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Reposted by John Newman, MD, PhD

The Buck Institute for Research on Aging @buckinstitute.org · Sep 3

Another packed house today for Dr John Newman’s (@GeriSciDoc.bsky.social) talk on How to Be Your Own Geriatrician. To register for our upcoming seminar: How Did Our Bodies End Up This Way on Oct 1: buckinstitute.org/events/lblseminars

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Reposted by John Newman, MD, PhD

Bakar Aging Research Institute @ucsfaging.bsky.social · Apr 14

Today is a special day! It's our second BARI symposium at the de Young Museum in the beautiful Golden Gate Park.

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John Newman, MD, PhD @geriscidoc.bsky.social · Mar 31

Outstanding work, Emily! I'm so excited to see this cool story out! What a great example of "that's odd" being the most important words in science.

Emily Goldberg @dremilygoldberg.bsky.social · Mar 26

I could not be more excited to have our lab's first story online where we report our discovery that HDACs ~reverse~ their activity to ADD acyl groups to lysine! We found this for our favorite ketone body, BHB, but this pathway controls other lysine modifications too!🧵

www.nature.com/articles/s41...

Reversible histone deacetylase activity catalyzes lysine acylation - Nature Chemical Biology

Tsusaka et al. discover that histone deacetylases, which are well known to remove protein modifications, such as lysine acetylation and β-hydroxybutyrylation, can also reverse their chemical activity ...

www.nature.com

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Reposted by John Newman, MD, PhD

Emily Goldberg @dremilygoldberg.bsky.social · Mar 26

I could not be more excited to have our lab's first story online where we report our discovery that HDACs ~reverse~ their activity to ADD acyl groups to lysine! We found this for our favorite ketone body, BHB, but this pathway controls other lysine modifications too!🧵

www.nature.com/articles/s41...

Reversible histone deacetylase activity catalyzes lysine acylation - Nature Chemical Biology

Tsusaka et al. discover that histone deacetylases, which are well known to remove protein modifications, such as lysine acetylation and β-hydroxybutyrylation, can also reverse their chemical activity ...

www.nature.com

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Reposted by John Newman, MD, PhD

The Buck Institute for Research on Aging @buckinstitute.org · Mar 8

Come visit the Buck booth at North Bay Science Discovery Day at the Sonoma County Fairgrounds today! We’re in The Hall of Flowers. Booth 24. We’ve got some really cool experiments to check out! @northbayscience

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John Newman, MD, PhD @geriscidoc.bsky.social · Mar 6

"I'm not here because I want to live forever... but I hope you can help me live better." - Goals of care elicited in geriatric medicine clinic from a real 87 year-old women, and one of the best mission statements I've heard for #geroscience - and #geriatrics!

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John Newman, MD, PhD @geriscidoc.bsky.social · Mar 6

One key theme will be about biological mechanisms of aging as common drivers of chronic disease both in the brain and in the rest of the body, simultaneously. What are the gaps and opportunities to bring this #geroscience concept into clinical practice?

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John Newman, MD, PhD @geriscidoc.bsky.social · Mar 6

We're kicking off an NIA-AGS symposium on the intersection of Alzheimer's disease and multiple chronic conditions - exactly the sort of interdisciplinary, un-siloed, patient-centered science that National Institute on Aging does so uniquely well! www.americangeriatrics.org/r13conference

INTERSECTION OF MULTIPLE CHRONIC CONDITIONS (MCCS) AND ALZHEIMER'S DISEASE AND ALZHEIMER'S DISEASE RELATED DEMENTIAS (AD/ADRD)

Intersection of Multiple Chronic Conditions (MCCs) and Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD) (2025)

www.americangeriatrics.org

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Reposted by John Newman, MD, PhD

The Buck Institute for Research on Aging @buckinstitute.org · Feb 28

Learn how to be your own geriatrician! Buck was thrilled to partner with Vivalon this week providing valuable info to older adults on how to best advocate for themselves in a medical system that often lets them down. Kudos to Dr. John Newman! www.youtube.com/watch?v=-6A-... @geriscidoc.bsky.social

Learn How to Be Your Own Geriatrician - The Buck Institute for Research on Aging at Vivalon

YouTube video by Vivalon

www.youtube.com

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Reposted by John Newman, MD, PhD

Benjamin Seligman @errorbars.bsky.social · Feb 26

Cuts to the VA research have been hard. I've lost colleagues, including one studying Veteran homelessness. But losing VA research hurts us all.
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(I'm expressing my own views and not necessarily those of the VA or the US government.)

Aidan Wright @aidangcw.bsky.social · Feb 25

NIH cuts are getting the press, but VA research is getting slashed too. What do we lose when VA research goes away? Here's some greatest hits: The nicotine patch, invention of the cardiac pacemaker, first successful liver transplant, development of the CAT/CT scan

prospect.org/health/2025-...

VA Research Funding Slashed

Though not as prominent as the NIH, VA researchers play a major role in advancing basic health science. Hundreds of projects have been cut.

prospect.org

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John Newman, MD, PhD @geriscidoc.bsky.social · Feb 24

Well done, Jade and @serogersmd.bsky.social! What a fantastic NIH-funded MSTAR project.

UCSF Geriatrics @ucsfgeriatrics.bsky.social · Feb 21

MSTAR student Jade Mulvey, Drs. Stephanie Rogers (@serogersmd.bsky.social), James Harrison, & team published in *Journal of Nursing Care Quality*: "Mobility Loss in Hospitalized Adults Predicts Poor Clinical Outcomes." Read more: https://buff.ly/4gMdxpr #geriatrics #nursing

Mobility Loss in Hospitalized Adults Predicts Poor Clinical ... : Journal of Nursing Care Quality

as used. Patients were categorized into 3 groups (gain, loss, no change in mobility) using the Johns Hopkins Highest Level of Mobility (JH-HLM) scores. The association between mobility loss and falls...

buff.ly

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Reposted by John Newman, MD, PhD

UCSF Geriatrics @ucsfgeriatrics.bsky.social · Feb 14

📢 Save the date! The 2025 California Academic Geriatrics Institutions (CAGI) Conference is happening May 30 at UC Irvine. Join geriatrics professionals from across CA to connect & collaborate. Coordinated with support from Drs. Todd James (@Geri_IPE) & @susanschneiderucsf.bsky.social! #CAGI2025

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Reposted by John Newman, MD, PhD

The Buck Institute for Research on Aging @buckinstitute.org · Feb 13

Our CEO, Eric Verdin answered questions about the administration’s proposed budget cuts to the NIH at a hearing before the Senate Special Committee on Aging this afternoon. Hear his exchange with Angela Alsobrook D-MD here: youtu.be/XrhHldez1AI

Eric Verdin, MD, President of the Buck Institute in hearing of the Senate Special Committee on Aging

YouTube video by Buck Institute for Research on Aging

youtu.be

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John Newman, MD, PhD @geriscidoc.bsky.social · Feb 12

Just two more days to apply to UCSF MSTAR! Applications due Friday Feb 14. A unique opportunity for medical students to immerse themselves in aging research!

John Newman, MD, PhD @geriscidoc.bsky.social · Jan 31

Calling all medical students - aging research needs you! Apply now for UCSF 2025 MSTAR summer research program. Learn from all-star mentors how to solve the most meaningful and complex problems facing society. Apps open now, due Feb 14. #Geriatrics #Aging geriatrics.ucsf.edu/education/me...

MSTAR | Geriatrics

The MSTAR program at UCSF is a summer research practicum in San Francisco, CA, designed to immerse first year medical students in aging research.

geriatrics.ucsf.edu

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Reposted by John Newman, MD, PhD

John Newman, MD, PhD @geriscidoc.bsky.social · Jan 31

Calling all medical students - aging research needs you! Apply now for UCSF 2025 MSTAR summer research program. Learn from all-star mentors how to solve the most meaningful and complex problems facing society. Apps open now, due Feb 14. #Geriatrics #Aging geriatrics.ucsf.edu/education/me...

MSTAR | Geriatrics

The MSTAR program at UCSF is a summer research practicum in San Francisco, CA, designed to immerse first year medical students in aging research.

geriatrics.ucsf.edu

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John Newman, MD, PhD @geriscidoc.bsky.social · Jan 31

Lots more details on the UCSF MSTAR website, including instructions and tips to write a strong application. We're looking for students passionate about aging research and care of older adults. Join MSTAR!

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John Newman, MD, PhD @geriscidoc.bsky.social · Jan 31

MSTAR includes summer research support, lecture series, meet-the-profs discussions, a symposium for you, and clinical shadowing in geriatric medicine. You can even co-mentor a high school student. And you will submit your data to present at the national #AGS meeting!

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John Newman, MD, PhD @geriscidoc.bsky.social · Jan 31

MSTAR projects span the entire aging research field, basic science to clinical research, quantitative to qualitative. Over 70 volunteer faculty mentors, including geriatricians, geroscientists, dermatologists, intensivists, & many other subspecialists who focus on older adults.

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John Newman, MD, PhD @geriscidoc.bsky.social · Jan 31

Calling all medical students - aging research needs you! Apply now for UCSF 2025 MSTAR summer research program. Learn from all-star mentors how to solve the most meaningful and complex problems facing society. Apps open now, due Feb 14. #Geriatrics #Aging geriatrics.ucsf.edu/education/me...

MSTAR | Geriatrics

The MSTAR program at UCSF is a summer research practicum in San Francisco, CA, designed to immerse first year medical students in aging research.

geriatrics.ucsf.edu

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Reposted by John Newman, MD, PhD

Ken Covinsky @kencovinsky.bsky.social · Jan 26

I strongly support the NIH Diversity Supplement Program. Addressing the severe lack of diversity among biomedical researchers improves the quality of research. It's not a level playing field. This program helps restore equity through mentored training. Rescinding this program is a big mistake

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Reposted by John Newman, MD, PhD

Eric Widera, MD @ewidera.bsky.social · Jan 22

What other departments or divisions are doing faculty sessions on teaching how to get on BlueSky? @ucsfgeriatrics.bsky.social is! Thanks @lwaltermd.bsky.social for setting this up! #geriatrics #gerisky

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Reposted by John Newman, MD, PhD

The Buck Institute for Research on Aging @buckinstitute.org · Dec 19

Thrilled to announce up to $52M award from ARPA_H for groundbreaking PATH program: Personalized Analytics for Transforming Health. Along with our strategic partner Phenome Health our aim is to predict and prevent diseases to increase individual #healthspan. www.buckinstitute.org/news/buck-in...

Buck Institute and Phenome Health Awarded up to $52M from ARPA-H

Award Aims to Transform Healthcare with Personalized Analytics

www.buckinstitute.org

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Reposted by John Newman, MD, PhD

Kenny Wilson @kennywilson.bsky.social · Dec 3

Since I've met many new people on @bsky.app, I wanted to re-share this paper we published earlier this year in @naturecomms.bsky.social! We found OXR1, which regulates #longevity and #brainaging through neuronal endocytic recycling. Read below for a summary 👇
www.nature.com/articles/s41...
#GeroSky

OXR1 maintains the retromer to delay brain aging under dietary restriction - Nature Communications

Dietary restriction promotes healthy brain aging, but the mechanism is unknown. Here, the authors show that OXR1 is upregulated by dietary restriction and confers age-related neuroprotection by m...

www.nature.com

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Reposted by John Newman, MD, PhD

Bluesky @bsky.app · Dec 3

Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪

Altmetric @altmetric.com · Dec 3

There are already many articles for which there is more attention on Bluesky than on other comparable micro-blogging sites, meaning the academic community and the general public have clearly adopted Bluesky as one of its core places to disseminate and discuss new research.

A Place of Joy.

‘A place of joy’: why scientists are joining the rush to Bluesky
Researchers say the social-media platform — an alternative to X — offers more control over the content they see and the people they engage with.: https://www.nature.com/articles/d41586-024-03784-6

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John Newman, MD, PhD @geriscidoc.bsky.social · Dec 2

Our latest work: a new link between metabolism and proteostasis, relevant to Alzheimer's disease. Out today in Cell Chemical Biology as open access! Stay tuned for more discussion of what we found and what it means... @buckinstitute.bsky.social @cellpress.bsky.social
www.cell.com/cell-chemica...

β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain

Madhavan et al. identify and characterize the selective regulation of protein solubility by the ketone body β-hydroxybutyrate (βHB) across a range of models. βHB exposure rescues cell-based and C. ele...

www.cell.com

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