 PM
It‘s been a pleasure to host @mucusman.bsky.social as a guest speaker for the CRC1371 #microbiomesignatures here at #TUM. Two days filled with productive and fun #gobletcell exchanges and a fantastic talk on #mucus #autphagy #erstress and #antibiotics. Thanks for making the trip Shai! #mucusmatters
For all the #mucus fans out there who believe in our knight in slimy armour and want to join the starter pack 👇 contact @gobletcellguy.bsky.social
#mucusmatters
#mucusmatters
Just in case any new #mucus, #Goblet cell or #mucin folks have joined up recently, we have a small but growing starter pack for this area - let me know if you want in 🫡
go.bsky.app/7Z84CmG
go.bsky.app/7Z84CmG
February 17, 2025 at 2:18 PM
For all the #mucus fans out there who believe in our knight in slimy armour and want to join the starter pack 👇 contact @gobletcellguy.bsky.social
#mucusmatters
#mucusmatters
Better late than never...finally made the move to #bluesky!
I am back from #maternityleave and excited to dive into the science world again, and catch up on #mucus updates ✌️ I've probably missed lots 😱 #mucusmatters #academicchatter #academicmum
I am back from #maternityleave and excited to dive into the science world again, and catch up on #mucus updates ✌️ I've probably missed lots 😱 #mucusmatters #academicchatter #academicmum
a man standing in a hallway with the words listen i know i 'm late i can explain
ALT: a man standing in a hallway with the words listen i know i 'm late i can explain
media.tenor.com
February 16, 2025 at 6:23 AM
Better late than never...finally made the move to #bluesky!
I am back from #maternityleave and excited to dive into the science world again, and catch up on #mucus updates ✌️ I've probably missed lots 😱 #mucusmatters #academicchatter #academicmum
I am back from #maternityleave and excited to dive into the science world again, and catch up on #mucus updates ✌️ I've probably missed lots 😱 #mucusmatters #academicchatter #academicmum