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Olivia Coleman

@ocoleman.bsky.social

170 followers 410 following 11 posts

Post-doc @TU_Muenchen curious about the intestinal microbiota, mucus and colorectal cancer. Travel lover, dog lover, rum lover, proud mum and wife.

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Olivia Coleman @ocoleman.bsky.social · Sep 2

Very happy to share our latest publication unravelling how the #ERstress sensor ATF6 stirs up trouble (and tumors) in #colorectalcancer. ATF6 drives CRC by reshaping lipid #metabolism and the intestinal #microbiota. A huge thank you to all co-authors! #lifesciences
www.nature.com/articles/s42...

ATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation - Nature Metabolism

The transcription factor ATF6 causes an enrichment in long-chain fatty acids in the colonic epithelium, which leads to changes in the gut microbiota and contributes to the development of colorectal ca...

www.nature.com

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Reposted by Olivia Coleman

Alexander Bartelt @barteltlab.bsky.social · 14d

@ocoleman.bsky.social way to go!

Technische Universität München @tum.de · 14d

Researchers identified a #cellularmechanism that alters the #gutmicrobiome in a way that promotes #cancer. The study could demonstrate the increased formation of long-chain #fattyacids – the preferred food of certain cancer-promoting #bacteria: go.tum.de/864170

📷A.Eckert

How chronic cellular stress alters the gut microbiome

TUM researchers have identified a cellular mechanism through which cancer-promoting bacteria in the gut can multiply and adapt the gut microbiome.

go.tum.de

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Reposted by Olivia Coleman

Alexander Bartelt @barteltlab.bsky.social · Sep 7

@ocoleman.bsky.social way to go!

Eric Chevet @ericchevet.bsky.social · Sep 7

This week selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: ATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation www.nature.com/articles/s42...

bims-proteo 2025-09-07 papers

biomed.news

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Olivia Coleman @ocoleman.bsky.social · Sep 7

Thank you for including our Paper as a highlight! for anyone interested in the accompanying blog post: go.nature.com/4mFNYdb

Unravelling how the stress sensor ATF6 stirs up trouble (and tumors)

go.nature.com

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Olivia Coleman @ocoleman.bsky.social · Sep 4

For an extra read on our new publication in #naturemetabolism, read my Blog Post: Unravelling how the stress sensor ATF6 stirs up trouble (and tumors)
communities.springernature.com/posts/unrave...
#lifesciences #colorectalcancer #microbiota #erstress #metabolism

Unravelling how the stress sensor ATF6 stirs up trouble (and tumors)

communities.springernature.com

Olivia Coleman @ocoleman.bsky.social · Sep 2

ATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation - Nature Metabolism

www.nature.com

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Reposted by Olivia Coleman

FEBS Letters @febsletters.bsky.social · Aug 8

🚀 What’s it like to launch a new lab? Hans-Georg Sprenger shares challenges, early wins & the joy of mentoring in molecular metabolism research. @mpiage.bsky.social
Read the interview: febs.onlinelibrary.wiley.com/doi/10.1002/...
#ScienceCareers #Mentoring #ResearchLife

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Olivia Coleman @ocoleman.bsky.social · Jul 31

Road trip starts tomorrow. Journal proofs still MIA. Guess the laptop’s coming after all… #academiclife #firstauthorpriviliges

a man wearing headphones sits at a desk with a laptop on it on the beach

ALT: a man wearing headphones sits at a desk with a laptop on it on the beach

media.tenor.com

Reposted by Olivia Coleman

Lydia Lynch @lydialynch.bsky.social · Jul 28

This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥
www.nature.com/articles/s42...

The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism

This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

www.nature.com

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Olivia Coleman @ocoleman.bsky.social · Jul 27

This isn't the crispest image, unfortunately, but getting my mouse intestinal organoid to take on the shape of a mouse (nibbling on a chow pellet?) is my achievement of the week 🤩

p.s. @gobletcellguy.bsky.social: this is the mCherry Muc2...the signal is definitely there 🤜

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Olivia Coleman @ocoleman.bsky.social · Jul 24

@hallerlab.bsky.social @adamsorbie.bsky.social

Olivia Coleman @ocoleman.bsky.social · Jul 23

Happy to share our latest paper showing that intestinal inflammation (IL10-/-) + an UPRER diva protein (ATF6) = a perfect storm for colon cancer: Susceptibility to inflammatory bowel diseases promotes invasive carcinomas in a murine model of ATF6-driven colon cancer. academic.oup.com/ecco-jcc/art...

Susceptibility to inflammatory bowel diseases promotes invasive carcinomas in a murine model of ATF6-driven colon cancer

AbstractBackground and aims. Chronic inflammation in inflammatory bowel disease (IBD) patients represents a risk factor for developing colitis-associated c

academic.oup.com

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Reposted by Olivia Coleman

VIB Training & Conferences @vibtrainconf.bsky.social · May 15

The 5th Ghent Gut Inflammation Group Meeting #GGIG2025 is live! 🚨 Hosted by Ghent University & VIB, this 2-day event spotlights junior scientists in gut research. Great start with Jochem Bernink of @amsterdamumc.bsky.social on immune-mediated regeneration in the gut! More info: vibbio.tech/GGIG2025

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Reposted by Olivia Coleman

George Birchenough @gobletcellguy.bsky.social · May 5

Happy to see this finally published 🙌 Thanks to the editors and reviewers for the constructive process 😎

Journal of Experimental Medicine @jem.org · May 5

The colonic mucus barrier & sentinel goblet cells protect the distal gut from microbial challenges. Johansson, @gobletcellguy.bsky.social et al show that microbial colonization drives sequential development of both of these barrier mechanisms in the pre-weaning intestine. rupress.org/jem/article/...

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Olivia Coleman @ocoleman.bsky.social · Feb 19

It‘s been a pleasure to host @mucusman.bsky.social as a guest speaker for the CRC1371 #microbiomesignatures here at #TUM. Two days filled with productive and fun #gobletcell exchanges and a fantastic talk on #mucus #autphagy #erstress and #antibiotics. Thanks for making the trip Shai! #mucusmatters

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Olivia Coleman @ocoleman.bsky.social · Feb 17

For all the #mucus fans out there who believe in our knight in slimy armour and want to join the starter pack 👇 contact @gobletcellguy.bsky.social
#mucusmatters

George Birchenough @gobletcellguy.bsky.social · Feb 11

Just in case any new #mucus, #Goblet cell or #mucin folks have joined up recently, we have a small but growing starter pack for this area - let me know if you want in 🫡
go.bsky.app/7Z84CmG

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Olivia Coleman @ocoleman.bsky.social · Feb 17

Great thanks!

Olivia Coleman @ocoleman.bsky.social · Feb 16

Better late than never...finally made the move to #bluesky!
I am back from #maternityleave and excited to dive into the science world again, and catch up on #mucus updates ✌️ I've probably missed lots 😱 #mucusmatters #academicchatter #academicmum

a man standing in a hallway with the words listen i know i 'm late i can explain

ALT: a man standing in a hallway with the words listen i know i 'm late i can explain

media.tenor.com

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