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Emily Goldberg @dremilygoldberg.bsky.social · 16d

Thanks Matt, didn't realize you were in the e-audience!

Reposted by Emily Goldberg

Vijay Ramani @vram142.bsky.social · 18d

Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up!
www.biorxiv.org/content/10.1...
A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)

The eukaryotic replisome intrinsically generates asymmetric daughter chromatin fibers

DNA replication is molecularly asymmetric, due to distinct mechanisms for lagging and leading strand DNA synthesis. Whether chromatin assembly on newly replicated strands is also asymmetric remains un...

www.biorxiv.org

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Emily Goldberg @dremilygoldberg.bsky.social · 18d

##caturday blep

Orange cat caught with the tip of his tongue sticking out

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Reposted by Emily Goldberg

Stand Up for Science! @standupforscience.bsky.social · 21d

You asked for it! We delivered Quack-O-Grams to our members of Congress urging them to #ImpeachRFK, and get that Quack out of office!

There's still time for you to get in on this fluffy, feathery action: Send your own duck at zurl.co/W1ZnB and keep the momentum going! 🦆

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Emily Goldberg @dremilygoldberg.bsky.social · Sep 7

Courage is contagious. Visibly fighting back empowers others to do the same

Senator Scott Wiener @scottwiener.bsky.social · Sep 7

.@ezraklein is right: We need to take risks to stop this creeping fascism. Saying no — whether states, Democrats in Congress, universities, health systems, law firms — is scary & painful. But it’s our only option. Otherwise fascism is normalized. We can’t let that happen.

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Emily Goldberg @dremilygoldberg.bsky.social · Sep 5

Send quack-o-grams to your congress members

Colette Delawalla @cdelawalla.bsky.social · Sep 4

🐥If this Senate hearing with Bobby "The Quack" Jr pissed you off, send a message: Quack-O-Gram delivery begins on 9/15🐥

🐥 $3. Man in a duck suit. Rubber duck with "impeach the quack" message to YOUR Rep🐥

Link: www.standupforscience.net/quack-o-grams
#ImpeachTheQuack
@standupforscience.bsky.social

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Emily Goldberg @dremilygoldberg.bsky.social · Aug 24

PUT YOUR ACTIVISM SHOES ON

Colette Delawalla @cdelawalla.bsky.social · Aug 23

As one can imagine, I have some thoughts. Here’s a thread no one asked for:

1. SCIENCE IN THE US IS POLITICAL. No matter how much you want to ignore that fact, it is supported by taxpayer dollars and is therefore, political by nature.

2. BUT it has had bipartisan support for decades, which…

The Atlantic @theatlantic.com · Aug 23

For some scientists fighting partisan attacks, the goal is to defend their work from political interference. But in retaliating, @katherinejwu.com reports, they also run the risk of advancing the narrative that they want to fight.

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Emily Goldberg @dremilygoldberg.bsky.social · Aug 24

Especially important to read the fine print on who's paying for the flyers in your mailbox during contentious elections

Alissa McLean @alissakmclean.bsky.social · Aug 23

🚨📣 HEADS UP, Californians! 📣🚨

This absolute nonsense propaganda is coming to your mailbox, and you need to see it for what it is and warn everyone you know: (1/x)

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Reposted by Emily Goldberg

@LaBonneLaB @labonnelab.bsky.social · Aug 23

💯this. The window for stopping the total destruction of US science is short - ask a scientist in Hungary. This is a time for bravery, resolve and action, not for putting your head down and “focusing on the science”. We need all hands on deck.

Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · Aug 23

If you believe that data, evidence and expertise should inform policy, then you should fight for it.

And that may make you an activist (temporarily), but that’s where we are now.

Otherwise, we will lose the very institutions that contributed to this country’s cultural and economic success.

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Emily Goldberg @dremilygoldberg.bsky.social · Aug 21

I'm certain there are Etsy shops that can do this!

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Emily Goldberg @dremilygoldberg.bsky.social · Aug 20

This matches a bunch of data we generated showing that knocking down or inhibiting acyltransferases does not impact global protein lactylation levels. Read the paper (open access!) to get more detail about why we think this pathway is so interesting and physiologically relevant! And more to come!

western blot image showing that knockdown of p300, CBP, or HBO1 do not influence protein lactylation

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Emily Goldberg @dremilygoldberg.bsky.social · Aug 20

Cultured cells contain lactylated proteins but adding HDAC inhibitors reduces this. Importantly, this inhibition is independent of intracellular lactate or lactyl-CoA concentrations (thank you @mzspectrum.bsky.social for helping with this!). We uncoupled Kla from lactyl-CoA!

(A) Western blot showing that culturing cells with HDAC inhibitors blocks Kla (protein lactylation) formation, independent experiments are quantified in (B). (E) Intracellular lactate concentrations and (F) lactyl-CoA concentrations were not altered by HDAC inhibitor treatment

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Emily Goldberg @dremilygoldberg.bsky.social · Aug 20

We established biochemically that HDACs can indeed catalyze the lactylation of proteins. A lysine protection assay with fluorescent peptide also revealed the reaction can occur well within physiological lactate levels, making this basally more likely than the proposed lactyl-CoA mechanism

(A) Western blot of in vitro reconstitution assay showing that recombinant HDACs can lactylate protein. (B-C) Schematic and results of lactylation kinetics of an H3K9 peptide

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Emily Goldberg @dremilygoldberg.bsky.social · Aug 20

This is a follow up to our prior work where we published our discovery about HDACs beta-hydroxybutyrylating proteins

www.nature.com/articles/s41...

Reversible histone deacetylase activity catalyzes lysine acylation - Nature Chemical Biology

Tsusaka et al. discover that histone deacetylases, which are well known to remove protein modifications, such as lysine acetylation and β-hydroxybutyrylation, can also reverse their chemical activity ...

www.nature.com

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Emily Goldberg @dremilygoldberg.bsky.social · Aug 20

Thrilled to finally write up a little thread on our recent paper with @gburslem.bsky.social describing how HDACs reversibility contributes to protein lactylation!

www.jbc.org/article/S002...

Cartoon illustrating our proposed pathway of HDAC reversibility to act as both a "writer" and "eraser" for protein acyl modifications

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Reposted by Emily Goldberg

George Burslem @gburslem.bsky.social · Aug 18

New paper online from our long-standing collaboration with @dremilygoldberg.bsky.social on lysine lactylation catalysed by HDACs! www.jbc.org/article/S002...

Class I histone deacetylases catalyze lysine lactylation

Metabolism and post-translational modifications (PTMs) are intrinsically linked and the number of identified metabolites that can covalently modify proteins continues to increase. This metabolism/PTM ...

www.jbc.org

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Reposted by Emily Goldberg

Gen Wojcik @genandgenes.bsky.social · Aug 18

There is no common ground with those who don't see you as a full human being. You can't change minds but you can make their goals untenable. While the attention economy has rotted our collective brains, use it. Fight smarter and be vicious.

There is no high road in hell.

Prisonculture @prisonculture.bsky.social · Aug 17

What's your take on the moment we're living through in 50 words or less. [you able to quote post]

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Reposted by Emily Goldberg

Caroline Bartman @cbartman.bsky.social · Aug 15

Happy to get to contribute to this perspective in JEM!

Journal of Experimental Medicine @jem.org · Aug 15

#WomenInSTEM becoming independent: People should feel free to be themselves and do great science. We asked ten women researchers about their science and the process of setting up a lab as an independent researcher: rupress.org/jem/article/...

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Reposted by Emily Goldberg

Journal of Experimental Medicine @jem.org · Aug 15

Thank you @sophialiu.bsky.social, Margarida Saraiva, @cbartman.bsky.social, Nathalie Saurat, @pcrosato1.bsky.social, @licona-limonlab.bsky.social, @thepenkpanther.bsky.social, @guthmillerjenna.bsky.social, @coraline-mly.bsky.social, and @dremilygoldberg.bsky.social! rupress.org/jem/article/...

Women in STEM becoming independent: People should feel free to be themselves and do great science | Journal of Experimental Medicine | Rockefeller University Press

In this viewpoint, we hear from a cross section of women, across multiple research fields, discussing their science and the process of setting up a lab as

rupress.org

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Reposted by Emily Goldberg

Tressie McMillan Cottom @tressiemcphd.bsky.social · Aug 15

Firing and demoralizing feminized jobs as enemies of the state while brazenly bribing men with violent jobs that almost instantly puts them into the middle of middle class is very basic gendered warfare. Fulfilling the manosphere’s promise.

Santiago Mayer @santiagomayer.com · Aug 15

It is insane to me that the government can find money to pay ICE agents increasingly larger sums of money, yet teachers have to buy their own pencils.

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Emily Goldberg @dremilygoldberg.bsky.social · Aug 14

I had fun thinking about this and reading the advice from other women that I really respect! Thank you @jem.org for the opportunity.

Find your people and do science with your friends

Lucie Van Emmenis @lucie-jexpmed.bsky.social · Aug 11

The first Viewpoint in our 2025 #WomenInSTEM series is up! Take a look here 👉 hubs.la/Q03BYXzY0

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Reposted by Emily Goldberg

BK. Titanji @boghuma.bsky.social · Aug 12

They recovered over 180 bullet shells at the CDC. Debris from shattered glass is still being cleaned up. I am completely stunned at how quickly the news cycle has moved on. This was an act of terrorism targeting public health experts, and the response seems to be a collective shrug.

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Reposted by Emily Goldberg

Danielle L. Schmitt 🔬 @schmittwitt.bsky.social · Aug 8

I never went into academic science because I wanted to be wealthy—I fully knew the opposite is true. Instead I went into academic science because I have a lot of questions about how our cells work and I enjoy mentoring young scientists.

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Reposted by Emily Goldberg

Kate Starbird @katestarbird.bsky.social · Aug 4

I’ve been having a few too many conversations like this. Them: Hi Kate, how are things with your work, with the world? Me: the university is under attack, democratic norms being broken in half, so, pretty bad. Them: But everything is going to come back and be okay after the midterms. Me: Uhh, no.

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Reposted by Emily Goldberg

Jenna Norton @jenna-m-norton.bsky.social · Aug 3

Many of us have long been worried about the harm of the 50% multiyear funding (MYF) requirement.

When NCI published their payline at 4% AND cited MYF as the cause, I thought: “Someone in NCI is a hero. They took a huge risk to make the community aware.”

www.cancer.gov/grants-train...

Funding Policy - Research Grants

NCI funding policy for research project grant (RPG) awards reflects the funding goals of the institute, NIH, and HHS.

www.cancer.gov

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