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@genikhovich.bsky.social

280 followers 180 following 74 posts

Evolution of developmental mechanisms, especially axial patterning. Experimental embryology. 🪸🪼

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genikhovich.bsky.social @genikhovich.bsky.social · Jun 13

David’s @davidmoersdorf.bsky.social cool paper about the role of Chordin in BMP signaling in the sea anemone Nematostella is finally out www.science.org/doi/10.1126/...

Chordin-mediated BMP shuttling patterns the secondary body axis in a cnidarian

Chordin-mediated BMP shuttling is the candidate mechanism for generating bilateral symmetry in the cnidarian-bilaterian ancestor.

www.science.org

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genikhovich.bsky.social @genikhovich.bsky.social · 2d

Cool-cool-cool

Thibaut Brunet @thibautbrunet.bsky.social · 3d

Latest from ours: www.cell.com/cell-reports...

This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵

genikhovich.bsky.social @genikhovich.bsky.social · 6d

Hi, can someone point me to good commercial polyclonal anti-FMRF amide antibody, which is not from rabbit? Ideally, tested on cnidarians. Thanks in advance!

genikhovich.bsky.social @genikhovich.bsky.social · 11d

www.pnas.org/doi/10.1073/...

Dual Bmp-negative feedback loops modulate function of both AER and ZPA to buffer and constrain postaxial digit number | PNAS

Several lines of evidence indicate that posterior (postaxial) digit number in tetrapod vertebrates is constrained to the pentadactyl state by inter...

www.pnas.org

genikhovich.bsky.social @genikhovich.bsky.social · 20d

Sanjay's amazing story is available on www.biorxiv.org/content/10.1... Congratulations to @sanjay-n.bsky.social, @ulrichtechnau.bsky.social and everyone else 🎉

Notch coordinates self-organization of germ layers and axial polarity in cnidarian gastruloids

Dissociation and reaggregation experiments in several animal systems have revealed the stunning capacity of self-organization. Reaggregated early gastrula cells (here called gastruloids) of the sea an...

www.biorxiv.org

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genikhovich.bsky.social @genikhovich.bsky.social · 23d

Congratulations Venky!

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genikhovich.bsky.social @genikhovich.bsky.social · 27d

Congratulations to Dr. Paul Knabl @paulknabl.bsky.social Fantastic work and excellent defense!

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genikhovich.bsky.social @genikhovich.bsky.social · Aug 28

Congratulations! 🎉

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genikhovich.bsky.social @genikhovich.bsky.social · Aug 28

I don't know about "twice". My memory is crappier...

Harmit Singh Malik @harmitmalik.bsky.social · Aug 27

One of the best things about having a crappy memory is that you get to appreciate data generated by your awesome trainees twice.

First, at their lab meeting(s).

Second, when you read drafts of their papers, you are impressed de novo because you forgot the data they presented at the lab meeting.

genikhovich.bsky.social @genikhovich.bsky.social · Aug 27

Thanks Max (although it's primarily @emmanuelhaillot.bsky.social who deserves the congratulations here). May I suggest that you also look at this paper www.nature.com/articles/s41... - the fit together really well.

β-catenin-driven endomesoderm specification is a Bilateria-specific novelty - Nature Communications

Lebedeva et al. show that unlike Bilateria, the embryo of the cnidarian Nematostella specifies its endomesoderm in the β-catenin-negative domain. In contrast, subsequent β-catenin-dependent axial patt...

www.nature.com

genikhovich.bsky.social @genikhovich.bsky.social · Aug 27

www.nature.com/articles/s41... Cool paper by @emmanuelhaillot.bsky.social et al. from Uli Technau's group. @tclebedeva.bsky.social and I were also involved 🙃

Segregation of endoderm and mesoderm germ layer identities in the diploblast Nematostella vectensis - Nature Communications

Recent work suggested that diploblast embryos (Cnidaria) may have germ layers that are similar to those seen in bilaterians, but how these are specified remained unclear. Here, they use scRNA-seq and ...

www.nature.com

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Reposted

Nature @nature.com · Aug 15

Nature research paper: The genomic origin of the unique chaetognath body plan

go.nature.com/3HAsyyV

The genomic origin of the unique chaetognath body plan - Nature

Genomic, single-cell transcriptomic and epigenetic analyses show that chaetognaths, following extensive gene loss in the gnathiferan lineage, relied on newly evolved genes and lineage-specific tandem duplications, not caused by a whole-genome duplication event, to shape their distinctive body plan.

go.nature.com

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genikhovich.bsky.social @genikhovich.bsky.social · Aug 13

www.biorxiv.org/content/10.1...

Loss of Twist impairs tentacle development and induces epithelial neoplasia in the sea anemone Nematostella vectensis

The basic helix-loop helix transcription factor Twist plays diverse roles in mesodermal development across bilaterians, but its function in cnidarians remains unclear. Here, we investigate the role of...

www.biorxiv.org

genikhovich.bsky.social @genikhovich.bsky.social · Aug 10

www.biorxiv.org/content/10.1...

Depletion of a neural cell adhesion molecule disrupts both epithelial and germ layer identity in sea anemone embryos

Assembly of cells into epithelial layers marks the early steps of tissue organization and embryonic development in most animals. Although several conserved proteins are known to be essential for epith...

www.biorxiv.org

Reposted

Pawel Burkhardt @pawelburkhardt.bsky.social · Aug 7

Ctenophores possess a unique aboral organ that acts as a multisensory center, controlling complex behaviors. We’ve now created a ctenophore model integrated with our 3D volume EM data. Puts it into perspective.

Check out our recent work here: www.biorxiv.org/content/10.1...

#ctenophores #volumeEM

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genikhovich.bsky.social @genikhovich.bsky.social · Aug 5

www.biorxiv.org/content/10.1...

Gastruloids employ an alternative morphogenetic route to generate a posterior body axis on adherent substrates

Morphogenesis emerges from the integration of genetic programs with environmental signals, yet studying this interplay in embryos remains challenging due to the inherent complexity of embryonic system...

www.biorxiv.org

Reposted

James Briscoe @jamesbriscoe.bsky.social · Aug 4

A Summer reading recommendation: new primer in @dev-journal.bsky.social explains how dynamical systems theory unlocks the logic of developmental patterning

Everything from bistable switches & oscillators to phase portraits & more with Python code to explore

journals.biologists.com/dev/article/...

From genes to patterns: five key dynamical systems concepts to decode developmental regulatory mechanisms

Summary: Dynamical systems theory provides a powerful quantitative and intuitive framework to understand developmental processes. This Primer brings key concepts of this framework to the ever-growing ...

journals.biologists.com

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Reposted

Tiago Simões @trsimoes.bsky.social · Jul 22

A rare job opportunity for Invertebrate Zoology: fieldmuseum.hrmdirect.com/employment/j...

Assistant Curator of Invertebrate Zoology, Careers At Field Museum

Position Assistant Curator of Invertebrate Zoology FLSA Status Exempt Department Negaunee Integrative Research Center Our Mission Since the 1893 World Columbian Exposition our organization has aimed...

fieldmuseum.hrmdirect.com

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Reposted

Rebecca R Helm @rebeccarhelm.bsky.social · Jul 10

BEHOLD! One of Earth's greatest lineages of life: the lil wiggle arm guys, Meteora.

These single-celled critters, originally found in deep-sea sediments, are SO DIFFERENT from other lifeforms on Earth that they're likely in their own kingdom (as in, the Animal Kingdom, the Plant Kingdom etc). 🧪🌿

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genikhovich.bsky.social @genikhovich.bsky.social · Jul 14

Tsuyo's cool paper on Wnt3 being both a canonical and a PCP Wnt in Clytia is out doi.org/10.7554/eLif... Congratulations to everyone involved! @biodev-vlfr.bsky.social

Planar cell polarity coordination in a cnidarian embryo provides clues to animal body axis evolution

The jellyfish embryonic body axis is globally coordinated by conserved planar cell polarity (PCP) mechanisms and oriented by localised Wnt3 in two steps, highlighting PCP’s role in animal axis evoluti...

doi.org

genikhovich.bsky.social @genikhovich.bsky.social · Jul 12

I don't know... Depends on the context in which you have been cited. Imagine a sentence like "Prof. Moran's ridiculous claims that..." 😜

genikhovich.bsky.social @genikhovich.bsky.social · Jun 28

Congratulations!

genikhovich.bsky.social @genikhovich.bsky.social · Jun 28

Thanks, you are very kind. We'll keep trying.

genikhovich.bsky.social @genikhovich.bsky.social · Jun 28

Congratulations 🎉

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genikhovich.bsky.social @genikhovich.bsky.social · Jun 20

Uri does really cool stuff in Hydractinia

Uri Frank @thecocodium.bsky.social · Jun 20

I am looking for a new postdoc to join the lab. Interested in pluripotency, germ cells, and in investigating these in a genetically tractable cnidarian? Get in touch! We offer a long-term contract, excellent research environment, and a lovely city #Galway. www.urifranklab.org

genikhovich.bsky.social @genikhovich.bsky.social · Jun 17

Thanks, Uli!