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Reposted by Yori Dola

bioRxiv Plant Bio @biorxiv-plants.bsky.social · 2d

A secreted citrus protease cleaves an outer membrane protein of the Huanglongbing pathogen https://www.biorxiv.org/content/10.1101/2025.10.06.680679v1

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Reposted by Yori Dola

GeminiTeamLab @geminiteamlab.bsky.social · 5d

How do geminiviruses maximize their limited coding capacity? Our recent preprint uncovers splicing of viral transcripts as one more strategy used by this viral family. We show that RNA splicing is prevalent in the geminivirus TYLCV — and required for infectivity! www.biorxiv.org/content/10.1...

Pervasive splicing in a plant DNA virus

Viruses maximize their limited coding space through strategies that increase transcript and protein diversity. In mammalian viruses, splicing is a well-established mechanism for proteome expansion, ye...

www.biorxiv.org

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Yori Dola @gene-boy.bsky.social · 7d

Cool new paper from the Doudna lab!

1. A Cas10 enzyme was found to constitutively synthesise cyclic nucleotides.
2. These stopped a toxic protein from dimerising and killing the cell.
3. Viruses which disrupt immunity also compromise the Cas10, triggering cell death!

www.nature.com/articles/s41...

A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling - Nature

Panoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed.

www.nature.com

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Yori Dola @gene-boy.bsky.social · 8d

#plantediting

Yori Dola @gene-boy.bsky.social · 8d

Have folks had the chance to try out the free-to-use OpenCRISPR yet?

It seems to offer a great alternative for cash-strapped startups.

www.nature.com/articles/s41...

Design of highly functional genome editors by modelling CRISPR–Cas sequences - Nature

Gene editors designed using artificial intelligence can undertake precision editing of the human genome.

www.nature.com

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Yori Dola @gene-boy.bsky.social · 8d

Students are not a monolithic group

Those who apply themselves are rightfully appalled to receive slop-py AI feedback. Folks pay to be taught by teachers, and this is a fundamental betrayal of that

Those who just need a diploma wouldn't mind AI feedback. Theyd just feed it into ChatGPT and move on

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Yori Dola @gene-boy.bsky.social · 12d

Recently reviewed a preprint written with AI. Not inherently an issue, but the resulting text lacked ...excitement? Turns of phrase were banal, words like "comprehensive" overused and often inappropriately (never before read of a *comprehensive* gene panel). Finishing the review felt like a chore...

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Reposted by Yori Dola

Drew Scanlon @drewscanlon.bsky.social · 12d

Hi Internet! I'm Drew and THIS IS MY FACE.

If this GIF has ever brought you joy in the past, I humbly ask you to consider making a donation to the National MS Society. It would mean a lot to me and to those I know affected by the disease!

Donate at blinkingguy.com

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Yori Dola @gene-boy.bsky.social · 12d

Wow!

Reposted by Yori Dola

Jasmin Schreiber @schreibersnaturarium.de · 16d

Die Kinder, die jetzt aufwachsen, finden es normal, dass Schmetterlinge Tiere sind, die man nur selten sieht. Sie haben vermutlich noch nie eine Feldlerche gehört, wissen nicht, was ein Rebhuhn ist. Über das Phänomen der sich verschiebenden Basislinien.

steady.page/de/jasminsch...

Die Natur, die wir vergessen, zu vermissen

🪶 Feldlerchen, Kiebitze, Insekten: Vieles verschwindet, ohne dass wir es merken oder vermissen. Ein Text über schleichenden Verlust und unsere verschobene Wahrnehmung.

steady.page

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Yori Dola @gene-boy.bsky.social · 16d

Organic farming was the norm for millenia. The food was expensive, and the food supply was less certain.

Some in the EU (BG) still spend >20% of income on food, and the EU is promoting organic?? We can not afford it.

We want healthy, affordable, sustainably produced food. Focus on that.

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Reposted by Yori Dola

Matt @xenomatt.bsky.social · 17d

Today's fish is definitely one of the more eye-catching ones. This is an intermediate-phase Leopard Wrasse (Macropharyngodon meleagris). Pic from Anilao

#MarineLife 🐟🌿

A smallish fish. Its white body is covered in irregular black spots and patches; these continue onto its yellow fins.

#Nature #Wildlife #NaturePhotography #UnderwaterPhotography #WildlifePhotography

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Yori Dola @gene-boy.bsky.social · 18d

You are right! But not all labs are non-commercial, and even non-commercial labs have to reckon with the convoluted IP landscape if they try to bring their science out of the lab. It has been a major decelerator of progress in the GE field.

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Yori Dola @gene-boy.bsky.social · 20d

While it is nice that an AI has been created to help novices with things like guide RNA design, the article pushes the strange opinion that this somehow "democratizes" GE.

The real barriers to GE for many labs are things like Cas9 IP and tissue culture. This has, unfortunately, not changed.

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Reposted by Yori Dola

PlantEvolution 🌱🌾 @plantevolution.bsky.social · 22d

👇🏼👇🏼👇🏼

Dezene Huber 🍁 🌻 @dezene.me · 23d

"Considering the long history of liars winning debates by lying, you would have thought that intellectuals might have learned to stop debating liars." @hormiga.bsky.social

...from old timey creationism "debates", to climate etc. social media today. 🧪

scienceforeveryone.science/debating-is-...

Debating is bad. Professor Watchlists are bad.

Disagreement and listening is good. Taking facts seriously is good.

scienceforeveryone.science

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Reposted by Yori Dola

Fantomaus 🎄 @fantomaus.bsky.social · 22d

Eine Weltklasseleistung 🥳

6,30 m übersprungen durch Armond Duplantis.

Habe ich gestern live im TV gesehen, aber diese Einstellung zeigt erst richtig, was für eine Leistung es war.

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Reposted by Yori Dola

Etienne Bucher 🌾🧬🇪🇺 @plantepigenetics.ch · 24d

Musk is STILL a member of @royalsociety.org … even after calling for violence.
Which scientists would like to be in the same society as this despicable person?

Joerg Lau @joerglau.bsky.social · 24d

Musk calls for regime change in UK, promotes violence at far-right rally.
Why is this allowed to continue? How can Europe (UK included) counter hybrid war by the world's richest man and owner of a "platform"?
This is a direct and imminent threat to democracy.

www.theguardian.com/technology/2...

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Reposted by Yori Dola

Jack C.M @foxmental.bsky.social · 26d

New pathway engineered into plants lets them suck up more CO₂. Via @arstechnica #Science #CRISPR 🔭🔬🧪🥼🧑‍🔬 #Botany #GeneticEngineering #ClimateChange 🌎♨️

New pathway engineered into plants lets them suck up more CO₂

Engineered pathway lets carbon be plugged directly into key metabolic pathways.

arstechnica.com

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Reposted by Yori Dola

Maite Saura @maitesaura.bsky.social · 28d

New preprint! 🐛 Root-knot nematodes hijack root cells, turning them into feeding sites and making plants very sick. Using a cross-species scRNA-seq approach we mapped this process and show how this knowledge can be used to engineer resistant crops.🌱 A summary🧵 :
www.biorxiv.org/content/10.1...

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Reposted by Yori Dola

wyotitania @wyotitania.bsky.social · Sep 8

Oh. My. Goodness. Look at this moth! LOOK AT THOSE WINGS!! Honestly didn't know that moth wings could be that frilly and lacy - like bird feathers - but apparently there is a whole family of "many plumed moths". This one is from the genus Alucita and found in China, and is just spectacular. (1/3)

An alucita moth, with frilly, lacy wings, in a photo taken by Timmy Wong in China.

Source: https://www.inaturalist.org/observations/232780177?fbclid=IwY2xjawMsKF1leHRuA2FlbQIxMABicmlkETFyeEllRVFqekE3TlZiWUhnAR7crKukQCvxnpLzBA1e2rvrMO177PwoCqamq_fC-XgtqthxwbWDSHur3uuYWQ_aem_JoIYMoZvp03bfyCWcUH9xw

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Reposted by Yori Dola

Marc Veldhoen @marcveld.bsky.social · Sep 6

Hope for diabetes: CRISPR-edited cells pump out insulin in a person – and evade immune detection

Edits create cells that don’t trigger an immune response, allowing implant recipient to forego immune-suppressing drugs.

www.nature.com/artic...
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Hope for diabetes: CRISPR-edited cells pump out insulin in a person – and evade immune detection

Nature - Edits create cells that don’t trigger an immune response, allowing implant recipient to forego immune-suppressing drugs.

www.nature.com

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Yori Dola @gene-boy.bsky.social · Sep 5

Taking part in a #PreprintPizzaParty is always a pleasure!

It's an enjoyable and natural way to learn how to critically and constructively review science. It's also very valuable to see how others approach the same manuscript.

I hope to see more institutions adopting this format!

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Reposted by Yori Dola

Bruno Ngou @brunongou.bsky.social · Sep 4

Very happy to share our latest work “Systematic discovery and engineering of synthetic immune receptors in plants” out in @science.org !

www.science.org/doi/10.1126/...

Systematic discovery and engineering of synthetic immune receptors in plants

Plants deploy a diverse array of pattern recognition receptors (PRRs), which perceive microbe-associated molecular patterns to activate immune responses. Leucine-rich repeat receptor-like kinase subgr...

www.science.org

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Andy Murdock @andymurdock.bsky.social · Sep 3

This is one of the coolest, most impactful things coming out of the #CRISPR world, but also one of the hardest to get anyone to pay attention to. Sure, we can repair genetic diseases, but have you heard about apomixis in crop plants? No really

Innovative Genomics Institute @innovativegenomics.bsky.social · Sep 3

Self-cloning crops could transform agriculture – thanks to research from IGI's Venkatesan Sundaresan, who was awarded the 2024 Wolf Prize for his research on apomixis. Read more in this feature from @nature.com: ow.ly/Q7v350WQyne

illustrations of scientists manipulating DNA in a seed in a steam punk style

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Yori Dola @gene-boy.bsky.social · Sep 3

You're very welcome 😊